Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLXNB1	5364	broad.mit.edu	37	3	48451952	48451952	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr3:48451952A>C	ENST00000358536.4	-	30	5701	c.5432T>G	c.(5431-5433)gTg>gGg	p.V1811G	PLXNB1_ENST00000456774.1_Missense_Mutation_p.V1628G|PLXNB1_ENST00000296440.6_Missense_Mutation_p.V1811G|PLXNB1_ENST00000358459.4_Missense_Mutation_p.V1628G|PLXNB1_ENST00000448774.2_Missense_Mutation_p.V422G	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1811					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding	p.V1811G(1)		NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGCCCGGCCACCCCAGACCG	0.592000													7	21					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3649787	3649787	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr12:3649787T>C	ENST00000382622.3	+	2	481	c.91T>C	c.(91-93)Tcc>Ccc	p.S31P	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Missense_Mutation_p.S22P	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	31					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CAGCCCCCCCTCCCAGCCCCC	0.652000													9	59					0	0	1	0	0
WDR37	22884	broad.mit.edu	37	10	1175152	1175152	+	Splice_Site	SNP	G	G	C			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr10:1175152G>C	ENST00000358220.1	+	14	1497		c.e14-1		WDR37_ENST00000263150.4_Splice_Site|WDR37_ENST00000482165.1_Splice_Site			Q9Y2I8	WDR37_HUMAN	WD repeat domain 37											breast(2)|endometrium(2)|kidney(1)|lung(9)|prostate(2)|skin(1)	17		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		ATCATCACTAGGGCCACAGGA	0.458000													3	41					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	31144181	31144181	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr4:31144181C>T	ENST00000543491.1	+	3	3478	c.3478C>T	c.(3478-3480)Ccg>Tcg	p.P1160S				O60245	PCDH7_HUMAN	protocadherin 7	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CTGCTGGATGCCGGTCCGCAC	0.537000													4	106					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705312	101705312	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr1:101705312G>A	ENST00000305352.6	+	2	1147	c.772G>A	c.(772-774)Gta>Ata	p.V258I		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	258					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						GCTCAAGACCGTAATTATCGT	0.587000													4	121					0	0	1	0	0
LRRC28	123355	broad.mit.edu	37	15	99926292	99926292	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr15:99926292T>G	ENST00000301981.3	+	10	1329	c.1089T>G	c.(1087-1089)ttT>ttG	p.F363L	LRRC28_ENST00000422500.2_Missense_Mutation_p.F294L|LRRC28_ENST00000558879.1_3'UTR|LRRC28_ENST00000331450.5_Missense_Mutation_p.F89L|LRRC28_ENST00000447360.2_Missense_Mutation_p.L310W	NM_144598.2	NP_653199.2	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	363										endometrium(2)|large_intestine(3)|lung(6)|prostate(1)	12	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			TGCAGACTTTTGACCTGCTGA	0.512000													17	369					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124210197	124210197	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr3:124210197G>A	ENST00000360013.3	+	31	4736	c.4609G>A	c.(4609-4611)Gtg>Atg	p.V1537M	KALRN_ENST00000240874.3_Missense_Mutation_p.V1537M|KALRN_ENST00000460856.1_Missense_Mutation_p.V1528M	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1537	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GACCGAGCACGTGGAGGGCGA	0.572000													13	60					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7673068	7673068	+	Silent	SNP	G	G	A			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr19:7673068G>A	ENST00000446248.2	+	7	860	c.759G>A	c.(757-759)gtG>gtA	p.V253V	CAMSAP3_ENST00000160298.4_Silent_p.V226V	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	226	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						TCCCGACGGTGACCAGCCTCC	0.662000													9	67					0	0	1	0	0
PCDHGA1	0	broad.mit.edu	37	5	140712131	140712131	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr5:140712131G>A	ENST00000517417.1	+	1	1880	c.1880G>A	c.(1879-1881)cGc>cAc	p.R627H	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.R627H	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGGTGCGCACGGCGCGA	0.697000													4	87					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40351257	40351257	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr4:40351257G>A	ENST00000310169.2	+	4	863	c.724G>A	c.(724-726)Gtc>Atc	p.V242I		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	242					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GTTCTATATCGTCAACCTCCT	0.527000													8	624					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													5	166					0	0	1	0	0
SDHAP1	0	broad.mit.edu	37	3	195692347	195692347	+	RNA	SNP	G	G	A	rs62282794	by1000genomes	TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr3:195692347G>A	ENST00000427841.1	-	0	2155					NR_003264.2																						TTCCTCCAGTGCTCCTCAAAG	0.572000													4	17					0	0	1	0	0
CCT6P3	0	broad.mit.edu	37	7	64498737	64498737	+	RNA	SNP	C	C	A			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr7:64498737C>A	ENST00000426828.1	+	0	0					NR_033416.1																						gaggcggtggcggcggcggca	0.786000													4	13					1.23904e-05	1.39392e-05	1	1	0
SEMA3B	7869	broad.mit.edu	37	3	50311108	50311108	+	RNA	SNP	A	A	G			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr3:50311108A>G	ENST00000418948.1	+	0	1156							Q13214	SEM3B_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B						axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			central_nervous_system(2)|kidney(1)|lung(2)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GGGGTTGGGGAGGGGGGCAGC	0.701000											OREG0015583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	51					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	42					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99160855	99160855	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr10:99160855G>A	ENST00000370992.4	-	1	245	c.134C>T	c.(133-135)cCg>cTg	p.P45L	RRP12_ENST00000315563.6_Missense_Mutation_p.P45L|RRP12_ENST00000414986.1_Missense_Mutation_p.P45L	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	45						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GCTACCTGACGGCCGGCTGAA	0.682000													4	13					0	0	1	0	0
AC016995.3	0	broad.mit.edu	37	2	38710019	38710019	+	RNA	DEL	T	T	-	rs2005502	by1000genomes	TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr2:38710019delT	ENST00000417039.1	-	0	696																											CTTtaaaaaataaataaataa	0.244													4	9	---	---	---	---					
AC074391.1	0	broad.mit.edu	37	2	65738847	65738847	+	RNA	DEL	T	T	-	rs111377658		TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr2:65738847delT	ENST00000377977.3	+	0	862																											ttttTTGAAATTTTTTTTTTT	0.294													5	2	---	---	---	---					
LOXL3	84695	broad.mit.edu	37	2	74763923	74763924	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DJ-A3V9-01A-11D-A23M-08	TCGA-DJ-A3V9-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	baade73f-8f3c-429d-909a-7e617bebfff6	9c28bb06-bac1-433f-8fa5-ff1a88710057	g.chr2:74763923_74763924insC	ENST00000264094.3	-	5	895_896	c.824_825insG	c.(823-825)gccfs	p.A275fs	LOXL3_ENST00000409549.1_Frame_Shift_Ins_p.A275fs|LOXL3_ENST00000409986.1_Intron|LOXL3_ENST00000393937.2_Intron|LOXL3_ENST00000409249.1_Frame_Shift_Ins_p.A275fs	NM_032603.2	NP_115992.1	P58215	LOXL3_HUMAN	lysyl oxidase-like 3	275	SRCR 2.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity	p.A277fs*57(1)		endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30						CCACTGCAGGGCCCCCCCCAGG	0.649													7	144	---	---	---	---