Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RANBP2	5903	broad.mit.edu	37	2	109382494	109382494	+	Silent	SNP	T	T	G			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr2:109382494T>G	ENST00000283195.6	+	20	5625	c.5499T>G	c.(5497-5499)tcT>tcG	p.S1833S		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	1833					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						ATGACTCTTCTGGAAGTCAGG	0.413000													29	65					0	0	0.007291	0	0
VWA3B	200403	broad.mit.edu	37	2	98853095	98853095	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr2:98853095C>A	ENST00000477737.1	+	19	2779	c.2575C>A	c.(2575-2577)Ctc>Atc	p.L859I		NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	859										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CGCCAAGAAACTCACCCTCAT	0.478000													8	93					1.06961e-07	6.68508e-07	0.003080	1	0
RABEP1	9135	broad.mit.edu	37	17	5253769	5253769	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr17:5253769C>T	ENST00000262477.6	+	7	1032	c.808C>T	c.(808-810)Cga>Tga	p.R270*	RABEP1_ENST00000341923.6_Nonsense_Mutation_p.R270*|RABEP1_ENST00000546142.2_Nonsense_Mutation_p.R270*|RABEP1_ENST00000537505.1_Nonsense_Mutation_p.R227*|RABEP1_ENST00000408982.2_Nonsense_Mutation_p.R270*	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	270					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						GGAGCAAGAGCGACAACAACA	0.418000													8	85					0	0	0.003080	0	0
ZNF709	163051	broad.mit.edu	37	19	12575380	12575380	+	Silent	SNP	C	C	T			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr19:12575380C>T	ENST00000397732.3	-	4	1527	c.1356G>A	c.(1354-1356)caG>caA	p.Q452Q	ZNF709_ENST00000428311.1_Silent_p.Q452Q|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						CTTTACCACACTGTTTACATT	0.403000													4	159					0	0	0.000248	0	0
CSMD2	114784	broad.mit.edu	37	1	34190211	34190211	+	Silent	SNP	G	G	A			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr1:34190211G>A	ENST00000373381.4	-	18	2966	c.2790C>T	c.(2788-2790)acC>acT	p.T930T		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	890	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CACAGCTGAAGGTCACCAGCG	0.562000													5	66					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179455272	179455272	+	Missense_Mutation	SNP	T	T	G			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr2:179455272T>G	ENST00000589042.1	-	304	61404	c.61180A>C	c.(61180-61182)Aag>Cag	p.K20394Q	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K18753Q|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.K17826Q|TTN_ENST00000342175.6_Missense_Mutation_p.K11521Q|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K11454Q|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K11329Q|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18753	Fibronectin type-III 47.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAGAGGCTTTGTCCACACC	0.443000													54	94					0	0	0.003610	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				23	41					0	0	0.002299	0	0
WASH3P	0	broad.mit.edu	37	15	102516473	102516473	+	RNA	SNP	G	G	A			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr15:102516473G>A	ENST00000557932.1	+	0	1421																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						ATCCTAGGGGGCTCCATGACA	0.642000													4	57					0	0	0.000602	0	0
FILIP1L	11259	broad.mit.edu	37	3	99569769	99569769	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr3:99569769C>T	ENST00000331335.5	-	5	1221	c.751G>A	c.(751-753)Gca>Aca	p.A251T	FILIP1L_ENST00000383694.2_Missense_Mutation_p.A11T|CMSS1_ENST00000496116.1_Intron|CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000354552.3_Missense_Mutation_p.A251T|FILIP1L_ENST00000471562.1_Missense_Mutation_p.A11T|FILIP1L_ENST00000487087.1_Intron|FILIP1L_ENST00000476723.1_Intron	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	251						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						GTGAGCTGTGCCGTCAGCCTT	0.488000													4	144					0	0	0.000248	0	0
BMS1	9790	broad.mit.edu	37	10	43318651	43318651	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr10:43318651A>G	ENST00000374518.4	+	20	3281	c.3218A>G	c.(3217-3219)aAa>aGa	p.K1073R		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1073					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CAGATCAAGAAAGCACTCCGA	0.498000													3	76					0	0	0.000248	0	0
