Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTLL7	79739	broad.mit.edu	37	1	84376919	84376919	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr1:84376919T>C	ENST00000260505.8	-	15	2092	c.1715A>G	c.(1714-1716)aAt>aGt	p.N572S	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	572					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TCTTTTCTTATTTTGGTACTC	0.338000													9	51					0	0	0.058154	0	0
KCNS2	3788	broad.mit.edu	37	8	99441073	99441073	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr8:99441073A>G	ENST00000287042.4	+	2	1216	c.866A>G	c.(865-867)aAc>aGc	p.N289S	KCNS2_ENST00000521839.1_Missense_Mutation_p.N289S	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	289						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			ACTTTAGCCAACTTGGGCAGG	0.562000													5	69					0	0	0.014758	0	0
LAMB2	3913	broad.mit.edu	37	3	49169025	49169025	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr3:49169025C>A	ENST00000418109.1	-	6	755	c.591G>T	c.(589-591)tgG>tgT	p.W197C	LAMB2_ENST00000305544.4_Missense_Mutation_p.W197C	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	197	Laminin N-terminal.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTACATCATCCCAGTGCCGTG	0.592000													5	149					0.00116845	0.00229794	0.021553	1	0
CDH10	1008	broad.mit.edu	37	5	24537754	24537754	+	Silent	SNP	T	T	A			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr5:24537754T>A	ENST00000264463.4	-	3	768	c.261A>T	c.(259-261)ggA>ggT	p.G87G		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	87	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATTTGAGTGATCCATCTCCTT	0.373000										HNSCC(23;0.051)			6	13					0	0	0.021553	0	0
DNAJC16	23341	broad.mit.edu	37	1	15863305	15863305	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr1:15863305A>T	ENST00000375847.3	+	4	734	c.570A>T	c.(568-570)gaA>gaT	p.E190D	DNAJC16_ENST00000375849.1_Missense_Mutation_p.E190D|DNAJC16_ENST00000375838.1_Missense_Mutation_p.E190D	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	190	Thioredoxin.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AACTGGAAGAATTGGGTAAGA	0.398000													17	24					0	0	0.146539	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	49					0	0	0.009096	0	0
DNAH3	55567	broad.mit.edu	37	16	21170720	21170720	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr16:21170720G>A	ENST00000261383.3	-	1	42	c.43C>T	c.(43-45)Ccc>Tcc	p.P15S	TMEM159_ENST00000572599.1_Intron|TMEM159_ENST00000451578.2_Intron|TMEM159_ENST00000572258.1_Intron|DNAH3_ENST00000415178.1_Missense_Mutation_p.P15S|TMEM159_ENST00000574092.1_Intron|TMEM159_ENST00000261388.3_Intron|TMEM159_ENST00000233047.4_Intron	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	15	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCCGGATGGGGAGGGGCGGCC	0.622000													48	68					0	0	0.139131	0	0
SEC16A	9919	broad.mit.edu	37	9	139371685	139371685	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr9:139371685A>C	ENST00000313050.7	-	1	456	c.383T>G	c.(382-384)tTg>tGg	p.L128W		NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	2098					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TGAAGGTGTCAATGCACCAGA	0.567000													37	55					0	0	0.080422	0	0
RYR3	6263	broad.mit.edu	37	15	33962623	33962623	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr15:33962623T>G	ENST00000389232.4	+	38	5796	c.5726T>G	c.(5725-5727)gTt>gGt	p.V1909G	RYR3_ENST00000415757.3_Missense_Mutation_p.V1909G	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1909	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.V1909G(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGCTAGGGGTTCCTTTggaa	0.473000													10	26					0	0	0.093190	0	0
DENND5A	23258	broad.mit.edu	37	11	9161345	9161345	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr11:9161345T>C	ENST00000328194.3	-	23	4057	c.3737A>G	c.(3736-3738)cAc>cGc	p.H1246R	DENND5A_ENST00000527700.1_Missense_Mutation_p.H589R|DENND5A_ENST00000530044.1_Missense_Mutation_p.T1235A	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	1246	RUN 2.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CTCATACATGTGTGCAGTGAT	0.542000													14	25					0	0	0.105934	0	0
NUP93	9688	broad.mit.edu	37	16	56782202	56782202	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr16:56782202C>T	ENST00000569842.1	+	2	139	c.43C>T	c.(43-45)Cag>Tag	p.Q15*	NUP93_ENST00000308159.5_Nonsense_Mutation_p.Q15*			Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	15					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.Q15*(1)		breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						GCAAGCTGAACAGCTTGCTGC	0.517000													17	38					0	0	0.038395	0	0
