Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTPRG	5793	broad.mit.edu	37	3	62188855	62188855	+	Silent	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:62188855G>A	ENST00000474889.1	+	12	1763	c.1386G>A	c.(1384-1386)gcG>gcA	p.A462A	PTPRG_ENST00000295874.10_Silent_p.A462A	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	462					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		AGCCCACAGCGTCTCCTGCCT	0.547000													33	62					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													6	158					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139078198	139078198	+	Silent	SNP	A	A	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:139078198A>G	ENST00000333188.5	-	18	2398	c.2217T>C	c.(2215-2217)gaT>gaC	p.D739D	COPB2_ENST00000507777.1_Silent_p.D710D	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	739					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						CTAGGCAGGCATCAACCCTAA	0.393000													29	37					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952007	178952007	+	Missense_Mutation	SNP	A	A	G	rs121913288		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:178952007A>G	ENST00000263967.3	+	21	3219	c.3062A>G	c.(3061-3063)tAc>tGc	p.Y1021C		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1021	PI3K/PI4K.		Y -> C (in cancer).|Y -> H (in cancer).|Y -> N (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Y1021C(23)|p.Y1021F(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GACATTGCATACATTCGAAAG	0.388000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			126	25					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29614328	29614328	+	Splice_Site	SNP	G	G	A	rs137860963	by1000genomes	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr20:29614328G>A	ENST00000278882.3	+	2	320		c.e2+1		FRG1B_ENST00000358464.4_Splice_Site|FRG1B_ENST00000439954.2_Splice_Site																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGATACGTTGGTGAGTCAGTT	0.289000													3	36					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69724960	69724960	+	Missense_Mutation	SNP	C	C	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr16:69724960C>A	ENST00000349945.1	+	13	3162	c.1610C>A	c.(1609-1611)aCa>aAa	p.T537K	NFAT5_ENST00000566899.1_Missense_Mutation_p.T537K|NFAT5_ENST00000393742.2_Missense_Mutation_p.T537K|NFAT5_ENST00000567239.1_Missense_Mutation_p.T630K|NFAT5_ENST00000354436.2_Missense_Mutation_p.T613K|NFAT5_ENST00000432919.1_Missense_Mutation_p.T631K	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	613					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						ATGGAAGTAACAGCAGAAAAA	0.328000													13	31					7.03913e-09	7.67265e-09	1	1	0
NUDT14	256281	broad.mit.edu	37	14	105639417	105639417	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr14:105639417C>T	ENST00000392568.2	-	5	703	c.610G>A	c.(610-612)Gtc>Atc	p.V204I	RP11-44N21.4_ENST00000548203.1_RNA|NUDT14_ENST00000550912.1_5'UTR	NM_177533.4	NP_803877.2	O95848	NUD14_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 14	204	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity	p.V204I(1)		cervix(2)|endometrium(1)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	14		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCAAAGATGACGCCGAGGGTC	0.627000										HNSCC(42;0.11)			57	22					0	0	1	0	0
APOBEC1	339	broad.mit.edu	37	12	7803729	7803729	+	Missense_Mutation	SNP	G	G	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:7803729G>T	ENST00000229304.4	-	4	471	c.451C>A	c.(451-453)Cac>Aac	p.H151N		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	151					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						CTCCAGCAGTGATAATACTCT	0.458000													48	25					1.23103e-26	1.35537e-26	1	1	0
GARNL3	84253	broad.mit.edu	37	9	130095380	130095380	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr9:130095380G>A	ENST00000373387.4	+	9	1101	c.749G>A	c.(748-750)cGt>cAt	p.R250H	GARNL3_ENST00000314904.5_Missense_Mutation_p.R250H|GARNL3_ENST00000435213.2_Missense_Mutation_p.R228H	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	250	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						ACGGGCTACCGTGGCGGTCTG	0.428000													49	5					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15497073	15497073	+	Silent	SNP	G	G	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr6:15497073G>T	ENST00000341776.2	+	7	1861	c.1617G>T	c.(1615-1617)tcG>tcT	p.S539S	JARID2_ENST00000397311.3_Silent_p.S367S|JARID2_ENST00000541660.1_Silent_p.S501S	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	539					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding	p.S539S(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CGCAGGACTCGGGCAAGGCCG	0.657000													21	33					4.96729e-08	5.36074e-08	1	1	0
C12orf42	374470	broad.mit.edu	37	12	103696308	103696308	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:103696308C>T	ENST00000548048.1	-	9	956	c.460G>A	c.(460-462)Ggc>Agc	p.G154S	C12orf42_ENST00000315192.8_Intron|C12orf42_ENST00000548883.1_Missense_Mutation_p.G221S|C12orf42_ENST00000378113.2_Missense_Mutation_p.G221S			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	221										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						CTGCAGAGGCCGATGGCAGTG	0.667000													34	57					0	0	1	0	0
