Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID Genome_Change Annotation_Transcript Transcript_Strand Transcript_Exon Transcript_Position cDNA_Change Codon_Change Protein_Change Other_Transcripts Refseq_mRNA_Id Refseq_prot_Id SwissProt_acc_Id SwissProt_entry_Id Description UniProt_AApos UniProt_Region UniProt_Site UniProt_Natural_Variations UniProt_Experimental_Info GO_Biological_Process GO_Cellular_Component GO_Molecular_Function COSMIC_overlapping_mutations COSMIC_fusion_genes COSMIC_tissue_types_affected COSMIC_total_alterations_in_gene Tumorscape_Amplification_Peaks Tumorscape_Deletion_Peaks TCGAscape_Amplification_Peaks TCGAscape_Deletion_Peaks DrugBank ref_context gc_content CCLE_ONCOMAP_overlapping_mutations CCLE_ONCOMAP_total_mutations_in_gene CGC_Mutation_Type CGC_Translocation_Partner CGC_Tumor_Types_Somatic CGC_Tumor_Types_Germline CGC_Other_Diseases DNARepairGenes_Role FamilialCancerDatabase_Syndromes MUTSIG_Published_Results OREGANNO_ID OREGANNO_Values t_alt_count t_ref_count validation_alt_allele validation_method validation_status validation_tumor_sample pox qox pox_cutoff isArtifactMode oxoGCut BTN2A3P 0 broad.mit.edu 37 6 26422353 26422353 + RNA SNP C C T rs141013110 TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr6:26422353C>T ENST00000466808.2 + 0 7 p.P3S(2) GCTCATGGAACCAGCTGCTGC 0.622000 4 86 0 0 1 0 0 POM121L9P 0 broad.mit.edu 37 22 24659593 24659593 + RNA SNP C C T TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr22:24659593C>T ENST00000414583.2 + 0 3118 NR_003714.1 TCACTGACATCGAAGGCTGCC 0.632000 4 13 0 0 1 0 0 ZNF324B 388569 broad.mit.edu 37 19 58967094 58967094 + Silent SNP G G A TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr19:58967094G>A ENST00000391696.1 + 3 1685 c.753G>A c.(751-753)gcG>gcA p.A251A ZNF324B_ENST00000545523.1_Silent_p.A261A|ZNF324B_ENST00000336614.4_Silent_p.A261A Q6AW86 Z324B_HUMAN zinc finger protein 324B 261 regulation of transcription, DNA-dependent|transcription, DNA-dependent nucleus DNA binding|zinc ion binding endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1) 20 all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232) UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179) AATGCAGGGCGTGCAGCAAAG 0.647000 3 24 0 0 1 0 0 SEMA5B 54437 broad.mit.edu 37 3 122667454 122667454 + Missense_Mutation SNP A A T rs145228820 byFrequency TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr3:122667454A>T ENST00000195173.4 - 3 530 c.227T>A c.(226-228)cTg>cAg p.L76Q SEMA5B_ENST00000465147.1_5'UTR|SEMA5B_ENST00000357599.3_Missense_Mutation_p.L76Q|SEMA5B_ENST00000451055.2_Missense_Mutation_p.L130Q Q9P283 SEM5B_HUMAN sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 76 cell differentiation|nervous system development integral to membrane receptor activity breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3) 55 GBM - Glioblastoma multiforme(114;0.0367) GGACACCAGCAGTGTGAGGCT 0.637000 3 39 0 0 1 0 0 LL22NC03-80A10.6 0 broad.mit.edu 37 22 22661318 22661318 + RNA SNP T T C rs1044437 by1000genomes TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr22:22661318T>C ENST00000426066.1 + 0 360 NR_027293.1 TGTGTAGAACTTTGACCCCCG 0.488000 3 40 0 0 1 0 0 HIC2 23119 broad.mit.edu 37 22 21799594 21799594 + Missense_Mutation SNP G G A TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr22:21799594G>A ENST00000443632.2 + 2 782 c.410G>A c.