Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C5orf51	285636	broad.mit.edu	37	5	41904475	41904475	+	Silent	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:41904475G>C	ENST00000381647.2	+	1	25	c.6G>C	c.(4-6)gcG>gcC	p.A2A	C5orf51_ENST00000505931.2_Intron	NM_175921.4	NP_787117.3	A6NDU8	CE051_HUMAN	chromosome 5 open reading frame 51	2										endometrium(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TGGCCATGGCGGCCGCAGTCT	0.662000													14	21					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42693949	42693949	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr15:42693949C>G	ENST00000397163.3	+	11	1684	c.1465C>G	c.(1465-1467)Cgg>Ggg	p.R489G	CAPN3_ENST00000357568.3_Missense_Mutation_p.R489G|CAPN3_ENST00000349748.3_Missense_Mutation_p.R441G|CAPN3_ENST00000356316.3_Missense_Mutation_p.R402G|CAPN3_ENST00000318023.7_Missense_Mutation_p.R489G|RP11-164J13.1_ENST00000495723.1_RNA	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	489	Domain III.		R -> Q (in LGMD2A).|R -> W (in LGMD2A).		muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		GCAGAAGAACCGGCGGAAGGA	0.572000													10	39					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196736583	196736583	+	Silent	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:196736583G>A	ENST00000296350.5	-	11	1544	c.1431C>T	c.(1429-1431)caC>caT	p.H477H		NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	477	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CGAAACCGGCGTGGCAGGAGC	0.637000													51	28					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908297	164908297	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:164908297G>T	ENST00000475390.1	-	2	765	c.322C>A	c.(322-324)Ctt>Att	p.L108I	SLITRK3_ENST00000241274.3_Missense_Mutation_p.L108I			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	108						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TTGTTCCCAAGATTAATAGAC	0.343000										HNSCC(40;0.11)			23	10					1.22574e-08	1.35865e-08	1	1	0
IGF2R	3482	broad.mit.edu	37	6	160517488	160517488	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:160517488G>C	ENST00000356956.1	+	45	6821	c.6673G>C	c.(6673-6675)Gtg>Ctg	p.V2225L	IGF2R_ENST00000475584.1_3'UTR	NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	2225					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity	p.V2225M(1)		breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TCTCGATGTCGTGTTTGCCTC	0.512000													19	196					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65784607	65784607	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:65784607G>T	ENST00000312106.5	-	11	2377	c.2240C>A	c.(2239-2241)gCa>gAa	p.A747E		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	747					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CTCCACGCTTGCCACCAGCTG	0.642000													13	16					0.00185496	0.00189618	1	1	0
ACACB	32	broad.mit.edu	37	12	109696795	109696795	+	Silent	SNP	A	A	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr12:109696795A>G	ENST00000338432.7	+	47	6497	c.6378A>G	c.(6376-6378)ggA>ggG	p.G2126G	ACACB_ENST00000377854.5_Silent_p.G2056G|ACACB_ENST00000543201.1_Silent_p.G792G|ACACB_ENST00000377848.3_Silent_p.G2126G			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2126	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGCAGGCAGGACAGGTGTGGT	0.577000											OREG0007682	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=ACACB|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	44	188					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40231702	40231702	+	Silent	SNP	A	A	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:40231702A>G	ENST00000302541.6	+	10	1755	c.1413A>G	c.(1411-1413)agA>agG	p.R471R	MYRIP_ENST00000396217.3_Silent_p.R382R|MYRIP_ENST00000539167.1_Silent_p.R284R|MYRIP_ENST00000425621.1_Silent_p.R471R|MYRIP_ENST00000444716.1_Silent_p.R471R|MYRIP_ENST00000459828.1_3'UTR	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	471	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		ACCAGGCCAGACTGTCCTGGT	0.622000													32	60					0	0	1	0	0
PRSS3P2	0	broad.mit.edu	37	7	142478853	142478853	+	RNA	SNP	T	T	C	rs141495203	by1000genomes	TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:142478853T>C	ENST00000603901.1	+	0	14					NR_001296.3																						AATCCACTCCTGATCCTTGCC	0.572000													4	29					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363519	22363519	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr19:22363519C>G	ENST00000397121.2	-	3	1317	c.1000G>C	c.(1000-1002)Gag>Cag	p.E334Q		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TAGGGTTTCTCTCCAGCATGA	0.408000													32	34					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133664065	133664065	+	Silent	SNP	G	G	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:133664065G>T	ENST00000310926.4	-	10	1608	c.1335C>A	c.(1333-1335)cgC>cgA	p.R445R	SLCO2A1_ENST00000493729.1_Silent_p.R369R	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	445	Kazal-like.				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						AGCAGTCCCTGCGGCAGGCAG	0.522000													56	305					5.73376e-24	6.59382e-24	1	1	0
