Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPID	5481	broad.mit.edu	37	4	159644365	159644365	+	Missense_Mutation	SNP	C	C	T			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr4:159644365C>T	ENST00000307720.3	-	1	183	c.76G>A	c.(76-78)Ggg>Agg	p.G26R		NM_005038.2	NP_005029.1	Q08752	PPID_HUMAN	peptidylprolyl isomerase D	26	PPIase cyclophilin-type.				protein folding	cytoplasm|intermediate filament cytoskeleton	cyclosporin A binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0159)		CCTCGCTCCCCTCCGATGTCC	0.632000													17	12					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48750437	48750437	+	Missense_Mutation	SNP	T	T	C	rs141577167		TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr17:48750437T>C	ENST00000285238.8	+	18	2427	c.2347T>C	c.(2347-2349)Tct>Cct	p.S783P		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	783	ABC transporter 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CGCGGTGGACTCTCATGTGGC	0.592000													4	52					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59989372	59989372	+	Missense_Mutation	SNP	G	G	A			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr17:59989372G>A	ENST00000444766.3	-	6	808	c.733C>T	c.(733-735)Cgc>Tgc	p.R245C	INTS2_ENST00000251334.6_Missense_Mutation_p.R237C	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	245					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						TCTGTCCTGCGCCTTCCTCCA	0.428000													24	135					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31323335	31323335	+	Silent	SNP	G	G	A			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr6:31323335G>A	ENST00000412585.2	-	4	682	c.654C>T	c.(652-654)atC>atT	p.I218I		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						CATGGTCAGAGATGGGGTGGT	0.582000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				55	52					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													3	25					0	0	1	0	0
ABHD17A	81926	broad.mit.edu	37	19	1879997	1879997	+	Silent	SNP	G	G	A	rs139072903	byFrequency	TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr19:1879997G>A	ENST00000292577.7	-	3	883	c.450C>T	c.(448-450)taC>taT	p.Y150Y	ABHD17A_ENST00000590661.1_Silent_p.Y132Y|ABHD17A_ENST00000250974.9_Silent_p.Y201Y	NM_001130111.1	NP_001123583.1			abhydrolase domain containing 17A																		AGCTGGCACCGTAGCCGGAGT	0.667000													3	35					0	0	1	0	0
SRPX	8406	broad.mit.edu	37	X	38016255	38016255	+	Missense_Mutation	SNP	G	G	A	rs146651232	byFrequency	TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chrX:38016255G>A	ENST00000378533.3	-	8	1089	c.983C>T	c.(982-984)aCg>aTg	p.T328M	SRPX_ENST00000538295.1_Missense_Mutation_p.T328M|SRPX_ENST00000432886.2_Missense_Mutation_p.T269M|SRPX_ENST00000479015.1_5'UTR|TM4SF2_ENST00000465127.1_Intron|SRPX_ENST00000343800.6_Missense_Mutation_p.T315M|SRPX_ENST00000544439.1_Missense_Mutation_p.T308M	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	328					cell adhesion	cell surface|membrane				autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						TGCAGCTGCCGTTCTGACACC	0.498000													22	34					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29121000	29121000	+	Missense_Mutation	SNP	T	T	C			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr22:29121000T>C	ENST00000382580.2	-	5	761	c.686A>G	c.(685-687)aAt>aGt	p.N229S	CHEK2_ENST00000544772.1_5'UTR|CHEK2_ENST00000328354.6_Missense_Mutation_p.N186S|CHEK2_ENST00000404276.1_Missense_Mutation_p.N186S|CHEK2_ENST00000382578.1_Intron|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Missense_Mutation_p.N186S|CHEK2_ENST00000382566.1_Missense_Mutation_p.N186S|CHEK2_ENST00000405598.1_Missense_Mutation_p.N186S|CHEK2_ENST00000403642.1_Intron|CHEK2_ENST00000348295.3_Missense_Mutation_p.N186S	NM_001005735.1	NP_001005735.1	O96017	CHK2_HUMAN	checkpoint kinase 2	186	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						AATTTCAGAATTGTTATTCAA	0.338000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	23					0	0	1	0	0
TFE3	7030	broad.mit.edu	37	X	48888961	48888961	+	Missense_Mutation	SNP	C	C	T			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chrX:48888961C>T	ENST00000315869.7	-	9	1494	c.1235G>A	c.(1234-1236)cGg>cAg	p.R412Q	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	412	Leucine-zipper.				humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						GGATCGCTGCCGGCTCTCCAG	0.597000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								8	11					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810393	123810393	+	Missense_Mutation	SNP	C	C	T			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr11:123810393C>T	ENST00000307033.2	+	1	144	c.70C>T	c.(70-72)Cgg>Tgg	p.R24W		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGGGAGCTTCGGTTTGTTTT	0.468000													40	39					0	0	1	0	0
