Ojini(Irene),Gammie(Alison) G3 (Bethesda) 2016-06-02

...TOP1 resistance targets for two compounds, canavanine and camptothecin, respectively. We have also experimentally valida...

Venkat Reddy(Putta),Reddy(Mallepally Rajen... Anal Biochem 2016-04-06

...TOP1 was performed using LibDock.

Reisen(Felix),Sauty de Chalon(Amelie),Pfei... Assay Drug Dev Technol 2016-08-12

...TOP1, HMGCR, TUB), signaling pathways (e.g., PIK3/AKT/mTOR), or gene sets associated with diseases (e.g., psoriasis, leu...

Xu(Yang),Her(Chengtao) Biomolecules 2016-03-25

...TOP1) and its inhibitors, as well as the underlying DNA repair pathways and the use of TOP1 inhibitors in cancer therapy...

Gou(Wen-feng),Shen(Dao-fu),Yang(Xue-feng),... Oncotarget 2016-05-23

...TOP1, TOP2, MLH1, MRP1, BRCP1 and GST-π). ING5 expression was higher in gastric cancer than matched mucosa. It was inver...

Iannascoli(Chiara),Palermo(Valentina),Murf... Nucleic Acids Res 2016-03-29

...TOP1 inhibitor camptothecin, loss of the WRN exonuclease resulted in enhanced degradation and ssDNA formation at nascent...

Lee(Yu-Chieh),Lee(Chii-Hong),Tsai(Hsiang-P... PLoS One 2016-05-01

...TOP1) levels of several human neoplasms are higher than those of normal tissues. TOP1 inhibitors are widely used in trea...

Yu(Le-Mao),Zhang(Xiao-Ru),Li(Xiao-Bing),Ya... Eur J Med Chem 2016-05-24

...Top1 catalytic inhibitors. Top1-mediated unwinding assay demonstrated that 14, 22 and 26 were Top1 catalytic inhibitors ...

Yadav(Puja),Harcy(Victoria),Argueso(Juan L... PLoS Genet 2016-01-29

...Top1, a G4 DNA-forming sequence becomes a strong hotspot of gross chromosomal rearrangements and loss of heterozygosity ...

Kaur(Gurmeet),Reinhart(Russell A),Monks(An... Cancer Lett 2016-06-14

...TOP1 mRNA expression or topoisomerase 1 and topoisomerase 2 protein did not account for the range in the sensitivity to ...