MXD1	4084	broad.mit.edu	37	2	70165331	70165331	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:70165331G>C	ENST00000264444.2	+	6	841	c.581G>C	c.(580-582)aGc>aCc	p.S194T	MXD1_ENST00000540449.1_Missense_Mutation_p.S184T|MXD1_ENST00000465446.1_3'UTR	NM_001202513.1|NM_001202514.1|NM_002357.3	NP_001189442.1|NP_001189443.1|NP_002348.1	Q05195	MAD1_HUMAN	MAX dimerization protein 1	194					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						AGCATGCAGAGCCTCGGCAGT	0.562000													33	77					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578502	7578502	+	Missense_Mutation	SNP	A	A	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:7578502A>C	ENST00000420246.2	-	5	560	c.428T>G	c.(427-429)gTg>gGg	p.V143G	TP53_ENST00000445888.2_Missense_Mutation_p.V143G|TP53_ENST00000359597.4_Missense_Mutation_p.V143G|TP53_ENST00000413465.2_Missense_Mutation_p.V143G|TP53_ENST00000269305.4_Missense_Mutation_p.V143G|TP53_ENST00000455263.2_Missense_Mutation_p.V143G	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	143	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143A(18)|p.0?(8)|p.V143E(5)|p.V11A(2)|p.V50A(2)|p.L137_W146del10(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.A138_V143delAKTCPV(1)|p.V143G(1)|p.V143_S149del(1)|p.C141fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCACAGCTGCACAGGGCAGGT	0.587000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	1					0	0	1	0	0
USP51	158880	broad.mit.edu	37	X	55515333	55515333	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrX:55515333C>T	ENST00000500968.3	-	2	122	c.40G>A	c.(40-42)Ggg>Agg	p.G14R		NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	14					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						CAGCGGACCCCAGAGCCGGAG	0.627000													8	16					0	0	1	0	0
MSC	9242	broad.mit.edu	37	8	72756427	72756427	+	Translation_Start_Site	SNP	T	T	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:72756427T>A	ENST00000325509.4	-	0	276				RP11-383H13.1_ENST00000457356.4_3'UTR|RP11-383H13.1_ENST00000521467.1_Intron|RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron	NM_005098.3	NP_005089.2	O60682	MUSC_HUMAN	musculin						transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(4)|skin(2)	26	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			GTTGTCCCCCTTGCCCACACG	0.692000													29	17					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	15596	15596	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrM:15596G>C	ENST00000361789.2	+	1	850	c.850G>C	c.(850-852)Gtc>Ctc	p.284_284insL						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						TTCTCCGATCCGTCCCTAACA	0.458000											OREG0007583	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	18	84					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84792334	84792334	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr16:84792334A>G	ENST00000219473.7	+	5	1318	c.1205A>G	c.(1204-1206)aAt>aGt	p.N402S	USP10_ENST00000570191.1_Missense_Mutation_p.N406S	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	402					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						TTGCTGGAGAATGTAACCCTA	0.438000													24	52					0	0	1	0	0
LINC00854	0	broad.mit.edu	37	17	41381938	41381938	+	RNA	SNP	C	C	G	rs4986161		TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:41381938C>G	ENST00000433702.2	-	0	14					NR_047479.1																						aagagctgatcttatgcaggg	0.552000													4	29					0	0	1	0	0
FZD2	2535	broad.mit.edu	37	17	42636744	42636744	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:42636744C>T	ENST00000315323.3	+	1	1820	c.1688C>T	c.(1687-1689)aCc>aTc	p.T563I		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	563					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CACGGTGAGACCACCGTGTGA	0.597000													19	12					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31848029	31848029	+	Silent	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:31848029G>A	ENST00000395728.3	-	27	3635	c.3636C>T	c.(3634-3636)ggC>ggT	p.G1212G	EHMT2_ENST00000375528.4_Silent_p.G1178G|EHMT2_ENST00000375530.4_Silent_p.G1121G|EHMT2_ENST00000375537.4_Silent_p.G1155G|EHMT2_ENST00000480912.1_5'UTR			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1155					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						AGAAGCGGTCGCCATAGTCAA	0.567000													4	37					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6700933	6700933	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr12:6700933C>T	ENST00000309577.6	-	21	3312	c.3149G>A	c.(3148-3150)gGg>gAg	p.G1050E	CHD4_ENST00000357008.2_Missense_Mutation_p.G1050E|CHD4_ENST00000544484.1_Missense_Mutation_p.G1047E|CHD4_ENST00000544040.1_Missense_Mutation_p.G1043E			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1050					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CAATAATTTCCCAGATGCTCT	0.443000													65	3					0	0	1	0	0
