Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SULT1E1	6783	broad.mit.edu	37	4	70723283	70723283	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr4:70723283C>T	ENST00000226444.3	-	2	192	c.80G>A	c.(79-81)tGg>tAg	p.W27*		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	27					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CACATTATCCCAATATTTGAC	0.343000													4	56					0	0	1	0	0
FBXL2	25827	broad.mit.edu	37	3	33415072	33415072	+	Translation_Start_Site	SNP	A	A	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr3:33415072A>T	ENST00000542085.1	+	0	669				FBXL2_ENST00000446237.3_De_novo_Start_OutOfFrame|FBXL2_ENST00000283627.6_3'UTR|FBXL2_ENST00000538892.1_Intron|FBXL2_ENST00000538181.1_Missense_Mutation_p.E69V|FBXL2_ENST00000507198.1_Intron|FBXL2_ENST00000484457.1_Missense_Mutation_p.E153V			Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2						interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|urinary_tract(1)	15						TCTCTCAGTGAGGGCTGCCGA	0.488000													3	40					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													3	75					0	0	1	0	0
CD101	9398	broad.mit.edu	37	1	117560956	117560956	+	Missense_Mutation	SNP	C	C	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr1:117560956C>A	ENST00000256652.4	+	6	1849	c.1791C>A	c.(1789-1791)caC>caA	p.H597Q	CD101_ENST00000369470.1_Missense_Mutation_p.H597Q	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	597	Ig-like C2-type 5.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GAATCACCCACAATGGCACTA	0.498000													3	49					1	1	1	1	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													3	48					0	0	1	0	0
SPSB3	90864	broad.mit.edu	37	16	1828487	1828487	+	Silent	SNP	G	G	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr16:1828487G>A	ENST00000566339.1	-	3	583	c.253C>T	c.(253-255)Ctg>Ttg	p.L85L	SPSB3_ENST00000301717.4_Silent_p.L85L	NM_080861.3	NP_543137.2	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box containing 3	85	B30.2/SPRY.				intracellular signal transduction					endometrium(1)|kidney(4)|lung(3)|prostate(2)	10						GCCGAGTGCAGGCTGCTACAG	0.701000													6	45					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967413	142967413	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chrX:142967413C>T	ENST00000370494.1	+	1	241	c.211C>T	c.(211-213)Cgt>Tgt	p.R71C		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	71							acid-amino acid ligase activity	p.R71G(1)		breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTAAAGTACGTTTCATGAC	0.423000													10	84					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37168499	37168499	+	Silent	SNP	G	G	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr20:37168499G>A	ENST00000262879.6	+	17	2744	c.2460G>A	c.(2458-2460)cgG>cgA	p.R820R	RALGAPB_ENST00000397038.1_Silent_p.R598R|RALGAPB_ENST00000397040.1_Silent_p.R820R|RALGAPB_ENST00000397042.3_Silent_p.R816R			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	820					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AGTGTAGTCGGCCAGCTCCTT	0.483000													3	51					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169791766	169791766	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr2:169791766G>A	ENST00000263817.6	-	23	3108	c.2984C>T	c.(2983-2985)gCg>gTg	p.A995V		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	995	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism	p.A995V(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	AGCAGAATTCGCAATAAACAT	0.448000													9	89					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V|FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													4	36					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				7	41					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299387	58299387	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr13:58299387C>T	ENST00000377918.3	+	4	3465	c.3439C>T	c.(3439-3441)Caa>Taa	p.Q1147*		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1147					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TAAGCTTTTGCAAGACTGCCG	0.443000													18	139					0	0	1	0	0
SULT1E1	6783	broad.mit.edu	37	4	70723283	70723283	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr4:70723283C>T	ENST00000226444.3	-	2	192	c.80G>A	c.(79-81)tGg>tAg	p.W27*		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	27					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CACATTATCCCAATATTTGAC	0.343000													4	56					0	0	1	0	0
