Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DRD5	0	broad.mit.edu	37	4	9783838	9783838	+	Missense_Mutation	SNP	G	G	C	rs2227840	by1000genomes	TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr4:9783838G>C	ENST00000304374.2	+	1	581	c.185G>C	c.(184-186)tGc>tCc	p.C62S		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	62			C -> S (in dbSNP:rs2227840).		activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GTGCTGGTGTGCGCAGCCATC	0.662000													4	50					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97866233	97866233	+	Missense_Mutation	SNP	A	A	G			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr2:97866233A>G	ENST00000420699.2	+	46	3072	c.2828A>G	c.(2827-2829)gAa>gGa	p.E943G	ANKRD36_ENST00000461153.2_Missense_Mutation_p.E943G	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	943										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						ATAACCAGAGAAAAAAAGGAT	0.333000													7	10					0	0	1	0	0
TLE3	7090	broad.mit.edu	37	15	70366914	70366914	+	Silent	SNP	G	G	A			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr15:70366914G>A	ENST00000558939.1	-	6	1707	c.330C>T	c.(328-330)cgC>cgT	p.R110R	TLE3_ENST00000558379.1_Silent_p.R110R|TLE3_ENST00000451782.2_Silent_p.R110R|TLE3_ENST00000560939.1_Silent_p.R116R|TLE3_ENST00000559929.1_Silent_p.R110R|TLE3_ENST00000559048.1_Silent_p.R116R|TLE3_ENST00000557997.1_Silent_p.R110R|TLE3_ENST00000317509.8_Silent_p.R110R|TLE3_ENST00000442299.2_Silent_p.R110R|TLE3_ENST00000559191.1_Intron|TLE3_ENST00000558201.1_Silent_p.R116R|TLE3_ENST00000560589.1_Silent_p.R54R|TLE3_ENST00000557907.1_Silent_p.R110R|TLE3_ENST00000440567.3_Silent_p.R103R|TLE3_ENST00000539550.1_Silent_p.R44R			Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	110	Gln-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CCTGCTTGGCGCGCTCCACTG	0.587000													15	9					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216011417	216011417	+	Missense_Mutation	SNP	A	A	G			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr1:216011417A>G	ENST00000366943.2	-	47	9673	c.9287T>C	c.(9286-9288)gTg>gCg	p.V3096A	USH2A_ENST00000307340.3_Missense_Mutation_p.V3096A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3096	Fibronectin type-III 17.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTGCTTTTCACGCAGGCATA	0.368000										HNSCC(13;0.011)			4	140					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144060770	144060770	+	Silent	SNP	T	T	C	rs141931104	by1000genomes	TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr7:144060770T>C	ENST00000056217.5	+	2	1182	c.1008T>C	c.(1006-1008)aaT>aaC	p.N336N		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	336					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity	p.N336N(5)		breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					CAGAAGAGAATAGGGCGGACT	0.512000													5	98					0	0	1	0	0
TBC1D3P2	0	broad.mit.edu	37	17	60342186	60342186	+	RNA	SNP	T	T	C	rs79096325		TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr17:60342186T>C	ENST00000581291.1	-	0	1967																				breast(2)|kidney(1)|lung(2)	5						GCTGGGGGTGTTGGGAGGGGC	0.498000													3	23					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56582201	56582201	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr17:56582201C>T	ENST00000323456.5	-	12	1362	c.1238G>A	c.(1237-1239)cGc>cAc	p.R413H	MTMR4_ENST00000579925.1_Missense_Mutation_p.R413H	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	413	Myotubularin phosphatase.|Substrate binding (By similarity).					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCGGTGTGCGGTCCCAGCC	0.532000													4	132					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31391686	31391686	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr16:31391686G>T	ENST00000268296.4	+	27	3281	c.3160G>T	c.(3160-3162)Ggc>Tgc	p.G1054C	ITGAX_ENST00000562522.1_Missense_Mutation_p.G1054C	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	1054					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CCTCAGCTTTGGCTGGGTCCG	0.652000													3	36					1	1	1	1	0