BCL2L13	23786	broad.mit.edu	37	22	18185097	18185097	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr22:18185097G>C	ENST00000317582.5	+	6	892	c.545G>C	c.(544-546)gGc>gCc	p.G182A	BCL2L13_ENST00000418951.2_Intron|BCL2L13_ENST00000543133.1_Missense_Mutation_p.G20A|BCL2L13_ENST00000493680.1_Missense_Mutation_p.G182A|BCL2L13_ENST00000355028.3_Intron|BCL2L13_ENST00000538149.1_Missense_Mutation_p.G58A|BCL2L13_ENST00000399782.1_Missense_Mutation_p.G182A|BCL2L13_ENST00000337612.5_Missense_Mutation_p.G20A	NM_015367.2	NP_056182.2	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	182					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			breast(2)|central_nervous_system(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(3)|urinary_tract(2)	15		all_epithelial(15;0.123)		Lung(27;0.199)		CTGCAGTTTGGCGTGACATAC	0.403000													37	47					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64111265	64111265	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:64111265C>T	ENST00000356786.5	+	13	1378	c.1334C>T	c.(1333-1335)gCg>gTg	p.A445V	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	445					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTAGCAGGAGCGGCCCCCTCG	0.637000													6	10					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241713633	241713633	+	Missense_Mutation	SNP	T	T	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:241713633T>A	ENST00000498729.2	-	12	1250	c.1004A>T	c.(1003-1005)gAc>gTc	p.D335V	KIF1A_ENST00000320389.7_Missense_Mutation_p.D335V	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	335	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GTAGTTGATGTCTGCAGGACT	0.587000													27	8					0	0	1	0	0
SLC25A39	51629	broad.mit.edu	37	17	42398463	42398463	+	Silent	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:42398463G>A	ENST00000225308.8	-	8	804	c.630C>T	c.(628-630)ggC>ggT	p.G210G	SLC25A39_ENST00000590194.1_Silent_p.G210G|SLC25A39_ENST00000537904.2_Silent_p.G195G|SLC25A39_ENST00000586016.1_Silent_p.G86G|SLC25A39_ENST00000377095.5_Silent_p.G218G	NM_016016.2	NP_057100.1	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39	218					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGGGGCCCCAGCCCAGCCACA	0.637000													10	36					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141108430	141108430	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:141108430G>A	ENST00000389484.3	-	77	12799	c.11828C>T	c.(11827-11829)cCa>cTa	p.P3943L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3943					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATTCCGCCTGGATTAAACTG	0.328000										TSP Lung(27;0.18)			31	16					0	0	1	0	0
LPPR4	0	broad.mit.edu	37	1	99764627	99764627	+	Missense_Mutation	SNP	T	T	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:99764627T>A	ENST00000370185.3	+	4	1072	c.575T>A	c.(574-576)aTt>aAt	p.I192N	LPPR4_ENST00000457765.1_Missense_Mutation_p.I192N|LPPR4_ENST00000370184.1_Missense_Mutation_p.I34N	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		192							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ACAGCTCTCATTACAGATATC	0.368000													11	16					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106796138	106796138	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrX:106796138C>A	ENST00000276185.4	+	8	723	c.723C>A	c.(721-723)gaC>gaA	p.D241E	FRMPD3_ENST00000477796.1_3'UTR			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	241	FERM.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						TTCTTCAGGACAAGCAACCCC	0.463000													11	14					6.40141e-05	6.84802e-05	1	1	0
KIAA0895L	653319	broad.mit.edu	37	16	67214278	67214278	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr16:67214278C>T	ENST00000290881.7	-	3	1162	c.236G>A	c.(235-237)cGc>cAc	p.R79H	KIAA0895L_ENST00000563902.1_Missense_Mutation_p.R79H|KIAA0895L_ENST00000563831.2_Intron|KIAA0895L_ENST00000561621.1_Missense_Mutation_p.R79H			Q68EN5	K895L_HUMAN	KIAA0895-like	79										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						GCTCTCACTGCGACGCATGTG	0.692000													7	6					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725559	32725559	+	Missense_Mutation	SNP	C	C	T	rs113761247	byFrequency	TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:32725559C>T	ENST00000435145.2	-	4	809	c.748G>A	c.(748-750)Ggt>Agt	p.G250S	HLA-DQB2_ENST00000437316.2_Missense_Mutation_p.G250S|HLA-DQB2_ENST00000411527.1_Intron			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CCTTTCTGACCCCTGTGACGG	0.552000													6	39					0	0	1	0	0
TMEM144	55314	broad.mit.edu	37	4	159140504	159140504	+	Silent	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr4:159140504G>A	ENST00000514558.1	+	5	2171	c.375G>A	c.(373-375)ccG>ccA	p.P125P	TMEM144_ENST00000296529.6_Silent_p.P125P			Q7Z5S9	TM144_HUMAN	transmembrane protein 144	125						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(7)|lung(9)|prostate(1)	19	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		TATCAAATCCGCTGCTAAATT	0.363000													31	74					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76115089	76115089	+	Splice_Site	SNP	G	G	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:76115089G>T	ENST00000296677.4	+	1	288	c.82_splice	c.e1+1	p.G28_splice		NM_005242.4	NP_005233.3	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	28					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		CACCATCCAAGGTGAGAAACC	0.672000													4	7					0.014758	0.0149202	1	1	0
