Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHRNA2	0	broad.mit.edu	37	8	27319199	27319199	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr8:27319199A>G	ENST00000407991.1	-	7	2145	c.1537T>C	c.(1537-1539)Ttc>Ctc	p.F513L	CHRNA2_ENST00000520933.2_Missense_Mutation_p.F513L|CHRNA2_ENST00000240132.2_Missense_Mutation_p.F498L	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	513						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GTCCCCAGGAAGCAGACGATG	0.572000													17	41					0	0	1	0	0
TRAFD1	10906	broad.mit.edu	37	12	112578720	112578720	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr12:112578720G>A	ENST00000257604.5	+	5	952	c.335G>A	c.(334-336)cGg>cAg	p.R112Q	TRAFD1_ENST00000412615.2_Missense_Mutation_p.R112Q	NM_001143906.1	NP_001137378.1	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	112					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding			kidney(5)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	17						TGTGGTGCCCGGACGGAACTA	0.483000													15	42					0	0	1	0	0
HPDL	84842	broad.mit.edu	37	1	45793454	45793454	+	Silent	SNP	C	C	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr1:45793454C>T	ENST00000334815.3	+	1	910	c.634C>T	c.(634-636)Ctg>Ttg	p.L212L		NM_032756.2	NP_116145.1	Q96IR7	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like	212					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	Acute lymphoblastic leukemia(166;0.155)					GCTTGGGGGACTGAGGCTTAC	0.642000													11	52					0	0	1	0	0
HDDC3	374659	broad.mit.edu	37	15	91475311	91475311	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr15:91475311C>T	ENST00000330334.3	-	2	147	c.142G>A	c.(142-144)Gga>Aga	p.G48R	HDDC3_ENST00000394272.3_Missense_Mutation_p.G48R|UNC45A_ENST00000394275.2_Intron|HDDC3_ENST00000559898.1_Missense_Mutation_p.G48R	NM_198527.2	NP_940929.1	Q8N4P3	MESH1_HUMAN	HD domain containing 3	48	HD.						guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity|metal ion binding|phosphoric diester hydrolase activity			NS(1)|ovary(1)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TCAGTGATTCCCGCCTCGTGG	0.592000											OREG0023475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	13					0	0	1	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49284490	49284490	+	Missense_Mutation	SNP	G	G	A	rs140688864		TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr15:49284490G>A	ENST00000559471.1	-	18	3520	c.3257C>T	c.(3256-3258)tCg>tTg	p.S1086L	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.S1041L	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	1086										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						TTTGTTGAGCGAGCTGCAGTT	0.552000													7	47					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37523045	37523045	+	Missense_Mutation	SNP	T	T	G			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr3:37523045T>G	ENST00000264741.5	+	4	747	c.491T>G	c.(490-492)aTc>aGc	p.I164S	ITGA9_ENST00000422441.1_Missense_Mutation_p.I164S	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	164					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TTCTGCTACATCATCCCCTCC	0.537000													32	49					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114149937	114149937	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr13:114149937C>T	ENST00000434316.2	+	2	400	c.41C>T	c.(40-42)cCc>cTc	p.P14L	TMCO3_ENST00000474393.1_3'UTR|TMCO3_ENST00000375391.1_Missense_Mutation_p.P14L	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	14						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GTGCTGTTTCCCGTCCTTCCC	0.642000													5	25					0	0	1	0	0
TMEM143	55260	broad.mit.edu	37	19	48866617	48866617	+	Missense_Mutation	SNP	G	G	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr19:48866617G>T	ENST00000293261.3	-	2	511	c.195C>A	c.(193-195)gaC>gaA	p.D65E	TMEM143_ENST00000541566.1_Intron|TMEM143_ENST00000598012.1_5'UTR|TMEM143_ENST00000436660.2_Missense_Mutation_p.D65E|TMEM143_ENST00000435956.3_Missense_Mutation_p.D65E|TMEM143_ENST00000377431.2_Missense_Mutation_p.D65E	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	65						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GCTGGGCCCAGTCGCGGGGCT	0.667000													9	30					3.86212e-05	3.97247e-05	1	1	0
IFNL2	282616	broad.mit.edu	37	19	39759357	39759357	+	Silent	SNP	C	C	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr19:39759357C>T	ENST00000331982.5	+	2	106	c.51C>T	c.(49-51)gcC>gcT	p.A17A		NM_172138.1	NP_742150.1			interferon, lambda 2																		TGCTGATGGCCGCAGTGCTGA	0.637000													7	44					0	0	1	0	0
IGKV1D-12	0	broad.mit.edu	37	2	90198917	90198917	+	RNA	SNP	G	G	C			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr2:90198917G>C	ENST00000390276.2	+	0	259																											ACATCCAGATGACCCAGTCTC	0.458000													11	55					0	0	1	0	0
