RAD51基因详情-基因数据库-基因云馆

RAD51 (RAD51 recombinase)

symbol:: RAD51
locus group:: protein-coding gene
location:: 15q15.1
gene_family:
alias symbol:: HsRad51|HsT16930|BRCC5|FANCR
alias name:: BRCA1/BRCA2-containing complex, ...
entrez id:: 5888
ensembl gene id:: ENSG00000051180
ucsc gene id:: uc001zmi.5
refseq accession:: NM_002875|NM_133487
hgnc_id:: HGNC:9817
approved reserved:: 1993-05-26

15q15.1

RAD51是RAD51基因家族的核心成员，属于重组酶家族，在DNA同源重组修复（HRR）中发挥关键作用。它编码一种高度保守的ATP依赖性重组酶，能够催化单链DNA侵入同源双链DNA，形成D-loop结构，从而启动DNA损伤修复。RAD51主要在减数分裂和有丝分裂期间参与双链断裂（DSB）的精确修复，维持基因组稳定性。其表达产物RAD51蛋白在细胞核内形成核蛋白纤维，与BRCA1、BRCA2等乳腺癌易感蛋白协同作用。突变会导致HRR功能缺陷，引起基因组不稳定性增加，与乳腺癌、卵巢癌等遗传性癌症高度相关。RAD51过表达可能促进肿瘤细胞对DNA损伤治疗的抵抗，而表达降低则导致染色体异常和细胞凋亡增加。该基因属于RAD51基因家族，包括RAD51B、RAD51C、RAD51D等旁系同源基因，家族成员均参与DNA修复但功能存在分化。RAD51家族蛋白均含有保守的RecA结构域，具有DNA结合和ATP酶活性。研究发现RAD51表达水平异常与化疗耐药性相关，其抑制剂正在作为抗癌药物靶点被开发。此外，RAD51在减数分裂重组中的精确调控对配子形成至关重要，其功能异常可能导致不育。

中文English

由该基因编码的蛋白质是RAD51蛋白家族的一个成员。 RAD51家族成员是高度相似的细菌的RecA和酿酒酵母的Rad51，并已知参与同源重组和DNA修复。这种蛋白质可以与ssDNA结合蛋白的RPA和RAD52交互，并且它被认为在同源配对和DNA的链转移作用。这种蛋白也发现与BRCA1和BRCA2相互作用，这可能是对DNA损伤的细胞应答非常重要的。 BRCA2被示出为双向调节细胞内定位和该蛋白质的DNA结合的能力。以下BRCA2失活这些控件的损失可能导致基因组不稳定和肿瘤发生的重要事件。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的，2009年08月提供]

OMIM数据库中对RAD51基因的介绍 Wikipedia数据库中对RAD51基因的介绍

RAD51基因的碱基序列：[NCBI]

Loading Gene Browser...

蛋白质序列

1MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK
41LEEAGFHTVE AVAYAPKKEL INIKGISEAK ADKILAEAAK
81
LVPMGFTTA TEFHQRRSEI IQITTGSKEL DKLLQGGIET
121GSITEMFGEF RTGKTQICHT LAVTCQLPID RGGGEGKAMY
161I
DTEGTFRP ERLLAVAERY GLSGSDVLDN VAYARAFNTD
201HQTQLLYQAS AMMVESRYAL LIVDSATALY RTDYSGRGEL
241SA
RQMHLAR FLRMLLRLAD EFGVAVVITN QVVAQVDGAA
281MFAADPKKPI GGNIIAHAST TRLYLRKGRG ETRICKIYDS
321PCL
PEAEAM FAINADGVGD AKD

结构预测来自 AlphaFold DB（UniProt: Q06609），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

RAD51基因的碱基突变：仅显示部分snp

rs1801320 rs1801321 rs2619679 rs2619680 rs2619681 rs3092981 rs5030789 rs5030790 rs5030791 rs7171780 rs28373018 rs28439060 rs34445444 rs34504099 rs35104813 rs35302835 rs35722406

