Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RAB36	9609	broad.mit.edu	37	22	23487734	23487734	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr22:23487734C>T	ENST00000263116.2	+	1	222	c.182C>T	c.(181-183)tCg>tTg	p.S61L	RAB36_ENST00000341989.4_Missense_Mutation_p.S61L	NM_004914.2	NP_004905.2	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	61					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		TCACAGCCATCGCTGGTGAGT	0.721000													3	41					0	0	0.009096	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94639989	94639989	+	Silent	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:94639989C>T	ENST00000260526.6	-	23	3404	c.3222G>A	c.(3220-3222)caG>caA	p.Q1074Q		NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	1074					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GTAGAGTTTGCTGGTCAAAGC	0.388000													5	226					0	0	0.014758	0	0
TRIM52	84851	broad.mit.edu	37	5	180687578	180687578	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr5:180687578G>C	ENST00000327767.4	-	1	541	c.237C>G	c.(235-237)gaC>gaG	p.D79E	CTC-338M12.4_ENST00000511331.1_RNA|TRIM52_ENST00000514805.1_5'UTR	NM_032765.2	NP_116154.1	Q96A61	TRI52_HUMAN	tripartite motif containing 52	79	Glu-rich.					intracellular	zinc ion binding			endometrium(1)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	8	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.0106)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0588)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.232)		GAATGGAGCCGTCCCATCCAT	0.552000													4	199					0	0	0.014758	0	0
MDC1	9656	broad.mit.edu	37	6	30681830	30681830	+	Silent	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr6:30681830G>A	ENST00000376406.3	-	3	914	c.267C>T	c.(265-267)ctC>ctT	p.L89L	MDC1_ENST00000376405.2_Silent_p.L89L	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	89	FHA.|Interaction with CHEK2.|Interaction with the MRN complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CACAGTCTCGGAGGATAGGTG	0.517000								Other conserved DNA damage response genes					4	98					0	0	0.014758	0	0
DNASE2	1777	broad.mit.edu	37	19	12991901	12991901	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr19:12991901T>C	ENST00000222219.3	-	2	244	c.152A>G	c.(151-153)tAc>tGc	p.Y51C	CTD-2265O21.7_ENST00000592400.1_RNA|DNASE2_ENST00000538460.1_Missense_Mutation_p.Y51C	NM_001375.2	NP_001366.1	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal	51					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)	7						CAGATACTTGTACTGCAGCCC	0.647000													29	55					0	0	0.054565	0	0
FANCD2	2177	broad.mit.edu	37	3	10091163	10091163	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:10091163A>G	ENST00000287647.3	+	17	1612	c.1519A>G	c.(1519-1521)Atg>Gtg	p.M507V	FANCD2_ENST00000419585.1_Missense_Mutation_p.M507V|FANCD2_ENST00000383806.1_Missense_Mutation_p.M507V|FANCD2_ENST00000383807.1_Missense_Mutation_p.M507V	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	507					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CCCATCTGCTATGATGATGAA	0.418000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	258					0	0	0.029380	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37720621	37720621	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr8:37720621G>A	ENST00000330843.4	-	6	3656	c.3644C>T	c.(3643-3645)cCc>cTc	p.P1215L	RAB11FIP1_ENST00000523182.1_5'UTR|RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.P581L|RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.P433L	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	1215	FIP-RBD.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AGGGTCCGAGGGGCTGTATTT	0.448000													5	134					0	0	0.021553	0	0
LCTL	197021	broad.mit.edu	37	15	66842425	66842425	+	Silent	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr15:66842425G>C	ENST00000341509.5	-	12	1673	c.1542C>G	c.(1540-1542)ctC>ctG	p.L514L	LCTL_ENST00000537670.1_Silent_p.L341L	NM_207338.2	NP_997221.2	Q6UWM7	LCTL_HUMAN	lactase-like	514					carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CCAAAGCTTTGAGGTACCAAC	0.308000													3	61					0	0	0.009096	0	0
