RAD51AP1 (RAD51 associated protein 1)

Gene Basic Information

Gene Basic Information

symbol:
RAD51AP1
locus group:
protein-coding gene
location:
12p13.32
gene_family:
alias symbol:
PIR51
alias name:
None
entrez id:
10635
ensembl gene id:
ENSG00000111247
ucsc gene id:
uc001qmu.4
refseq accession:
NM_006479
hgnc_id:
HGNC:16956
approved reserved:
2004-09-16

Chromosome Location

Chromosome Location

12p13.32

Gene Summary

Gene Summary

RAD51AP1（RAD51-associated protein 1）是一种与DNA修复密切相关的基因，属于RAD51基因家族。该家族的核心成员RAD51在DNA同源重组修复（HR）中起关键作用，这是一种高保真修复DNA双链断裂的机制。RAD51AP1作为辅助因子，通过与RAD51直接结合增强其功能，促进RAD51在损伤位点的聚集和DNA链交换效率。其表达产物是一种核蛋白，主要作用于细胞周期的S/G2期，此时HR修复最为活跃。突变或缺失RAD51AP1会导致HR修复缺陷，表现为基因组不稳定、染色体异常和细胞对电离辐射或DNA交联剂的敏感性增加。这类缺陷与多种癌症（如乳腺癌、卵巢癌）的发生发展相关，尤其在BRCA1/2突变背景下可能加剧肿瘤风险。当RAD51AP1过表达时，可能异常激活HR通路，导致肿瘤细胞对化疗药物产生耐药性；而低表达则削弱修复能力，增加突变积累。该基因家族（RAD51家族）的共性是通过调控DNA重组维持基因组稳定性，成员间常形成复合物协同工作，如RAD51B/C/D、XRCC2/3等。研究还发现RAD51AP1与减数分裂中的染色体联会有关，其异常可能影响生殖细胞发育。目前针对RAD51AP1的干预策略正在探索中，例如通过抑制剂靶向HR通路增强肿瘤对放疗的敏感性。术语解释：同源重组修复（HR）指细胞利用同源DNA模板精确修复断裂的机制；基因组不稳定指DNA频繁发生突变或结构变异的状态。

ChineseEnglish

None

OMIM entry for RAD51AP1     Wikipedia entry for RAD51AP1

Gene Sequence

Gene Sequence

Nucleotide sequence of RAD51AP1:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MVRPVRHKKP VNYSQFDHSD SDDDFVSATV PLNKKSRTAP
41KELKQDKPKP NLNNLRKEEI PVQEKTPKKR LPEGTFSIPA
81 SAVPCTKMA LDDKLYQRDL EVALALSVKE LPTVTTNVQN
121SQDKSIEKHG SSKIETMNKS PHISNCSVAS DYLDLDKITV
161E DDVGGVQG KRKAASKAAA QQRKILLEGS DGDSANDTEP
201DFAPGEDSED DSDFCESEDN DEDFSMRKSK VKEIKKKEVK
241VK SPVEKKE KKSKSKCNAL VTSVDSAPAA VKSESQSLPK
281KVSLSSDTTR KPLEIRSPSA ESKKPKWVPP AASGGSRSSS
321SPL VVVSVK SPNQSLRLGL SRLARVKPLH PNATST
结构预测来自 AlphaFold DB（UniProt: Q96B01），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of RAD51AP1:           Showing partial SNPs
rs2240767       rs12828064       rs16931530       rs34361540       rs34683814       rs71459907       rs74061946       rs74061947       rs74061948       rs74061951       rs74692787       rs75633979       rs76125004       rs77327306       rs78024958       rs114378416       rs116707632      

Gene Expression

Gene Expression

Tissue expression of RAD51AP1:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GAAGATTCTTCTGGAAGGCAG
59
TCCTCAGAATCTTCACCAGG
59
GAAGATTCTTCTGGAAGGCAG
59
TCCTCAGAATCTTCACCAGG
59
GAAGATTCTTCTGGAAGGCAG
59
TCCTCAGAATCTTCACCAGG
59
CCTGTGAGACATAAGAAACCA
58
CGGAGATTGTTCAAGTTAGGT
58
GTGCCTTGTACAAAGATGGC
60
GTTCCTTCACTGATAAAGCTAGTG
60
CCTGTGAGACATAAGAAACCA
58
CGGAGATTGTTCAAGTTAGGT
58
CCTGTGAGACATAAGAAACCA
58
CGGAGATTGTTCAAGTTAGGT
58
CCTGTGAGACATAAGAAACCA
58
CGGAGATTGTTCAAGTTAGGT
58
ATGACGAAGACTTCTCTATGAG
57
TTTCCTAGTGGTATCCAAAGC
58
AATGTAATGCTTTGGCGGC
60
ACTCTGATTGGGAGACTTCAC
60

