Beck(Daniel E),Lv(Wei),Abdelmalak(Monica),... Bioorg Med Chem 2016-11-08

...Top1) poisons. A number of strategies were employed in the present investigation to enhance the Top1 inhibitory potencie...

Zhao(Wuli),Zhang(Caixia),Bi(Chongwen),Ye(C... Onco Targets Ther 2016-06-09

...top1) activity by stabilizing DNA-top1 complex and induce mitochondria-mediated apoptosis by promoting DNA single- and d...

Bacilieri(Magdalena),Paoletta(Silvia),Basi... Mol Inform 2016-07-30

...Top1) selective inhibitors. The CPT analogs dataset has been recently analyzed by Hansch and Verma using a classical 2D-...

Tangeman(Larissa),McIlhatton(Michael A),Gr... Genes (Basel) 2016-09-23

...TOP1) in the nucleolus. The mechanisms regulating localization of BLM to the nucleolus are unknown. In this study, we id...

Weinstein(Justin),Rothstein(Rodney) DNA Repair (Amst) 2015-01-16

...Top1 activity, sgs1 mutants are severely growth impaired. Here, we investigate the role of Sgs1 helicase activity and it...

Zhi(Yi),Yang(Jin),Tian(Shengchao),Yuan(Fan... Int J Mol Sci 2015-10-26

...Top1 inhibitory activity in human renal cell carcinoma cell line SN12C were selected to establish 3D-QSAR models using C...

Veloso(Artur),Biewen(Benjamin),Paulsen(Mic... PLoS One 2015-02-24

The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalent...

Wang(W-L),Huang(H-C),Kao(S-H),Hsu(Y-C),Wan... Oncogene 2015-04-24

...TOP1, DNA Ligase IV and Rad17, reduces cell proliferation, delays S-phase progression and contributes to genome instabil...

Powers(James F),Korgaonkar(Parimal G),Flie... PLoS One 2015-05-22

...TOP1) inhibitors are drugs that interfere with mechanisms that maintain DNA integrity during transcription in both quies...

Wright(Christine M),van der Merwe(Marié),D... J Biol Chem 2015-08-03

...Top1 share a common reaction mechanism and domain structure. However, the human Top1 is ∼100-fold more sensitive to CPT....