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Genetic Predisposition to Pancreatic Cancer: A Systematic Review of Hereditar...

Baraian(CS),Turculet(CS),Negoi(I) Cancers (Basel) 2026-03-18

...BRCA1/2, MLH1, and MSH2. We aimed to evaluate the risk of pancreatic cancer associated with inherited genetic mutations ...

Pan-Cancer Targeted Sequencing Reveals Genomic Heterogeneity and Prognostic S...

Ugrinovski(D),Saidi(S),Stankov(V),Ambardji... Cancers (Basel) 2026-03-22

...BRCA1 and ALK, were also detected, reflecting the extended coverage of the panel. TP53 mutations were independently asso...

Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficien...

Huang(L),Yang(Y),Duan(D),Dai(L),Zhai(B),Qi... Molecules 2026-03-20

...BRCA1 and RAD51, which may contribute to impaired DNA-damage repair and increased sensitivity to Olaparib. In summary, t...

Interplay Between Poly(ADP-ribosyl)ation and Specific Inner Cellular Events T...

Xu(L),Kong(X),Zhang(B),Ma(H),Li(X),Deng(Y)... Pharmaceutics 2026-03-12

...BRCA1/2 alterations develop resistance, and patient eligibility remains limited by the low prevalence of HRD mutations. ...

Development of Stearic Acid Nanoemulsion for Therapeutic Delivery of Talazopa...

Zhang(J),Zhang(Z),Xia(X),Feng(K),Yao(S),Wa... Pharmaceutics 2026-03-19

...BRCA1, RAD51, and SLFN11, in a manner consistent with impaired DNA repair capacity. In vivo, high-dose SANE-TZL achieved...

Regulatory BC200 RNA promotes breast carcinogenesis by repressing BRCA1 gene ...

Berardi(V),Muslimov(IA),Sun(D),Militello(G... iScience 2026-04-17

...BRCA1 mRNA, BC200 RNA reduces BRCA1 protein expression in breast epithelial cells, leading to increased DNA damage and c...

Next-Generation Therapeutic Targets in Triple-Negative Breast Cancer.

Saleem(KM),Amirova(MF),Rahimov(JA),Musayev... Eur J Breast Health 2026-06-17

...BRCA1/2-mutant and homologous recombination-deficient tumors, are being extended through rational combinations that inte...

Natural menopause, menarche and breast cancer risk in BRCA1 and BRCA2 pathoge...

Mavaddat(N),Barnes(DR),Michailidou(K),Zhao... Br J Cancer 2026-05-00

...BRCA1, and between AAM and BC risk in BRCA1 and BRCA2 PV carriers. These results may aid risk prediction models and gene...

Genetic Testing in Breast Cancer: Narrative Review and Clinical Insights.

Bistriceanu(I),Ungureanu(CO),Stoica(RA),Gi... Maedica (Bucur) 2026-03-00

...BRCA1 and BRCA2) remain central to hereditary breast and ovarian cancers, progress in cancer genetics has shifted clinic...

Germline pathogenic variant spectrum and prevalence among colorectal cancer p...

Baltayev(N),Abdikerim(S),Afonin(G),Rasulov... Sci Rep 2026-04-14

...BRCA1 (6.46%). Missense (35.5%) and frameshift (32.3%) variants predominated. A high number of PVs was found in individu...

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