PINK1	65018	broad.mit.edu	37	1	20975019	20975019	+	Missense_Mutation	SNP	T	T	C			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr1:20975019T>C	ENST00000321556.4	+	6	1239	c.1145T>C	c.(1144-1146)aTc>aCc	p.I382T	PINK1_ENST00000492302.1_3'UTR|PINK1-AS_ENST00000451424.1_RNA	NM_032409.2	NP_115785.1	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1	382	Protein kinase.				cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)	14		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TGGCTGGTGATCGCAGATTTT	0.602000													9	25					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1484922	1484922	+	Missense_Mutation	SNP	C	C	T			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr7:1484922C>T	ENST00000297508.7	-	6	959	c.784G>A	c.(784-786)Gcc>Acc	p.A262T	MICALL2_ENST00000405088.4_Missense_Mutation_p.A50T	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	262						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		ACACCCATGGCCCCTGGCTGT	0.687000													17	15					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31656510	31656510	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr6:31656510G>A	ENST00000375842.4	-	14	1569	c.583C>T	c.(583-585)Cag>Tag	p.Q195*	ABHD16A_ENST00000440843.2_Nonsense_Mutation_p.Q381*|ABHD16A_ENST00000471644.1_5'UTR|ABHD16A_ENST00000395952.3_Nonsense_Mutation_p.Q414*|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	414						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						CTGCACAGCTGCTCCGCGTTG	0.582000													17	13					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43576025	43576025	+	Missense_Mutation	SNP	T	T	C			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr19:43576025T>C	ENST00000406487.1	-	4	889	c.791A>G	c.(790-792)aAc>aGc	p.N264S		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	264	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				TGGGTTAGAGTTCGCGAAGCA	0.443000													86	109					0	0	1	0	0
MICA	100507436	broad.mit.edu	37	6	31378425	31378425	+	Missense_Mutation	SNP	A	A	G	rs1051786	by1000genomes	TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr6:31378425A>G	ENST00000449934.2	+	2	230	c.176A>G	c.(175-177)tAt>tGt	p.Y59C	HCP5_ENST00000414046.2_RNA	NM_001177519.1	NP_001170990.1	Q29983	MICA_HUMAN	MHC class I polypeptide-related sequence A	59			C -> Y (in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056; dbSNP:rs1051786).		antigen processing and presentation|cytolysis|defense response to bacterium|defense response to virus|gamma-delta T cell activation|immune response to tumor cell|response to DNA damage stimulus|response to heat|stimulatory C-type lectin receptor signaling pathway	cell surface|cytoplasm|extracellular space|integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			breast(1)|endometrium(3)|kidney(1)	5		Ovarian(999;0.0253)				TTCCTGCGCTATGACAGGCAG	0.542000													3	30					0	0	1	0	0
PCDHB10	0	broad.mit.edu	37	5	140574155	140574155	+	Missense_Mutation	SNP	C	C	T			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr5:140574155C>T	ENST00000239446.4	+	1	2214	c.2030C>T	c.(2029-2031)gCc>gTc	p.A677V		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		677					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGAGGCGGCCCCGGCCCAG	0.687000													6	19					0	0	1	0	0
MICA	100507436	broad.mit.edu	37	6	31378387	31378387	+	Silent	SNP	T	T	C	rs78945208	by1000genomes	TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr6:31378387T>C	ENST00000449934.2	+	2	192	c.138T>C	c.(136-138)ctT>ctC	p.L46L	HCP5_ENST00000414046.2_RNA	NM_001177519.1	NP_001170990.1	Q29983	MICA_HUMAN	MHC class I polypeptide-related sequence A	46					antigen processing and presentation|cytolysis|defense response to bacterium|defense response to virus|gamma-delta T cell activation|immune response to tumor cell|response to DNA damage stimulus|response to heat|stimulatory C-type lectin receptor signaling pathway	cell surface|cytoplasm|extracellular space|integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			breast(1)|endometrium(3)|kidney(1)	5		Ovarian(999;0.0253)				CAGGGTTTCTTGCTGAGGTAC	0.532000													3	34					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156779137	156779137	+	Missense_Mutation	SNP	A	A	G			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr1:156779137A>G	ENST00000392306.2	-	7	1029	c.890T>C	c.(889-891)aTa>aCa	p.I297T	SH2D2A_ENST00000368198.3_Missense_Mutation_p.I269T|SH2D2A_ENST00000368199.3_Missense_Mutation_p.I287T	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	287	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ATAGAAAGCTATGGGTTCATC	0.612000													8	123					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77817854	77817854	+	Silent	SNP	G	G	A			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr4:77817854G>A	ENST00000334306.2	-	1	1148	c.1149C>T	c.