FBXL2	25827	broad.mit.edu	37	3	33415072	33415072	+	Translation_Start_Site	SNP	A	A	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr3:33415072A>T	ENST00000542085.1	+	0	669				FBXL2_ENST00000538892.1_Intron|FBXL2_ENST00000538181.1_Missense_Mutation_p.E69V|FBXL2_ENST00000507198.1_Intron|FBXL2_ENST00000484457.1_Missense_Mutation_p.E153V|FBXL2_ENST00000446237.3_De_novo_Start_OutOfFrame|FBXL2_ENST00000283627.6_3'UTR			Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2						interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|urinary_tract(1)	15						TCTCTCAGTGAGGGCTGCCGA	0.488000													3	40					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													4	41					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													3	48					0	0	1	0	0
CD101	9398	broad.mit.edu	37	1	117560956	117560956	+	Missense_Mutation	SNP	C	C	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr1:117560956C>A	ENST00000256652.4	+	6	1849	c.1791C>A	c.(1789-1791)caC>caA	p.H597Q	CD101_ENST00000369470.1_Missense_Mutation_p.H597Q	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	597	Ig-like C2-type 5.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GAATCACCCACAATGGCACTA	0.498000													3	49					1	1	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								9	53					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713944	142713944	+	RNA	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr1:142713944C>T	ENST00000369381.2	-	0	661																											TGATTACCTCCGAAGTTAAAG	0.308000													3	12					0	0	1	0	0
ANKRD30BP2	0	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													3	10					0	0	1	0	0
SPSB3	90864	broad.mit.edu	37	16	1828487	1828487	+	Silent	SNP	G	G	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr16:1828487G>A	ENST00000566339.1	-	3	583	c.253C>T	c.(253-255)Ctg>Ttg	p.L85L	SPSB3_ENST00000301717.4_Silent_p.L85L	NM_080861.3	NP_543137.2	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box containing 3	85	B30.2/SPRY.				intracellular signal transduction					endometrium(1)|kidney(4)|lung(3)|prostate(2)	10						GCCGAGTGCAGGCTGCTACAG	0.701000													6	45					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													5	20					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967413	142967413	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chrX:142967413C>T	ENST00000370494.1	+	1	241	c.211C>T	c.(211-213)Cgt>Tgt	p.R71C		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	71							acid-amino acid ligase activity	p.R71G(1)		breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTAAAGTACGTTTCATGAC	0.423000													10	84					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37168499	37168499	+	Silent	SNP	G	G	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr20:37168499G>A	ENST00000262879.6	+	17	2744	c.2460G>A	c.(2458-2460)cgG>cgA	p.R820R	RALGAPB_ENST00000397042.3_Silent_p.R816R|RALGAPB_ENST00000397038.1_Silent_p.R598R|RALGAPB_ENST00000397040.1_Silent_p.R820R			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	820					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AGTGTAGTCGGCCAGCTCCTT	0.483000													3	51					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169791766	169791766	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr2:169791766G>A	ENST00000263817.6	-	23	3108	c.2984C>T	c.(2983-2985)gCg>gTg	p.A995V		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	995	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism	p.A995V(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	AGCAGAATTCGCAATAAACAT	0.448000													9	89					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V|FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													4	36					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				7	41					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299387	58299387	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr13:58299387C>T	ENST00000377918.3	+	4	3465	c.3439C>T	c.(3439-3441)Caa>Taa	p.Q1147*		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1147					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TAAGCTTTTGCAAGACTGCCG	0.443000													18	139					0	0	1	0	0
C17orf82	388407	broad.mit.edu	37	17	59489871	59489877	+	Frame_Shift_Del	DEL	GGCCTCG	GGCCTCG	-			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	c9a09595-df86-4d5d-a085-8acb85b0e05e	g.chr17:59489871_59489877delGGCCTCG	ENST00000335108.2	+	1	760_766	c.535_541delGGCCTCG	c.(535-543)ggfs	p.GLG179fs		NM_203425.1	NP_982249.1	Q86X59	CQ082_HUMAN	chromosome 17 open reading frame 82	179										cervix(1)|lung(1)	2						AGCCCGCCCAGGCCTCGGGCCTCGGCA	0.734													3	4	---	---	---	---					
RP11-25I15.2	0	broad.mit.edu	37	12	43072603	43072603	+	RNA	DEL	T	T	-			TCGA-FY-A3TY-01A-11D-A22Z-08	TCGA-FY-A3TY-11A-12D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f84ece22-b5e5-4f7b-ad54-1f0d5c782a06	2d89bc5a-baa3-4ef2-81a2-62ed2e60c685	g.chr12:43072603delT	ENST00000548764.1	+	0	465																											AGAACTCTGCttttttttttt	0.413													5	2	---	---	---	---