Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ABCC9	10060	broad.mit.edu	37	12	22048219	22048219	+	Missense_Mutation	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr12:22048219G>A	ENST00000261200.4	-	11	1648	c.1649C>T	c.(1648-1650)gCt>gTt	p.A550V	ABCC9_ENST00000261201.4_Missense_Mutation_p.A550V|ABCC9_ENST00000345162.2_Missense_Mutation_p.A550V	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	550	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGCAAGAACAGCTGCTATGGG	0.313000													13	24					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884216	228884216	+	Missense_Mutation	SNP	C	C	T			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr2:228884216C>T	ENST00000392056.3	-	7	1400	c.1354G>A	c.(1354-1356)Gtt>Att	p.V452I	SPHKAP_ENST00000344657.5_Missense_Mutation_p.V452I	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	452						cytoplasm	protein binding	p.V452I(2)		NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCTGAACAACGACGATTTTG	0.507000													4	77					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			37	57					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92442625	92442625	+	Missense_Mutation	SNP	C	C	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr1:92442625C>A	ENST00000370389.2	+	6	1349	c.425C>A	c.(424-426)gCa>gAa	p.A142E	BRDT_ENST00000402388.1_Missense_Mutation_p.A215E|BRDT_ENST00000362005.3_Missense_Mutation_p.A215E|BRDT_ENST00000394530.3_Missense_Mutation_p.A169E|BRDT_ENST00000399546.2_Missense_Mutation_p.A215E	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AAGAGGAAAGCAGATACAACA	0.343000													10	14					4.68919e-08	4.68919e-08	1	1	0
MT-ND5	4540	broad.mit.edu	37	MT	12763	12763	+	Missense_Mutation	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chrM:12763G>A	ENST00000361567.2	+	1	427	c.427G>A	c.(427-429)Ggc>Agc	p.G143S				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	143					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	AACTGTTCATCGGCTGAGAGG	0.418000													14	1					0	0	1	0	0
SLC9A8	23315	broad.mit.edu	37	20	48500445	48500445	+	Missense_Mutation	SNP	C	C	T			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr20:48500445C>T	ENST00000417961.1	+	14	1591	c.1381C>T	c.(1381-1383)Cgg>Tgg	p.R461W	SLC9A8_ENST00000361573.2_Missense_Mutation_p.R445W|SLC9A8_ENST00000541138.1_Missense_Mutation_p.R145W|SLC9A8_ENST00000539601.1_Missense_Mutation_p.R226W	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	445						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			CATGGAGAAGCGGCAGCTCAT	0.617000													5	69					0	0	1	0	0
GRIA1	0	broad.mit.edu	37	5	153174277	153174277	+	Silent	SNP	C	C	T			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr5:153174277C>T	ENST00000285900.5	+	14	2710	c.2367C>T	c.(2365-2367)agC>agT	p.S789S	GRIA1_ENST00000518783.1_Silent_p.S799S|GRIA1_ENST00000448073.4_Intron|GRIA1_ENST00000518142.1_Silent_p.S709S|GRIA1_ENST00000521843.2_Silent_p.S720S|GRIA1_ENST00000340592.5_Intron	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	789					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGTGCGGCAGCGGGGGAGGTG	0.463000													16	23					0	0	1	0	0
TAOK3	51347	broad.mit.edu	37	12	118598096	118598096	+	Missense_Mutation	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr12:118598096G>A	ENST00000392533.3	-	19	2697	c.2207C>T	c.(2206-2208)gCa>gTa	p.A736V	TAOK3_ENST00000537952.1_Missense_Mutation_p.A276V|TAOK3_ENST00000419821.2_Missense_Mutation_p.A736V|TAOK3_ENST00000543709.1_5'UTR	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	736					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATTCTTGAGTGCTTTATACTG	0.368000													34	66					0	0	1	0	0
THUMPD3	25917	broad.mit.edu	37	3	9413207	9413207	+	Missense_Mutation	SNP	A	A	G			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr3:9413207A>G	ENST00000345094.3	+	4	1128	c.794A>G	c.(793-795)aAc>aGc	p.N265S	THUMPD3_ENST00000452837.2_Missense_Mutation_p.N265S|SETD5-AS1_ENST00000468186.1_RNA|THUMPD3_ENST00000515662.2_Missense_Mutation_p.N265S	NM_001114092.1|NM_015453.2	NP_001107564.1|NP_056268.2	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	265	THUMP.						methyltransferase activity|protein binding|RNA binding			NS(1)|central_nervous_system(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	19	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)		GACATGACCAACTTTGATGTG	0.423000													62	78					0	0	1	0	0