PLXNA4	91584	broad.mit.edu	37	7	131870080	131870080	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr7:131870080C>G	ENST00000359827.3	-	16	4098	c.3136G>C	c.(3136-3138)Gag>Cag	p.E1046Q	PLXNA4_ENST00000321063.4_Missense_Mutation_p.E1046Q			Q9HCM2	PLXA4_HUMAN	plexin A4	1046	IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CATTCTGGCTCAATCCGCACG	0.547000													3	60					0	0	0.115264	0	0
HTRA3	94031	broad.mit.edu	37	4	8307709	8307709	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr4:8307709A>G	ENST00000307358.2	+	9	1412	c.1208A>G	c.(1207-1209)cAa>cGa	p.Q403R		NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	403	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						GGCGGCATCCAAGATGGTGAC	0.647000													3	66					0	0	0.014758	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr16:90161902A>G	ENST00000567960.1	+	0	638				TUBB8P7_ENST00000564451.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													3	25					0	0	0.014758	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826174	34826174	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr6:34826174A>G	ENST00000192788.5	+	14	2212	c.2041A>G	c.(2041-2043)Acc>Gcc	p.T681A	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.T681A	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	681										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						TCAGCCTAATACCCTCCCTCC	0.488000													4	130					0	0	0.009096	0	0
OR52N4	390072	broad.mit.edu	37	11	5776224	5776224	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr11:5776224G>A	ENST00000317254.3	+	1	302	c.254G>A	c.(253-255)tGc>tAc	p.C85Y	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		AAAGCCCTCTGCATCTTCTGG	0.468000													31	37					0	0	0.125774	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													6	45					0	0	0.021553	0	0
CD248	57124	broad.mit.edu	37	11	66082772	66082772	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr11:66082772C>A	ENST00000311330.3	-	1	1743	c.1727G>T	c.(1726-1728)aGa>aTa	p.R576I	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	576	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	GGCCTGGGTTCTGAGGACAAG	0.607000													37	48					9.8876e-21	2.01162e-20	0.074837	1	0
CD163	9332	broad.mit.edu	37	12	7651554	7651554	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr12:7651554C>T	ENST00000359156.4	-	4	890	c.688G>A	c.(688-690)Gga>Aga	p.G230R	CD163_ENST00000432237.2_Missense_Mutation_p.G230R|CD163_ENST00000541972.1_Missense_Mutation_p.G218R|CD163_ENST00000396620.3_Missense_Mutation_p.G230R	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	230	SRCR 2.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GACTCATTTCCGTTGCATATA	0.433000													10	183					0	0	0.080935	0	0
ANKRD30BP2	0	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													3	52					0	0	0.009096	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				19	27					0	0	0.049695	0	0
CWC25	54883	broad.mit.edu	37	17	36959028	36959028	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr17:36959028A>G	ENST00000225428.4	-	9	1385	c.1088T>C	c.(1087-1089)cTc>cCc	p.L363P	CWC25_ENST00000536127.1_Missense_Mutation_p.L300P	NM_017748.3	NP_060218.1	Q9NXE8	CWC25_HUMAN	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	363										central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	14						ATGCCTCTTGAGGATGTTCAG	0.517000													3	114					0	0	0.115264	0	0
HRNR	388697	broad.mit.edu	37	1	152193154	152193154	+	Silent	SNP	C	C	G			TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr1:152193154C>G	ENST00000368801.2	-	3	1026	c.951G>C	c.(949-951)ggG>ggC	p.G317G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	317					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGAGGAGTGCCCCGAACCGG	0.612000													3	110					0	0	0.115264	0	0
TPTEP1	0	broad.mit.edu	37	22	17131430	17131432	+	RNA	DEL	CAC	CAC	-	rs142037179		TCGA-DJ-A2Q4-01A-21D-A18F-08	TCGA-DJ-A2Q4-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9aa45da9-1edf-4aa5-914f-6e92a34427e2	7f85393d-8a76-4321-9d4d-788f57266a46	g.chr22:17131430_17131432delCAC	ENST00000426585.1	+	0	2456_2458																											caccatccatcaccaacagaaac	0.443													4	3	---	---	---	---