CYP2D7P1	0	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr22:42538870A>C	ENST00000358097.4	-	0	449				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000424775.1_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													3	37					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	15					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132473	91132473	+	Missense_Mutation	SNP	T	T	C			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chrX:91132473T>C	ENST00000373094.1	+	2	2079	c.1234T>C	c.(1234-1236)Ttc>Ctc	p.F412L	PCDH11X_ENST00000373097.1_Missense_Mutation_p.F412L|PCDH11X_ENST00000361724.1_Missense_Mutation_p.F412L|PCDH11X_ENST00000361655.2_Missense_Mutation_p.F412L|PCDH11X_ENST00000395337.2_Missense_Mutation_p.F412L|PCDH11X_ENST00000298274.8_Missense_Mutation_p.F412L|PCDH11X_ENST00000504220.1_Missense_Mutation_p.F412L|PCDH11X_ENST00000406881.1_Missense_Mutation_p.F412L|PCDH11X_ENST00000373088.1_Missense_Mutation_p.F412L	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	412	Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AAGGCCAGTATTCAGTAATCA	0.438000													8	193					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6083476	6083476	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr4:6083476G>A	ENST00000409021.3	-	6	1410	c.961C>T	c.(961-963)Cgc>Tgc	p.R321C	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.R156C|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.R321C|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.R156C|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.R321C	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	321	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCTCGTGAGCGTTTCAGCTGT	0.542000													35	49					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000584398.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													4	106					0.150653	0.154725	1	1	0
DRD5	0	broad.mit.edu	37	4	9783834	9783834	+	Missense_Mutation	SNP	G	G	A	rs113223975	by1000genomes	TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr4:9783834G>A	ENST00000304374.2	+	1	577	c.181G>A	c.(181-183)Gtg>Atg	p.V61M		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	61					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CAACGTGCTGGTGTGCGCAGC	0.672000													4	48					0	0	1	0	0
C15orf41	84529	broad.mit.edu	37	15	37002124	37002124	+	Silent	SNP	C	C	T			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr15:37002124C>T	ENST00000566621.1	+	10	928	c.678C>T	c.(676-678)caC>caT	p.H226H	C15orf41_ENST00000569302.1_Silent_p.H232H|C15orf41_ENST00000437989.2_Silent_p.H226H|C15orf41_ENST00000567389.1_Silent_p.H128H|C15orf41_ENST00000562489.1_Silent_p.H50H|C15orf41_ENST00000562877.1_Silent_p.H128H|C15orf41_ENST00000338183.4_Silent_p.H128H|C15orf41_ENST00000565792.1_3'UTR	NM_001130010.1	NP_001123482.1	Q9Y2V0	CO041_HUMAN	chromosome 15 open reading frame 41	226							protein binding			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)		GTAGCCACCACGCCTACCTGC	0.393000													8	134					0	0	1	0	0
TMLHE	55217	broad.mit.edu	37	X	154774817	154774817	+	Missense_Mutation	SNP	A	A	C			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chrX:154774817A>C	ENST00000334398.3	-	2	266	c.121T>G	c.(121-123)Tgg>Ggg	p.W41G	TMLHE-AS1_ENST00000452506.1_RNA|TMLHE_ENST00000369439.4_Missense_Mutation_p.W41G	NM_018196.3	NP_060666.1	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	41					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	GTATGGTGCCAATGGACAGCT	0.463000													49	63					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	15					6.4e-05	7.3697e-05	1	1	0