HERC2P2	0	broad.mit.edu	37	15	23300080	23300080	+	RNA	SNP	T	T	C	rs28482434	by1000genomes	TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr15:23300080T>C	ENST00000560464.1	-	0	4207																											TGCTGCACGTTGACAGGCGTG	0.612000													5	39					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	42					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr17:39274291T>C	ENST00000391413.2	-	1	315	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(4)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													4	60					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	424018	424018	+	Missense_Mutation	SNP	G	G	C			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr5:424018G>C	ENST00000316418.5	+	7	690	c.646G>C	c.(646-648)Gag>Cag	p.E216Q	AHRR_ENST00000505113.1_Missense_Mutation_p.E216Q|AHRR_ENST00000506456.1_Missense_Mutation_p.E72Q|AHRR_ENST00000512529.1_Missense_Mutation_p.E62Q	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CACGCCCACCGAGTACTCGGC	0.682000													19	45					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10714146	10714146	+	Silent	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr1:10714146G>A	ENST00000377022.3	-	11	2285	c.1968C>T	c.(1966-1968)taC>taT	p.Y656Y	RP4-734G22.3_ENST00000606802.1_RNA|CASZ1_ENST00000344008.5_Silent_p.Y656Y	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGCAGCCCTCGTACTTGCACT	0.557000													16	27					0	0	1	0	0
SLC25A15	10166	broad.mit.edu	37	13	41379306	41379306	+	Missense_Mutation	SNP	G	G	C			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr13:41379306G>C	ENST00000338625.4	+	4	603	c.367G>C	c.(367-369)Gtg>Ctg	p.V123L	SLC25A15_ENST00000478827.1_3'UTR	NM_014252.3	NP_055067.1	Q9Y619	ORNT1_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	123					cellular amino acid metabolic process|mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|stomach(1)|urinary_tract(1)	14		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.48e-08)|Epithelial(112;7.51e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000191)|GBM - Glioblastoma multiforme(144;0.00231)|BRCA - Breast invasive adenocarcinoma(63;0.0704)	L-Ornithine(DB00129)	TGCTGCACTGGTGCTCTGCCC	0.542000													22	38					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62812686	62812686	+	Missense_Mutation	SNP	C	C	T			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr4:62812686C>T	ENST00000512091.1	+	15	3017	c.2270C>T	c.(2269-2271)aCg>aTg	p.T757M	LPHN3_ENST00000511324.1_Missense_Mutation_p.T825M|LPHN3_ENST00000514591.1_Missense_Mutation_p.T757M|LPHN3_ENST00000508078.1_3'UTR|LPHN3_ENST00000504896.1_Missense_Mutation_p.T757M|LPHN3_ENST00000509896.1_Missense_Mutation_p.T825M|LPHN3_ENST00000506700.1_Missense_Mutation_p.T757M|LPHN3_ENST00000507164.1_Missense_Mutation_p.T825M|LPHN3_ENST00000506720.1_Missense_Mutation_p.T825M|LPHN3_ENST00000508693.1_Missense_Mutation_p.T825M|LPHN3_ENST00000514996.1_Missense_Mutation_p.T757M|LPHN3_ENST00000507625.1_Missense_Mutation_p.T825M|LPHN3_ENST00000545650.1_Missense_Mutation_p.T757M|LPHN3_ENST00000514157.1_Missense_Mutation_p.T757M|LPHN3_ENST00000508946.1_Missense_Mutation_p.T757M|LPHN3_ENST00000506746.1_Missense_Mutation_p.T825M			Q9HAR2	LPHN3_HUMAN	latrophilin 3	744					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.T757M(2)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TATTTATCCACGGAGAATGCC	0.393000													4	160					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808501	8808501	+	Missense_Mutation	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr19:8808501G>A	ENST00000324436.3	-	1	671	c.551C>T	c.(550-552)tCt>tTt	p.S184F		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	184						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						GGCGTAGACAGACAGCACCGA	0.662000													18	44					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33261517	33261517	+	Silent	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr15:33261517G>A	ENST00000334528.9	-	4	1715	c.1716C>T	c.