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The DNA helicase HELQ promotes replication fork reversal in coordination with...

Dunbayev(Y),Chen(YJ),Sassi(L),Lee(EA),Ra(J... Nucleic Acids Res 2026-04-23

...XRCC2 (BCDX2), a key mediator of replication fork reversal. Using DNA fiber assays, we show that HELQ and BCDX2 act epis...

Transcriptional profiling of circulating extracellular vesicles from prebiops...

Werner(S),Tennstedt(P),Pose(RC),Müller(C),... Mol Oncol 2026-03-26

...XRCC2 were significantly elevated in EVs from patients with significant prostate cancer (n = 14) compared with cancer-fr...

Distinct functions of mammalian RAD51 paralogs in genome maintenance.

Dwivedi(HK),Bhattacharya(D),Kadupatil(S),N... Biochem Soc Trans 2026-09-23

...XRCC2, and XRCC3) are evolutionarily conserved essential proteins for cell survival and genome maintenance. RAD51 paralo...

Whole genome sequencing approach to assess homologous recombination deficienc...

Al Assaad(M),Hadi(K),Levine(MF),Guevara(D)... Commun Med (Lond) 2026-01-12

...XRCC2, and FANCC, and deleterious structural variants. In a subset of cases, the whole genome sequencing-based classifie...

Cryo-electron microscopic visualization of RAD51 filament assembly and end-ca...

Greenhough(LA),Galanti(L),Liang(CC),Boulto... Science 2026-02-26

...XRCC2 (RAD51B complex) and XRCC3-RAD51C-RAD51D-XRCC2 (XRCC3 complex). The RAD51B complex promotes dynamic adenosine trip...

The RAD51 paralogue HvXRCC2 affects meiosis and recombination in barley.

Colas(I),Macaulay(M),Arrieta(M),Schreiber(... J Exp Bot 2026-06-24

...XRCC2 (X-Ray Repair Cross Complementing 2). In barley XRCC2 mutants, the initial meiotic progression is normal, albeit w...

Integrated case-control and in silico analysis of DNA double-strand break rep...

Sistla(HC),Seshachalam(A),Rathnam(KK),Raja... Gene 2026-03-15

...XRCC2 and XRCC4 showed no significant associations. However, XRCC2 variants correlated with tumor grade and menopausal s...

Heat shock factor 1 promotes proliferation and chemoresistance in diffuse lar...

Fang(Y),Cheng(L),Huang(M),Cao(Y),Zou(Q),Ca... Cell Death Dis 2025-07-17

...XRCC2, were directly regulated by HSF1 in a protein arginine methyltransferase 5 (PRMT5) -dependent manner. These findin...

Predictive value of homologous recombination-related gene mutations in surviv...

Lee(Y),Kim(HD),Lee(SY),Lee(H),Hyung(J),Moo... Gastric Cancer 2025-11-00

...XRCC2) was assessed using targeted next-generation sequencing. Among patients treated with nivolumab plus chemotherapy, ...

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous rec...

Rein(HL),Rawal(Y),Palovcak-Lightbourn(AL),... Nat Commun 2025-07-16

...XRCC2 (BCDX2) complex. With yeast 3-hybrid and biochemical analyses, we identify a mutation cluster of the RAD51C Walker...

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