CD207	50489	broad.mit.edu	37	2	71058862	71058862	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr2:71058862T>C	ENST00000410009.3	-	5	851	c.806A>G	c.(805-807)gAc>gGc	p.D269G		NM_015717.3	NP_056532.3	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	269	C-type lectin.				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						GAATGGCGTGTCATCCACCCA	0.572000													5	125					0	0	0.014758	0	0
ASAP1	50807	broad.mit.edu	37	8	131067027	131067027	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr8:131067027C>T	ENST00000357668.1	-	29	3367	c.3340G>A	c.(3340-3342)Gaa>Aaa	p.E1114K	ASAP1_ENST00000518721.1_Missense_Mutation_p.E1114K			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	1114	SH3.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						CCCTTCCTTTCAGGCTGTCCT	0.527000													6	127					0	0	0.047766	0	0
TTC14	151613	broad.mit.edu	37	3	180328136	180328136	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:180328136A>G	ENST00000296015.4	+	12	2251	c.2119A>G	c.(2119-2121)Aca>Gca	p.T707A	TTC14_ENST00000412756.2_3'UTR|TTC14_ENST00000382584.4_Intron	NM_133462.3	NP_597719.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	707							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CCGTTTAAATACAAATCAAGG	0.378000													3	101					0	0	0.115264	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													4	40					0	0	0.014758	0	0
RUNX1T1	862	broad.mit.edu	37	8	92972658	92972658	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr8:92972658C>G	ENST00000523629.1	-	12	2081	c.1627G>C	c.(1627-1629)Gac>Cac	p.D543H	RUNX1T1_ENST00000422361.2_Missense_Mutation_p.D506H|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.D516H|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.D506H|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.D554H|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.D516H|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.D506H|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.D543H	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	543					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCTCCCAGTCTTTGTGCTGG	0.567000													5	51					0	0	0.021553	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													4	40					0	0	0.014758	0	0
CCT2	10576	broad.mit.edu	37	12	69985902	69985902	+	Missense_Mutation	SNP	T	T	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr12:69985902T>G	ENST00000543146.2	+	8	1054	c.572T>G	c.(571-573)cTt>cGt	p.L191R	CCT2_ENST00000544368.2_Missense_Mutation_p.L238R|CCT2_ENST00000299300.6_Missense_Mutation_p.L238R	NM_001198842.1	NP_001185771.1	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2 (beta)	238					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(1)	24	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GCTAAAATTCTTATTGCAAAT	0.299000													38	56					0	0	0.111260	0	0
OR1N2	138882	broad.mit.edu	37	9	125315950	125315950	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr9:125315950C>G	ENST00000373688.2	+	1	560	c.502C>G	c.(502-504)Cta>Gta	p.L168V		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						GTGCTGGGTGCTAACCAACTG	0.532000													17	184					0	0	0.146539	0	0
TTN	7273	broad.mit.edu	37	2	179408637	179408637	+	Silent	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr2:179408637G>A	ENST00000589042.1	-	346	96458	c.96234C>T	c.(96232-96234)taC>taT	p.Y32078Y	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342175.6_Silent_p.Y23205Y|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342992.6_Silent_p.Y29510Y|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Silent_p.Y23138Y|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Silent_p.Y30437Y|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000460472.2_Silent_p.Y23013Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30437	Fibronectin type-III 132.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCAGCATCGTACCGATTAA	0.413000													44	74					0	0	0.111260	0	0
GRID2	2895	broad.mit.edu	37	4	94693647	94693647	+	Nonstop_Mutation	SNP	T	T	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr4:94693647T>C	ENST00000282020.4	+	16	3280	c.3022T>C	c.(3022-3024)Tga>Cga	p.*1008R	GRID2_ENST00000510992.1_Nonstop_Mutation_p.*913R	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	0					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CACCTCCATATGAGCATCAAA	0.403000													25	61					0	0	0.108266	0	0