SETDB1	9869	broad.mit.edu	37	1	150921998	150921998	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:150921998A>G	ENST00000271640.5	+	12	1767	c.1577A>G	c.(1576-1578)tAt>tGt	p.Y526C	SETDB1_ENST00000368969.4_Missense_Mutation_p.Y526C|SETDB1_ENST00000459773.1_Intron	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AACCAGACATATAGGTGAGAA	0.502000													27	89					0	0	1	0	0
WASH3P	0	broad.mit.edu	37	15	102515250	102515250	+	RNA	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr15:102515250C>T	ENST00000557932.1	+	0	1096																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TTGACCCCTCCGGTGGCCGGG	0.642000													5	10					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122387246	122387246	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrX:122387246C>A	ENST00000264357.5	+	3	653	c.361C>A	c.(361-363)Cac>Aac	p.H121N	GRIA3_ENST00000371256.5_Missense_Mutation_p.H121N|GRIA3_ENST00000542149.1_Missense_Mutation_p.H121N|GRIA3_ENST00000479118.1_3'UTR|GRIA3_ENST00000541091.1_Missense_Mutation_p.H105N|GRIA3_ENST00000371251.1_Missense_Mutation_p.H121N	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	121					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.H121N(2)		breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TGGGGCCCTGCACACATCCTT	0.537000													27	89					8.58068e-18	9.74596e-18	1	1	0
C1orf74	148304	broad.mit.edu	37	1	209956665	209956665	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:209956665C>G	ENST00000294811.1	-	2	571	c.315G>C	c.(313-315)gaG>gaC	p.E105D		NM_152485.2	NP_689698.1	Q96LT6	CA074_HUMAN	chromosome 1 open reading frame 74	105										endometrium(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	15				OV - Ovarian serous cystadenocarcinoma(81;0.0328)		GCAGCACCTGCTCCAAGTGCT	0.532000													16	45					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61951483	61951483	+	Silent	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr20:61951483C>T	ENST00000422202.1	+	23	3098	c.3030C>T	c.(3028-3030)ccC>ccT	p.P1010P	COL20A1_ENST00000435874.1_Silent_p.P1010P|COL20A1_ENST00000358894.6_Silent_p.P1003P|COL20A1_ENST00000326996.6_Silent_p.P1003P			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1003	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GCAGCCCACCCGCTGCGGGCT	0.716000													10	4					0	0	1	0	0
DIRAS2	0	broad.mit.edu	37	9	93375839	93375839	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr9:93375839G>A	ENST00000375765.3	-	2	659	c.271C>T	c.(271-273)Cga>Tga	p.R91*		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	91					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						AAGGACTGTCGGCTGGTAATG	0.582000													86	4					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76490708	76490708	+	Silent	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:76490708G>A	ENST00000389840.5	-	40	6319	c.6195C>T	c.(6193-6195)gaC>gaT	p.D2065D	DNAH17_ENST00000585328.1_Silent_p.D2074D|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCGAGGCACGTCCAGAGCCG	0.587000													30	130					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	49033926	49033926	+	Missense_Mutation	SNP	T	T	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr13:49033926T>G	ENST00000267163.4	+	20	2201	c.2063T>G	c.(2062-2064)cTg>cGg	p.L688R		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	688	Domain B.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)|p.L688P(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGCACACCCTGCAGAATGAG	0.443000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			34	1					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386693	56386693	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:56386693C>T	ENST00000355701.3	-	22	4810	c.3940G>A	c.(3940-3942)Gag>Aag	p.E1314K	BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1254K|BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1314K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1314						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGATCTGCTCCAAGATCTCC	0.577000													42	47					0	0	1	0	0