FBXW7	0	broad.mit.edu	37	4	153249384	153249384	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:153249384C>G	ENST00000281708.4	-	9	2623	c.1394G>C	c.(1393-1395)cGt>cCt	p.R465P	FBXW7_ENST00000296555.5_Missense_Mutation_p.R347P|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465P|FBXW7_ENST00000263981.5_Missense_Mutation_p.R385P|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465P|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289P	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465H(69)|p.R385H(16)|p.R226H(16)|p.R465L(4)|p.R347H(4)|p.R465Y(2)|p.?(1)|p.R385L(1)|p.R226L(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATGCATACAACGCACAGTGGA	0.408000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								42	57					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36091420	36091420	+	Missense_Mutation	SNP	T	T	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:36091420T>G	ENST00000378660.1	+	4	543	c.355T>G	c.(355-357)Ttc>Gtc	p.F119V	CHDC2_ENST00000313548.4_Missense_Mutation_p.F119V					calponin homology domain containing 2																		ACAGACCTGGTTCAGTCTCTT	0.403000													35	41					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V|FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													4	72					0	0	1	0	0
USF1	7391	broad.mit.edu	37	1	161010072	161010072	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:161010072G>A	ENST00000368021.3	-	10	967	c.763C>T	c.(763-765)Cgg>Tgg	p.R255W	USF1_ENST00000368019.1_Missense_Mutation_p.R227W|USF1_ENST00000368020.1_Missense_Mutation_p.R255W|USF1_ENST00000435396.1_Missense_Mutation_p.R196W	NM_007122.3	NP_009053.1	P22415	USF1_HUMAN	upstream transcription factor 1	255	Helix-loop-helix motif.				cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|large_intestine(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TTACTCTGCCGAAGCTCCTGG	0.478000													4	152					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6686974	6686974	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:6686974T>C	ENST00000309577.6	-	36	5585	c.5422A>G	c.(5422-5424)Aaa>Gaa	p.K1808E	CHD4_ENST00000544484.1_Missense_Mutation_p.K1805E|CHD4_ENST00000544040.1_Missense_Mutation_p.K1773E|CHD4_ENST00000357008.2_Missense_Mutation_p.K1780E			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1780	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCTAGAAATTTATTCTTGATC	0.468000													100	2					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141882	133141882	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr8:133141882G>A	ENST00000388996.4	-	15	2666	c.2246C>T	c.(2245-2247)cCt>cTt	p.P749L	KCNQ3_ENST00000521134.1_Missense_Mutation_p.P629L|KCNQ3_ENST00000519445.1_Missense_Mutation_p.P737L	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	749					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AGTCAAGATAGGCAGGACCGT	0.617000													34	44					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122616806	122616806	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:122616806T>C	ENST00000264357.5	+	15	2888	c.2596T>C	c.(2596-2598)Ttt>Ctt	p.F866L	GRIA3_ENST00000542149.1_3'UTR|GRIA3_ENST00000371256.5_Missense_Mutation_p.F866L|GRIA3_ENST00000371251.1_Missense_Mutation_p.F866L	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	866					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CACCCAAAACTTTAAGCCTGC	0.468000													27	66					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076216	57076216	+	Silent	SNP	G	G	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr11:57076216G>C	ENST00000532437.1	-	5	4280	c.3969C>G	c.(3967-3969)acC>acG	p.T1323T	TNKS1BP1_ENST00000358252.3_Silent_p.T1323T			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1323	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTGGGTCACAGGTCACCTCCA	0.612000													206	252					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101551128	101551128	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:101551128C>G	ENST00000536262.2	-	15	2320	c.1762G>C	c.(1762-1764)Gat>Cat	p.D588H		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	588					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCAGGATTATCAGTTCCACCA	0.388000													11	15					0	0	1	0	0
SPANXN3	139067	broad.mit.edu	37	X	142605155	142605155	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:142605155T>C	ENST00000370503.2	-	1	148	c.65A>G	c.(64-66)aAa>aGa	p.K22R		NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	22										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					ATCATTTTTTTTGTTATTGGA	0.453000													5	121					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28023623	28023623	+	Silent	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr10:28023623C>T	ENST00000375790.5	-	5	1032	c.600G>A	c.(598-600)gcG>gcA	p.A200A	MKX_ENST00000419761.1_Silent_p.A200A			Q8IYA7	MKX_HUMAN	mohawk homeobox	200					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						GCCTCACTCCCGCTTTGATGA	0.488000													22	83					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096275	167096275	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:167096275C>T	ENST00000361200.2	+	6	2073	c.1907C>T	c.(1906-1908)aCg>aTg	p.T636M	DUSP27_ENST00000271385.5_Missense_Mutation_p.T636M|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.T636M			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	636					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGCCGGCAGACGCTGGAGGAG	0.632000													27	28					0	0	1	0	0