ZBTB22	0	broad.mit.edu	37	6	33283196	33283196	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr6:33283196G>A	ENST00000431845.2	-	2	1649	c.1498C>T	c.(1498-1500)Cgg>Tgg	p.R500W	ZBTB22_ENST00000418724.1_Missense_Mutation_p.R500W	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	500					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R500W(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						TGCCGGTCCCGCATGCTCTTG	0.567000													5	245					0	0	0.014758	0	0
HTR2B	3357	broad.mit.edu	37	2	231973299	231973299	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr2:231973299G>C	ENST00000258400.3	-	4	1890	c.1378C>G	c.(1378-1380)Cta>Gta	p.L460V	PSMD1_ENST00000373635.4_Intron|PSMD1_ENST00000308696.6_Intron|PSMD1_ENST00000409643.1_Intron|PSMD1_ENST00000488354.1_3'UTR	NM_000867.4	NP_000858.3	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	460					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	11		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	GTATCTAGTAGAATGATTGAT	0.393000													3	72					0	0	0.115264	0	0
ETF1	2107	broad.mit.edu	37	5	137844496	137844496	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr5:137844496C>G	ENST00000499810.2	-	10	1442	c.994G>C	c.(994-996)Gaa>Caa	p.E332Q	ETF1_ENST00000360541.5_Missense_Mutation_p.E365Q|ETF1_ENST00000503014.1_Missense_Mutation_p.E351Q			P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	365					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGCTCATGTTCCTGTCCGGTC	0.433000													8	161					0	0	0.038147	0	0
MUC5B	727897	broad.mit.edu	37	11	1264048	1264048	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr11:1264048G>A	ENST00000447027.1	+	31	6005	c.5947G>A	c.(5947-5949)Gtt>Att	p.V1983I	MUC5B_ENST00000529681.1_Missense_Mutation_p.V1980I|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1980	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGCTACCAGCGTTACACCCAT	0.632000													79	117					0	0	0.139131	0	0
TOPBP1	11073	broad.mit.edu	37	3	133329896	133329896	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:133329896C>G	ENST00000260810.5	-	25	4256	c.4125G>C	c.(4123-4125)atG>atC	p.M1375I		NM_007027.3	NP_008958.2	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1375					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	40						TTCTCCATCTCATTGCTGCAA	0.353000								Other conserved DNA damage response genes					8	167					0	0	0.038147	0	0
PPHLN1	51535	broad.mit.edu	37	12	42836501	42836501	+	Silent	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr12:42836501C>T	ENST00000432191.2	+	10	990	c.918C>T	c.(916-918)caC>caT	p.H306H	PPHLN1_ENST00000395568.2_Silent_p.H361H|PPHLN1_ENST00000317560.9_Intron|PPHLN1_ENST00000337898.6_Silent_p.H306H|PPHLN1_ENST00000256678.8_Silent_p.H241H	NM_001143787.1	NP_001137259.1	Q8NEY8	PPHLN_HUMAN	periphilin 1	361					keratinization	cytoplasm|nucleus				breast(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	16	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		aaatggatcacgacggaaccc	0.552000													22	279					0	0	0.083992	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717148	222717148	+	Silent	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:222717148G>A	ENST00000343410.6	-	2	763	c.705C>T	c.(703-705)gcC>gcT	p.A235A		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	235					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		CTACCTGCTCGGCAACAAAGA	0.622000													10	86					0	0	0.069234	0	0
PATL1	219988	broad.mit.edu	37	11	59421541	59421541	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr11:59421541G>C	ENST00000300146.9	-	9	1120	c.1036C>G	c.(1036-1038)Cag>Gag	p.Q346E		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	346	Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						ATTGGGGCCTGAGATCTAAGA	0.428000													3	116					0	0	0.115264	0	0
