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Gubbi(S),Moorthy(V),Grover(A),Al-Souri(D),... J Clin Transl Endocrinol 2026-08-00

...RAD50-NBS1 (MRN) complex is a key mediator of homologous recombination mode of double-strand break repair, and its role ...

Qutob(N),Hindiyeh(M),Zahdeh(F),Alian(A),Th... Front Genet None

...RAD50 (c.2524+3A>G) in Family I, a truncating MSH4 variant (c.328C>T; p.R110X) and a missense STAT6 variant (c.1216C>G; ...

Huang(ZD),Zhai(BY),Xu(C),Ding(Y),Zhang(ZH)... Zhonghua Bing Li Xue Za Zhi 2026-03-08

...RAD50, MRE11, and BRIP1-in three cases. One case showed somatic mutations in genes associated with signaling pathways an...

Gong(Y),Jiang(M),Wu(S),Guo(S),Lyu(Y) Front Endocrinol (Lausanne) None

...RAD50 gene. Western blotting revealed the presence of the Flag-tag and EGFP in RAD50-wt, but not in RAD50-mut (p.His1269...

Zheng(Z),Chi(H),Liu(X),Chen(X),Pan(Y),Gong(H) Animals (Basel) 2026-04-20

...RAD50 interactor 1). Weighted gene co-expression network analysis (WGCNA) of DEGs identified mapk9 (mitogen-activated pr...

Sevimli(M),Kurt(H),Sevimli(TS) Cell Biochem Biophys 2026-04-25

...RAD50, RAD51, Ku70, Ku80, XRCC1, and XRCC4.ASX inhibited the overexpression of many genes and enhanced the activity of R...

Boutet(T),Sakr(R),Marzullo(M),Goyal(M),Cat... Nucleic Acids Res 2026-04-13

...Rad50-Nbs). Loss of Rad50 disrupts histone modification patterns and causes inappropriate reactivation of embryonic gene...

Wang(X),Hua(WX),Liu(Y),Li(HD) Biol Direct 2026-04-03

...Rad50, NBS1, MRE11, XRCC1, LIG3, et al. Together, our findings suggest that miR-142-3p plays a radioresistant role in co...

Badakul(G),Maeda(J),Kato(TA) Front Oncol None

...RAD50-NBS1 (MRN) complex that senses DNA double-strand breaks (DSBs) and coordinates DNA damage response, including ATM ...

Huang(K),Brault(ME),Cong(K),Azazmeh(N),Col... Mol Cell 2026-05-21

...RAD50-NBS1 (MRN) complex levels, and phenocopies hypomorphic MRE11 mutations. MRE11pPAS-/- cells exhibit ectopic DNA rep...