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Uncovering Hereditary Risk: Germline Homologous Recombination Repair Variant Sp…

Kapoor(A),Uthale(S),Chain(A),Rungta(A),Anoop… JCO Glob Oncol 2026-08-00

...RAD51C, RAD51D, ATM, CHEK2, BRIP1, BARD1, RAD50, NBN, MRE11, and FANCC. Of 950 patients analyzed, 364 (38.3%) harbored v...

Results of a multigene panel testing approach targeting patients with suspected…

Buecher(B),Warcoin(M),Rolland(E),Abdullazoda… Eur J Hum Genet 2026-01-29

...RAD51C, RAD51D, STK11) was performed in 496 patients with pancreatic ductal adenocarcinoma and suspected genetic predisp...

Cryo-electron microscopic visualization of RAD51 filament assembly and end-capp…

Greenhough(LA),Galanti(L),Liang(CC),Boulton(… Science 2026-02-26

...RAD51C-RAD51D-XRCC2 (RAD51B complex) and XRCC3-RAD51C-RAD51D-XRCC2 (XRCC3 complex). The RAD51B complex promotes dynamic ...

Germline Pathogenic Variant Prediction Model for Tumor-Only Sequencing Based on…

Ikegami(M),Zhang(L),Hirata(M),Yamaguchi(T),O… Clin Cancer Res 2026-02-17

...RAD51C, BRCA1, PALB2, CHEK2, RET, BRCA2, and PMS2. Significant predictors included age <30, multiple cancers, gene type,...

Hereditary ovarian cancer in women with African ancestry: a scoping review.

Rossouw(B),Araujo(M),Krause(A),Baine-Savanhu… Fam Cancer 2026-01-31

...RAD51C, RAD51D, and the Lynch syndrome genes. The genetic basis of ovarian cancer in women of African ancestry, however,...

SyMetrics: an integrated machine learning model for evaluating the pathogenicit…

Bundalian(L),Strnadová(MS),Garten(F),Horn(S)… NAR Genom Bioinform 2026-03-00

...RAD51C and BAP1 variants. In a clinical cohort, we identified 15 predicted deleterious sSNVs in genes linked to patient ...

Hereditary Risk Assessment of Cancer Using Clinical History in Patients Diagnos…

Tholia(H),Pandey(V),Gangadevi(P),Pareek(P) Ann Afr Med 2026-01-21

...RAD51C, or BRIP) with the selected sociodemographic and clinical variables. Genetic counseling and testing for patients ...

Prevalence of Germline Variants in Breast, Ovarian, and Prostate Cancer in Urug…

Alzogaray(V) Clin Genet 2026-06-00

...RAD51C, MUTYH). No recurrent founder mutations were detected, although MUTYH c.452A>G was observed in multiple unrelated...

Leveraging tumor multigene panel testing to identify germline variants in gynec…

Parulekar(M),Kim(YN),Kim(K),Lee(S),No(JH),Le… Gynecol Oncol 2026-02-00

...RAD51C, RAD51D, ATM, and CHEK2) with a variant allele frequency (VAF) of ≥40 %; and (2) exclusion of epithelial ovarian ...

Genetic tumor syndromes in female cancer: insights into inherited cancer predis…

Krückel(A),Gocke(J),Hörner(M),Keller(K),Müll… Arch Gynecol Obstet 2026-01-13

...RAD51C, and RAD51D. Beyond HBOC, numerous additional hereditary tumor syndromes are of significance in senologic and/or ...

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