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Functional characterization and identification of mouse Rad51d splice variant...

Gruver(Aaron M),Yard(Brian D),McInnes(Camp... BMC Mol Biol 2009-05-22

...XRCC2 and that RAD51D+int3 interacted with XRCC2. In addition, the linker region (residues 54 through 77) of RAD51D was ...

Validating genetic risk associations for ovarian cancer through the internati...

Pearce(C L),Near(A M),Van Den Berg(D J),Ra... Br J Cancer 2009-03-10

...XRCC2 (P=0.095). Additional genotyping in other OCAC studies was undertaken and only the variant in CYP3A4, rs2740574, c...

Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent...

Kuznetsov(Sergey G),Haines(Diana C),Martin... Cancer Res 2009-03-23

...Xrcc2, and Xrcc3) are essential for DNA repair by homologous recombination, and their role in cancers has been anticipat...

Recurrent genomic alterations characterize medulloblastoma arising from DNA d...

Frappart(Pierre-Olivier),Lee(Youngsoo),Rus... Proc Natl Acad Sci U S A 2009-03-10

...Xrcc2, and Brca2, or combined Lig4/Xrcc2 during neural development using Nestin-cre. In all cases, inactivation of these...

A field synopsis on low-penetrance variants in DNA repair genes and cancer su...

Vineis(Paolo),Manuguerra(Maurizio),Kavvour... J Natl Cancer Inst 2009-01-22

...XRCC2, XRCC3, and XRCC4). XRCC1, XRCC2, TP53, and ERCC2 variants were each nominally associated with several types of ca...

Transcription-associated recombination is independent of XRCC2 and mechanisti...

Savolainen(Linda),Helleday(Thomas) Nucleic Acids Res 2009-02-27

...XRCC2 protein is not involved. Expression of the XRCC2 gene in XRCC2 mutated irs1 cells restores the defect in homologou...

Common single-nucleotide polymorphisms in DNA double-strand break repair gene...

Pooley(Karen A),Baynes(Caroline),Driver(Kr... Cancer Epidemiol Biomarkers... 2009-01-27

...XRCC2 rs3218536, R188H, which showed some evidence of a protective association for the rare allele [per allele odds rati...

Functional characterization of the RAD51D E233G genetic variant.

Nadkarni(Aditi),Furda(Amy),Rajesh(Changana... Pharmacogenet Genomics 2009-04-07

...XRCC2 and the variant were maintained. Molecular modeling suggested that the glutamic acid-233 forms a salt bridge with ...

Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells...

Wu(Wenqi),Wang(Minli),Mussfeldt(Tamara),Il... Radiat Res 2009-01-07

...XRCC2 and XRCC3 components of HRR. Using cell sorting to separate cells at defined times after irradiation, we measure r...

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(...

Roos(Wynand P),Nikolova(Teodora),Quiros(St... DNA Repair (Amst) 2009-02-26

...Xrcc2 and Brca2 mutants) are extremely sensitive to cell death by apoptosis and chromosomal aberration formation and les...

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