NEDD4	4734	broad.mit.edu	37	15	56142876	56142876	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr15:56142876G>A	ENST00000508342.1	-	10	2767	c.2468C>T	c.(2467-2469)tCc>tTc	p.S823F	NEDD4_ENST00000506154.1_Missense_Mutation_p.S807F|NEDD4_ENST00000338963.2_Missense_Mutation_p.S751F|NEDD4_ENST00000435532.3_Missense_Mutation_p.S404F			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	823	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		ATCACTGGTGGAGGCTTGTGA	0.498000													7	35					0	0	1	0	0
PELI1	57162	broad.mit.edu	37	2	64323615	64323615	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr2:64323615G>A	ENST00000358912.4	-	5	875	c.433C>T	c.(433-435)Cgg>Tgg	p.R145W		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	145					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						GGAGGATTCCGTTCACATATG	0.373000													5	17					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	SIRPB1_ENST00000381605.4_Intron|SIRPB1_ENST00000381603.3_Intron|RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													7	30					0	0	1	0	0
RIN1	9610	broad.mit.edu	37	11	66103088	66103088	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr11:66103088G>A	ENST00000311320.4	-	4	574	c.448C>T	c.(448-450)Cac>Tac	p.H150Y	RIN1_ENST00000530056.1_Missense_Mutation_p.H45Y|RP11-867G23.12_ENST00000526655.1_RNA|RIN1_ENST00000424433.2_Missense_Mutation_p.H45Y	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	150	SH2.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						CACCGGGTGTGGCAGTAGGCA	0.647000													6	14					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243462	46243462	+	Silent	SNP	A	A	G			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr12:46243462A>G	ENST00000334344.6	+	14	1987	c.1815A>G	c.(1813-1815)ccA>ccG	p.P605P	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Silent_p.P456P|ARID2_ENST00000444670.1_Silent_p.P215P	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	605					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GGGCTATACCACTTCCCATTC	0.463000			"""N, S, F"""		hepatocellular carcinoma								9	55					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211171	78211171	+	RNA	SNP	A	A	G	rs12592262	by1000genomes	TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr15:78211171A>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CTGGAAGAGCACGAGCCTCTC	0.602000													12	94					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27444633	27444633	+	Missense_Mutation	SNP	T	T	C			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr3:27444633T>C	ENST00000295736.5	-	15	2361	c.2291A>G	c.(2290-2292)tAc>tGc	p.Y764C	SLC4A7_ENST00000388777.4_Missense_Mutation_p.Y314C|SLC4A7_ENST00000435667.2_Missense_Mutation_p.Y649C|SLC4A7_ENST00000440156.1_Missense_Mutation_p.Y760C|SLC4A7_ENST00000445684.1_Missense_Mutation_p.Y760C|SLC4A7_ENST00000437179.1_Missense_Mutation_p.Y645C|SLC4A7_ENST00000428386.1_Missense_Mutation_p.Y640C|SLC4A7_ENST00000454389.1_Missense_Mutation_p.Y773C|SLC4A7_ENST00000455077.1_Missense_Mutation_p.Y645C|SLC4A7_ENST00000446700.1_Missense_Mutation_p.Y756C|SLC4A7_ENST00000425128.2_3'UTR	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	764						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TACTTACGAGTAGCTGGTCAG	0.328000													13	19					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140358578	140358578	+	Splice_Site	SNP	C	C	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr9:140358578C>T	ENST00000406427.1	-	28	3562	c.3226_splice	c.e28+1	p.G1076_splice	PNPLA7_ENST00000492278.1_5'UTR|PNPLA7_ENST00000371457.1_Splice_Site_p.G657_splice|PNPLA7_ENST00000277531.4_Splice_Site_p.G1051_splice	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1051	Patatin.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GAGTGCTCACCGTCGGTGTGG	0.692000													9	15					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105349547	105349547	+	Silent	SNP	T	T	C			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr14:105349547T>C	ENST00000453495.1	+	8	984	c.756T>C	c.(754-756)gaT>gaC	p.D252D	CEP170B_ENST00000418279.1_Silent_p.D181D|CEP170B_ENST00000414716.3_Silent_p.D251D|CEP170B_ENST00000556508.1_Silent_p.D181D					centrosomal protein 170B																		CCACGAAGGATGCAGAGGCAG	0.662000													6	32					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610400	10610400	+	Missense_Mutation	SNP	T	T	C			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr19:10610400T>C	ENST00000171111.5	-	2	857	c.310A>G	c.(310-312)Agc>Ggc	p.S104G	KEAP1_ENST00000393623.2_Missense_Mutation_p.S104G	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	104	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			AAGACAGGGCTGGATGAGGCC	0.622000													13	6					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5529772	5529772	+	Missense_Mutation	SNP	G	G	C			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr7:5529772G>C	ENST00000453700.3	-	5	2189	c.2072C>G	c.