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RAD51 localization and activation following DNA damage.

Tarsounas(Madalena),Davies(Adelina A),West... Philos Trans R Soc Lond B B... 2004-05-05

...XRCC2 and XRCC3), indicating that the components present within foci assemble in a carefully orchestrated and ordered ma...

Preferential binding to branched DNA strands and strand-annealing activity of...

Yokoyama(Hiroshi),Sarai(Naoyuki),Kagawa(Wa... Nucleic Acids Res 2004-06-30

...Xrcc2 proteins are Rad51 paralogs, and form a complex (BCDX2 complex) in mammalian cells. Mutant cells defective in any ...

DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers o...

Benhamou(Simone),Tuimala(Jarno),Bouchardy(... Int J Cancer 2004-11-26

...XRCC2 and XRCC3 genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking-related can...

Homologous recombination is a highly conserved determinant of the synergistic...

van Waardenburg(Robert C A M),de Jong(Laur... Mol Cancer Ther 2004-11-23

...XRCC2/3, respectively, the combination of these agents proved antagonistic, while greater than additive activity was evi...

Recombination repair pathway in the maintenance of chromosomal integrity agai...

Sasaki(M S),Takata(M),Sonoda(E),Tachibana(... Cytogenet Genome Res 2004-11-01

...Xrcc2 and Xrcc3 genes resulted in a dramatic reduction of spontaneous and MMC-induced SCEs. Interestingly, while HR-defi...

Telomere maintenance requires the RAD51D recombination/repair protein.

Tarsounas(Madalena),Muñoz(Purificacíon),Cl... Cell 2004-05-25

...XRCC2, and XRCC3) are required in mammalian cells for normal levels of genetic recombination and resistance to DNA-damag...

Domain mapping of the Rad51 paralog protein complexes.

Miller(Kristi A),Sawicka(Dorota),Barsky(Da... Nucleic Acids Res 2004-01-23

...Xrcc2 (BCDX2) and Rad51C-Xrcc3 (CX3). Based on the recent Pyrococcus furiosus Rad51 structure, we have used homology mod...

A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous ...

Mohindra(Atul),Bolderson(Emma),Stone(Jason... Hum Mol Genet 2004-08-18

...XRCC2 as well as the expression of the mutant XRCC2 allele. These results suggest that HRR pathways responding to stalle...

Polymorphisms in DNA double-strand break repair genes and breast cancer risk ...

Han(Jiali),Hankinson(Susan E),Ranu(Hardeep... Carcinogenesis 2004-03-17

...XRCC2, A4541G (5'-UTR), A17893G (IVS5-14) and C18067T (T241 M) in XRCC3, and C299T (5'-UTR) and T1977C (D501D) in Ligase...

Homologous recombination deficiency leads to profound genetic instability in ...

Deans(Bryan),Griffin(Carol S),O'Regan(Paul... Cancer Res 2004-02-27

...Xrcc2 deficiency. In addition, we find evidence for mild haploinsufficiency of Xrcc2. These responses are linked to seve...

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