Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMEM145	284339	broad.mit.edu	37	19	42827922	42827922	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr19:42827922T>C	ENST00000301204.3	+	14	1423	c.1382T>C	c.(1381-1383)aTc>aCc	p.I461T		NM_173633.2	NP_775904.2	Q8NBT3	TM145_HUMAN	transmembrane protein 145	461						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				CTCTTCTCCATCCCCCCGCCC	0.706000													3	114					0	0	0.014758	0	0
CNTLN	54875	broad.mit.edu	37	9	17236437	17236437	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr9:17236437G>A	ENST00000380647.3	+	5	784	c.700G>A	c.(700-702)Gag>Aag	p.E234K	CNTLN_ENST00000425824.1_Missense_Mutation_p.E234K|CNTLN_ENST00000380641.4_Missense_Mutation_p.E234K|CNTLN_ENST00000262360.5_Missense_Mutation_p.E234K			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	234						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		GAACAAAGAAGAGCAAAACAG	0.383000													14	61					0	0	0.007413	0	0
PVRL1	5818	broad.mit.edu	37	11	119548360	119548360	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr11:119548360A>G	ENST00000264025.3	-	3	1168	c.638T>C	c.(637-639)cTg>cCg	p.L213P	PVRL1_ENST00000341398.2_Missense_Mutation_p.L213P|PVRL1_ENST00000340882.2_Missense_Mutation_p.L213P|PVRL1_ENST00000524510.1_5'UTR	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	213	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GCTGGGCACCAGGCGGTAGCG	0.582000													3	106					0	0	0.009096	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77396028	77396028	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr16:77396028C>T	ENST00000282849.5	-	7	1608	c.1190G>A	c.(1189-1191)tGg>tAg	p.W397*		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	397	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTCATTCTTCCAAGAACAAAT	0.398000													7	27					0	0	0.001984	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132905792	132905792	+	Missense_Mutation	SNP	G	G	C	rs143919579	by1000genomes	TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr2:132905792G>C	ENST00000409867.1	-	6	938	c.689C>G	c.(688-690)tCt>tGt	p.S230C	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like									p.S230C(2)		endometrium(1)|kidney(3)	4						TGTTCCTTCAGATGTTCCTTC	0.443000													3	19					0	0	0.014758	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													3	37					0	0	0.004672	0	0
TRAFD1	10906	broad.mit.edu	37	12	112589709	112589709	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr12:112589709T>G	ENST00000257604.5	+	10	2001	c.1384T>G	c.(1384-1386)Tat>Gat	p.Y462D	TRAFD1_ENST00000412615.2_Missense_Mutation_p.Y462D	NM_001143906.1	NP_001137378.1	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	462					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding			kidney(5)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	17						GACAGCTACCTATAACCAGCT	0.542000													16	246					0	0	0.028581	0	0
PIK3CD	5293	broad.mit.edu	37	1	9783255	9783255	+	Silent	SNP	C	C	G			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr1:9783255C>G	ENST00000536656.1	+	20	2779	c.2571C>G	c.(2569-2571)acC>acG	p.T857T	PIK3CD_ENST00000377346.4_Silent_p.T833T|PIK3CD_ENST00000361110.2_Silent_p.T857T			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	833	PI3K/PI4K.				phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GTTCAGACACCATCGCCAACA	0.607000													7	239					0	0	0.003080	0	0
D86994.2	0	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	5					0	0	0.004672	0	0
NUAK1	9891	broad.mit.edu	37	12	106460871	106460871	+	Silent	SNP	G	G	A	rs142540856		TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr12:106460871G>A	ENST00000261402.2	-	7	3074	c.1695C>T	c.(1693-1695)taC>taT	p.Y565Y		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	565							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						AAGGGCGGCTGTAGCTCCGGG	0.632000													8	50					0	0	0.006214	0	0
CCDC170	80129	broad.mit.edu	37	6	151939128	151939128	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr6:151939128T>G	ENST00000367290.5	+	11	2104	c.2015T>G	c.(2014-2016)gTg>gGg	p.V672G	CCDC170_ENST00000239374.7_Missense_Mutation_p.V665G			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	665																	GGCTTGAACGTGACCAGCCTT	0.438000													20	79					0	0	0.008871	0	0
D86994.2	0	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	5					0.004672	0.00716373	0.004672	1	0
MCM10	55388	broad.mit.edu	37	10	13213015	13213015	+	Missense_Mutation	SNP	G	G	A	rs150335901		TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr10:13213015G>A	ENST00000378694.1	+	2	176	c.101G>A	c.(100-102)cGg>cAg	p.R34Q	MCM10_ENST00000484800.2_Missense_Mutation_p.R34Q|MCM10_ENST00000378714.3_Missense_Mutation_p.R34Q			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	34					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						TTCTTGACGCGGGAAAATGGC	0.488000													5	195					0	0	0.021553	0	0
RP11-254I22.1	0	broad.mit.edu	37	5	95414786	95414787	+	RNA	INS	-	-	TAAAA	rs80243332	by1000genomes	TCGA-EM-A3AJ-01A-11D-A202-08	TCGA-EM-A3AJ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57a666a-7a35-44c2-b805-ff1794f0526a	3919bfff-dedc-4025-87d7-6f8b2ab2c8a3	g.chr5:95414786_95414787insTAAAA	ENST00000507997.1	+	0	87				CTD-2337A12.1_ENST00000502645.2_RNA|CTD-2337A12.1_ENST00000511775.1_RNA																							acccatgcacttaaagttaaaa	0.361													4	2	---	---	---	---