FHL5	9457	broad.mit.edu	37	6	97051492	97051492	+	Translation_Start_Site	SNP	G	G	C			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr6:97051492G>C	ENST00000326771.2	+	3	383	c.3G>C	c.(1-3)atG>atC	p.M1I	FHL5_ENST00000541107.1_Start_Codon_SNP_p.M1I	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	1						nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		AAACCAAAATGACAACTGCTC	0.318000													4	73					0	0	0.001168	0	0
ZNF512B	57473	broad.mit.edu	37	20	62592689	62592689	+	Silent	SNP	T	T	C			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr20:62592689T>C	ENST00000450537.1	-	16	2460	c.2400A>G	c.(2398-2400)aaA>aaG	p.K800K	ZNF512B_ENST00000217130.3_Silent_p.K800K|ZNF512B_ENST00000369888.1_Silent_p.K800K			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	800					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGATGTGGTATTTGACGCCAC	0.647000													3	56					0	0	0.004672	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72664015	72664015	+	RNA	SNP	C	C	G			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr7:72664015C>G	ENST00000425256.1	-	0	885					NR_002164.1																						ATACCACCCCCGGGGCATGCC	0.507000													3	24					0	0	0.004672	0	0
MANBA	4126	broad.mit.edu	37	4	103557044	103557044	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr4:103557044G>A	ENST00000226578.4	-	15	2234	c.2135C>T	c.(2134-2136)tCg>tTg	p.S712L	MANBA_ENST00000505239.1_Missense_Mutation_p.S655L	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	712					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		CGAATAATCCGAGTGAAGATC	0.363000													4	69					0	0	0.000248	0	0
TES	26136	broad.mit.edu	37	7	115891896	115891896	+	Missense_Mutation	SNP	A	A	C			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr7:115891896A>C	ENST00000358204.4	+	5	1000	c.785A>C	c.(784-786)cAc>cCc	p.H262P	TES_ENST00000393481.2_Missense_Mutation_p.H253P|TES_ENST00000537767.1_Missense_Mutation_p.H20P|AC073130.3_ENST00000444244.1_RNA|AC002066.1_ENST00000446355.2_RNA	NM_015641.3	NP_056456.1	Q9UGI8	TES_HUMAN	testis derived transcript (3 LIM domains)	262	LIM zinc-binding 1.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding			endometrium(4)|large_intestine(4)|lung(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	12	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			AAACTGTGGCACCCAGCTTGT	0.468000													7	116					0	0	0.002450	0	0
KIF1B	23095	broad.mit.edu	37	1	10397153	10397153	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr1:10397153A>G	ENST00000377086.1	+	30	3353	c.3151A>G	c.(3151-3153)Atg>Gtg	p.M1051V	KIF1B_ENST00000263934.6_Missense_Mutation_p.M1005V|KIF1B_ENST00000377081.1_Missense_Mutation_p.M1051V			O60333	KIF1B_HUMAN	kinesin family member 1B	1051					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GTCTGTTGCAATGACTCGTTC	0.428000													53	120					0	0	0.003610	0	0
HAX1	10456	broad.mit.edu	37	1	154245864	154245866	+	In_Frame_Del	DEL	GAA	GAA	-	rs11556342		TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr1:154245864_154245866delGAA	ENST00000328703.7	+	2	319_321	c.106_108delGAA	c.(106-108)del	p.E40del	HAX1_ENST00000532105.1_Intron|HAX1_ENST00000457918.2_Intron|HAX1_ENST00000483970.2_In_Frame_Del_p.E40del	NM_006118.3	NP_006109.2	O00165	HAX1_HUMAN	HCLS1 associated protein X-1	40	Asp/Glu-rich (highly acidic).|Required for localization in mitochondria (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	15	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGATGATGAGGAAGAAGAAGAAG	0.522									Kostmann syndrome				7	82	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139390945	139390947	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr9:139390945_139390947delGTG	ENST00000277541.6	-	34	7319_7321	c.7244_7246delCAC	c.(7243-7248)cag>c	p.PQ2415del		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	2415	Poly-Pro.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.Q2417*(2)|p.P2416fs*11(1)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGTGCGGCTGTGGTGGTGGTGG	0.650			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			7	59	---	---	---	---					
RP11-179A10.1	0	broad.mit.edu	37	11	11158570	11158570	+	RNA	DEL	A	A	-	rs10574607		TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr11:11158570delA	ENST00000525758.1	+	0	108																											actctgtctcaaaaaaaaaaa	0.413													4	3	---	---	---	---					
RRN3P1	0	broad.mit.edu	37	16	21817398	21817399	+	RNA	INS	-	-	A	rs144931984	by1000genomes	TCGA-ET-A25K-01A-11D-A16O-08	TCGA-ET-A25K-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3aafad5c-a33b-4e15-bc2a-2cb2f0fe4207	030113e6-9473-4c38-8aaa-a0e3bd28c248	g.chr16:21817398_21817399insA	ENST00000546471.1	-	0	1607																											TAAATGaaaataaaaaaataaa	0.302													2	4	---	---	---	---