Marinello(Jessica),Bertoncini(Stefania),Al... PLoS One 2016-08-04

...Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1...

Zubovych(Iryna O),Sethi(Anirudh),Kulkarni(... Mol Cancer Ther 2016-10-18

...Top1) but not topoisomerase 2. SW044248 inhibited Top1 differently from camptothecin and camptothecin did not show the s...

Cristini(Agnese),Park(Joon-Hyung),Capranic... Nucleic Acids Res 2016-07-06

...Top1cc and show that those DSBs are generated during Top1cc repair from Top1 peptide-linked DNA single-strand breaks gen...

Sakasai(Ryo),Iwabuchi(Kuniyoshi) Genes Genet Syst 2016-10-13

...Top1) through a non-catalytic mechanism that stabilizes the Top1-DNA cleavage complex (Top1cc) and blocks the DNA re-lig...

Yadav(Puja),Owiti(Norah),Kim(Nayun) Nucleic Acids Res 2016-06-20

...Top1. Together, our data provide a strong support for a function of Top1 in suppressing genome instability at the guanin...

Zhao(Wuli),Jiang(Guohua),Bi(Chongwen),Li(Y... Oncotarget 2016-09-20

...top1 and top2α. Here, we validated cyclizing-berberine A35, which is a dual top inhibitor and preferentially targets top...

Baranello(Laura),Wojtowicz(Damian),Cui(Kai... Cell 2016-08-31

...TOP1 activity using topoisomerase 1 sequencing (TOP1-seq), a method reported here to map catalytically engaged TOP1, TOP...

Tsyganov(M M),Rodionov(E O),Miller(S V),Li... Antibiot Khimioter 2016-06-09

...TOP1, TOP2a, TUBB3 and TYMS are characteristic of lung cancer. Clinical trials demonstrating the efficiency of their use...

Rialdi(Alex),Campisi(Laura),Zhao(Nan),Lagd... Science 2016-07-25

...Top1 protected mice from death in experimental models of lethal inflammation. Our results indicate that Top1 inhibition ...

Dahmane(Narimane),Gadelle(Danièle),Delmas(... Nucleic Acids Res 2016-08-24

...Top1 inhibitors, LMP744 and lamellarin D. This newly described thermostable topoisomerases IB should be a promising new ...