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Uptake of cascade tests in relatives of patients undergoing cancer precision me…

Matsubayashi(H),Kiyozumi(Y),Ishihara(E),Hara… Jpn J Clin Oncol 2026-05-07

...RAD51C [1]. The 23 patients with GPVs had 43 relatives eligible for cascade test and 22 non-eligible relatives (includin...

Homologous recombination deficiency in primary ER-positive and HER2-negative br…

Davies(HR),Black(D),Kvist(A),Sigurjónsdóttir… Commun Med (Lond) 2026-02-16

...RAD51C/PALB2 together, providing a plausible HR-inactivation mechanism for 71.4% of HRD tumors. Our modelled estimate of...

Evaluation of homologous recombination testing in ovarian carcinoma.

Witjes(VM),de Hullu(JA),van Remortele(A),Vre… Virchows Arch 2026-04-00

...RAD51C promoter methylation and HRD was assessed in 244 samples without a PV in HRR genes. BRCA1/RAD51C promoter methyla...

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard ge…

Sahoo(S),Nagraj(T),Bhattacharya(D),Nagar(N),… Sci Adv 2026-02-20

...RAD51C-XRCC3 (CX3) complex of RAD51 paralogs participates in the FA pathway of R-loop tolerance mechanism. CX3 complex s...

[Hereditary breast cancer : Syndromes, pathology, clinical aspects].

Lebeau(A),Schmutzler(R) Pathologie (Heidelb) 2026-09-00

...RAD51C/D, BARD1) and genes associated with classic tumor predisposition syndromes (TP53, PTEN, STK11, CDH1, NF1) are ass...

Unravelling genetic susceptibility and causal factors in liver health using MRI…

Meena(D),Pansini(M),Fichera(A),Huang(J),Ahme… Hum Genomics 2026-02-28

...RAD51C) and proteins (e.g., RAB2B, GPN1, GSTM4) with putative mechanistic roles. Fine-mapping refined several signals (G...

Structural insight into how RAD51 paralog exchange regulates RAD51 filament for…

Rawal(Y),Kwon(Y),Jia(L),Ruben(EA),Ji(JH),Guo… Nat Struct Mol Biol 2026-05-00

...RAD51C, XRCC3, RAD51D and XRCC2. Here, using cryo-electron microscopy, we find that the RAD51-XRCC3-RAD51C complex (RAD5...

Immuno-molecular features associated with exceptional recurrence-free survivors…

Blanc-Durand(F),Yaniz Galende(E),Ferron(G),K… NPJ Genom Med 2026-04-23

...RAD51C promoter methylation assays, shallow whole genome and multiplex immunofluorescence. Homologous recombination defi...

BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments.

Koo(CW),Xiao(J),Coassolo(S),Liu(J),Yu(C),Azu… Nature 2026-05-00

...RAD51C-RAD51D-XRCC2 (BCDX2) and RAD51C-XRCC3 (CX3), that act independently at different stages of homologous recombinati...

The Impact of Conventional Chemotherapy Regimens and Targeted Drugs on Ovarian …

Haskoylu(S),Sahin(SB),Altıntas(A),Yildiz(S),… Reprod Sci 2026-04-00

...RAD51C, RAD51D, and TP53) to chemotherapy-induced gonadotoxicity remains unclear. Although animal data shows depletion o...

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