FARSB	10056	broad.mit.edu	37	2	223499175	223499175	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr2:223499175T>C	ENST00000281828.6	-	6	804	c.541A>G	c.(541-543)Atc>Gtc	p.I181V	FARSB_ENST00000536361.1_Missense_Mutation_p.I82V	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	181					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	TTGAATTTGATATCTGAAGGA	0.398000													11	21					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502614	91502614	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:91502614G>A	ENST00000266718.4	-	2	597	c.143C>T	c.(142-144)cCa>cTa	p.P48L	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	48	Cys-rich.|LRRNT.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						CATGGCACTTGGGTAGCTTTC	0.418000													18	23					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18622331	18622331	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr9:18622331C>T	ENST00000380548.4	+	5	904	c.565C>T	c.(565-567)Cga>Tga	p.R189*	ADAMTSL1_ENST00000276935.6_Nonsense_Mutation_p.R189*|ADAMTSL1_ENST00000380570.4_Nonsense_Mutation_p.R189*|ADAMTSL1_ENST00000327883.7_Nonsense_Mutation_p.R189*|ADAMTSL1_ENST00000380566.4_Nonsense_Mutation_p.R189*	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	189						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCGGCTGGTCCGAGGGCAGTA	0.532000													29	61					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51920476	51920476	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:51920476C>T	ENST00000353836.5	-	2	502	c.281G>A	c.(280-282)gGg>gAg	p.G94E	CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.G94E|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.G94E|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.G94E|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.G94E|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.G94E|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.G94E|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.G94E|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.G94E	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	94	Ig-like V-type.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GGCGGGATCCCCAGTGAGCTG	0.562000													51	37					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58533811	58533811	+	Silent	SNP	G	G	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr20:58533811G>C	ENST00000348616.4	+	1	330	c.30G>C	c.(28-30)tcG>tcC	p.S10S	CDH26_ENST00000244047.5_Silent_p.S10S	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	10					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GGCACCCCTCgctgctgctgc	0.587000													23	57					0	0	1	0	0
SLC25A28	81894	broad.mit.edu	37	10	101379857	101379857	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr10:101379857C>G	ENST00000370495.4	-	1	264	c.236G>C	c.(235-237)gGc>gCc	p.G79A	SLC25A28_ENST00000496035.1_Intron	NM_031212.3	NP_112489.3	Q96A46	MFRN2_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 28	79					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|stomach(1)	11		Colorectal(252;0.234)		Epithelial(162;2.57e-10)|all cancers(201;2.01e-08)		TGCCACGGCGCCTGCCACCAT	0.692000													8	17					0	0	1	0	0
KLHL4	0	broad.mit.edu	37	X	86869493	86869493	+	Missense_Mutation	SNP	T	T	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:86869493T>A	ENST00000373119.4	+	3	792	c.647T>A	c.(646-648)cTt>cAt	p.L216H	KLHL4_ENST00000373114.4_Missense_Mutation_p.L216H	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	216	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						AATGATGTGCTTGAAGCCAAA	0.378000													16	18					0	0	1	0	0
RP11-14N7.2	0	broad.mit.edu	37	1	148933289	148933289	+	RNA	SNP	A	A	G	rs9729175	by1000genomes	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:148933289A>G	ENST00000539543.1	+	0	176					NR_027355.1																						TGCTGCCCGCAGGATATTGTG	0.562000													5	27					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26116637	26116637	+	Missense_Mutation	SNP	G	G	A	rs141421929	byFrequency	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:26116637G>A	ENST00000313735.6	-	3	421	c.188C>T	c.(187-189)aCg>aTg	p.T63M		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	63					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GACCTTTCCCGTCTCCACGAG	0.567000													78	3					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814196	106814196	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr8:106814196C>T	ENST00000407775.2	+	8	2136	c.1886C>T	c.(1885-1887)tCc>tTc	p.S629F	RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S497F|ZFPM2_ENST00000520492.1_Missense_Mutation_p.S497F|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S360F|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	629					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ATCAATTCTTCCACTGTCTTA	0.443000													24	72					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42004014	42004014	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr7:42004014T>C	ENST00000395925.3	-	15	4741	c.4657A>G	c.(4657-4659)Agc>Ggc	p.S1553G	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1553					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TTGGTGGTGCTCATGGACAGC	0.547000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				29	33					0	0	1	0	0
IFT74	80173	broad.mit.edu	37	9	26961996	26961996	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr9:26961996C>T	ENST00000443698.1	+	2	202	c.31C>T	c.(31-33)Cgc>Tgc	p.R11C	IFT74_ENST00000429045.2_Missense_Mutation_p.R11C|IFT74_ENST00000433700.1_Missense_Mutation_p.R11C|IFT74_ENST00000380062.5_Missense_Mutation_p.R11C	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)	11						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TTCAGCAGCTCGCCCTGTTTC	0.433000													45	42					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664056	22664056	+	RNA	SNP	T	T	C	rs3178309		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr22:22664056T>C	ENST00000426066.1	+	0	623					NR_027293.1																						ATAAAGTATATGATTTTGTGT	0.348000													3	26					0	0	1	0	0