PDZD3	79849	broad.mit.edu	37	11	119057301	119057301	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:119057301G>A	ENST00000531114.1	+	2	979	c.430G>A	c.(430-432)Gtg>Atg	p.V144M	PDZD3_ENST00000355547.5_Missense_Mutation_p.V78M|PDZD3_ENST00000322712.4_Missense_Mutation_p.V78M|PDZD3_ENST00000525131.1_Missense_Mutation_p.V65M|PDZD3_ENST00000392817.2_Missense_Mutation_p.V144M			Q86UT5	NHRF4_HUMAN	PDZ domain containing 3	144	PDZ 1.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	14	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		GGTGTGCAGGGTGGACCCAGG	0.597000													45	1					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113585824	113585824	+	Silent	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:113585824G>A	ENST00000297405.5	-	24	4192	c.3948C>T	c.(3946-3948)cgC>cgT	p.R1316R	CSMD3_ENST00000455883.2_Silent_p.R1212R|CSMD3_ENST00000352409.3_Silent_p.R1316R|CSMD3_ENST00000343508.3_Silent_p.R1276R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1316	CUB 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTGTCAGTCCGCGCATAGATG	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	143					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132161820	132161820	+	Silent	SNP	A	A	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrX:132161820A>T	ENST00000511190.1	-	6	898	c.429T>A	c.(427-429)tcT>tcA	p.S143S	USP26_ENST00000406273.1_Silent_p.S143S|USP26_ENST00000370832.1_Silent_p.S143S	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	143					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					CTATCTCAAAAGATTTGCTAC	0.408000													12	28					0	0	1	0	0
SCD	6319	broad.mit.edu	37	10	102108089	102108089	+	Missense_Mutation	SNP	A	A	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr10:102108089A>T	ENST00000370355.2	+	2	677	c.296A>T	c.(295-297)tAc>tTc	p.Y99F		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	99					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TGCAAGTTCTACACCTGGCTT	0.493000													95	68					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143792722	143792722	+	Silent	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:143792722C>T	ENST00000408949.2	+	1	582	c.522C>T	c.(520-522)aaC>aaT	p.N174N		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					AAAAGATCAACCACTTTTTCT	0.463000													33	72					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106552814	106552814	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:106552814C>A	ENST00000369096.4	+	5	1013	c.779C>A	c.(778-780)cCc>cAc	p.P260H	PRDM1_ENST00000369091.2_Missense_Mutation_p.P224H|PRDM1_ENST00000369089.3_Missense_Mutation_p.P126H	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	260					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GACTCCAACCCCTCCAAAGGA	0.468000			"""D, N, Mis, F, S"""		DLBCL								201	223					7.15978e-92	8.33798e-92	1	1	0
LMOD2	442721	broad.mit.edu	37	7	123302950	123302950	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:123302950G>T	ENST00000458573.2	+	2	1467	c.1310G>T	c.(1309-1311)aGg>aTg	p.R437M	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	437	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding										tcttcccaaaggctgccacca	0.572000													7	2					8.12818e-05	8.59532e-05	1	1	0
UACA	55075	broad.mit.edu	37	15	70959158	70959158	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr15:70959158G>C	ENST00000322954.6	-	16	4050	c.3865C>G	c.(3865-3867)Cag>Gag	p.Q1289E	UACA_ENST00000560441.1_Missense_Mutation_p.Q1274E|UACA_ENST00000379983.2_Missense_Mutation_p.Q1276E|UACA_ENST00000539319.1_Missense_Mutation_p.Q1180E	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	1289						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						CGTTCCTTCTGATCCTTAATT	0.348000													7	50					0	0	1	0	0
FFAR2	2867	broad.mit.edu	37	19	35941555	35941555	+	Silent	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr19:35941555C>T	ENST00000599180.1	+	2	1019	c.939C>T	c.(937-939)gaC>gaT	p.D313D	FFAR2_ENST00000246549.2_Silent_p.D313D|FFAR2_ENST00000601590.1_Intron			O15552	FFAR2_HUMAN	free fatty acid receptor 2	313						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAAATGAGGACAGGGGTGTGG	0.587000													16	59					0	0	1	0	0
ALG12	79087	broad.mit.edu	37	22	50297568	50297568	+	Missense_Mutation	SNP	A	A	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr22:50297568A>C	ENST00000330817.5	-	10	1658	c.1385T>G	c.(1384-1386)cTg>cGg	p.L462R		NM_024105.3	NP_077010.1	Q9BV10	ALG12_HUMAN	ALG12, alpha-1,6-mannosyltransferase	462					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(3)	12		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		GGTCAGGTTCAGACTCACACC	0.657000													11	48					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103182702	103182702	+	Silent	SNP	T	T	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:103182702T>C	ENST00000375735.2	+	79	11733	c.11589T>C	c.(11587-11589)gcT>gcC	p.A3863A	DYNC2H1_ENST00000398093.3_Silent_p.A3870A|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3863	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GAGCTCATGCTCTCTTCAGTC	0.363000													45	4					0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55265552	55265552	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:55265552C>T	ENST00000381298.2	-	4	508	c.196G>A	c.(196-198)Gtc>Atc	p.V66I	IL6ST_ENST00000381293.2_Intron|IL6ST_ENST00000536319.1_Missense_Mutation_p.V66I|IL6ST_ENST00000502326.3_Missense_Mutation_p.V66I|IL6ST_ENST00000522633.2_Missense_Mutation_p.V66I|IL6ST_ENST00000577363.1_Intron|IL6ST_ENST00000336909.5_Missense_Mutation_p.V66I|IL6ST_ENST00000381294.3_Missense_Mutation_p.V66I|IL6ST_ENST00000381287.4_Missense_Mutation_p.V66I|IL6ST_ENST00000396816.1_Intron|IL6ST_ENST00000381286.3_Intron	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	66	Ig-like C2-type.