The spectrum of somatic TP53 single basepair substitutions detected in 955 cancers was compared with that of 2,224 diffe...
...TP53 has been described in some ovarian carcinomas. The temporal relationship of these mutations, i.e. early or late eve...
...TP53 tumor suppressor gene has been reported in all grades of astrocytomas. Little is known, however, about 17p deletion...
...TP53 mutations. Exons 4 to 8 of the TP53 gene were amplified by the polymerase chain reaction, and mutations were identi...
...TP53 tumor suppressor gene and loss of loci, detected by loss of heterozygosity (LOH), on chromosome arms 8p, 10q, 16q, ...
...TP53 cDNAs revealed normal TP53 sequences in the cell lines with MDM2 amplification; these results are consistent with t...
...TP53 gene. All predisposition genes are able to transmit susceptibility due to a mutation or inherited microdeletion.
...TP53 gene, despite the fact that mutations in TP53 do not occur in testis cancer. Since a high frequency of LOH at DCC (...
...TP53. In contrast, no constitutional TP53 mutations were found in a "classic" Li-Fraumeni family. In this family positiv...
...TP53 mutations may be characterised by aetiological heterogeneity, we analysed a group of 107 patients with primary Duke...
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