DBN1	1627	broad.mit.edu	37	5	176893800	176893800	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr5:176893800C>G	ENST00000292385.5	-	9	1359	c.750G>C	c.(748-750)aaG>aaC	p.K250N	DBN1_ENST00000309007.5_Missense_Mutation_p.K248N|DBN1_ENST00000393565.1_Missense_Mutation_p.K248N	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	248					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCAACCGCCTCTTGGCCTCTT	0.602000													4	260					0	0	0.009096	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389861	77389861	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr16:77389861C>T	ENST00000282849.5	-	9	1854	c.1436G>A	c.(1435-1437)cGc>cAc	p.R479H		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	479	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R479H(1)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GAGATACTGGCGGCTGCAGGA	0.488000													46	58					0	0	0.124865	0	0
MTMR4	9110	broad.mit.edu	37	17	56582201	56582201	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr17:56582201C>T	ENST00000323456.5	-	12	1362	c.1238G>A	c.(1237-1239)cGc>cAc	p.R413H	MTMR4_ENST00000579925.1_Missense_Mutation_p.R413H	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	413	Myotubularin phosphatase.|Substrate binding (By similarity).					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCGGTGTGCGGTCCCAGCC	0.532000													4	153					0	0	0.021553	0	0
CACNA1E	777	broad.mit.edu	37	1	181731728	181731728	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:181731728T>C	ENST00000526775.1	+	32	4732	c.4567T>C	c.(4567-4569)Tgg>Cgg	p.W1523R	CACNA1E_ENST00000358338.5_Missense_Mutation_p.W1474R|CACNA1E_ENST00000367570.1_Missense_Mutation_p.W1542R|CACNA1E_ENST00000367573.2_Missense_Mutation_p.W1542R|CACNA1E_ENST00000360108.3_Missense_Mutation_p.W1523R|CACNA1E_ENST00000367567.4_Missense_Mutation_p.W1149R|CACNA1E_ENST00000357570.5_Missense_Mutation_p.W1493R	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1542					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCGAGACACCTGGAATATCTT	0.363000													11	45					0	0	0.080935	0	0
ATR	545	broad.mit.edu	37	3	142268516	142268516	+	Splice_Site	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:142268516C>G	ENST00000350721.4	-	15	3098		c.e15-1		ATR_ENST00000383101.3_Splice_Site	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related						cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						GTAATGTCCTCTGAAAAAGAA	0.343000								Other conserved DNA damage response genes					3	49					0	0	0.014758	0	0
TK1	7083	broad.mit.edu	37	17	76170913	76170913	+	Missense_Mutation	SNP	T	T	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr17:76170913T>G	ENST00000588734.1	-	6	969	c.731A>C	c.(730-732)aAg>aCg	p.K244T	TK1_ENST00000590862.1_Intron|TK1_ENST00000590430.1_3'UTR|TK1_ENST00000405273.1_Missense_Mutation_p.K211T|TK1_ENST00000301634.7_Missense_Mutation_p.K211T			P04183	KITH_HUMAN	thymidine kinase 1, soluble	211					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding			endometrium(1)|large_intestine(1)|urinary_tract(2)	4			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			TTCCCCTGGCTTTCCTGGCAC	0.632000													8	11					0	0	0.058154	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55286820	55286820	+	Missense_Mutation	SNP	C	C	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr19:55286820C>A	ENST00000336077.6	+	4	614	c.574C>A	c.(574-576)Cac>Aac	p.H192N	KIR2DL1_ENST00000291633.7_Missense_Mutation_p.H192N|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL3_ENST00000434419.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	192	Ig-like C2-type 2.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CCCTGCCACCCACGGAGGGAC	0.567000													8	148					0.00307968	0.00328499	0.038147	1	0
A2M	2	broad.mit.edu	37	12	9264798	9264798	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr12:9264798C>T	ENST00000318602.7	-	4	747	c.440G>A	c.(439-441)cGt>cAt	p.R147H		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	147					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GGAGACAACACGAAATTTCAC	0.393000													13	35					0	0	0.132662	0	0
KIF2C	11004	broad.mit.edu	37	1	45218863	45218863	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:45218863G>A	ENST00000372217.1	+	5	688	c.337G>A	c.(337-339)Gag>Aag	p.E113K	KIF2C_ENST00000372218.4_Intron|KIF2C_ENST00000493027.1_Intron|KIF2C_ENST00000372224.4_Missense_Mutation_p.E167K|KIF2C_ENST00000372222.3_Missense_Mutation_p.E54K			Q99661	KIF2C_HUMAN	kinesin family member 2C	167	Globular (Potential).				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(1)|skin(1)|urinary_tract(1)	34	Acute lymphoblastic leukemia(166;0.155)					GATGGTCAGCGAGGAGATGGA	0.532000													4	130					0	0	0.014758	0	0