RAD51基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GGACTACAGGTGGAATTGAG

CGTATGACAGATCTGGGTC

TACTTCAAGGTGGAATTGAGAC

TATGACAGATCTGGGTCTTCC

TTTCACGGTTAGAGCAGTG

ATTAGCTCCTTCTTTGGCG

CTACTTCAAGGTGGAATTGAGAC

ATGACAGATCTGGGTCTTCC

AAATTCTGACGGAGTCTCG

AGGAGAATCACTTGAACCTG

GAACAGACTACTCGGGTCG

CAGATACAATCTCATCAGCGAG

TACTTCAAGGTGGAATTGAGAC

TATGACAGATCTGGGTCTTCC

TTCCATACTGTGGAGGCTG

TCCAGTCTCAATTCCACCAG

CAACAACCAGATTGTATCTGAGG

GCTTCAGGAAGACAGGGAG

TTTCACGGTTAGAGCAGTG

ATTAGCTCCTTCTTTGGCG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

BRCA2

RAD51

Unknown

12967658; 17515904; 19628690; 20729859

CREBBP

RAD51

Unknown

23285190

E2F1

RAD51

Unknown

23285190

E2F4

RAD51

Repression

20133863; 21701264

E2F4

RAD51

Unknown

17001309

EP300

RAD51

Unknown

23285190

HSF4

RAD51

Unknown

22587838

MEN1

RAD51

Unknown

23648481

RAD51

SP1

Activation

18769160

RBL2

RAD51

Repression

21701264

RAD51基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

RAD51基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000166

E9PI54 (UniProtKB)

IEA

GO:0003677

E9PJ30 (UniProtKB)

IEA

GO:0005524

E9PJ30 (UniProtKB)

IEA

GO:0006281

E9PJ30 (UniProtKB)

IEA

GO:0008094

E9PJ30 (UniProtKB)

IEA

GO:0003677

E9PNT5 (UniProtKB)

IEA

GO:0005524

E9PNT5 (UniProtKB)

IEA

GO:0005730

E9PNT5 (UniProtKB)

IDA

GO:0005737

E9PNT5 (UniProtKB)

IDA

GO:0006281

E9PNT5 (UniProtKB)

IEA

GO:0008094

E9PNT5 (UniProtKB)

IEA

GO:0000166

H0YD61 (UniProtKB)

IEA

GO:0000150

Q06609 (UniProtKB)

IBA

GO:0000228

Q06609 (UniProtKB)

IDA

GO:0000400

Q06609 (UniProtKB)

IBA

GO:0000722

Q06609 (UniProtKB)

ISS

GO:0000724

Q06609 (UniProtKB)

TAS

GO:0000724

Q06609 (UniProtKB)

IDA

GO:0000724

Q06609 (UniProtKB)

IMP

GO:0000724

Q06609 (UniProtKB)

IMP

GO:0000730

Q06609 (UniProtKB)

IBA

GO:0000731

Q06609 (UniProtKB)

TAS

GO:0000732

Q06609 (UniProtKB)

TAS

GO:0000784

Q06609 (UniProtKB)

IDA

GO:0000785

Q06609 (UniProtKB)

IDA

GO:0000793

Q06609 (UniProtKB)

ISS

GO:0000794

Q06609 (UniProtKB)

ISS

GO:0000794

Q06609 (UniProtKB)

IBA

GO:0000800

Q06609 (UniProtKB)

IEA

GO:0001932

Q06609 (UniProtKB)

IEA

GO:0003682

Q06609 (UniProtKB)

IEA

GO:0003690

Q06609 (UniProtKB)

IDA

GO:0003697

Q06609 (UniProtKB)

IDA

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005515

Q06609 (UniProtKB)

IPI

GO:0005524

Q06609 (UniProtKB)

IDA

GO:0005634

Q06609 (UniProtKB)

ISS

GO:0005634

Q06609 (UniProtKB)

IDA

GO:0005634

Q06609 (UniProtKB)

IDA

GO:0005634

Q06609 (UniProtKB)

IDA

GO:0005634

Q06609 (UniProtKB)

IDA

GO:0005634

Q06609 (UniProtKB)

IDA

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005654

Q06609 (UniProtKB)

