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Xrcc2 is required for genetic stability, embryonic neurogenesis and viability i…

Deans(B),Griffin(C S),Maconochie(M),Thacker(… EMBO J 2001-02-08

...Xrcc2 in mice. No Xrcc2(-/-) animals were found alive, with embryonic lethality occurring from mid-gestation. Xrcc2(-/-)...

Homologous recombination as a potential target for caffeine radiosensitization …

Asaad(N A),Zeng(Z C),Guan(J),Thacker(J),Ilia… Oncogene 2001-01-04

...XRCC2. Despite the reduced radiosensitization, caffeine effectively abrogates checkpoints in S and G2 phases in XRCC2 mu...

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hy…

Sale(J E),Calandrini(D M),Takata(M),Takeda(S… Nature 2001-09-27

...XRCC2, XRCC3 or RAD51B are ablated the pattern of diversification of the immunoglobulin V gene in the chicken DT40 B-cel...

XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus…

O'Regan(P),Wilson(C),Townsend(S),Thacker(J) J Biol Chem 2001-07-19

...XRCC2 because transfection of the gene into irs1 restored normal levels of focus formation. Surprisingly, XRCC2 genes ca...

Chromosome instability and defective recombinational repair in knockout mutants…

Takata(M),Sasaki(M S),Tachiiri(S),Fukushima(… Mol Cell Biol 2001-04-19

...XRCC2 and -3, are implicated in HR on the basis of their sequence similarity to Rad51 (Rad51 paralogs). We generated mut...

Double-strand-break-induced homologous recombination in mammalian cells.

Johnson(R D),Jasin(M) Biochem Soc Trans 2001-09-06

...XRCC2, XRCC3 and BRCA1. This paper summarizes results from a number of recent studies.

Complex formation by the human RAD51C and XRCC3 recombination repair proteins.

Masson(J Y),Stasiak(A Z),Stasiak(A),Benson(F… Proc Natl Acad Sci U S A 2001-08-30

...XRCC2, and XRCC3, have been identified and also shown to be required for recombination and genome stability. At the pres...

The XRCC2 human repair gene influences recombinational rearrangements leading t…

Mozdarani(H),Liu(N),Jones(N J),Bryant(P E) Int J Radiat Biol 2001-10-11

...XRCC2 mutation) and irs2 (XRCC8 mutation), two WT V79 lines and GT621-1 (irs1 transfected with the XRCC2 gene) were labe...

In vitro evidence for homologous recombinational repair in resistance to melpha…

Wang(Z M),Chen(Z P),Xu(Z Y),Christodoulopoul… J Natl Cancer Inst 2001-12-04

...Xrcc2, Xrcc3, and Rad52) or by nonhomologous endjoining involving DNA-dependent protein kinase (DNA-PK) and Ku proteins....

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome…

Griffin(C S),Simpson(P J),Wilson(C R),Thacke… Nat Cell Biol 2000-12-19

...XRCC2 and XRCC3. This increased missegregation is associated with fragmentation of the centrosome, a component of the mi...

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