ASRGL1	80150	broad.mit.edu	37	11	62123836	62123836	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr11:62123836T>C	ENST00000415229.2	+	3	445	c.230T>C	c.(229-231)aTg>aCg	p.M77T	ASRGL1_ENST00000301776.5_Missense_Mutation_p.M77T|ASRGL1_ENST00000535727.1_Intron	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	77					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	GAGGTTGAAATGGATGCTAGT	0.453000													64	95					0	0	0.139131	0	0
CAMKV	79012	broad.mit.edu	37	3	49899480	49899480	+	Silent	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:49899480C>T	ENST00000477224.1	-	3	703	c.225G>A	c.(223-225)aaG>aaA	p.K75K	CAMKV_ENST00000467248.1_5'UTR|CAMKV_ENST00000466940.1_Silent_p.K75K|CAMKV_ENST00000498324.1_5'UTR|CAMKV_ENST00000488336.1_Silent_p.K75K|CAMKV_ENST00000296471.7_Silent_p.K75K|CAMKV_ENST00000463537.1_Silent_p.K75K			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	75	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		AAACTCACATCTTGAGGATGC	0.597000													4	48					0	0	0.009096	0	0
KIF2C	11004	broad.mit.edu	37	1	45218850	45218850	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:45218850G>C	ENST00000372217.1	+	5	675	c.324G>C	c.(322-324)ttG>ttC	p.L108F	KIF2C_ENST00000372218.4_Intron|KIF2C_ENST00000493027.1_Intron|KIF2C_ENST00000372224.4_Missense_Mutation_p.L162F|KIF2C_ENST00000372222.3_Missense_Mutation_p.L49F			Q99661	KIF2C_HUMAN	kinesin family member 2C	162	Globular (Potential).				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(1)|skin(1)|urinary_tract(1)	34	Acute lymphoblastic leukemia(166;0.155)					AAATACCATTGAGGATGGTCA	0.547000													3	135					0	0	0.009096	0	0
ITGAL	0	broad.mit.edu	37	16	30521697	30521697	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr16:30521697C>T	ENST00000356798.6	+	22	2704	c.2524C>T	c.(2524-2526)Cct>Tct	p.P842S	ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Missense_Mutation_p.P758S	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	842					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TAGCCAGATACCTGTGAGCTG	0.557000													78	134					0	0	0.139131	0	0
RP11-458D21.5	0	broad.mit.edu	37	1	145293128	145293128	+	Missense_Mutation	SNP	C	C	T	rs7366463	by1000genomes	TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:145293128C>T	ENST00000468030.1	+	5	985	c.649C>T	c.(649-651)Cgc>Tgc	p.R217C	NBPF10_ENST00000369338.1_5'UTR|NBPF10_ENST00000369339.2_Intron																							TTACCTGGCACGCTGGCCACA	0.498000													3	18					0	0	0.115264	0	0
CIT	11113	broad.mit.edu	37	12	120241044	120241044	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr12:120241044A>G	ENST00000392521.2	-	10	1316	c.1261T>C	c.(1261-1263)Tac>Cac	p.Y421H	CIT_ENST00000261833.7_Missense_Mutation_p.Y421H	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	421	AGC-kinase C-terminal.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GCCTTGCTGTACGAAAACCCC	0.488000													3	101					0	0	0.009096	0	0
CSF3R	1441	broad.mit.edu	37	1	36937076	36937076	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:36937076C>T	ENST00000373103.1	-	10	1790	c.1243G>A	c.(1243-1245)Ggg>Agg	p.G415R	CSF3R_ENST00000418048.2_Missense_Mutation_p.G415R|CSF3R_ENST00000373104.1_Missense_Mutation_p.G415R|CSF3R_ENST00000373106.1_Missense_Mutation_p.G415R|CSF3R_ENST00000361632.4_Missense_Mutation_p.G415R|CSF3R_ENST00000338937.5_Missense_Mutation_p.G415R|CSF3R_ENST00000331941.5_Missense_Mutation_p.G415R|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000440588.2_Missense_Mutation_p.G415R	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	415	Fibronectin type-III 3.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CGAGAGGTCCCGGCTGAGTTA	0.592000													139	180					0	0	0.139131	0	0
