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The Oligomeric State of Rad6-Rad18 and Its Interactions with Translesion Synthe…

Woodward(TJ),Ripley(BM),Ling(JA),Washington(… Biomolecules 2026-08-12

Translesion synthesis is a major DNA damage bypass pathway in which specialized DNA polymerases, such as pol η and Rev1,...

Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadr…

Ketkar(A),Paxton(BC),Zuniga(OE),Sewilam(RS),… Nucleic Acids Res 2026-06-08

...REV1 is central to coordination of G4 resolution, replication fidelity, and tolerance of G4 stabilization. REV1 loss swi...

Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus u…

Bezalel-Buch(R),Stith(C),Makarova(AV),Binz(S… Nucleic Acids Res 2026-06-08

...Rev1's single BRCT domain, is required for the inhibitory activity of Rev1 on undamaged DNA. Mutations in the M1 motif r...

Mapping the genetic landscape of the DNA damage response with Cas12a-based comb…

Hayward(SB),Vaitsiankova(A),Lama-Diaz(T),Cho… bioRxiv 2026-06-08

...REV1-Pol ζ complex and the MCM8-MCM9-HROB DNA helicase complex; 2) Fanconi Anemia (FA) proteins and the mitotic DNA repa...

A sibling study of variation in parental mutation rates.

Getseva(V),Poyraz(P),Stolyarova(A),Agarwal(I… bioRxiv 2026-05-15

...REV1 and LIG1 increase germline mutation rates, and thus that rare mutator alleles segregate in population cohorts.

Targeted tumor starvation strategy augments radiosensitivity and enhances radio…

Zhang(Y),Liu(ZP),Zhang(ZY),Tian(J),Luo(RL),D… Acta Pharmacol Sin 2026-07-00

...Rev1 and SOD2, thereby impairing ROS scavenging and sensitizing tumor cells to RAI-induced oxidative stress. In vivo, th...

Conjunctival administration of H38ΔwbkF rough vaccine as an effective strategy …

Lopez(N),Andrés-Barranco(S),De Miguel(MJ),Zú… Vet Res 2026-03-08

...Rev1, protects against both infections but induces antibodies detected by S-LPS-based tests used for B. melitensis surve...

Elevated mutation in haploid yeast driven by error-prone Rev1 polymerase.

Fredette-Roman(J),Smith(DR),Omari(SB),Sharp(… Genetics 2026-07-15

...REV1+ haploids than in REV1+ diploids. Deleting the REV1 gene caused this difference to vanish, with mutation rates in h...

Pathogenesis of Brucella abortus and Brucella melitensis in bovine and ovine-de…

Elizalde-Bielsa(A),Loperena-Barber(M),Pfarre… Vet Res 2026-07-07

...Rev1 vaccine strain. Although its initial rate of infection was comparable to B. melitensis 16M, Rev1 exhibited a delay ...

Targeting MAD2L2-dependent translesion synthesis impairs DNA damage tolerance a…

Ayiku(PJ),Barda(N),Weiss(OE),Sherman(C),Litv… Front Cell Dev Biol None

...Rev1 axis was further supported by reduced formation of MAD2L2-Rev1 complexes, as assessed by proximity ligation assay. ...

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