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SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation ...

Mnatsakanyan(H),Sammarco(A),Hewett(A),Awwa... Cell Rep 2026-04-13

...RAD51 to compromise homologous recombination and induce parthanatos. These findings uncover a lipid-mediated vulnerabili...

Multiomics profiling and experiments in preclinical models revealed RAD51-IN-...

Meng(H),Chang(Q),Zhang(Y),Ren(J),Guo(H),Yu... Sci Adv 2026-04-17

...RAD51 inhibitor RAD51-IN-1, which outperformed the Notch inhibitor FLI-06 in resistant patient-derived organoids. Mechan...

PGK1/PHGDH axis drives radioresistance in glioblastoma stem cells.

Cheng(Z),Ding(F),Yin(J),Wang(Y),Gao(Y),Ge(... Cancer Lett 2026-07-10

...RAD51 to engage homologous recombination (HR)-mediated DNA damage repair to confer resistance of GSCs to IR. Importantly...

Control of DNA double-strand break repair by the KDM8 histone demethylase.

Fages(J),Bergoglio(V),Julia(E),Cintori(L),... Cell Cycle 2026-12-00

...Rad51 after DNA damage induced by camptothecin. These findings identify KDM8 as a key player in DSB repair, specifically...

miRNAs as Theragnostic Markers for PARP Inhibitor Resistance in Breast Cancer...

Molavand(M),Golchin(A),Yousefi(B) Curr Cancer Drug Targets 2026-03-27

...RAD51, respectively. These findings emphasize the complex role of miRNAs in ther-apy, highlighting their potential as bo...

Structures and molecular mechanisms of RAD54B in modulating homologous recomb...

Liang(P),Tye(S),Ertl da Costa(J),Maharshi(... bioRxiv 2026-03-24

...RAD51-DNA filaments, inhibits RAD51 ATPase activity, and promotes strand invasion, D-loop formation and strand exchange....

Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1...

Chapman(IG),Wu(X),Veuger(S),Jowsey(PA) PLoS One None

...RAD51 to DNA double strand breaks (DSBs) during HRR, though the magnitude of this defect in human cells is not entirely ...

BMAL2 is a druggable target for ovarian clear cell carcinoma (OCCC).

Tan(GYT),Lin(PY),Cheng(LT),Tsai Yuan(YS),H... EMBO Mol Med 2026-05-00

...RAD51, a core enzyme of the homologous recombination (HR) pathway. This led to DNA double-stranded break accumulation, d...

Targeting IP6 signaling to destabilize homologous recombination proteins to o...

Lee(SG),Seo(Y),Jeong(S),Chung(Y),Kong(S),K... Nat Commun 2026-04-04

...RAD51, CtIP, and CHK1. Further analysis identifies WDR5 as a DCAF protein that facilitates Cul4A-mediated proteolysis of...

BRCA2-dependent maturation of nascent strands during DNA replication.

Milano(L),Wells(S),Vaitsiankova(A),Drummon... Mol Cell 2026-04-16

...RAD51 recombinase in chromatin. Our data identify nascent strand gaps that are induced by olaparib independently of repl...

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