(1147-1149)cgC>cgT	p.R383R		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	383																	AACGAATGCTGCGAAAGACAG	0.572000													35	58					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97771737	97771737	+	Silent	SNP	C	C	T			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr1:97771737C>T	ENST00000370192.3	-	17	2275	c.2175G>A	c.(2173-2175)aaG>aaA	p.K725K	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	725					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TCTTACCTTCCTTTGCAGCTC	0.438000													11	224					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75557769	75557769	+	Missense_Mutation	SNP	A	A	G			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr10:75557769A>G	ENST00000604729.1	+	19	4190	c.3893A>G	c.(3892-3894)aAc>aGc	p.N1298S	ZSWIM8_ENST00000603114.1_Missense_Mutation_p.N1260S|NDST2_ENST00000456638.1_5'UTR|ZSWIM8_ENST00000398706.2_Missense_Mutation_p.N1298S|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.N1293S|ZSWIM8_ENST00000604524.1_Missense_Mutation_p.N1293S					zinc finger, SWIM-type containing 8																		GGCCTGCACAACTTTGTTTCT	0.507000													24	26					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134421632	134421632	+	Missense_Mutation	SNP	G	G	A			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chrX:134421632G>A	ENST00000370766.3	-	7	3679	c.970C>T	c.(970-972)Cac>Tac	p.H324Y	ZNF75D_ENST00000494295.1_Intron|ZNF75D_ENST00000370764.1_Missense_Mutation_p.H229Y	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	324					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TGTACACTGTGTGTATCACCA	0.388000													21	96					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212473	26212473	+	Silent	SNP	C	C	T			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chrX:26212473C>T	ENST00000379034.1	+	2	659	c.510C>T	c.(508-510)gcC>gcT	p.A170A		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	170										breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						ATGTGGCTGCCGAGGGTGAAG	0.517000													11	65					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201751394	201751394	+	Missense_Mutation	SNP	G	G	A			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr1:201751394G>A	ENST00000367296.4	+	6	2174	c.1754G>A	c.(1753-1755)cGc>cAc	p.R585H	IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367295.1_Missense_Mutation_p.R194H|NAV1_ENST00000295624.6_Missense_Mutation_p.R585H|NAV1_ENST00000367302.1_Missense_Mutation_p.R598H|NAV1_ENST00000367300.3_Missense_Mutation_p.R585H|NAV1_ENST00000367297.4_Missense_Mutation_p.R585H	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	585					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						GGTCGGGACCGCCTGAGTGAT	0.587000													4	82					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70828156	70828156	+	Missense_Mutation	SNP	C	C	G			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr5:70828156C>G	ENST00000358731.4	+	26	6057	c.5794C>G	c.(5794-5796)Cca>Gca	p.P1932A	BDP1_ENST00000380675.2_Missense_Mutation_p.P69A	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1932					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TGTGAATGTCCCAGATGTAGG	0.338000													12	14					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133759490	133759492	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr9:133759490_133759492delAAG	ENST00000318560.5	+	11	2194_2196	c.1813_1815delAAG	c.(1813-1815)del	p.K609del		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	609	Poly-Lys.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CGCCTTGATCAAGAAGAAGAAGA	0.616			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								8	133	---	---	---	---					
NPIPA5	100288332	broad.mit.edu	37	16	15457565	15457566	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr16:15457565_15457566delAC	ENST00000360151.4	-	8	1002_1003	c.1003_1004delGT	c.(1003-1005)cfs	p.V335fs		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5																		GAGTGAGCAGACACACTCGGGA	0.446													7	27	---	---	---	---					
HAMP	57817	broad.mit.edu	37	19	35773520	35773522	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-CE-A484-01A-11D-A23U-08	TCGA-CE-A484-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eef9504e-6f7b-4b5d-b47b-45e2ab7c6bef	641a0220-6eec-434a-b606-e256113b65da	g.chr19:35773520_35773522delCTC	ENST00000598398.1	+	2	336_338	c.40_42delCTC	c.(40-42)del	p.L18del	HAMP_ENST00000222304.3_In_Frame_Del_p.L18del	NM_021175.2	NP_066998.1	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide	18					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGCCTCCTGCTCCTCCTCCTCC	0.640													7	163	---	---	---	---