TAS

GO:0005730

Q06609 (UniProtKB)

IDA

GO:0005737

Q06609 (UniProtKB)

IDA

GO:0005737

Q06609 (UniProtKB)

IDA

GO:0005737

Q06609 (UniProtKB)

IDA

GO:0005739

Q06609 (UniProtKB)

IDA

GO:0005759

Q06609 (UniProtKB)

IEA

GO:0005815

Q06609 (UniProtKB)

IEA

GO:0006268

Q06609 (UniProtKB)

IDA

GO:0006281

Q06609 (UniProtKB)

TAS

GO:0006310

Q06609 (UniProtKB)

TAS

GO:0006312

Q06609 (UniProtKB)

TAS

GO:0006974

Q06609 (UniProtKB)

IDA

GO:0006974

Q06609 (UniProtKB)

IDA

GO:0007126

Q06609 (UniProtKB)

ISS

GO:0007131

Q06609 (UniProtKB)

TAS

GO:0008022

Q06609 (UniProtKB)

IPI

GO:0009636

Q06609 (UniProtKB)

IEA

GO:0010165

Q06609 (UniProtKB)

IEA

GO:0010569

Q06609 (UniProtKB)

IDA

GO:0010833

Q06609 (UniProtKB)

ISS

GO:0016605

Q06609 (UniProtKB)

IDA

GO:0031297

Q06609 (UniProtKB)

IMP

GO:0031297

Q06609 (UniProtKB)

IDA

GO:0035861

Q06609 (UniProtKB)

IDA

GO:0042148

Q06609 (UniProtKB)

IBA

GO:0042493

Q06609 (UniProtKB)

IEA

GO:0042802

Q06609 (UniProtKB)

IPI

GO:0042802

Q06609 (UniProtKB)

IPI

GO:0042802

Q06609 (UniProtKB)

IPI

GO:0042802

Q06609 (UniProtKB)

IPI

GO:0043142

Q06609 (UniProtKB)

IDA

GO:0043142

Q06609 (UniProtKB)

IDA

GO:0048471

Q06609 (UniProtKB)

IDA

GO:0051106

Q06609 (UniProtKB)

IDA

GO:0051260

Q06609 (UniProtKB)

IPI

GO:0070182

Q06609 (UniProtKB)

IPI

GO:0070192

Q06609 (UniProtKB)

IBA

GO:0071479

Q06609 (UniProtKB)

IDA

GO:0071479

Q06609 (UniProtKB)

IDA

GO:0071480

Q06609 (UniProtKB)

IEA

GO:0072711

Q06609 (UniProtKB)

IEA

GO:0072719

Q06609 (UniProtKB)

IEA

GO:0072757

Q06609 (UniProtKB)

IDA

GO:1902521

Q06609 (UniProtKB)

IEA

GO:1990414

Q06609 (UniProtKB)

IEA

GO:1990426

Q06609 (UniProtKB)

IEA

GO:0004520

Q06609 (UniProtKB)

IBA

GO:0000166

Q9NZG9 (UniProtKB)

IEA

GO:0005730

Q9NZG9 (UniProtKB)

IDA

GO:0005737

Q9NZG9 (UniProtKB)

IDA

可能调控 RAD51基因的相关microRNA：

hsa-miR-103 hsa-miR-124 hsa-miR-192 hsa-miR-193b hsa-miR-197 hsa-miR-215 hsa-miR-23b hsa-miR-92a-1*

String

BioGrid

IntAct

mentha

MINT

Reactome

加载中…

关联基因	作用方式	资源库来源/分值

KEGG
Reactomepathway

名称
3440 Homologous recombination [PATH:hsa03440]
3460 Fanconi anemia pathway [PATH:hsa03460]
5200 Pathways in cancer [PATH:hsa05200]
5212 Pancreatic cancer [PATH:hsa05212]

名称
Assembly of the RAD51-ssDNA nucleoprotein complex
Cell Cycle
DNA Repair
Double-Strand Break Repair
Homologous DNA pairing and strand exchange
Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks
Meiosis
Meiotic recombination
Presynaptic phase of homologous DNA pairing and strand exchange