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				GTTTTCCAGACAATGTAATTA	0.318000			O		hepatocellular ca								13	35					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64056826	64056826	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr11:64056826C>T	ENST00000411458.1	+	9	1445	c.1417C>T	c.(1417-1419)Ccg>Tcg	p.P473S	GPR137_ENST00000539851.1_3'UTR|GPR137_ENST00000438980.2_3'UTR|GPR137_ENST00000313074.3_Missense_Mutation_p.P415S|GPR137_ENST00000377702.4_3'UTR	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	415						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						TGAGCTTGTGCCGTCCCCCTA	0.647000													5	98					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76555943	76555943	+	Silent	SNP	A	A	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr16:76555943A>T	ENST00000307431.8	+	18	2926	c.2541A>T	c.(2539-2541)acA>acT	p.T847T	CNTNAP4_ENST00000377504.4_Silent_p.T799T|CNTNAP4_ENST00000478060.1_Silent_p.T775T|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Silent_p.T851T	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	848	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CAGCTCCGACAGTAGTGACTT	0.453000													47	103					0	0	1	0	0
STX7	8417	broad.mit.edu	37	6	132792624	132792624	+	Missense_Mutation	SNP	A	A	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:132792624A>C	ENST00000367941.2	-	5	478	c.365T>G	c.(364-366)gTa>gGa	p.V122G	STX7_ENST00000448348.3_5'UTR|STX7_ENST00000367937.4_Missense_Mutation_p.V122G	NM_003569.2	NP_003560.2	O15400	STX7_HUMAN	syntaxin 7	122					intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(1)|lung(5)	19	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		ACTGGCTCTTACTCGAGCAAC	0.428000													38	55					0	0	1	0	0
RD3	343035	broad.mit.edu	37	1	211652494	211652494	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:211652494G>A	ENST00000367002.4	-	3	1635	c.472C>T	c.(472-474)Cgc>Tgc	p.R158C	RD3_ENST00000484910.1_5'UTR	NM_001164688.1|NM_183059.2	NP_001158160.1|NP_898882.1	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	158					response to stimulus|visual perception					central_nervous_system(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GGCGAGATGCGCGCGCGGGTC	0.692000													9	31					0	0	1	0	0
MT-TL1	0	broad.mit.edu	37	MT	3242	3242	+	RNA	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chrM:3242G>A	ENST00000386347.1	+	0	13																											ttaagatggcagagcccggta	0.433000													92	6					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49415614	49415614	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr12:49415614G>C	ENST00000301067.7	-	54	16562	c.16563C>G	c.(16561-16563)caC>caG	p.H5521Q		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGGGGATCTTGTGCTGATCGT	0.512000													13	42					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150715385	150715385	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:150715385C>T	ENST00000605938.1	-	7	1943	c.1868G>A	c.(1867-1869)cGa>cAa	p.R623Q	ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000377974.2_Missense_Mutation_p.R623Q|ATG9B_ENST00000444312.1_Missense_Mutation_p.R109Q	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	623					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCACCGCTCGGTACTGCAG	0.711000											OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	27					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41162265	41162265	+	Missense_Mutation	SNP	A	A	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr6:41162265A>C	ENST00000483722.1	-	3	868	c.683T>G	c.(682-684)aTc>aGc	p.I228S		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	228					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTTAGTGGAGATGGATTCTGG	0.622000													21	18					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164704992	164704992	+	Missense_Mutation	SNP	T	T	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:164704992T>G	ENST00000264382.3	-	45	5193	c.5131A>C	c.(5131-5133)Att>Ctt	p.I1711L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1711	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCAGCAACAATGAGCTTCATG	0.343000										HNSCC(35;0.089)			12	29					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113358408	113358408	+	Silent	SNP	A	A	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:113358408A>C	ENST00000297405.5	-	41	6604	c.6360T>G	c.(6358-6360)ggT>ggG	p.G2120G	CSMD3_ENST00000455883.2_Silent_p.G2016G|CSMD3_ENST00000352409.3_Silent_p.G2050G|CSMD3_ENST00000343508.3_Silent_p.G2080G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2120	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGAGGATCACACCACTGAAGT	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			71	48					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139400313	139400313	+	Nonsense_Mutation	SNP	A	A	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr9:139400313A>T	ENST00000277541.6	-	25	4110	c.4035T>A	c.(4033-4035)tgT>tgA	p.C1345*		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1345	EGF-like 34.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGTCATTCTCACACGTGGCGC	0.726000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			9	2					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52431061	52431061	+	Splice_Site	SNP	G	G	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:52431061G>A	ENST00000420323.2	+	73	12048		c.e73+1			NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1						ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGACCTCCACGTGAGTCCAGC	0.632000													6	10					0	0	1	0	0
