Shapiro(J),Greenfield(B),Cohen(I),Dodiuk-G... Diagnostics (Basel) 2026-01-25

...Top1 (exact match), Top3 (correct within top three), Partial, or No match. Results: The study included 154 image descrip...

Takefuji(Y) Mar Pollut Bull 2026-05-00

...top1-out procedure to test ranking stability. Random Forest and XGBoost with and without SHAP show pronounced instabilit...

Jha(RK),Kouzine(F),Wang(B),Phelan(JD),Das(... bioRxiv 2026-01-19

...TOP1 either through genetic knockdown or low-dose inhibition potentiates transcription amplification by MYC. This enhanc...

Wang(S),Xiang(Z),Wang(K),Nian(X),Song(Y),W... Water Res 2026-08-15

...Top1 branch localization reached 100%. Sensitivity analyses further showed that larger inflow magnitudes and hydraulical...

Wang(W),Li(D),Liu(J),Li(L),Zhang(Q),Zhang(... J Med Chem 2026-08-13

...TOP1/PARP1 inhibitors that simultaneously induce SSBs via TOP1 inhibition and block their repair via PARP1 inhibition, c...

Liao(L),Tang(Z),Luo(P),Tang(R),Li(H),He(G)... Toxicol Appl Pharmacol 2026-10-00

...TOP1 and CDK2 mRNA, decreased the Bcl-2/Bax ratio, and increased cleaved caspase-3 levels. Quantitative validation by Ed...

Chiappa(M),Villa(V),Sias(F),Grasselli(C),S... Exp Hematol Oncol 2026-09-15

...TOP1i) emerged as the most effective partner. The combination of TOP1 inhibitors with PARPi showed strong synergistic an...

Martínez-Esquivias(F),Pech-Santiago(EO),Gu... Curr Comput Aided Drug Des 2026-05-13

...TOP1 is associated with B-cell and macrophage infiltration. Finally, molecular docking and molecular dynamics confirm st...

Liang(K),Zhou(X),Li(H),Lu(Y),Zhang(F),Zeng... Bioconjug Chem 2026-06-17

...TOP1) inhibitor-based ADC. We found that elevated column temperature used in the RP-HPLC method induced payload detachme...

Bournique(E),Sanchez(A),Ha(K),Yan(KM),Manj... Nucleic Acids Res 2026-05-20

...TOP1) inhibition is strongly increased when cells are treated in combination with PARP inhibitors. Mechanistically, we d...