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Preferential formation of NUP98-KDM5A condensates at specific H3K4me3-rich lo...

Berrocal(A),Sandoval(JE),Khetan(N),Ma(A),W... bioRxiv 2026-03-17

...single-cell sequencing data from patients further supports a correlation between local H3K4me3 density and transcription...

A Rare T-Cell Factor 4 Lineage-negative Epithelial Stem Cell Supports Wound R...

Thorpe(AV),Mosbruger(T),Georges(SJ),Crowle... bioRxiv 2026-03-18

...single-cell sequencing, we have identified a rare, non-CBC, T-cell factor 4 lineage-negative (Tcf4 Lin-) stem cell popul...

Insights into tick-pathogen interactions - a single cell RNA sequencing appro...

Adegoke(A),Aspinwall(J),McNinch(C),Ho(MCW)... bioRxiv 2026-03-20

...Single-cell RNA sequencing revealed 15 distinct cell clusters present. Although ISE6 cells are heterogeneous, they do no...

Patches: A Representation Learning Framework for Decoding Shared and Conditio...

Beker(O),Van Deursen(S),Tarnow(M),Amador(D... bioRxiv 2026-03-19

Single-cell genomics enables the study of cell states and cell state transitions across biological conditions like aging...

One Chromatin, Many Structures: From Ensemble Contact Maps to Single-Cell 3D ...

Carignano(MA),Backman(V),Kröger(M),Almassa... bioRxiv 2026-03-21

...single-cell chromosome conformation capture (Hi-C), and robust ensemble-level contact enrichment consistent with topolog...

POLQ-driven repair scars shape the immunogenic landscape of homologous recomb...

Park(W),Umeda(S),Hilmi(M),O'Connor(C),Shar... bioRxiv 2026-03-17

Pancreatic cancer (PC) is broadly resistant to immune checkpoint blockade, although a subset of homologous recombination...

High-Fidelity Long-term Whole-embryo Lineage and Fate Reconstruction by Itera...

Wang(M),Zhang(Q),Wang(C),Chi(Y),Zheng(W),M... bioRxiv 2026-03-16

Reconstructing the complete cell lineages and fate maps of a living embryo has remained a central challenge in developme...

Diverse high-fat diets drive multi-omic reprogramming that persists after die...

Van Camp(AG),Park(J),Ozcelik(E),Eskiocak(O... bioRxiv 2026-04-23

...single-cell RNA sequencing, we defined the shared and dietary fat-specific responses across host and microbiome compartm...

A mouse model of autosomal dominant spastic ataxia and myopathy caused by a m...

Hines(TJ),Funke(JR),Pratt(SL),Rice(AD),Twi... bioRxiv 2026-03-09

Hereditary ataxias are a heterogeneous group of neurodegenerative disorders characterized by impaired balance and coordi...

Gateway analysis reveals transient molecular programs at cell-fate transition...

Cang(H),Sun(S) bioRxiv 2026-03-16

Single-cell atlases have transformed our view of cell identity, but they still struggle to resolve the transient states ...

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