(409-411)cGc>cAc p.R137H HIC2_ENST00000407464.2_Missense_Mutation_p.R137H|HIC2_ENST00000407598.2_Missense_Mutation_p.R137H Q96JB3 HIC2_HUMAN hypermethylated in cancer 2 137 negative regulation of transcription, DNA-dependent|transcription, DNA-dependent focal adhesion|nucleus DNA binding|protein C-terminus binding|zinc ion binding NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1) 16 Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968) Lung SC(17;0.0262)|all_lung(157;0.205) CTCTGCCGCCGCAAACTCAAG 0.706000 4 41 0 0 1 0 0 TCERG1L 256536 broad.mit.edu 37 10 132944819 132944819 + Missense_Mutation SNP T T C TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr10:132944819T>C ENST00000368642.4 - 7 1224 c.1139A>G c.(1138-1140)aAc>aGc p.N380S NM_174937.3 NP_777597.2 Q5VWI1 TCRGL_HUMAN transcription elongation regulator 1-like 380 cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1) 31 all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09) all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276) AATGATCCTGTTGAGGTCTCC 0.542000 4 46 0 0 1 0 0 CHEK2 11200 broad.mit.edu 37 22 29091841 29091841 + Silent SNP G G A rs146546850 byFrequency TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr22:29091841G>A ENST00000544772.1 - 12 1889 c.453C>T c.(451-453)tcC>tcT p.S151S CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S NM_001257387.1 NP_001244316.1 O96017 CHK2_HUMAN checkpoint kinase 2 372 FHA. cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence PML body ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity p.S372S(8) central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2) 50 CCAAAATCTTGGAGTGCCCAA 0.413000 F breast Direct reversal of damage;Other conserved DNA damage response genes 4 54 0 0 1 0 0 GCKR 2646 broad.mit.edu 37 2 27728639 27728639 + Silent SNP C C T TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr2:27728639C>T ENST00000264717.2 + 10 868 c.805C>T c.(805-807)Ctg>Ttg p.L269L GCKR_ENST00000424318.2_Silent_p.L79L NM_001486.3 NP_001477.2 Q14397 GCKR_HUMAN glucokinase (hexokinase 4) regulator 269 SIS 1. carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process cytosol|nucleoplasm fructose-6-phosphate binding|protein binding breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2) 29 Acute lymphoblastic leukemia(172;0.155) CACCAAGATTCTGCTGGAAAC 0.532000 4 75 0 0 1 0 0 POM121L9P 0 broad.mit.edu 37 22 24659591 24659591 + RNA SNP A A G TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr22:24659591A>G ENST00000414583.2 + 0 3116 NR_003714.1 ACTCACTGACATCGAAGGCTG 0.632000 4 14 0 0 1 0 0 EYA4 2070 broad.mit.edu 37 6 133802618 133802618 + Missense_Mutation SNP C C A TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr6:133802618C>A ENST00000367895.5 + 12 1452 c.988C>A c.(988-990)Cag>Aag p.Q330K EYA4_ENST00000431403.2_Missense_Mutation_p.Q330K|EYA4_ENST00000430974.2_Missense_Mutation_p.Q282K|EYA4_ENST00000452339.2_Missense_Mutation_p.Q276K|EYA4_ENST00000531901.1_Missense_Mutation_p.Q336K|EYA4_ENST00000355286.6_Missense_Mutation_p.Q307K|EYA4_ENST00000525849.1_Missense_Mutation_p.Q307K|EYA4_ENST00000355167.3_Missense_Mutation_p.Q330K NM_004100.4 NP_004091.3 O95677 EYA4_HUMAN eyes absent homolog 4 (Drosophila) 330 anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception cytoplasm|nucleus metal ion binding|protein tyrosine phosphatase activity breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1) 48 Colorectal(23;0.221) GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152) CGATACCATGCAGAGTCCCTC 0.413000 13 100 2.61681e-11 2.71027e-11 1 1 0 WASH3P 0 broad.mit.edu 37 15 102515257 102515257 + RNA SNP C C T TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr15:102515257C>T ENST00000557932.1 + 0 1103 central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1) 25 CTCCGGTGGCCGGGCCACTCT 0.647000 3 11 0 0 1 0 0 CYP4Z2P 0 broad.mit.edu 37 1 47325354 47325354 + RNA SNP G G A rs4660360 by1000genomes TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr1:47325354G>A ENST00000505841.1 - 0 1175 NR_002788.2 CATCTGGAAAGGTAATGGGTT 0.438000 9 78 0 0 1 0 0 CHEK2 11200 broad.mit.edu 37 22 29091840 29091840 + Missense_Mutation SNP T T C rs142470496 byFrequency TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr22:29091840T>C ENST00000544772.1 - 12 1890 c.454A>G c.