RP11-483E23.2	0	broad.mit.edu	37	15	28599954	28599954	+	RNA	SNP	A	A	G	rs144345425	by1000genomes	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr15:28599954A>G	ENST00000568624.1	-	0	452																											GGCTGTAGTAAAGTGCCATCT	0.478000													5	107					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110438053	110438053	+	Silent	SNP	A	A	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr5:110438053A>G	ENST00000506538.2	+	6	1293	c.720A>G	c.(718-720)ctA>ctG	p.L240L	WDR36_ENST00000513710.2_Silent_p.L240L|WDR36_ENST00000505303.1_Silent_p.L184L	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	240					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GTAAACTTCTATATACATTTC	0.303000													19	9					0	0	1	0	0
TLR1	7096	broad.mit.edu	37	4	38800071	38800071	+	Missense_Mutation	SNP	C	C	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:38800071C>A	ENST00000308979.2	-	4	655	c.382G>T	c.(382-384)Gcc>Tcc	p.A128S	TLR1_ENST00000502213.2_Missense_Mutation_p.A128S	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	128					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						ATAGGCAGGGCATCAAATGCA	0.418000													46	62					5.48756e-27	6.10351e-27	1	1	0
GAA	2548	broad.mit.edu	37	17	78081505	78081505	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:78081505G>A	ENST00000302262.3	+	4	1061	c.842G>A	c.(841-843)cGg>cAg	p.R281Q	GAA_ENST00000390015.3_Missense_Mutation_p.R281Q	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	281					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	CTGTGGAACCGGGACCTTGCG	0.692000													68	41					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43401078	43401078	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr6:43401078C>T	ENST00000244533.3	+	1	1590	c.1231C>T	c.(1231-1233)Cac>Tac	p.H411Y	ABCC10_ENST00000372530.4_Missense_Mutation_p.H454Y|ABCC10_ENST00000443426.2_3'UTR	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	454	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			AATGCTACAGCACAAGGATGC	0.597000													32	23					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152287054	152287054	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:152287054T>C	ENST00000368799.1	-	3	343	c.308A>G	c.(307-309)aAg>aGg	p.K103R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	103					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGACTGTGCTTTCTGTGCTT	0.363000									Ichthyosis				11	87					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296373	145296373	+	Missense_Mutation	SNP	G	G	T	rs3969711		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:145296373G>T	ENST00000342960.5	+	3	330	c.295G>T	c.(295-297)Gtt>Ttt	p.V99F	NBPF10_ENST00000369338.1_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	99								p.V99F(1)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TAAAGTCCTAGTTCACTCTCA	0.473000													5	221					0.184627	0.186337	1	1	0
UTRN	7402	broad.mit.edu	37	6	144780347	144780347	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr6:144780347T>C	ENST00000367545.3	+	20	2564	c.2564T>C	c.(2563-2565)aTt>aCt	p.I855T		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	855	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CACCCCAAAATTGAAATGGCT	0.498000													11	56					0	0	1	0	0
CCL14	6358	broad.mit.edu	37	17	34310906	34310906	+	Silent	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:34310906G>A	ENST00000480944.2	-	2	2685	c.279C>T	c.(277-279)ggC>ggT	p.G93G	CCL15-CCL14_ENST00000481427.2_3'UTR|CTB-186H2.3_ENST00000593057.1_Intron|CCL14_ENST00000536149.1_Silent_p.G87G|CCL14_ENST00000394509.4_Silent_p.G71G|CCL14_ENST00000586216.1_3'UTR|CCL14_ENST00000435911.2_Silent_p.G87G			Q16627	CCL14_HUMAN	chemokine (C-C motif) ligand 14	71					cellular calcium ion homeostasis|immune response|positive regulation of cell proliferation	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|lung(6)	7		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGACGGAATGGCCCCTTTTGG	0.557000													5	52					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15704527	15704527	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:15704527C>T	ENST00000281171.4	+	15	2810	c.2480C>T	c.(2479-2481)gCc>gTc	p.A827V	PTPRO_ENST00000544244.1_Missense_Mutation_p.A16V|PTPRO_ENST00000445537.2_Missense_Mutation_p.A16V|PTPRO_ENST00000442921.2_Missense_Mutation_p.A16V|PTPRO_ENST00000542557.1_Missense_Mutation_p.A16V|PTPRO_ENST00000348962.2_Missense_Mutation_p.A827V	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	827						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TCCGTGCTGGCCATCCTTAGC	0.383000													4	116					0	0	1	0	0
NSUN3	63899	broad.mit.edu	37	3	93813928	93813928	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:93813928G>A	ENST00000314622.4	+	5	884	c.673G>A	c.(673-675)Gac>Aac	p.D225N		NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	225							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						GTTTTCTTCTGACTCTCAGAA	0.383000													18	30					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108203563	108203563	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr5:108203563C>T	ENST00000281092.4	+	6	961	c.577C>T	c.(577-579)Cag>Tag	p.Q193*	FER_ENST00000438717.2_Nonsense_Mutation_p.Q18*|FER_ENST00000536402.1_Nonsense_Mutation_p.Q193*	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	193	Important for interaction with membranes containing phosphoinositides.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GAAAGGGGCACAGCTCCATCA	0.403000													7	32					0	0	1	0	0