MSLN	10232	broad.mit.edu	37	16	814961	814961	+	Silent	SNP	G	G	A			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr16:814961G>A	ENST00000566549.1	+	7	852	c.435G>A	c.(433-435)acG>acA	p.T145T	MSLN_ENST00000382862.3_Silent_p.T145T|MSLN_ENST00000563941.1_Silent_p.T145T|MSLN_ENST00000545450.2_Silent_p.T145T			Q13421	MSLN_HUMAN	mesothelin	145					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				CCCGCATCACGAAGGCCAATG	0.701000													13	31					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20490475	20490475	+	Silent	SNP	C	C	T			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr4:20490475C>T	ENST00000504154.1	+	8	897	c.645C>T	c.(643-645)tgC>tgT	p.C215C	SLIT2_ENST00000503837.1_Silent_p.C215C|SLIT2_ENST00000503823.1_Silent_p.C215C|SLIT2_ENST00000273739.5_Silent_p.C215C	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	215	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATTGTGACTGCCACCTGGCCT	0.473000													89	154					0	0	1	0	0
MT-CO2	4513	broad.mit.edu	37	MT	8027	8027	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chrM:8027G>A	ENST00000361739.1	+	1	442	c.442G>A	c.(442-444)Gcc>Acc	p.A148T						mitochondrially encoded cytochrome c oxidase II											endometrium(5)|kidney(8)|lung(2)|pancreas(3)|prostate(1)	19						TCCCGATTGAAGCCCCCATTC	0.468000													2	0					0	0	1	0	0
SEMA3B	7869	broad.mit.edu	37	3	50311108	50311108	+	RNA	SNP	A	A	G			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr3:50311108A>G	ENST00000418948.1	+	0	1156							Q13214	SEM3B_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B						axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			central_nervous_system(2)|kidney(1)|lung(2)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GGGGTTGGGGAGGGGGGCAGC	0.701000											OREG0015583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	47					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				42	47					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38991659	38991659	+	Silent	SNP	G	G	T			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr3:38991659G>T	ENST00000302328.3	-	1	393	c.195C>A	c.(193-195)ctC>ctA	p.L65L	SCN11A_ENST00000456224.3_Silent_p.L65L|SCN11A_ENST00000450244.1_Silent_p.L65L|SCN11A_ENST00000444237.2_Silent_p.L65L	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	65					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGTCGCCATAGAGCTTGGGCA	0.532000													4	185					0.150653	0.154725	1	1	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													6	93					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247597549	247597549	+	Silent	SNP	C	C	T			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr1:247597549C>T	ENST00000366497.2	+	6	3252	c.2472C>T	c.(2470-2472)caC>caT	p.H824H	NLRP3_ENST00000336119.3_Silent_p.H824H|NLRP3_ENST00000391828.3_Silent_p.H824H|NLRP3_ENST00000348069.2_Silent_p.H767H|NLRP3_ENST00000366496.2_Silent_p.H824H|NLRP3_ENST00000391827.2_Silent_p.H767H	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	881					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GACTGAAGCACCTGTTGTGCA	0.587000													4	117					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546506	11546508	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr12:11546506_11546508delTTG	ENST00000389362.4	-	3	539_541	c.504_506delCAA	c.(502-507)aag>aa	p.NK168del	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			ACTTCGGGACTTGTTGTCTCCTT	0.596													8	764	---	---	---	---					
CTD-2540L5.5	0	broad.mit.edu	37	14	71067484	71067504	+	RNA	DEL	GGCAGGAGAGAGGCAGGGGGT	GGCAGGAGAGAGGCAGGGGGT	-			TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr14:71067484_71067504delGGCAGGAGAGAGGCAGGGGGT	ENST00000553982.1	-	0	294																											gggcggggcgggcaggagagaggcagggggtggaggtgcgg	0.710													3	3	---	---	---	---					
IGHJ6	0	broad.mit.edu	37	14	106329450	106329451	+	RNA	INS	-	-	ACC	rs74454466	by1000genomes	TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr14:106329450_106329451insACC	ENST00000390560.2	-	0	17_18																											CAGACGTCCATGTAGTAGTAGT	0.540													9	89	---	---	---	---					
RRN3P2	0	broad.mit.edu	37	16	29113498	29113498	+	RNA	DEL	T	T	-	rs11366120		TCGA-KS-A4I1-01A-11D-A257-08	TCGA-KS-A4I1-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa5b5812-355d-4716-a55a-38071b50593c	f758e38b-90f4-4aea-9c72-2b506baf6678	g.chr16:29113498delT	ENST00000564580.1	+	0	1360																											AGGAGGTGGAttttttttttc	0.542													7	37	---	---	---	---