ESPL1	9700	broad.mit.edu	37	12	53680377	53680377	+	Missense_Mutation	SNP	A	A	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr12:53680377A>T	ENST00000257934.4	+	18	3948	c.3857A>T	c.(3856-3858)cAa>cTa	p.Q1286L	ESPL1_ENST00000552462.1_Missense_Mutation_p.Q1286L	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1286					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						TGTACTACCCAACTTTTTGCA	0.552000													7	124					0	0	0.029380	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150531845	150531845	+	Missense_Mutation	SNP	C	C	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:150531845C>A	ENST00000271643.4	+	17	3082	c.2846C>A	c.(2845-2847)tCt>tAt	p.S949Y	ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.S972Y|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.S949Y	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	949	TSP type-1 5.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AACGTGACTTCTCCGAGCAAC	0.612000											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	75	95					5.44642e-36	5.88802e-36	0.139131	1	0
BNC1	646	broad.mit.edu	37	15	83932102	83932102	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr15:83932102C>T	ENST00000345382.2	-	4	1986	c.1901G>A	c.(1900-1902)aGg>aAg	p.R634K	BNC1_ENST00000569704.1_Missense_Mutation_p.R627K|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	634					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						CTCAGTCTCCCTCTCTGAATT	0.552000													5	175					0	0	0.014758	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84582013	84582013	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr15:84582013G>A	ENST00000286744.5	+	16	2094	c.1870G>A	c.(1870-1872)Gca>Aca	p.A624T	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.A624T	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	624	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCTCCTGGAAGCATGTGATGA	0.617000													25	32					0	0	0.076483	0	0
PRKDC	5591	broad.mit.edu	37	8	48772221	48772221	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr8:48772221G>C	ENST00000314191.2	-	47	6211	c.6155C>G	c.(6154-6156)tCa>tGa	p.S2052*	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Nonsense_Mutation_p.S2052*	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2053					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding	p.S2052*(1)|p.S2053*(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGAGCTGTATGAATAGCTCTG	0.438000								Non-homologous end-joining					6	206					0	0	0.021553	0	0
KIAA0922	23240	broad.mit.edu	37	4	154533507	154533507	+	Silent	SNP	T	T	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr4:154533507T>C	ENST00000409663.3	+	26	3571	c.3519T>C	c.(3517-3519)tcT>tcC	p.S1173S	KIAA0922_ENST00000409959.3_Silent_p.S1174S|KIAA0922_ENST00000440693.1_Silent_p.S1090S	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	1173						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				ACAAAACATCTAGAGAAGACA	0.343000													35	38					0	0	0.054565	0	0
ANK2	287	broad.mit.edu	37	4	114263046	114263046	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr4:114263046G>A	ENST00000357077.4	+	33	4149	c.4096G>A	c.(4096-4098)Gag>Aag	p.E1366K	ANK2_ENST00000264366.6_Missense_Mutation_p.E1333K|ANK2_ENST00000510275.2_Missense_Mutation_p.E18K|ANK2_ENST00000506722.1_Missense_Mutation_p.E1357K|ANK2_ENST00000394537.3_Missense_Mutation_p.E1366K|ANK2_ENST00000509550.1_Missense_Mutation_p.E542K	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1333					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAATTTTGCTGAGGTGGCCAG	0.373000													12	102					0	0	0.105934	0	0
ELF3	1999	broad.mit.edu	37	1	201981484	201981484	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:201981484C>T	ENST00000359651.3	+	3	3590	c.398C>T	c.(397-399)tCt>tTt	p.S133F	ELF3_ENST00000367283.3_Missense_Mutation_p.S133F|ELF3_ENST00000367284.5_Missense_Mutation_p.S133F|ELF3_ENST00000495848.1_3'UTR|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	133					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						TCCAGCTCTTCTGATGAGCTC	0.582000													4	112					0	0	0.009096	0	0
EPS15L1	58513	broad.mit.edu	37	19	16548625	16548625	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr19:16548625C>T	ENST00000597937.1	-	5	269	c.265G>A	c.(265-267)Gtt>Att	p.V89I	EPS15L1_ENST00000594975.1_Missense_Mutation_p.V89I|EPS15L1_ENST00000248070.6_Missense_Mutation_p.V89I|EPS15L1_ENST00000455140.2_Missense_Mutation_p.V89I|EPS15L1_ENST00000535753.2_Missense_Mutation_p.V89I	NM_001258376.1	NP_001245305.1	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	89	EH 1.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						CTCAAGGTAACTTCATGGCCA	0.468000													7	53					0	0	0.029380	0	0