(454-456)Aag>Gag p.K152E CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E NM_001257387.1 NP_001244316.1 O96017 CHK2_HUMAN checkpoint kinase 2 373 FHA. cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence PML body ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity p.K373E(9) central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2) 50 CCCAAAATCTTGGAGTGCCCA 0.418000 F breast Direct reversal of damage;Other conserved DNA damage response genes 4 53 0 0 1 0 0 MBIP 51562 broad.mit.edu 37 14 36783808 36783808 + Missense_Mutation SNP T T C TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr14:36783808T>C ENST00000416007.4 - 4 568 c.481A>G c.(481-483)Aga>Gga p.R161G MBIP_ENST00000318473.7_Missense_Mutation_p.R161G|MBIP_ENST00000359527.7_Missense_Mutation_p.R161G NM_001144891.1|NM_016586.2 NP_001138363.1|NP_057670.2 Q9NS73 MBIP1_HUMAN MAP3K12 binding inhibitory protein 1 161 histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus identical protein binding|protein kinase inhibitor activity breast(2)|large_intestine(1)|lung(5) 8 all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164) Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781) GBM - Glioblastoma multiforme(112;0.0191) GATATTCGTCTGTCAATCTAC 0.338000 5 31 0 0 1 0 0 KIAA0556 23247 broad.mit.edu 37 16 27761090 27761090 + Missense_Mutation SNP G G T rs139603388 byFrequency TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr16:27761090G>T ENST00000261588.4 + 16 2828 c.2809G>T c.(2809-2811)Gac>Tac p.D937Y NM_015202.2 NP_056017.2 O60303 K0556_HUMAN KIAA0556 937 breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3) 76 CCGGCACAGCGACTTGCCCCC 0.637000 3 40 0.115264 0.115264 1 1 0 ANKRD36BP2 0 broad.mit.edu 37 2 89083945 89083946 + RNA INS - - GC TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr2:89083945_89083946insGC ENST00000393525.3 + 0 576 GTATTCCTTTTTTTTCAGTGTA 0.347 2 4 --- --- --- --- TRGC1 0 broad.mit.edu 37 7 38301855 38301856 + RNA DEL GT GT - TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr7:38301855_38301856delGT ENST00000443402.2 - 0 330 NM_001003799.1|NM_001003806.1 NP_001003799.1|NP_001003806.1 TCAATTGTTCGTGTGTGTGTGT 0.356 9 111 --- --- --- --- STAG3L4 0 broad.mit.edu 37 7 66767610 66767611 + RNA INS - - G rs71293166 by1000genomes TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr7:66767610_66767611insG ENST00000416602.2 + 0 3_4 NR_040586.1 Q8TBR4 STG34_HUMAN endometrium(2)|lung(5) 7 Lung NSC(55;0.0839)|all_lung(88;0.181) CACCGGACTGCTTTTTTTTTTT 0.545 4 2 --- --- --- --- MAN2B1 4125 broad.mit.edu 37 19 12777488 12777488 + Frame_Shift_Del DEL C C - TCGA-DJ-A4V0-01A-11D-A257-08 TCGA-DJ-A4V0-10A-01D-A25A-08 Untested Somatic Phase_I WXS none Illumina GAIIx 0623e99e-5e86-4a2f-b418-13b9289ad3ec 7c4bd7f5-84f4-42c0-9fc7-c37f8fdf8476 g.chr19:12777488delC ENST00000456935.2 - 1 68 c.28delG c.(28-30)tcfs p.V10fs CTD-2192J16.24_ENST00000597961.1_Intron|MAN2B1_ENST00000221363.4_Frame_Shift_Del_p.V10fs NM_000528.3|NM_001173498.1 NP_000519.2|NP_001166969.1 O00754 MA2B1_HUMAN mannosidase, alpha, class 2B, member 1 10 protein deglycosylation lysosome alpha-mannosidase activity|zinc ion binding breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1) 33 CGAGCGCAGACCCCCGAAGCC 0.721 2 4 --- --- --- ---