Park(BE),Yang(DH) Front Cardiovasc Med None

...RIT1 variant was identified without desmosomal mutations. This case was interpreted as a RASopathy-associated arrhythmog...

Werner(S),Tennstedt(P),Pose(RC),Müller(C),Be… Mol Oncol 2026-03-26

...RIT1, S100A2, THBS1, and XRCC2 were significantly elevated in EVs from patients with significant prostate cancer (n = 14...

Prevedello(F),Ali(DS),Piccolo(C),Rigon(C),Fo… Am J Med Genet A 2026-08-00

...RIT1 variant (c.229G>C, p.(Ala77Pro), 16.45% VAF), both meeting criteria for pathogenicity. The RIT1 variant was validat...

López-Guillén(JL),Carcavilla(A),Díez-Sebasti… Pediatr Res 2026-07-14

...RIT1 (13% each). Patients with Noonan syndrome underwent significantly more therapeutic strategies (p = 0.026). Increase...

Rice(SM),Makhamreh(MM),Wodoslawsky(S),Toro(M… Am J Med Genet A 2026-08-20

...RIT1, SOS1, RYR1, FLT4, LMOD2, KMT2D, PUF60, and BLTP1. Two additional cases were diagnosed upon reclassification of unc...

Guo(R),Duan(C),Zarrei(M),Reuter(MS),Dong(R),… Sci Rep 2025-07-26

...RIT1, and SMAD6. Trio sequencing facilitated the identification of pathogenic variation (55.6% were de novo missense var...

Monge(C),Waldrup(B),Carranza(FG),Manjarrez(S… Int J Mol Sci 2025-08-08

...RIT1 (RTK/RAS), and CTNNB1 (WNT). No significant survival differences were observed in H/L patients, but NHW patients wi...

DiMarco(AV),Ravichandran(M),Lau(J),Lima(A),L… Cancer Res 2025-09-02

...RIT1 alterations. In this study, we generated a murine model of RIT1M90I-mutant lung cancer. RIT1M90I expression induced...

Mozzarelli(AM),Cuevas-Navarro(A),Shuldiner(E… Cancer Res 2025-09-02

RIT1 is a small GTPase of the RAS family, and RIT1 mutations have been identified in lung cancer, leukemia, and the deve...

Wu(CP),Vaishnavi(A) Cancer Res 2025-09-02

...RIT1-mutant lung tumors to SHP2 or RAS tricomplex inhibitors. Collectively, these findings highlight the importance of R...