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High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemica…

Darrah(KE),Hemker(SL),Rawal(Y),Goff(NJ),Park… bioRxiv 2026-01-11

...RAD51C interface within the BCDX2 complex as essential for regulating its ATPase activity. We hypothesize that, paradoxi...

Uptake of cascade tests in relatives of patients undergoing cancer precision me…

Matsubayashi(H),Kiyozumi(Y),Ishihara(E),Hara… Jpn J Clin Oncol 2026-05-07

...RAD51C [1]. The 23 patients with GPVs had 43 relatives eligible for cascade test and 22 non-eligible relatives (includin...

Homologous recombination deficiency in primary ER-positive and HER2-negative br…

Davies(HR),Black(D),Kvist(A),Sigurjónsdóttir… Commun Med (Lond) 2026-02-16

...RAD51C/PALB2 together, providing a plausible HR-inactivation mechanism for 71.4% of HRD tumors. Our modelled estimate of...

Evaluation of homologous recombination testing in ovarian carcinoma.

Witjes(VM),de Hullu(JA),van Remortele(A),Vre… Virchows Arch 2026-04-00

...RAD51C promoter methylation and HRD was assessed in 244 samples without a PV in HRR genes. BRCA1/RAD51C promoter methyla...

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regula…

Hale(A),Nusawardhana(A),Straka(J),Nicolae(CM… bioRxiv 2026-04-15

...RAD51C and the RNA helicase DDX21 as genes required for BPA resistance. Moreover, we show that BPA exposure increases th...

The DNA helicase HELQ promotes replication fork reversal in coordination with B…

Dunbayev(Y),Chen(YJ),Sassi(L),Lee(EA),Ra(JS)… Nucleic Acids Res 2026-04-23

...RAD51C-RAD51D-XRCC2 (BCDX2), a key mediator of replication fork reversal. Using DNA fiber assays, we show that HELQ and ...

Real-world genetic testing data of ovarian cancer patients: Informing counselin…

Shachar(E),Rotkop(G),Haas(R),Frankenthal(R),… Gynecol Oncol 2026-06-00

...RAD51C/D remained stable. PMS2 were more common than previously reported and declined with age (p = 0.03). Patients ≥70 ...

Results of breast cancer risk assessment and hereditary cancer genetic testing …

Waldman(R),DeFrancesco(M),Feltz(J),Welling(D… J Obstet Gynaecol 2026-12-00

...RAD51C, BRIP1 (n = 1 each). Most patients undergoing genetic testing did not carry an inherited mutation; however, over ...

Pancreatic Adenocarcinoma Associated With a Germline RAD51C Mutation.

Lawrence(A),Villanueva(I),Parikh(J),Mandalia… ACG Case Rep J 2026-05-00

...RAD51C mutation. The patient declined treatment and genetic counseling, electing for palliative care. RAD51C plays a cri...

Structural insight into how RAD51 paralog exchange regulates RAD51 filament for…

Rawal(Y),Kwon(Y),Jia(L),Ruben(EA),Ji(JH),Guo… Nat Struct Mol Biol 2026-05-00

...RAD51C, XRCC3, RAD51D and XRCC2. Here, using cryo-electron microscopy, we find that the RAD51-XRCC3-RAD51C complex (RAD5...

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