MEMO1	51072	broad.mit.edu	37	2	32108519	32108519	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr2:32108519C>G	ENST00000295065.4	-	7	902	c.593G>C	c.(592-594)cGt>cCt	p.R198P	MEMO1_ENST00000404530.1_Missense_Mutation_p.R198P|DPY30_ENST00000446765.1_5'UTR|MEMO1_ENST00000490459.1_Intron|MEMO1_ENST00000379383.3_Missense_Mutation_p.R201P|MEMO1_ENST00000426310.2_Missense_Mutation_p.R175P	NM_015955.2	NP_057039.1	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1	198					regulation of microtubule-based process	cytosol|nucleus				NS(1)|breast(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	17	Acute lymphoblastic leukemia(172;0.155)					GTAACTGTAACGGAACCTTTG	0.338000													61	126					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	157014118	157014118	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:157014118C>G	ENST00000368194.3	-	1	1044	c.5G>C	c.(4-6)aGt>aCt	p.S2T	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.S2T	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	2					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TAACCTTACACTCATGGTTTC	0.433000													60	49					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578448	9578448	+	Missense_Mutation	SNP	A	A	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:9578448A>G	ENST00000301480.4	-	10	1388	c.1175T>C	c.(1174-1176)cTt>cCt	p.L392P		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TACATGTTCAAGAAAGCCTGA	0.428000													35	56					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55102969	55102969	+	Silent	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr18:55102969C>G	ENST00000491143.2	+	1	53	c.21C>G	c.(19-21)gcC>gcG	p.A7A		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	7					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		CCTACACCGCCTATCGATGCC	0.721000													8	20					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17250147	17250147	+	Silent	SNP	A	A	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr21:17250147A>G	ENST00000285681.2	+	24	3297	c.2928A>G	c.(2926-2928)gaA>gaG	p.E976E	USP25_ENST00000285679.6_Silent_p.E944E|USP25_ENST00000351097.5_Silent_p.E339E|USP25_ENST00000400183.2_Silent_p.E1014E			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	944					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AACTCTTCGAATCTGGAGAGG	0.333000													8	12					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13470526	13470526	+	Missense_Mutation	SNP	C	C	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:13470526C>A	ENST00000360228.5	-	6	871	c.872G>T	c.(871-873)tGg>tTg	p.W291L	CACNA1A_ENST00000573710.2_Missense_Mutation_p.W291L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	291					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGGCCCTTCCCAGTAGGGCTG	0.547000													5	4					0.00116845	0.00121296	1	1	0
GCSAML	148823	broad.mit.edu	37	1	247737614	247737614	+	Missense_Mutation	SNP	T	T	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:247737614T>G	ENST00000366491.2	+	7	775	c.278T>G	c.(277-279)cTt>cGt	p.L93R	GCSAML_ENST00000366489.1_Missense_Mutation_p.L93R|GCSAML_ENST00000463359.1_Missense_Mutation_p.L81R|RP11-978I15.10_ENST00000446347.1_RNA|GCSAML_ENST00000366488.4_Missense_Mutation_p.L113R|GCSAML_ENST00000527084.1_Missense_Mutation_p.L81R|GCSAML_ENST00000536561.1_Missense_Mutation_p.L93R|GCSAML_ENST00000527541.1_Missense_Mutation_p.L81R|RP11-978I15.10_ENST00000435333.1_RNA					germinal center-associated, signaling and motility-like																		TATGCCCTTCTTAGGACTTCT	0.448000													18	61					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540472	169540472	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:169540472G>A	ENST00000340806.6	+	1	763	c.763G>A	c.(763-765)Gag>Aag	p.E255K		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	255										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						GAGCTTCGCCGAGCTCAGGAA	0.607000													95	21					0	0	1	0	0
UBL4A	8266	broad.mit.edu	37	X	153714147	153714147	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:153714147G>A	ENST00000369660.4	-	3	411	c.326C>T	c.(325-327)gCg>gTg	p.A109V	UBL4A_ENST00000369653.4_Missense_Mutation_p.A109V|UBL4A_ENST00000477777.1_5'UTR	NM_014235.3	NP_055050.1	P11441	UBL4A_HUMAN	ubiquitin-like 4A	109					protein modification process|tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	small conjugating protein ligase activity	p.A109V(1)		endometrium(5)|lung(1)|urinary_tract(1)	7	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGCATCTGCCGCACTGAAGTG	0.622000													62	111					0	0	1	0	0