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
MEN1
RAD51AP1
Unknown
23648481

Gene Ontology

Subcellular localization of RAD51AP1 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RAD51AP1:

GO ID
Protein
Source DB
GO:0000724
Q96B01 (UniProtKB)
NAS
GO:0000731
Q96B01 (UniProtKB)
TAS
GO:0000732
Q96B01 (UniProtKB)
TAS
GO:0003690
Q96B01 (UniProtKB)
IDA
GO:0003697
Q96B01 (UniProtKB)
IDA
GO:0003723
Q96B01 (UniProtKB)
IDA
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005515
Q96B01 (UniProtKB)
IPI
GO:0005634
Q96B01 (UniProtKB)
IC
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0005654
Q96B01 (UniProtKB)
TAS
GO:0006281
Q96B01 (UniProtKB)
NAS
GO:0010569
Q96B01 (UniProtKB)
IDA
GO:0071479
Q96B01 (UniProtKB)
IDA

Related microRNA

Related microRNA

microRNAs potentially regulating RAD51AP1:     

Gene Interactions

Gene Interactions

String
BioGrid
IntAct
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Cholangiocarcinoma 0.00272435 1 0 LHGDN
Alcoholic Intoxication, Chronic 0.002367032 1 0 GAD
Intrahepatic Cholangiocarcinoma 0.000271442 1 0 BeFree
Aggressive Non-Hodgkin Lymphoma 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 0.000271442 1 0 BeFree
Small Lymphocytic Lymphoma 0.000271442 1 0 BeFree

Related Publications

Related Publications

RAD51AP1-MYC-Sam68 positive transcriptional feedback loop maintains lung cancer stemness.
Liu R, Li M, Hu Z, Yang S, Zhu G, Cao P, Fan H, Wang J, Zhang Z, Chen J iScience 2026-09-18
G quadruplex DNA facilitates a pervasive path to homologous recombination.
Thakur BL, Basak P, Khurana S, Sharma S, Lai YH, Nguyen T, Ramanarayanan V, Zhao X, Batista PJ, Stracker TH, Oberdoerffer P bioRxiv 2026-06-07
PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.
He H, Hu Y, Lu Y, Deng M, Bao Q, Zu D, Zhong Y, Zhang C, You C, Du X, Liu S, He Y, Liu M, Gao L, Gao X, Liu H, Huang Y, Chen Y, Rong D, Tainer JA, Jing J, Shi Y, Shen HM, Ye Z, Cheng X Cancer Res IF: 22.6 2026-06-18
Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G-Quadruplex Resolution to Maintain DNA Repair and Tumor Survival.
Ji Q, Sun X, Sun Z, Li M, Cheng X, Tian S, Thorne RF, Li J, Liu G, Wu M, Liu X Adv Sci (Weinh) IF: 9.034 2026-05-00
DLGAP5 protects glioblastoma cells against DNA damage through E2F1-transcripted RAD51AP1.
Liu Y, Chen R, Liu G, Chen J, Zhou J, Chen Y, Li Z, Li Y, Deng L, Cui H Biochim Biophys Acta Mol Basis Dis IF: 5.0 2026-08-00
Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer.
Pai AKA, Dcunha L, Gopalakrishnan AP, Ummar S, Rajeev AC, Raju R Front Syst Biol None
ITGA5 promotes homologous recombination mediated radioresistance in esophageal squamous cell carcinoma by upregulating RAD51AP1 expression.
Huang X, Liu J, Ren J, Yuan J, Huo W, Zhang Z, Chen M, Tian B, Chen D Oncogene IF: 9.1 2026-09-04
Epigenetically elevated RAD51AP1 regulates the RAD51-UAF1 complex contributing to temozolomide resistance in EGFRvIII glioblastoma.
Chang Y, Yang J, Li Z, Zhu X, Jiang T, Wang Q, Yu M, Han B, Liu X Chin Med J (Engl) IF: 9.1 2026-05-20

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