(1714-1716)tgC>tgT	p.C572C	FMN1_ENST00000559047.1_Silent_p.C795C|FMN1_ENST00000561249.1_Silent_p.C697C	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	795	Mediates interaction with alpha-catenin (By similarity).|Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TCTTTGGAGGGCAGTCATCAT	0.458000													5	335					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256897	63256897	+	Missense_Mutation	SNP	C	C	T			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr5:63256897C>T	ENST00000323865.3	-	1	883	c.650G>A	c.(649-651)cGc>cAc	p.R217H	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	217					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TCGGAATATGCGCCCATAGAG	0.587000													4	172					0	0	1	0	0
CPEB4	80315	broad.mit.edu	37	5	173317377	173317377	+	Missense_Mutation	SNP	T	T	G			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr5:173317377T>G	ENST00000265085.5	+	1	2095	c.641T>G	c.(640-642)gTc>gGc	p.V214G	CPEB4_ENST00000519835.1_Missense_Mutation_p.V214G|CPEB4_ENST00000334035.5_Missense_Mutation_p.V214G|CPEB4_ENST00000520867.1_Missense_Mutation_p.V214G	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	214							nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCCCATCATGTCAGCCCTGGC	0.512000													46	68					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519446	113519446	+	Silent	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr7:113519446G>A	ENST00000284601.3	-	4	1769	c.1701C>T	c.(1699-1701)agC>agT	p.S567S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	567					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CGGTATGTTCGCTCAGCAGAG	0.473000													29	56					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	42					0	0	1	0	0
SLC29A1	2030	broad.mit.edu	37	6	44198386	44198386	+	Missense_Mutation	SNP	T	T	C			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr6:44198386T>C	ENST00000393841.1	+	8	1162	c.671T>C	c.(670-672)cTg>cCg	p.L224P	SLC29A1_ENST00000472176.1_3'UTR|SLC29A1_ENST00000371708.1_Missense_Mutation_p.L224P|SLC29A1_ENST00000371731.1_Missense_Mutation_p.L224P|SLC29A1_ENST00000427851.2_Missense_Mutation_p.L224P|SLC29A1_ENST00000371724.1_Missense_Mutation_p.L224P|SLC29A1_ENST00000313248.7_Missense_Mutation_p.L303P|SLC29A1_ENST00000371755.3_Missense_Mutation_p.L224P|SLC29A1_ENST00000371740.5_Missense_Mutation_p.L224P|SLC29A1_ENST00000371713.1_Missense_Mutation_p.L224P|SLC29A1_ENST00000393844.1_Missense_Mutation_p.L224P	NM_001078177.1	NP_001071645.1	Q99808	S29A1_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 1	224					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	17	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	ATCTGTTACCTGGGCCTGCCC	0.547000													14	36					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325064	150325064	+	Missense_Mutation	SNP	G	G	T			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr7:150325064G>T	ENST00000328902.5	-	3	838	c.622C>A	c.(622-624)Cag>Aag	p.Q208K	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	208							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGCCTCCTGCTCCTCCCCC	0.537000													77	100					5.04879e-28	5.21165e-28	1	1	0
C6orf70	0	broad.mit.edu	37	6	170159117	170159117	+	Silent	SNP	C	C	T			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr6:170159117C>T	ENST00000588451.1	+	6	696	c.183C>T	c.(181-183)aaC>aaT	p.N61N	C6orf70_ENST00000392095.4_Silent_p.N61N|C6orf70_ENST00000418781.3_Silent_p.N187N|C6orf70_ENST00000366772.2_Silent_p.N187N|C6orf70_ENST00000366773.3_Silent_p.N187N			Q5T6L9	CF070_HUMAN		187						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		ACCTGCGTAACGTCTTATGGC	0.378000													36	67					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143623463	143623463	+	Missense_Mutation	SNP	G	G	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr8:143623463G>A	ENST00000517894.1	+	28	4762	c.3868G>A	c.(3868-3870)Ggc>Agc	p.G1290S	BAI1_ENST00000323289.5_Missense_Mutation_p.G1290S			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1290					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GCACCTGCACGGCTCACCCCG	0.662000													14	21					0	0	1	0	0
