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NKG2D Receptor and Its Ligands in Host Defense.

Lanier(Lewis L) Cancer Immunol Res 2016-02-24

...KLRK1) with limited polymorphism, the receptor recognizes an extensive repertoire of ligands, encoded by at least eight ...

Transcriptomic correlates of organ failure extent in sepsis.

Almansa(Raquel),Heredia-Rodríguez(María),G... J Infect 2016-01-15

...KLRK1, KLRD1) were inversely associated with SOFA and mortality.,The extent of organ failure in sepsis correlates direct...

Compromised natural killer cells in pulmonary embolism.

Zhang(Xiaoyu),Wang(Qiang),Shen(Yuqin),Song... Int J Clin Exp Pathol 2016-06-07

...KLRK1 and NCR1) on NK cells were remarkably down-regulated and the cytological experiment demonstrated the proportion of...

Aptamer-based proteomic signature of intensive phase treatment response in pu...

Nahid(Payam),Bliven-Sizemore(Erin),Jarlsbe... Tuberculosis (Edinb) 2015-01-05

...KLRK1).,Serum proteins involved in the coagulation cascade, neutrophil activity, immunity, inflammation, and tissue remo...

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK i...

Xing(Luzhou),Dai(Zhenpeng),Jabbari(Ali),Ce... Nat Med 2014-11-03

...KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8(+)NKG2D(+) T cells are both necessary and sufficie...

Inflammation-related genetic variations and survival in patients with advance...

Pu(X),Hildebrandt(M A T),Lu(C),Roth(J A),S... Clin Pharmacol Ther 2014-10-16

...KLRK1:rs2900420 was associated with reduced risk in the discovery (HR: 0.76; 95% CI: 0.60-0.96), internal validation (HR...

Identification of natural killer cell receptor genes in the genome of the mar...

van der Kraan(Lauren E),Wong(Emily S W),Lo... Immunogenetics 2013-02-22

...KLRK1, CD69, CLEC4E, CLEC1B, CLEC1A and an ortholog of an opossum NKC receptor. Characterisation of these regions in a s...

The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1), markedly in...

Antoun(Ayman),Vekaria(Dhruti),Salama(Rafik... Br J Haematol 2013-04-04

...KLRK1) is an activating receptor on natural killer (NK) and T-cells and binds a diverse panel of polymorphic ligands enc...

Efficacy and mechanism-of-action of a novel superagonist interleukin-15: inte...

Xu(Wenxin),Jones(Monica),Liu(Bai),Zhu(Xiao... Cancer Res 2013-07-22

...KLRK1) but not PD-1 (PDCD1) or CD25 (IL2RA) on their cell surfaces. ALT-803-activated CD8(+) memory T cells also exhibit...

Targeted resequencing implicates the familial Mediterranean fever gene MEFV a...

Kirino(Yohei),Zhou(Qing),Ishigatsubo(Yoshi... Proc Natl Acad Sci U S A 2013-07-25

...KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1R...

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