Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													3	54					0	0	0.115264	0	0
HEATR1	55127	broad.mit.edu	37	1	236734652	236734652	+	Splice_Site	SNP	G	G	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr1:236734652G>A	ENST00000366582.3	-	28	4061	c.3948_splice	c.e28+1	p.P1316_splice	HEATR1_ENST00000366581.2_Splice_Site_p.P1235_splice	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1316					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			AACGCTTACCGGAAATATTCC	0.403000													3	53					0	0	0.115264	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr16:15457701G>A	ENST00000360151.4	-	8	867	c.868C>T	c.(868-870)Ctc>Ttc	p.L290F		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5									p.L290F(2)									AGGGGAGTGAGCAGACACTCG	0.562000													3	77					0	0	0.009096	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													4	3					0	0	0.009096	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	38					0	0	0.021553	0	0
PCCA	5095	broad.mit.edu	37	13	100807310	100807310	+	Silent	SNP	C	C	G			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr13:100807310C>G	ENST00000376285.1	+	5	416	c.378C>G	c.(376-378)gcC>gcG	p.A126A	PCCA_ENST00000376286.4_Silent_p.A100A|PCCA_ENST00000485946.1_3'UTR|PCCA_ENST00000376279.3_Silent_p.A126A	NM_000282.3	NP_000273.2	P05165	PCCA_HUMAN	propionyl CoA carboxylase, alpha polypeptide	126	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|prostate(1)|skin(2)	26	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	ACATGGATGCCATCATGGAAG	0.458000													7	113					0	0	0.029380	0	0
SP4	6671	broad.mit.edu	37	7	21469100	21469100	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr7:21469100C>T	ENST00000222584.3	+	3	535	c.317C>T	c.(316-318)gCc>gTc	p.A106V		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	106					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding	p.A106V(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						CAACTTGTTGCCTCCACTCCT	0.438000													20	32					0	0	0.076483	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													5	44					0	0	0.014758	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000377425.4_Intron|AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000537089.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	80					0	0	0.021553	0	0
TCEAL3	85012	broad.mit.edu	37	X	102864105	102864105	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chrX:102864105T>C	ENST00000372628.1	+	3	471	c.113T>C	c.(112-114)gTg>gCg	p.V38A	TCEAL3_ENST00000243286.3_Missense_Mutation_p.V38A|TCEAL3_ENST00000477014.1_Intron|TCEAL3_ENST00000372627.5_Missense_Mutation_p.V38A			Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	38	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	16						aagccagacgtggaggggaag	0.498000													3	43					0	0	0.115264	0	0
STXBP5L	9515	broad.mit.edu	37	3	121097680	121097680	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr3:121097680G>A	ENST00000273666.6	+	22	2637	c.2366G>A	c.(2365-2367)cGa>cAa	p.R789Q	STXBP5L_ENST00000472879.1_Missense_Mutation_p.R765Q|STXBP5L_ENST00000471454.1_Missense_Mutation_p.R765Q|STXBP5L_ENST00000497029.1_Intron|STXBP5L_ENST00000492541.1_Missense_Mutation_p.R789Q	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	789					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CCACCATTTCGAAAGGCCCAG	0.398000													17	31					0	0	0.062417	0	0
RP11-483E23.2	0	broad.mit.edu	37	15	28600002	28600002	+	RNA	SNP	T	T	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr15:28600002T>A	ENST00000568624.1	-	0	404																											TTCGTATGGTTTGAACCTGGG	0.493000													4	89					0	0	0.021553	0	0
AC093838.4	0	broad.mit.edu	37	2	132258539	132258539	+	RNA	SNP	C	C	T			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr2:132258539C>T	ENST00000438378.2	+	0	723					NR_026922.1																						CTGCAGGGTCCTGTGAAGGCG	0.612000													7	6					0	0	0.047766	0	0
ANKAR	150709	broad.mit.edu	37	2	190595298	190595298	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr2:190595298C>G	ENST00000520309.1	+	16	3359	c.3271C>G	c.(3271-3273)Cta>Gta	p.L1091V	ANKAR_ENST00000281412.6_Intron|ANKAR_ENST00000438402.2_Intron|ANKAR_ENST00000431575.2_Missense_Mutation_p.L1020V|ANKAR_ENST00000313581.4_Missense_Mutation_p.L1091V	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1091						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TATCCAACTACTAAGAAATCA	0.338000													14	27					0	0	0.038395	0	0
AC093642.5	0	broad.mit.edu	37	2	243061143	243061143	+	RNA	SNP	A	A	G	rs117509304	by1000genomes	TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr2:243061143A>G	ENST00000456398.1	+	0	491																											CTTGGGAGAAACCTTTAATCG	0.358000													4	44					0	0	0.014758	0	0
