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Development of PROTACs for targeted degradation of oncogenic TRK fusions.

Kumar(S),Jiang(J),Donald-Paladino(MS),Chen... RSC Chem Biol 2026-04-16

...TPM3-TRKA fusion. JWJ-01-378 induced TPM3-TRKA degradation through the ubiquitin-proteasome system and proteomics analys...

Minimal residual disease assessment through ctDNA facilitates tailored immuno...

Rohlfing(S),Vladimirova(D),Berger(S),Bochu... Oncologist 2026-04-10

...TPM3-NTRK1 fusion, monitored through 13 serial liquid biopsies over 3 years. Dynamic changes in NTRK1-fusion allele freq...

TPM4::ALK Rearranged Cutaneous Epithelioid Vascular Tumor: A Case Report.

Wang(JS),Billings(SD),Ronen(S),McAfee(J),D... J Cutan Pathol 2026-07-00

...TPM3/4::ALK fusions have recently been added to this list, in a cohort of five cases. Herein, we report the sixth case (...

Oxidative stress-mediated cardio- and neurotoxicity of 2-ethylhexanol in Daph...

Eghan(K),Lee(S),Kamrus(AS),Lee(S),Kim(WK) Environ Pollut 2026-06-01

...tpm3) and neurotoxicity-related genes (drd2, slc6a3, and slc6a6) indicated mechanistic links to oxidative stress-mediate...

Transcriptional profiles of skeletal muscles from 11 different anatomical loc...

Kong(F),Wu(X),Zeng(B),Qi(X),Liu(Z),Yang(R)... Genomics 2026-05-00

...TPM3, TNNT1, TNNI1, TNNC1, MYL3, and MYL10 may serve as potential indicators of slow-twitch muscle in chicken. Collectiv...

Immunohistochemistry-Based Screening for Targetable Kinase Alterations in Non...

Sakamoto(K),Ko(K),Yoshioka(T),Morimoto(A),... Virchows Arch 2026-04-13

...TPM3::NTRK1, with RNA-based sequencing being limited by specimen quality in some cases, while DNA-based comprehensive ge...

Molecular landscape and biomarker associations of functional NTRK fusions: a ...

Zhou(J),Zong(Q),Sun(R),Wang(X),Huang(M),Yu(W) Transl Cancer Res 2026-03-31

...TPM3 and ETV6 were the most common gene fusion partners, with ETV6 being enriched in NTRK3 fusions. MSI-high (MSI-H) sta...

Targeted therapy for ALK-positive histiocytosis masquerading as optic nerve t...

Datta(D),Nzau(M) Childs Nerv Syst 2026-03-09

...TPM3-ALK, and others, leading to constitutive activation of downstream signaling pathways such as MAPK and PI3K/AKT/mTOR...

Congenital mesoblastic nephroma: a single-center retrospective study.

Li(J),Yan(M),Hu(T),Wu(L),Zhou(C),Zhao(Q),S... Transl Pediatr 2026-02-28

...TPM3::NTRK1 and EGFR-kinase domain duplication (EGFR-KDD), respectively. All patients underwent surgical resection with ...

HIF-1-regulated TPM3 links hypoxia to motility and invasion beyond the hypoxi...

Zhou(C),Crusher(JT),Friesen(K),Twigger(SA)... NPJ Breast Cancer 2026-03-14

...TPM3), an actin-binding protein that regulates filament stability. TPM3 is significantly upregulated in breast cancer, i...

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