KLF4	9314	broad.mit.edu	37	9	110249320	110249320	+	Missense_Mutation	SNP	C	C	A			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr9:110249320C>A	ENST00000374672.4	-	4	1726	c.1253G>T	c.(1252-1254)cGa>cTa	p.R418L		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	452					fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						TGTGTGGGTTCGCAGGTGTGC	0.587000													66	92					1.05635e-38	1.12677e-38	1	1	0
RP11-544M22.1	0	broad.mit.edu	37	1	160905975	160905975	+	RNA	DEL	T	T	-			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr1:160905975delT	ENST00000356006.3	+	0	629																											cttcttcttcttttttttttt	0.393													4	3	---	---	---	---					
RP11-739N20.2	0	broad.mit.edu	37	1	204363980	204363980	+	RNA	DEL	A	A	-			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr1:204363980delA	ENST00000443515.1	+	0	146																											tttgtttttcaaaaaaaaaaa	0.308													3	3	---	---	---	---					
AC226119.5	0	broad.mit.edu	37	4	3957083	3957083	+	RNA	DEL	C	C	-			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr4:3957083delC	ENST00000281228.8	-	0	65				FAM86EP_ENST00000313946.8_RNA																							GAGCGCGCCGCCAGGAAGCGG	0.736													2	4	---	---	---	---					
TEAD1	7003	broad.mit.edu	37	11	12923583	12923583	+	Frame_Shift_Del	DEL	T	T	-			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr11:12923583delT	ENST00000361905.4	+	10	1416	c.751delT	c.(751-753)ttfs	p.F251fs	TEAD1_ENST00000334310.6_Intron|TEAD1_ENST00000361985.2_Frame_Shift_Del_p.F266fs|TEAD1_ENST00000526600.1_Frame_Shift_Del_p.F170fs|TEAD1_ENST00000527575.1_Intron|TEAD1_ENST00000527636.1_Frame_Shift_Del_p.F266fs	NM_021961.5	NP_068780.2	P28347	TEAD1_HUMAN	TEA domain family member 1 (SV40 transcriptional enhancer factor)	266	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)	17				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TTATGACAAATTTCCTGAAAA	0.423													16	183	---	---	---	---					
RPS6KA4	8986	broad.mit.edu	37	11	64135606	64135606	+	Frame_Shift_Del	DEL	A	A	-			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr11:64135606delA	ENST00000528057.1	+	10	1162	c.1074delA	c.(1072-1074)ggfs	p.G358fs	RPS6KA4_ENST00000334205.4_Frame_Shift_Del_p.G358fs|RPS6KA4_ENST00000294261.4_Frame_Shift_Del_p.G358fs	NM_001006944.1	NP_001006945.1	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 4	358	AGC-kinase C-terminal.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			breast(1)|endometrium(3)|lung(7)|ovary(1)|prostate(1)	13						CCCTGCAGGGATACTCCTTTG	0.642													11	36	---	---	---	---					
POLE	5426	broad.mit.edu	37	12	133220099	133220100	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr12:133220099_133220100delCA	ENST00000320574.5	-	34	4380_4381	c.4337_4338delTG	c.(4336-4338)gfs	p.V1447fs	POLE_ENST00000535270.1_Frame_Shift_Del_p.V1420fs	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1447					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTTTATTGACCACACACACACA	0.604								DNA polymerases (catalytic subunits)					7	262	---	---	---	---					
RAP1GAP2	23108	broad.mit.edu	37	17	2929686	2929688	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chr17:2929686_2929688delCTC	ENST00000254695.8	+	21	1998_2000	c.1908_1910delCTC	c.(1906-1911)cgc>cg	p.RS636del	RAP1GAP2_ENST00000540393.2_In_Frame_Del_p.RS617del|RAP1GAP2_ENST00000542807.1_In_Frame_Del_p.RS636del|RAP1GAP2_ENST00000366401.4_In_Frame_Del_p.RS621del	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	636	Ser-rich.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CCATCTCCCGCTCCTCCTCCAGC	0.665													2	4	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165595	50165596	+	RNA	INS	-	-	AC	rs59226442		TCGA-MK-A84Z-01A-11D-A397-08	TCGA-MK-A84Z-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba6d50b1-3968-4b7f-a87f-03c977b442c4	3d90d12d-2584-4528-8e66-55b7401b9bdf	g.chrX:50165595_50165596insAC	ENST00000376025.2	-	0	816							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTAAAAGGTAAacacacacaca	0.411													3	5	---	---	---	---