...BRCA1/2, MLH1, and MSH2. We aimed to evaluate the risk of pancreatic cancer associated with inherited genetic mutations ...
...BRCA1 and ALK, were also detected, reflecting the extended coverage of the panel. TP53 mutations were independently asso...
...BRCA1 and RAD51, which may contribute to impaired DNA-damage repair and increased sensitivity to Olaparib. In summary, t...
...BRCA1/2 alterations develop resistance, and patient eligibility remains limited by the low prevalence of HRD mutations. ...
...BRCA1, RAD51, and SLFN11, in a manner consistent with impaired DNA repair capacity. In vivo, high-dose SANE-TZL achieved...
...BRCA1 mRNA, BC200 RNA reduces BRCA1 protein expression in breast epithelial cells, leading to increased DNA damage and c...
...BRCA1/2-mutant and homologous recombination-deficient tumors, are being extended through rational combinations that inte...
...BRCA1, and between AAM and BC risk in BRCA1 and BRCA2 PV carriers. These results may aid risk prediction models and gene...
...BRCA1 and BRCA2) remain central to hereditary breast and ovarian cancers, progress in cancer genetics has shifted clinic...
...BRCA1 (6.46%). Missense (35.5%) and frameshift (32.3%) variants predominated. A high number of PVs was found in individu...
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