UNC119	9094	broad.mit.edu	37	17	26875096	26875096	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:26875096C>T	ENST00000484980.1	-	2	3234	c.73G>A	c.(73-75)Gac>Aac	p.D25N	UNC119_ENST00000470125.1_Missense_Mutation_p.D25N|UNC119_ENST00000301032.4_Missense_Mutation_p.D120N|UNC119_ENST00000335765.4_Missense_Mutation_p.D120N			Q13432	U119A_HUMAN	unc-119 homolog (C. elegans)	120					phototransduction|synaptic transmission|visual perception	cytosol|soluble fraction				breast(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	7	Lung NSC(42;0.00431)					GGGTCCAGGTCCCGCCGGTTG	0.652000											OREG0024277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	2					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5701143	5701143	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr11:5701143C>T	ENST00000305836.5	-	2	567	c.265G>A	c.(265-267)Ggg>Agg	p.G89R	TRIM5_ENST00000380034.3_Missense_Mutation_p.G89R|TRIM5_ENST00000380027.1_Missense_Mutation_p.G89R|TRIM5_ENST00000396847.3_Missense_Mutation_p.G89R|TRIM5_ENST00000396853.4_Missense_Mutation_p.G89R|TRIM5_ENST00000396855.3_Missense_Mutation_p.G89R			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	89					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		ACTTTCTGCCCCTCTGGGCTC	0.532000													5	71					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24225888	24225888	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:24225888G>A	ENST00000379177.1	+	8	1283	c.856G>A	c.(856-858)Gat>Aat	p.D286N	ZFX_ENST00000459724.1_3'UTR|ZFX_ENST00000540034.1_Missense_Mutation_p.D325N|ZFX_ENST00000304543.5_Missense_Mutation_p.D286N|ZFX_ENST00000338565.3_Missense_Mutation_p.D236N|ZFX_ENST00000539115.1_Missense_Mutation_p.D57N|ZFX_ENST00000379188.3_Missense_Mutation_p.D286N	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						TGAACTGCTTGATCAGAACAG	0.408000													28	65					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8206865	8206865	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:8206865C>T	ENST00000600128.1	-	7	1112	c.698G>A	c.(697-699)cGc>cAc	p.R233H	FBN3_ENST00000270509.2_Missense_Mutation_p.R233H|FBN3_ENST00000601739.1_Missense_Mutation_p.R233H			Q75N90	FBN3_HUMAN	fibrillin 3	233	TB 1.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GAAGCCGCGGCGGCAGGGGTG	0.637000													20	51					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170494027	170494027	+	Silent	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr2:170494027C>T	ENST00000260970.3	+	14	2479	c.2259C>T	c.(2257-2259)agC>agT	p.S753S	PPIG_ENST00000448752.2_Silent_p.S753S|PPIG_ENST00000409714.3_Silent_p.S738S	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	753					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AAGACAAAAGCGGATGAGTGA	0.313000													14	11					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58234684	58234684	+	Missense_Mutation	SNP	A	A	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:58234684A>C	ENST00000317398.6	-	2	258	c.163T>G	c.(163-165)Ttt>Gtt	p.F55V	ZNF671_ENST00000596939.1_Intron|ZNF671_ENST00000594803.1_5'UTR|ZNF671_ENST00000335820.3_Intron|AC003006.7_ENST00000599221.1_Intron	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAGTATACAAACACATCCTCA	0.458000													5	186					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236746150	236746150	+	Silent	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:236746150T>C	ENST00000366582.3	-	19	2562	c.2448A>G	c.(2446-2448)gaA>gaG	p.E816E	HEATR1_ENST00000366581.2_Silent_p.E816E	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	816					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTTTCAGTTGTTCAGGATTCC	0.428000													21	66					0	0	1	0	0
CYSLTR1	0	broad.mit.edu	37	X	77528817	77528817	+	Missense_Mutation	SNP	C	C	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:77528817C>A	ENST00000373304.3	-	3	719	c.427G>T	c.(427-429)Gtg>Ttg	p.V143L		NM_006639.2	NP_006630.1	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	143					elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	CCTACACACACAAACCTGGCT	0.373000													5	13					0.184627	0.186337	1	1	0
MAGEC2	51438	broad.mit.edu	37	X	141291465	141291465	+	Missense_Mutation	SNP	G	G	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:141291465G>C	ENST00000247452.3	-	3	656	c.309C>G	c.(307-309)tgC>tgG	p.C103W		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	103	Ser-rich.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGGAGCAGCAGGAGCTCA	0.562000										HNSCC(46;0.14)			48	28					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49847420	49847420	+	Silent	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:49847420G>A	ENST00000333486.3	-	14	1988	c.1830C>T	c.(1828-1830)caC>caT	p.H610H		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	610					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CCTGCAGGGTGTGCTCGGCTG	0.612000													8	137					0	0	1	0	0
B4GALT7	11285	broad.mit.edu	37	5	177031297	177031297	+	Silent	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr5:177031297C>T	ENST00000029410.5	+	2	279	c.168C>T	c.(166-168)gaC>gaT	p.D56D		NM_007255.2	NP_009186.1	Q9UBV7	B4GT7_HUMAN	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7	56					fibril organization|glycosaminoglycan biosynthetic process|negative regulation of fibroblast proliferation|protein modification process|proteoglycan metabolic process	Golgi cisterna membrane|integral to membrane	metal ion binding|xylosylprotein 4-beta-galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|pancreas(1)|skin(1)|urinary_tract(1)	7	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTCTGGGGACGTGGCCCGGG	0.682000													4	26					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099186	133099186	+	Missense_Mutation	SNP	C	C	T	rs145373217	byFrequency	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:133099186C>T	ENST00000515826.1	+	3	754	c.631C>T	c.(631-633)Cgg>Tgg	p.R211W	TMEM108_ENST00000321871.6_Missense_Mutation_p.R211W|TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000393130.3_Missense_Mutation_p.R211W			Q6UXF1	TM108_HUMAN	transmembrane protein 108	211						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GGGGCAGAAGCGGCCCCTGGG	0.592000													36	32					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	57					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121435639	121435639	+	Silent	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:121435639G>A	ENST00000393667.3	-	9	1343	c.1233C>T	c.