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RAD51 succinylation regulates homologous recombination and contributes to the...

Wang(Z),Jin(M),Zhai(L),Huang(B),Jin(X),Wan... Mol Cell 2026-02-19

...RAD51 succinylation. OXCT1 succinylates RAD51 at K285, whereas HDAC11 removes this modification. RAD51 succinylation dis...

The Contribution of Genetic Modifiers to Ovarian Cancer Risk in BRCA1 and BRC...

Cylwik(D),Dwornik(R),Białkowska(K) Cancers (Basel) 2026-01-23

...RAD51, and 9p22.2. The analysis identified 11 variants affecting both BRCA1 and BRCA2 carriers, most of which increase r...

Combination of PARP and KRASG12D inhibitors enhances therapeutic efficacy by ...

Xu(X),Chen(X),Xu(R),Huo(Z),Li(C),Nowsheen(... Nat Commun 2026-02-24

...RAD51, and RPA32, creating a state of HR deficiency that sensitizes PDAC cells to poly(ADP-ribose) polymerase (PARP) inh...

KLF11 interacts with MDM2 to stabilize E2F1 and promotes DNA damage repair to...

Xia(Y),Wang(J),Zhao(D),Li(Y),Li(S),Li(M),D... Pathol Res Pract 2026-04-00

...RAD51 was significantly elevated in ESCC and RT-resistant ESCC tissues. Mechanistically, KLF11 promotes MDM2 expression,...

Condensins regulate resection-dependent DNA double-strand break repair pathwa...

Liu(M),Wei(Y),Weber(LM),Mladenov(E),Lin(X)... Nucleic Acids Res 2026-02-05

...RAD51 and RPA70 foci formation in G2 confirmed inhibition of HR and DNA end resection. The G2 checkpoint was also compro...

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard ...

Sahoo(S),Nagraj(T),Bhattacharya(D),Nagar(N... Sci Adv 2026-02-20

...RAD51 paralogs have been identified in FA-like disorders and cancers. Although the role of RAD51 paralogs is well establ...

Single-cell transcriptomics reveals the toxic mechanism and therapeutic targe...

Feng(W),Zhang(D),Feng(H),Zhao(C),He(J),Tan... Phytomedicine 2026-04-00

...Rad51, and disrupted chromosome pairing. SCENIC regulatory network analysis suggested that KDM5A is functionally associa...

SFPQ Promotes Homologous Recombination via mRNA Stabilization of RAD51 and It...

Gotthold(S),Hansen(KR),Brown(AN),Chowdhury... J Mol Biol 2026-04-15

...RAD51 paralog mRNA stability rather than through direct interaction with DSBs or RAD51 proteins. Ultimately, our results...

ssDNA-PLA, a proximity ligation assay to interrogate DNA damage response prot...

Yang(Y),Li(Y),Sun(XX),Dai(MS) Biol Methods Protoc None

...RAD51, and BLM. This approach can be used for studying the proximity of proteins to ssDNA that play roles in DNA end res...

SeSA-HCPT: A dual-targeting agent that induces DNA damage and inhibits repair...

Wang(Y),Wang(Q),Meng(L),Lian(X),Wu(X),Wang... iScience 2026-02-20

...RAD51 recruitment. In a PC-3 xenograft model, SeSA-HCPT significantly inhibited tumor growth relative to the combination...

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