Nakatani(Rie),Nakamori(Masayuki),Fujimura(... Sci Rep 2016-04-05

...TOP1) and TDP1, which are involved in single-strand break repair, enhanced large repeat contractions. Furthermore, knock...

Villalobos(Xenia),Rodríguez(Laura),Solé(An... Nucleic Acid Ther 2016-04-15

...TOP1, mTOR, MDM2, and MYC and tested them for mRNA levels, cytotoxicity, and apoptosis in prostate, pancreas, colon, and...

Xu(Yang),Her(Chengtao) Biomolecules 2016-03-25

...TOP1) and its inhibitors, as well as the underlying DNA repair pathways and the use of TOP1 inhibitors in cancer therapy...

Seol(Yeonee),Zhang(Hongliang),Agama(Keli),... Mol Cancer Ther 2016-09-06

...Top1 inhibitors. Using this assay, we determined the effects on Top1 supercoil relaxation activity of four Top1 inhibito...

Majumdar(Papiya),Bathula(Chandramohan),Bas... Eur J Med Chem 2016-06-14

...Top1 (HTop1) through stabilization of Top1-DNA cleavage complexes and showed selective anticancer activity against human...

Sønderstrup(Ida Marie Heeholm),Nygård(Sune... Mol Oncol 2016-02-08

...TOP1, CEN20, TOP2A and CEN17 status was previously published for this cohort.,The observed TOP1 gene copy numbers in the...

Li(Min),Pokharel(Subhash),Wang(Jiin-Tarng)... Nat Commun 2016-04-05

...TOP1 SUMOylation by facilitating the interaction between PIAS1, SRSF1 and TOP1. Unexpectedly, the topoisomerase activity...

Zakharenko(Alexandra),Khomenko(Tatyana),Zh... Bioorg Med Chem 2016-02-12

...Top1 poison-mediated DNA damage. Several novel benzopentathiepines were synthesized and tested as inhibitors of TDP1 usi...

Andersen(Sabrina L),Sloan(Roketa S),Petes(... PLoS Genet 2016-03-24

...Top1 is the covalent attachment of Top1 to the cleaved DNA. The resulting Top1 cleavage complex (Top1cc) is usually tran...

Zhao(Wuli),Jiang(Guohua),Bi(Chongwen),Li(Y... Oncotarget 2016-09-20

...top1 and top2α. Here, we validated cyclizing-berberine A35, which is a dual top inhibitor and preferentially targets top...