(1231-1233)ctC>ctT	p.L411L	GOLGB1_ENST00000340645.5_Silent_p.L406L	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	406					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TCTTATCTTGGAGAAGCTTTG	0.433000													18	28					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62892272	62892272	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:62892272C>G	ENST00000584306.1	-	3	1634	c.1104G>C	c.(1102-1104)gaG>gaC	p.E368D	RP11-927P21.1_ENST00000584959.1_RNA|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.E368D|RP11-927P21.1_ENST00000584131.1_RNA|RP11-927P21.1_ENST00000577938.1_RNA|LRRC37A3_ENST00000339474.5_Intron|LRRC37A3_ENST00000400877.3_Intron	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	368						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						CCCTAGAAGACTCAGAAGGCT	0.537000													90	399					0	0	1	0	0
WDR19	57728	broad.mit.edu	37	4	39229838	39229838	+	Silent	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:39229838C>T	ENST00000399820.3	+	16	1792	c.1638C>T	c.(1636-1638)gaC>gaT	p.D546D	WDR19_ENST00000288634.7_Silent_p.D386D	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	546					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AGGTCAATGACGCTACCTATG	0.383000													5	11					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285756	48285756	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr11:48285756T>C	ENST00000320048.1	+	1	344	c.344T>C	c.(343-345)gTg>gCg	p.V115A		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						CTCCTGATGGTGATGGCCTAT	0.517000													23	30					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22040812	22040812	+	Missense_Mutation	SNP	C	C	A	rs139539832		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr12:22040812C>A	ENST00000261200.4	-	13	1858	c.1859G>T	c.(1858-1860)cGa>cTa	p.R620L	ABCC9_ENST00000345162.2_Missense_Mutation_p.R620L|RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000261201.4_Missense_Mutation_p.R620L	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	620					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTCACCAGTTCGCCAACTGTC	0.383000													7	347					0.00307968	0.00316684	1	1	0
GSTCD	79807	broad.mit.edu	37	4	106638979	106638979	+	Missense_Mutation	SNP	A	A	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr4:106638979A>G	ENST00000515279.1	+	2	429	c.209A>G	c.(208-210)gAt>gGt	p.D70G	GSTCD_ENST00000394728.3_Missense_Mutation_p.D70G|GSTCD_ENST00000394730.3_Intron|GSTCD_ENST00000360505.5_Missense_Mutation_p.D70G|GSTCD_ENST00000507281.1_Intron|GSTCD_ENST00000515255.1_Intron			Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain containing	70						cytoplasm	rRNA methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	14		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		CTGATCCAGGATGTTGAAATA	0.383000													27	40					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													5	92					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21670532	21670532	+	Missense_Mutation	SNP	A	A	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:21670532A>G	ENST00000425654.2	+	21	3388	c.2908A>G	c.(2908-2910)Atc>Gtc	p.I970V	CNKSR2_ENST00000379510.3_Missense_Mutation_p.I1000V	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	1000					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TTTCTTGGATATCTGTCAAAA	0.398000													40	31					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7683556	7683556	+	Missense_Mutation	SNP	T	T	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr17:7683556T>A	ENST00000572933.1	+	37	7264	c.5804T>A	c.(5803-5805)cTc>cAc	p.L1935H	DNAH2_ENST00000389173.2_Missense_Mutation_p.L1935H			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1935	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GACTCCACCCTCATTGCAGAA	0.453000													10	149					0	0	1	0	0
KRTAP20-2	337976	broad.mit.edu	37	21	32007616	32007616	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr21:32007616C>T	ENST00000330798.2	+	1	62	c.34C>T	c.(34-36)Cgt>Tgt	p.R12C		NM_181616.1	NP_853647.1	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	12						intermediate filament				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|ovary(1)	8						TGGTGGTCTGCGTTATGGCTA	0.517000													45	55					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52715971	52715971	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:52715971C>G	ENST00000322088.6	+	5	594	c.536C>G	c.(535-537)cCc>cGc	p.P179R	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.P124R|PPP2R1A_ENST00000462990.1_5'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	179	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.P179R(21)|p.P179L(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATGACACCCCCATGGTGCGG	0.612000			Mis		clear cell ovarian carcinoma								31	42					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39556161	39556161	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr14:39556161G>A	ENST00000537403.1	-	2	1251	c.49C>T	c.(49-51)Cag>Tag	p.Q17*	SEC23A_ENST00000307712.6_Nonsense_Mutation_p.Q219*|SEC23A_ENST00000545328.2_Nonsense_Mutation_p.Q190*|SEC23A_ENST00000536508.1_Nonsense_Mutation_p.Q93*			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	219					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TGCTGTACCTGAGGACCACGT	0.383000													24	9					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	95940099	95940099	+	Silent	SNP	C	C	A			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chrX:95940099C>A	ENST00000324765.8	+	1	389	c.42C>A	c.(40-42)ggC>ggA	p.G14G	DIAPH2_ENST00000373054.4_Silent_p.G14G|DIAPH2_ENST00000373061.3_Silent_p.G14G|DIAPH2_ENST00000355827.4_Silent_p.G14G|DIAPH2_ENST00000373049.4_Silent_p.G14G			O60879	DIAP2_HUMAN	diaphanous-related formin 2	14					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						CGGGAGGCGGCAGCGAGGAAC	0.647000													5	11					0.000602214	0.000631167	1	1	0