(2071-2073)tCt>tGt	p.S691C	FBXL18_ENST00000382368.3_Intron			Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	691									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		AGTGGCTCGAGACGTCCTGGC	0.617000													9	7					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178392106	178392106	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr5:178392106A>G	ENST00000320129.3	+	5	1004	c.701A>G	c.(700-702)cAc>cGc	p.H234R	ZNF454_ENST00000519564.1_Missense_Mutation_p.H234R	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	234					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		CTTATCCATCACCAAAGAATT	0.388000													21	46					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121980815	121980815	+	Silent	SNP	C	C	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr3:121980815C>T	ENST00000498619.1	+	4	1371	c.933C>T	c.(931-933)ttC>ttT	p.F311F	CASR_ENST00000490131.1_Silent_p.F311F|CASR_ENST00000296154.5_Silent_p.F311F	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	311					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTCAGTACTTCCACGTGGTTG	0.597000													20	36					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4523662	4523662	+	Missense_Mutation	SNP	T	T	C			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr19:4523662T>C	ENST00000381848.3	-	8	1350	c.1270A>G	c.(1270-1272)Agg>Ggg	p.R424G		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	424						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CTCCCGTCCCTGTGCTCTGCC	0.701000											OREG0025168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	79					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35842863	35842863	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr19:35842863C>T	ENST00000246553.2	+	1	419	c.409C>T	c.(409-411)Cac>Tac	p.H137Y		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	137					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	CGTCCTGTGTCACCTGGGTCT	0.657000													16	48					0	0	1	0	0
CHSY1	22856	broad.mit.edu	37	15	101775489	101775489	+	Missense_Mutation	SNP	T	T	A			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr15:101775489T>A	ENST00000254190.3	-	2	1089	c.614A>T	c.(613-615)gAa>gTa	p.E205V		NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	205					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCCCATTTCTTCCGTGGTGCC	0.587000													9	38					0	0	1	0	0
EFCAB14	9813	broad.mit.edu	37	1	47182006	47182007	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr1:47182006_47182007insAA	ENST00000371933.3	-	2	1270_1271	c.294_295insTT	c.(292-297)ctaggafs	p.G99fs	EFCAB14_ENST00000544071.1_Frame_Shift_Ins_p.G99fs	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14																		AGATCCTCCTTGAGAGCAACCT	0.421													14	32	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72280990	72280991	+	RNA	DEL	AC	AC	-	rs6960315		TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr7:72280990_72280991delAC	ENST00000438125.1	-	0	336							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										gtgtgtgtgtacgtgtgtgtgc	0.381													7	72	---	---	---	---					
TRBV7-7	0	broad.mit.edu	37	7	142120209	142120210	+	RNA	DEL	TG	TG	-			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr7:142120209_142120210delTG	ENST00000390377.1	-	0	49																											cagacacacatgcatacacaca	0.436													7	126	---	---	---	---					
MIRLET7DHG	0	broad.mit.edu	37	9	96941099	96941100	+	RNA	INS	-	-	A			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr9:96941099_96941100insA	ENST00000416309.2	-	0	164				RP11-2B6.3_ENST00000602703.1_lincRNA	NR_046163.1																						AGACCAGCAAGAAAAAAAAAAT	0.376													2	4	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14284600	14284600	+	RNA	DEL	A	A	-	rs79477301		TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr11:14284600delA	ENST00000310358.7	+	0	2795				RP11-21L19.1_ENST00000534587.1_RNA			Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GGACCTGTTTaaaaaaaaaaa	0.463													3	4	---	---	---	---					
EIF3CL	728689	broad.mit.edu	37	16	28403353	28403355	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FY-A4B0-01A-21D-A23U-08	TCGA-FY-A4B0-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1c5369c0-0005-4ca1-b5c7-0f44174f556b	fadf7923-0df0-4bd1-bc7a-707eb8181477	g.chr16:28403353_28403355delTCC	ENST00000398943.3	-	9	1021_1023	c.885_887delGGA	c.(883-888)gac>ga	p.ED295del	EIF3CL_ENST00000380876.4_In_Frame_Del_p.ED295del|EIF3CL_ENST00000398944.3_In_Frame_Del_p.ED295del					eukaryotic translation initiation factor 3, subunit C-like																		GCCTTCATTGTCCTCCTCCTCCT	0.547													7	12	---	---	---	---