SCAF4	57466	broad.mit.edu	37	21	33043813	33043813	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr21:33043813C>G	ENST00000286835.7	-	20	3725	c.3343G>C	c.(3343-3345)Gag>Cag	p.E1115Q	SCAF4_ENST00000434667.3_Missense_Mutation_p.E1100Q|SCAF4_ENST00000399804.1_Missense_Mutation_p.E1093Q	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	1115						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						ACTGCAGCCTCAGACACCCCC	0.517000													7	100					0	0	0.038147	0	0
OR51V1	283111	broad.mit.edu	37	11	5221748	5221748	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr11:5221748C>G	ENST00000321255.1	-	1	182	c.183G>C	c.(181-183)gaG>gaC	p.E61D		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGGCTTGGCTCAGTCCATA	0.537000													13	72					0	0	0.146539	0	0
CHAT	1103	broad.mit.edu	37	10	50824648	50824648	+	Splice_Site	SNP	T	T	G	rs143723043		TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr10:50824648T>G	ENST00000395562.2	+	3	610	c.141_splice	c.e3+1	p.S47_splice	CHAT_ENST00000395559.2_Splice_Site_p.S11_splice|CHAT_ENST00000339797.1_Splice_Site_p.S11_splice|CHAT_ENST00000460699.1_3'UTR|CHAT_ENST00000337653.2_Splice_Site_p.S129_splice|CHAT_ENST00000455728.2_Splice_Site_p.S11_splice|CHAT_ENST00000351556.3_Splice_Site_p.S11_splice	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	129			D -> E (in dbSNP:rs3810948).		neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GTGAGGAGTCTGTGAGTGACT	0.567000													17	14					0	0	0.033300	0	0
AMOTL2	51421	broad.mit.edu	37	3	134089564	134089564	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:134089564G>A	ENST00000514516.1	-	2	1064	c.886C>T	c.(886-888)Cac>Tac	p.H296Y	AMOTL2_ENST00000422605.2_Missense_Mutation_p.H238Y|AMOTL2_ENST00000511759.1_Intron|AMOTL2_ENST00000513145.1_Missense_Mutation_p.H238Y|AMOTL2_ENST00000249883.5_Missense_Mutation_p.H238Y	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	238										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						TGCTGGAAGTGCGGGCTGCCG	0.587000													6	85					0	0	0.029380	0	0
NES	10763	broad.mit.edu	37	1	156641203	156641203	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr1:156641203C>T	ENST00000368223.3	-	4	2909	c.2777G>A	c.(2776-2778)gGa>gAa	p.G926E		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	926	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTGGTACTCTCCCTTTCCCAG	0.527000													6	246					0	0	0.021553	0	0
COPG2	26958	broad.mit.edu	37	7	130301860	130301860	+	Splice_Site	SNP	C	C	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr7:130301860C>A	ENST00000445977.2	-	6	489		c.e6+1					Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2						intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity			large_intestine(1)	1	Melanoma(18;0.0435)					AGATAACTTACATCGGTGATC	0.403000													22	39					0.0624174	0.0657025	0.062417	1	0
ARHGAP6	395	broad.mit.edu	37	X	11200233	11200233	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chrX:11200233G>A	ENST00000337414.4	-	6	2151	c.1279C>T	c.(1279-1281)Cag>Tag	p.Q427*	ARHGAP6_ENST00000534860.1_Nonsense_Mutation_p.Q252*|ARHGAP6_ENST00000380736.1_Nonsense_Mutation_p.Q224*|ARHGAP6_ENST00000303025.6_Nonsense_Mutation_p.Q224*|ARHGAP6_ENST00000413512.3_Nonsense_Mutation_p.Q236*|ARHGAP6_ENST00000380718.1_Nonsense_Mutation_p.Q427*|ARHGAP6_ENST00000380732.3_Nonsense_Mutation_p.Q459*	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	427	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CCCACTGTCTGGAGGCCTGCA	0.398000													6	165					0	0	0.021553	0	0
C17orf74	201243	broad.mit.edu	37	17	7330441	7330441	+	Silent	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr17:7330441C>T	ENST00000333870.3	+	3	1205	c.1131C>T	c.(1129-1131)gaC>gaT	p.D377D	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_3'UTR	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	377						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				GCTCCCAGGACCCCCGTGAGG	0.682000													10	27					0	0	0.058154	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				38	63					0	0	0.086207	0	0