ZFAT	57623	broad.mit.edu	37	8	135545196	135545196	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr8:135545196C>T	ENST00000520727.1	-	13	3259	c.2960G>A	c.(2959-2961)tGc>tAc	p.C987Y	ZFAT_ENST00000517307.1_5'UTR|ZFAT_ENST00000429442.2_Missense_Mutation_p.C987Y|ZFAT_ENST00000520214.1_Missense_Mutation_p.C987Y|ZFAT_ENST00000523399.1_Missense_Mutation_p.C937Y|ZFAT_ENST00000520356.1_Missense_Mutation_p.C987Y|ZFAT_ENST00000377838.3_Missense_Mutation_p.C999Y	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	999					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GGAGTAATGGCAATGGGCACA	0.587000													16	14					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99696771	99696771	+	Missense_Mutation	SNP	G	G	A	rs150260409		TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr7:99696771G>A	ENST00000303887.5	-	5	1102	c.457C>T	c.(457-459)Cgg>Tgg	p.R153W	MCM7_ENST00000354230.3_5'UTR|MCM7_ENST00000343023.6_Missense_Mutation_p.R153W	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	153					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GAGTCAGCCCGCACTTCCCGG	0.512000													8	158					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185252705	185252705	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr3:185252705C>T	ENST00000296252.4	-	2	406	c.265G>A	c.(265-267)Gat>Aat	p.D89N	LIPH_ENST00000424591.2_Missense_Mutation_p.D89N	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	89					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			ACTAAGTCATCCATCCAAACA	0.438000													153	45					0	0	1	0	0
HMGN2	3151	broad.mit.edu	37	1	26799107	26799107	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr1:26799107delC	ENST00000361427.5	+	1	98	c.4delC	c.(4-6)ccfs	p.P2fs		NM_005517.3	NP_005508.1	P05204	HMGN2_HUMAN	high mobility group nucleosomal binding domain 2	2					chromatin organization|regulation of transcription, DNA-dependent	chromatin|cytoplasm|nucleus	DNA binding|protein binding			breast(1)|lung(2)	3		all_cancers(24;1.9e-24)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.38e-49)|OV - Ovarian serous cystadenocarcinoma(117;5.38e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.026)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CGCCACCATGCCCAAGAGAAA	0.741													2	4	---	---	---	---					
TRBV29-1	0	broad.mit.edu	37	7	142448089	142448090	+	RNA	INS	-	-	T			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr7:142448089_142448090insT	ENST00000422143.2	+	0	37_38																											TTCTTAGTGCCTTTTCTCAGGG	0.475													2	4	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118383815	118383816	+	RNA	INS	-	-	CA	rs144051797	by1000genomes	TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr10:118383815_118383816insCA	ENST00000537242.1	+	0	230				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		acttacacattcacacacactg	0.485													3	4	---	---	---	---					
HNRNPC	3183	broad.mit.edu	37	14	21679709	21679711	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr14:21679709_21679711delATC	ENST00000430246.2	-	7	3603_3605	c.652_654delGAT	c.(652-654)del	p.D218del	HNRNPC_ENST00000556513.1_Intron|HNRNPC_ENST00000557201.1_In_Frame_Del_p.D231del|HNRNPC_ENST00000553753.1_In_Frame_Del_p.D218del|HNRNPC_ENST00000556897.1_In_Frame_Del_p.D218del|HNRNPC_ENST00000556628.1_In_Frame_Del_p.D151del|HNRNPC_ENST00000420743.2_In_Frame_Del_p.D231del|HNRNPC_ENST00000556142.1_Intron|HNRNPC_ENST00000555883.1_In_Frame_Del_p.D175del|HNRNPC_ENST00000555914.1_In_Frame_Del_p.D217del|HNRNPC_ENST00000555309.1_In_Frame_Del_p.D230del|HNRNPC_ENST00000554455.1_In_Frame_Del_p.D231del|HNRNPC_ENST00000554969.1_In_Frame_Del_p.D218del|HNRNPC_ENST00000320084.7_In_Frame_Del_p.D231del|HNRNPC_ENST00000336053.6_In_Frame_Del_p.D218del|HNRNPC_ENST00000553300.1_In_Frame_Del_p.D218del|HNRNPC_ENST00000449098.1_In_Frame_Del_p.D218del			P07910	HNRPC_HUMAN	heterogeneous nuclear ribonucleoprotein C (C1/C2)	231	Asp/Glu-rich (acidic).					catalytic step 2 spliceosome|nucleoplasm	identical protein binding|nucleotide binding|RNA binding			breast(1)|liver(1)|lung(6)|skin(1)	9	all_cancers(95;0.00176)		Epithelial(56;1.08e-06)|all cancers(55;8.95e-06)	GBM - Glioblastoma multiforme(265;0.00783)		CTTCTGACTTATCATTCTTCATC	0.512													7	13	---	---	---	---					
PPP1R37	284352	broad.mit.edu	37	19	45648903	45648903	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ND-A4WF-01A-11D-A28R-08	TCGA-ND-A4WF-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	272251fa-e9b3-4808-9f03-2b9c9ce7c175	3441e5ff-7295-4777-8516-a7238d9d441b	g.chr19:45648903delC	ENST00000221462.4	+	11	1953	c.1589delC	c.(1588-1590)gcfs	p.A530fs	PPP1R37_ENST00000421905.1_Frame_Shift_Del_p.A526fs	NM_019121.1	NP_061994.1	B5MDA4	B5MDA4_HUMAN	protein phosphatase 1, regulatory subunit 37	530																	CCCTGTCCTGCCCTGGTGCCC	0.706													2	4	---	---	---	---