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Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Gen...

Carrillo(Alexia M),Hicks(Mellissa),Khabele... Mol Cancer Res 2016-06-06

...Rad50-Nbs1 DNA repair complex. In ovarian cancer cells, where >90% have inactivated p53, Nutlin combined with the genoto...

Nijmegen breakage syndrome protein 1 (NBS1) modulates hypoxia inducible facto...

Kuo(Yi-Chih),Wu(Han-Tsang),Hung(Jung-Jyh),... Int J Biochem Cell Biol 2016-03-11

...RAD50-NBS1 complex, plays an important role in the cellular response to DNA damage but its overexpression contributes to...

The effect of immunological status, in-vitro treatment and culture time on ex...

Emam(Mehdi),Thompson-Crispi(Kathleen),Mall... BMC Immunol 2016-01-20

...RAD50 among all tested genes were consistent after treatment of cultured BMCs with C. albicans whole yeast extract and H...

Causal mechanisms and balancing selection inferred from genetic associations ...

Day(Felix R),Hinds(David A),Tung(Joyce Y),... Nat Commun 2016-05-24

...RAD50 and KRR1. Variants in/near three of the four epidermal growth factor receptor genes (ERBB2/HER2, ERBB3/HER3 and ER...

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Wijnhoven(Paul),Konietzny(Rebecca),Blackfo... Mol Cell 2016-02-11

...RAD50-NBS1 (MRN) complex and is required for CtIP recruitment to DNA damage sites. Furthermore, we show that USP4 is ubi...

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma...

Beumer(Jan H),Fu(Katherine Y),Anyang(Bean ... BMC Cancer 2016-06-17

...RAD50 and NBN; 2) ATR, ATRIP and TOPBP1; and 3) 15 FA genes.,No defects in ATM, ATR or Chk1 kinase activation, or FANCD2...

Single substitution in bacteriophage T4 RNase H alters the ratio between its ...

Kholod(Natalia),Sivogrivov(Dmitry),Latypov... Mutat Res 2016-02-09

...Rad50 complex). Genetic mapping of das13 (one of the das mutations) has shown it to be in the region of the rnh gene enc...

The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Br...

Liu(Hailong),Zhang(Haoxing),Wang(Xiaohui),... Cell Rep 2016-07-12

...RAD50-NBS1 (MRN) complex. Here, we find that the deubiquitylating enzyme USP4 directly participates in DSB resection and...

Chromatin perturbations during the DNA damage response in higher eukaryotes.

Bakkenist(Christopher J),Kastan(Michael B) DNA Repair (Amst) 2016-08-18

...RAD50-NBS1 (MRN) complex, which has a catalytic role in DNA repair, and the KAT5 (Tip60) acetyltransferase are required ...

When two is not enough: a CtIP tetramer is required for DNA repair by Homolog...

Forment(Josep V),Jackson(Stephen P),Pelleg... Nucleus 2016-04-29

...RAD50-NBS1 complex to link DNA ends. Although the exact mechanism of action remains to be elucidated, the remarkable evo...

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