PLCH1	23007	broad.mit.edu	37	3	155200705	155200705	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:155200705G>C	ENST00000460012.1	-	23	3377	c.3020C>G	c.(3019-3021)tCt>tGt	p.S1007C	PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000414191.1_Missense_Mutation_p.S1007C|PLCH1_ENST00000340059.7_Missense_Mutation_p.S1045C|PLCH1_ENST00000334686.6_Missense_Mutation_p.S1007C			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1045					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GTGGGCAGTAGATACAATGGT	0.463000													3	177					0	0	0.115264	0	0
EIF4G2	1982	broad.mit.edu	37	11	10822345	10822345	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr11:10822345A>G	ENST00000526148.1	-	16	2087	c.1577T>C	c.(1576-1578)aTc>aCc	p.I526T	RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000525681.1_Missense_Mutation_p.I526T|EIF4G2_ENST00000339995.5_Missense_Mutation_p.I526T|EIF4G2_ENST00000396525.2_Missense_Mutation_p.I488T	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	526					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CTTTTCCTGGATAAGCGGTGG	0.383000													48	75					0	0	0.139131	0	0
ITGAD	3681	broad.mit.edu	37	16	31435803	31435803	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr16:31435803G>C	ENST00000389202.2	+	29	3326	c.3277G>C	c.(3277-3279)Gaa>Caa	p.E1093Q		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	1093					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GATGGTGCTAGAAGAAGACGA	0.542000													6	105					0	0	0.021553	0	0
FAM135B	51059	broad.mit.edu	37	8	139163752	139163752	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr8:139163752A>G	ENST00000395297.1	-	13	3136	c.2966T>C	c.(2965-2967)gTg>gCg	p.V989A		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	989										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGAATGGGTCACAGTGGGGCA	0.493000										HNSCC(54;0.14)			41	70					0	0	0.080422	0	0
TMEM109	79073	broad.mit.edu	37	11	60689584	60689584	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr11:60689584C>T	ENST00000227525.3	+	4	1082	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C	RP11-881M11.4_ENST00000543907.1_RNA|TMEM109_ENST00000536171.1_Missense_Mutation_p.R227C	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	227						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						GGAGGAGCTGCGCTGGCGCCA	0.687000													5	39					0	0	0.014758	0	0
OR5H15	403274	broad.mit.edu	37	3	97887844	97887844	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr3:97887844delT	ENST00000356526.2	+	1	301	c.301delT	c.(301-303)ttfs	p.F102fs		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CAAGATACAATTTTTTTCCAT	0.383													8	334	---	---	---	---					
ACAD10	80724	broad.mit.edu	37	12	112185090	112185101	+	Splice_Site	DEL	CCCACTCAGGTT	CCCACTCAGGTT	-			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr12:112185090_112185101delCCCACTCAGGTT	ENST00000455480.2	+	17	2664_2667	c.2487_splice	c.e17-1	p.829_splice	ACAD10_ENST00000313698.4_Splice_Site_p.798_splice|ACAD10_ENST00000392636.2_Splice_Site_p.400_splice|ACAD10_ENST00000413681.3_3'UTR	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	798							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						GAATATGCTCCCCACTCAGGTTGCCTCTTCAG	0.561													34	56	---	---	---	---					
C17orf82	388407	broad.mit.edu	37	17	59489871	59489877	+	Frame_Shift_Del	DEL	GGCCTCG	GGCCTCG	-			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chr17:59489871_59489877delGGCCTCG	ENST00000335108.2	+	1	760_766	c.535_541delGGCCTCG	c.(535-543)ggfs	p.GLG179fs		NM_203425.1	NP_982249.1	Q86X59	CQ082_HUMAN	chromosome 17 open reading frame 82	179										cervix(1)|lung(1)	2						AGCCCGCCCAGGCCTCGGGCCTCGGCA	0.734													3	4	---	---	---	---					
TEX11	0	broad.mit.edu	37	X	70053437	70053438	+	Frame_Shift_Ins	INS	-	-	AACT			TCGA-BJ-A0ZB-01A-11D-A10S-08	TCGA-BJ-A0ZB-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add0b0f6-b4a8-4b73-b634-c3600dc567d5	d078cbf9-7e5f-47cb-9f33-725a33f31c1b	g.chrX:70053437_70053438insAACT	ENST00000395889.2	-	9	731_732	c.576_577insAGTT	c.(574-579)gtctcafs	p.S193fs	TEX11_ENST00000374333.2_Frame_Shift_Ins_p.S178fs|TEX11_ENST00000344304.3_Frame_Shift_Ins_p.S193fs	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	193							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					TCCCCTTGAGCAACTGCCTGAA	0.356													23	11	---	---	---	---