ANXA6	309	broad.mit.edu	37	5	150512081	150512081	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr5:150512081C>G	ENST00000354546.5	-	10	919	c.692G>C	c.(691-693)cGa>cCa	p.R231P	ANXA6_ENST00000523714.1_Missense_Mutation_p.R199P|ANXA6_ENST00000356496.5_Missense_Mutation_p.R231P|ANXA6_ENST00000521512.1_Intron|ANXA6_ENST00000377751.5_Intron	NM_001155.4	NP_001146.2	P08133	ANXA6_HUMAN	annexin A6	231						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding	p.R231Q(1)		endometrium(2)|kidney(1)|lung(9)	12		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCTCCCCTCGGATGCTGGC	0.552000													9	19					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42775253	42775253	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr21:42775253C>G	ENST00000330714.3	+	12	1817	c.1633C>G	c.(1633-1635)Ctt>Gtt	p.L545V		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	545					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				ATTTTTCAACCTTAACCAAAC	0.393000													33	28					0	0	1	0	0
SARM1	23098	broad.mit.edu	37	17	26715423	26715423	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:26715423G>C	ENST00000457710.3	+	7	2157	c.1686G>C	c.(1684-1686)gaG>gaC	p.E562D	SARM1_ENST00000379061.4_3'UTR	NM_015077.2	NP_055892.2	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	596	TIR.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity			cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TTGATGTGGAGAAGCTGGAAG	0.547000													30	43					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78044547	78044547	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:78044547C>A	ENST00000370801.3	-	11	2565	c.2090G>T	c.(2089-2091)aGc>aTc	p.S697I	ZZZ3_ENST00000476275.1_5'UTR|ZZZ3_ENST00000370798.1_Missense_Mutation_p.S203I	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	697	HTH myb-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						CTGTACTCGGCTGGCAACCTA	0.343000													5	10					1.23904e-05	1.35704e-05	1	1	0
C8orf76	84933	broad.mit.edu	37	8	124250155	124250155	+	Silent	SNP	G	G	T			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:124250155G>T	ENST00000276704.4	-	3	291	c.240C>A	c.(238-240)atC>atA	p.I80I	ZHX1-C8ORF76_ENST00000357082.4_Silent_p.I48I|C8orf76_ENST00000521310.1_5'UTR	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	80							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTTTCAGAGATACTGGAAT	0.423000													34	45					3.11337e-16	3.49305e-16	1	1	0
RP4-749H3.1	0	broad.mit.edu	37	1	20732487	20732488	+	RNA	INS	-	-	G	rs147656955	by1000genomes	TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:20732487_20732488insG	ENST00000426428.1	-	0	282					NR_033887.1																						TACCGTGGGGAGGGGGGATTAG	0.584													3	4	---	---	---	---					
RP11-417J8.6	0	broad.mit.edu	37	1	142640998	142640999	+	RNA	DEL	AA	AA	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:142640998_142640999delAA	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							gcaacatggcaaaaccctctct	0.500													2	4	---	---	---	---					
SEC22B	9554	broad.mit.edu	37	1	145109259	145109260	+	RNA	INS	-	-	A	rs61810755	by1000genomes	TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:145109259_145109260insA	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										cactccagcccgggggcagagc	0.480													3	6	---	---	---	---					
C1orf43	25912	broad.mit.edu	37	1	154179938	154179939	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr1:154179938_154179939delAC	ENST00000368521.5	-	7	950_951	c.752_753delGT	c.(751-753)afs	p.S251fs	C1orf43_ENST00000350592.3_Frame_Shift_Del_p.S217fs|C1orf43_ENST00000368519.1_Frame_Shift_Del_p.S233fs|C1orf43_ENST00000483282.1_5'UTR|C1orf43_ENST00000362076.4_Frame_Shift_Del_p.S199fs	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	251						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					GTCACAGAGTACTCTCCAATGT	0.510													9	149	---	---	---	---					
FMNL2	114793	broad.mit.edu	37	2	153415331	153415331	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:153415331delC	ENST00000288670.9	+	5	804	c.437delC	c.(436-438)ggfs	p.A146fs		NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	146	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						GCACAGTACGCGGTAACGTAA	0.378													6	13	---	---	---	---					