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Malignant neoplasm of breast	0.215831722	88	4	BeFree_GAD_UNIPROT
Mammary Neoplasms	0.150967744	16	0	BeFree_CTD_human_GAD_LHGDN
Head and Neck Neoplasms	0.127458414	4	0	CTD_human_GAD_LHGDN
Breast Cancer, Familial	0.122714419	10	4	BeFree_CLINVAR
IGA Glomerulonephritis	0.12	1	0	CTD_human
MIRROR MOVEMENTS 2	0.12	0	2	CLINVAR
Hereditary Breast and Ovarian Cancer Syndrome	0.12	0	0	ORPHANET
Cardiomyopathies	0.080271442	1	0	BeFree_RGD
Hypertensive disease	0.08	1	0	RGD
Liver Neoplasms, Experimental	0.08	1	0	RGD

Functional Characterization of POLE1 Variant Fibroblasts Reveals Replication Stress and Increased Sensitivity to Genotoxic Stress.

Khdeda E, Naumann-Bartsch N, Khdeda N, Cramer G, Hildebrand LS, Schiller P, Wagner PJ, Fahrmeier F, Hüffmeier U, Corradini S, Distel LV, Kuhlmann LCF Diseases 2026-03-04

NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and impairs gemcitabine response in pancreatic cancer.

Sun H, Yang C, Du J, Xu C, Chen Y, Chen J, Yue N, Gong R, Yang Z Cell Death Dis IF: 12.2 2026-03-28

MVGAE: A Multi-View Graph Auto-Encoder Model for Drug Prediction of Non-Small Cell Lung Cancer Based on Synthetic Lethality.

Hu S, Jiang R, Zhao N Curr Issues Mol Biol IF: 4.1 2026-03-03

Assessment of Homologous Recombination System Gene Expression in Chemologically Induced Carcinogenesis In Vivo Models.

Tsyganov MM, Bulatova DZ, Fedorenko AA, Loos DM, Nikiforov PE, Tsydenova IA, Bayanbayeva AA, Sharipkhanova Z, Timoshenko SS, Ibragimova MK Curr Issues Mol Biol IF: 4.1 2026-03-04

Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficient Triple-Negative Breast Cancer by Suppressing the Expression of BRCA1 and RAD51.

Huang L, Yang Y, Duan D, Dai L, Zhai B, Qian B Molecules IF: 2.861 2026-03-20

Interplay Between Poly(ADP-ribosyl)ation and Specific Inner Cellular Events That Suggest Combination Strategies for Overcoming PARP Inhibitor Resistance.

Xu L, Kong X, Zhang B, Ma H, Li X, Deng Y, Liu W, Ren W, Tang X, Zhang D Pharmaceutics 2026-03-12

Development of Stearic Acid Nanoemulsion for Therapeutic Delivery of Talazoparib Against Breast Cancer.

Zhang J, Zhang Z, Xia X, Feng K, Yao S, Wang Y, Wu M Pharmaceutics 2026-03-19

The Marchantia polymorpha recombinase MpRAD51 is at the crossroads of morphogenesis and the DNA damage response.

Trujillo-Esquivel E, Lorenzo-Manzanarez JL, Espinal-Centeno A, Méndez-Alvarez D, Aguilar-Cruz A, Brieba LG, Cruz-Ramírez A Plant Cell IF: 13.5 2026-06-02

PFOS-mediated suppression of SOX30 impairs DNA double-strand break repair leading to male reproductive dysfunction.

Liu K, He S, Hu Y, Liu Y, Zhu L, Zhang W, Jiang X, Gu J, Guo L, Zhang Z, Chen Q, Sun L, Cao J, Ao L, Liu J Ecotoxicol Environ Saf IF: 6.6 2026-04-01

TRF2-RAP1 inhibits homology-directed repair of telomeres by promoting BLM-mediated removal of telomere R-loops.

Liang F, Chang S Nucleic Acids Res IF: 15.0 2026-03-19

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RAD51 (RAD51 recombinase)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

编码蛋白质

编码蛋白质

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因相关评论

基因相关评论

联系地址

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