C10orf53	282966	broad.mit.edu	37	10	50902594	50902594	+	Silent	SNP	T	T	C			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr10:50902594T>C	ENST00000374111.3	+	3	240	c.228T>C	c.(226-228)ggT>ggC	p.G76G	C10orf53_ENST00000535836.1_Intron|C10orf53_ENST00000374112.3_Intron|C10orf53_ENST00000374113.3_3'UTR	NM_001042427.1	NP_001035892.1	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53	76										endometrium(1)|lung(6)	7		all_neural(218;0.107)				GAGGCGATGGTAAACTAGACC	0.458000													4	45					0	0	0.009096	0	0
IGF1R	3480	broad.mit.edu	37	15	99440012	99440012	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr15:99440012C>A	ENST00000268035.6	+	4	1591	c.980C>A	c.(979-981)cCt>cAt	p.P327H	IGF1R_ENST00000560432.1_3'UTR|IGF1R_ENST00000558762.1_Missense_Mutation_p.P327H	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	327					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TGTGAAGGTCCTTGCCCGAAG	0.393000													3	40					0.115264	0.125743	0.115264	1	0
IFI44	10561	broad.mit.edu	37	1	79116042	79116042	+	Silent	SNP	T	T	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr1:79116042T>A	ENST00000370747.4	+	2	247	c.162T>A	c.(160-162)atT>atA	p.I54I	IFI44_ENST00000545124.1_Intron|IFI44_ENST00000495254.1_Intron	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	54					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						TAACAGTGATTTATAGTGAAG	0.393000													4	153					0	0	0.014758	0	0
SPANXN1	494118	broad.mit.edu	37	X	144329165	144329165	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chrX:144329165A>G	ENST00000370493.3	+	1	818	c.59A>G	c.(58-60)aAc>aGc	p.N20S		NM_001009614.2	NP_001009614.1	Q5VSR9	SPXN1_HUMAN	SPANX family, member N1	20										endometrium(2)|kidney(2)|lung(8)|prostate(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					TGTGAATCCAACAATGAAAAT	0.448000													4	188					0	0	0.009096	0	0
OR2H2	7932	broad.mit.edu	37	6	29556434	29556434	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr6:29556434C>T	ENST00000383640.2	+	1	752	c.713C>T	c.(712-714)aCc>aTc	p.T238I	GABBR1_ENST00000355973.3_Intron	NM_007160.3	NP_009091.3	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H, member 2	238					defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	14						GCTTTTGGGACCTGCTCCTCC	0.532000													10	68					0	0	0.069234	0	0
FGF7	2252	broad.mit.edu	37	15	49776583	49776583	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr15:49776583G>A	ENST00000267843.4	+	4	1078	c.467G>A	c.(466-468)tGg>tAg	p.W156*	FAM227B_ENST00000299338.6_Intron|FGF7_ENST00000560704.1_3'UTR|FAM227B_ENST00000561064.1_Intron	NM_002009.3	NP_002000.1	P21781	FGF7_HUMAN	fibroblast growth factor 7	156					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	TCAGCTAAATGGACACACAAC	0.348000													3	66					0	0	0.115264	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				33	51					0	0	0.059317	0	0
ANKRD20A11P	0	broad.mit.edu	37	21	15352030	15352030	+	RNA	SNP	G	G	T			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr21:15352030G>T	ENST00000344693.5	-	0	728					NR_027270.1																						TACCTGTGCTGCTTGTCCAGG	0.716000													4	12					2.56e-06	2.88e-06	0.009096	1	0
BTBD17	388419	broad.mit.edu	37	17	72352829	72352829	+	Silent	SNP	G	G	A			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr17:72352829G>A	ENST00000375366.3	-	3	1530	c.1404C>T	c.(1402-1404)ccC>ccT	p.P468P		NM_001080466.1	NP_001073935.1	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17	468						extracellular region				endometrium(1)|kidney(1)|lung(4)	6						TGTGGTATACGGGCTTGACGA	0.652000													3	38					0	0	0.115264	0	0
BHLHE22	27319	broad.mit.edu	37	8	65493711	65493711	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr8:65493711delG	ENST00000321870.1	+	1	898	c.364delG	c.(364-366)ggfs	p.G122fs	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	122	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						CCTGCCGGCCGGGGCCGCCCT	0.751													2	4	---	---	---	---					
CTD-2509G16.5	0	broad.mit.edu	37	14	65748001	65748002	+	RNA	INS	-	-	TT	rs1760975		TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr14:65748001_65748002insTT	ENST00000553754.1	-	0	300																											TTCTTTCtttcttttttttttt	0.485													4	3	---	---	---	---					
GLG1	2734	broad.mit.edu	37	16	74640592	74640592	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr16:74640592delT	ENST00000422840.2	-	1	400	c.401delA	c.(400-402)acfs	p.N134fs	GLG1_ENST00000205061.5_Frame_Shift_Del_p.N134fs|GLG1_ENST00000447066.2_Frame_Shift_Del_p.N134fs	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	134						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						CACCGCCAGGTTGTTGCTCCA	0.706													24	49	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DJ-A1QI-01A-11D-A14W-08	TCGA-DJ-A1QI-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9130d132-2f6b-4b7f-a8a6-05556bb0605b	fafdd2c4-d678-4dd7-9aee-15d743c9f905	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													11	37	---	---	---	---