DPP4	1803	broad.mit.edu	37	2	162865080	162865089	+	Frame_Shift_Del	DEL	TCCCACCGGG	TCCCACCGGG	-	rs138430103	by1000genomes	TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr2:162865080_162865089delTCCCACCGGG	ENST00000360534.3	-	22	2530_2539	c.1970_1979delCCCGGTGGGA	c.(1969-1980)tgfs	p.SRWE657fs	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	657					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	ACCATAGTACTCCCACCGGGATACAGGCGC	0.471													24	19	---	---	---	---					
MED12L	116931	broad.mit.edu	37	3	150877759	150877760	+	Frame_Shift_Ins	INS	-	-	TCGAGTA			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr3:150877759_150877760insTCGAGTA	ENST00000474524.1	+	7	1016_1017	c.978_979insTCGAGTA	c.(976-981)aacgagfs	p.E327fs	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000422248.2_Frame_Shift_Ins_p.E327fs|MED12L_ENST00000309237.4_Frame_Shift_Ins_p.E327fs	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	327					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GACCAAACAACTCGAGTATCGG	0.609													7	205	---	---	---	---					
AF146191.4	0	broad.mit.edu	37	4	190767937	190767937	+	RNA	DEL	C	C	-	rs67778127		TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr4:190767937delC	ENST00000511785.1	-	0	425																											attctccgtgccgtgtccctc	0.642													3	6	---	---	---	---					
TNRC18	84629	broad.mit.edu	37	7	5352561	5352563	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:5352561_5352563delGAG	ENST00000399537.4	-	27	8307_8309	c.7959_7961delCTC	c.(7957-7962)tct>tc	p.SS2669del	TNRC18_ENST00000430969.1_In_Frame_Del_p.SS2669del			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2669	Ser-rich.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		ggacgaggaagaggaggaggagg	0.606													2	4	---	---	---	---					
RP4-798C17.6	0	broad.mit.edu	37	7	144030382	144030383	+	RNA	DEL	AC	AC	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr7:144030382_144030383delAC	ENST00000463561.1	-	0	411				RP4-798C17.6_ENST00000478806.1_RNA|RP4-798C17.6_ENST00000467944.1_RNA|RP4-798C17.6_ENST00000488041.1_RNA|RP4-798C17.6_ENST00000493539.1_RNA|RP4-798C17.6_ENST00000461843.1_RNA|RP4-798C17.6_ENST00000486094.1_RNA|RP4-798C17.6_ENST00000487102.1_RNA|RP4-798C17.6_ENST00000476560.1_RNA|RP4-798C17.6_ENST00000475089.1_RNA|RP4-798C17.6_ENST00000496968.1_RNA|RP4-798C17.6_ENST00000489488.1_RNA|RP4-798C17.6_ENST00000478925.1_RNA																							ctgaaaatgtacagactttttt	0.356													2	4	---	---	---	---					
RP11-22C11.2	0	broad.mit.edu	37	8	95650726	95650728	+	RNA	DEL	ATC	ATC	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr8:95650726_95650728delATC	ENST00000562760.1	-	0	967_969					NR_034034.1																						tgacctcgtgatccgcctcggcc	0.502													2	4	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68409713	68409714	+	RNA	INS	-	-	ACAC			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr9:68409713_68409714insACAC	ENST00000417843.2	-	0	67																											AAGAAAAAAAAACACGTCTCAG	0.554													2	4	---	---	---	---					
DPH6-AS1	0	broad.mit.edu	37	15	36067166	36067166	+	RNA	DEL	C	C	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr15:36067166delC	ENST00000501169.2	+	0	462					NR_038251.1																						CTCCAACTTACCCATTCTATA	0.403													2	4	---	---	---	---					
AC005562.1	0	broad.mit.edu	37	17	28960996	28960997	+	RNA	INS	-	-	TC			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr17:28960996_28960997insTC	ENST00000417404.1	+	0	1269				LRRC37BP1_ENST00000412831.1_RNA|SMURF2P1_ENST00000578265.1_RNA																							tttttctttttttttttttttt	0.302													2	4	---	---	---	---					
LIPE-AS1	0	broad.mit.edu	37	19	43155211	43155211	+	RNA	DEL	C	C	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr19:43155211delC	ENST00000594688.1	+	0	1450				LIPE-AS1_ENST00000594624.2_RNA	NR_073179.1																						tgtccctccaccccctcccaa	0.478													2	4	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29589385	29589385	+	RNA	DEL	T	T	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr20:29589385delT	ENST00000432067.1	-	0	152																											tgatttcttcttttacccaat	0.299													2	4	---	---	---	---					
CHD6	0	broad.mit.edu	37	20	40113160	40113161	+	Frame_Shift_Del	DEL	TC	TC	-	rs146144596		TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr20:40113160_40113161delTC	ENST00000373233.3	-	15	2265_2266	c.2088_2089delGA	c.(2086-2091)gacgfs	p.ET696fs	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	696					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TCAATGATCGTCTCTTGTTTGG	0.455													64	71	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11058882	11058882	+	RNA	DEL	A	A	-	rs145149071		TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr21:11058882delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATGTGGGGGAAAAAAATTAG	0.358													4	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11096512	11096516	+	RNA	DEL	GTTTT	GTTTT	-			TCGA-N5-A4RV-01A-21D-A28R-08	TCGA-N5-A4RV-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	058c10d9-88b8-4ac5-90a8-181dbad8b90c	17a3c4cd-4c9a-4b11-afae-e185e2f154f8	g.chr21:11096512_11096516delGTTTT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccATTTTTAAgttttgttttgtttt	0.493													4	8	---	---	---	---