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Germline pathogenic variant spectrum and prevalence among colorectal cancer p...

Baltayev(N),Abdikerim(S),Afonin(G),Rasulov... Sci Rep 2026-04-14

...PMS1 c.1258delC, MLH1 c.1291_1292delAT, NBN c.877delA, and EPCAM c.184 + 1G > A. The observed prevalence of clinically a...

Human PMS1-dependent non-canonical mismatch repair engages with MBD4 to repai...

Le Ven(A),Vanhuele(S),Ganier(O),Houy(A),Ka... Nucleic Acids Res 2026-08-10

...PMS1) and MutSα (MSH2-MSH6). We uncover the physical interaction between MBD4 and MutLβ and demonstrate that MBD4-mediat...

Targeted quantification assays for DNA repair and handling proteins and inter...

Greco(TM),Hutton(JE),Justice(JL),Reed(TJ),... bioRxiv 2026-07-29

...PMS1 interactions. Overall, we established a validated, transferable assay for quantifying DNA R/H proteins in perturbat...

PMS1 loss defines distinct mismatch repair complex deficiencies across dog an...

Wilsker(D),Begum(A),Brooks(A),Parchment(RE... Mol Cancer Ther 2026-07-22

...PMS1 as the binding partner of MLH1 in dogs, rather than PMS2. A novel monoclonal antibody was developed to detect PMS1 ...

Targeting DNA mismatch repair in Huntington's disease.

Bunting(EL),Panhale(A),McColgan(P),Koi(M),... Trends Neurosci 2026-07-11

...PMS1 as therapeutic targets for slowing somatic expansion and outline key safety considerations for emerging MMR-modulat...

KLF7 as a biomarker for the pre-metastatic state promotes colorectal cancer l...

Fang(X),Huang(H),Zhao(Z),Yang(L),Huang(F),... Cancer Lett 2026-02-28

...PMS1 and PMS2). We revealed that PMS1 exhibits high epithelial-mesenchymal transition (EMT) characteristics and is assoc...

Mismatch repair MLH complexes make distinct contributions to post-replicative...

Casazza(KM),Williams(GM),Johengen(L),Kelle... bioRxiv 2026-01-23

...Pms1 or Mlh1-Mlh2 exhibiting the strongest effects. Mutations in PMS1 and MLH3 were synergistic. We propose a model in w...

Sex-biased transcriptomic landscapes in bipolar disorder: integrating neurobi...

Davarinejad(O),Moradi(MT),Safarzadeh(A),Ja... Biol Sex Differ 2026-05-08

...PMS1). Analysis of the striatum identified 289 differentially expressed genes. The most significantly upregulated genes ...

Mechanism of MutLβ-dependent DNA expansions.

Kadyrova(LY),Kadyrov(FF),Hayward(B),Usdin(... Proc Natl Acad Sci U S A 2026-04-28

...PMS1 heterodimer) is a poorly understood eukaryotic MutL complex. Recent genetic studies have implicated MutLβ in the pr...

Genomic Instability and Adaptive Evolution Induced by RFA Insufficiency in Sa...

Zhang(R),Tian(L),He(M),Li(K) Curr Issues Mol Biol 2026-01-30

...PMS1, to survive RFA-induced stress. This hypermutant phenotype grants a certain degree of growth recovery on Low Galact...

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