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Next-generation sequencing facilitates detection of the classic E13-A20 EML4-...

Volckmar(Anna-Lena),Endris(Volker),Bozorgm... Diagn Pathol 0000-00-00

...ALK-positivity by IHC. Consequently, we diagnosed the case as ALK-positive rendering the patient eligible to crizotinib ...

Comparison of small biopsy specimens and surgical specimens for the detection...

Xiao(DeSheng),Lu(Can),Zhu(Wei),He(QiuYan),... Oncotarget 0000-00-00

...ALK (6.8%). However, 11.7% of the surgical specimens were EML4-ALK-positive, whereas the positive proportion in the smal...

Anaplastic lymphoma kinase inhibitors in elderly patients with advanced non-s...

Zaarour(Mazen),Nazha(Bassel),Weerasinghe(C... Expert Rev Anticancer Ther 0000-00-00

...ALK inhibitors in the elderly population remains scarce. In our review, we briefly discuss the current evidence of ALK i...

Benefit-Risk Summary of Crizotinib for the Treatment of Patients With ROS1 Al...

Kazandjian(Dickran),Blumenthal(Gideon M),L... Oncologist 0000-00-00

...ALK-positive mNSCLC trials. The most common (≥25%) adverse reactions and laboratory test abnormalities included vision d...

Phase I study of PF-03446962, a fully human monoclonal antibody against activ...

Simonelli(M),Zucali(P),Santoro(A),Thomas(M... Ann Oncol 0000-00-00

...ALK-1 function through ALK-1 pathway inhibition. Overall, treatment-related grade 3-4 AEs were reported in eight patient...

Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation ...

Heinig(Katja),Miya(Kazuhiro),Kamei(Tomonor... Bioanalysis 0000-00-00

...ALK) inhibitor for treatment of patients with ALK-positive non-small-cell lung cancer who have progressed on or are into...

MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switc...

Pietrantonio(Filippo),Oddo(Daniele),Gloghi... Cancer Discov 0000-00-00

...ALK-MET inhibitor crizotinib plus vemurafenib, thus switching to dual MET and BRAF blockade, with rapid and marked effec...

ALK immunohistochemistry for ALK gene rearrangement screening in non-small ce...

Pyo(Jung-Soo),Kang(Guhyun),Sohn(Jin Hee) Int J Biol Markers 0000-00-00

...ALK IHC and fluorescence in situ hybridization (FISH). The diagnostic accuracy of ALK IHC was analyzed based on ALK IHC ...

Baicalein attenuates hypertrophic scar formation via inhibition of the transf...

Zhang(Y F),Zhou(S Z),Cheng(X Y),Yi(B),Shan... Br J Dermatol 0000-00-00

...ALK)5.,Baicalein treatment significantly attenuated HPS formation and collagen deposition in a mechanical-load-induced m...

SUVmax and Tumour Location in PET-CT Predict Oncogene Status in Lung Cancer.

Putora(Paul M),Szentesi(Kinga),Glatzer(Mar... Oncol Res Treat 0000-00-00

...ALK+ tumours (15%, p = 0.002). Among EGFR/ALKwt tumours, 41% were central compared to 63% of ALK+ tumours (p = 0.235).,O...

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