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Integrated Multi-Omics and Spatial Transcriptomics Identify FBLL1 as a Malign...

Xie(J),Guo(S),Xiao(Y),Zhang(Y),Hong(A),Che... Cells 2026-01-27

...TCGA and ICGC cohorts, FBLL1 was identified as a key prognostic candidate gene. Its cellular and spatial distribution wa...

CD74-Targeted Cathepsin-Inhibitor Antibody-Drug Conjugate Triggers Apoptosis ...

Abd-Elrahman(I),Khairi(N),Sinai-Turyansky(... Cells 2026-02-04

...TCGA and GTEx) revealed that both CD74 and Cathepsin L (CTSL) are significantly overexpressed in diffuse large B-cell ly...

Establishment and validation of a prognostic model for oral squamous cell car...

Cai(L),Tang(E),Zhang(H),Wang(Y),Cai(Y) Discov Oncol 2026-02-12

...TCGA) OSCC cohort (328 OSCC samples and 32 control samples) and Gene Expression Omnibus datasets (GEO, GSE2355827: 27 OS...

Pan-cancer multi-omics dissection of podosome-related genes reveals their dua...

Xu(D),He(Y),Zhao(P),Liao(C),Tan(J) Discov Oncol 2026-02-12

...TCGA, GTEx, GDSC, TIDE, and CancerSEA. We integrated expression profiles with somatic mutations, DNA methylation, and co...

Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulat...

Machado(AL),Pinto(A),Carvalho(J),Fernandes... Cell Oncol (Dordr) 2026-02-12

...TCGA and GTEx transcriptomic data from 11,735 samples was analyzed to conduct an integrative assessment of key cholester...

Integrated analysis of glutamine metabolism and immune microenvironment ident...

Pan(X),Ye(T),Liu(J),Zheng(X) Discov Oncol 2026-02-12

...TCGA). A comprehensive evaluation of 21 glutamine metabolism-related genes in HNSCC tissues was conducted. A risk model ...

Influence of the tumor microenvironment on genetic mutations in thyroid carci...

Zhou(L),Xu(S),Song(Y),Jiang(D),Chen(S) PLoS One None

...TCGA) database. The ESTIMATE algorithm was first applied to calculate ImmuneScores and StromalScores. Samples were subse...

Targeting the ANXA2-CD63-exosomal PD-L1 axis in hepatocellular carcinoma: A n...

Zhang(J),Gu(Y),Zhao(F),Chen(Y),Xia(Y),Gao(... Neoplasia 2026-03-00

...TCGA) showed ANXA2 upregulation in HCC, correlating with fewer CD8⁺ T cells and poor survival. ANXA2 knockout (KO) in He...

Integrated bioinformatics and experimental validation identify CCDC78 as a pr...

Mo(Q),Du(M),Zheng(J),Yu(J),Ma(Z),Zhuang(S)... Sci Rep 2026-02-12

...TCGA)-COAD cohort and GSE39582 database, revealed CCDC78 overexpression correlated with advanced TNM stages (p < 0.001),...

Functional role of deubiquitinating enzyme USP39 in inhibiting pyroptosis in ...

Ji(X),Chai(T),Chen(X),Deng(J),Zhong(X),Gao... J Mol Histol 2026-02-13

...TCGA, GTEx, and GSE138702 datasets were applied for analysis of USP family genes differentially expressed. The biologica...

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