Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SMG1	23049	broad.mit.edu	37	16	18823096	18823096	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr16:18823096G>A	uc002dfm.3	-	61	11258	c.10895C>T	c.(10894-10896)tCa>tTa	p.S3632L	SMG1_uc010bwb.3_Missense_Mutation_p.S3492L|SMG1_uc010bwa.3_Missense_Mutation_p.S2363L|SMG1_uc021tec.1_5'Flank	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	Homo sapiens smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) (SMG1), mRNA.	3632	FATC.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						TTCAGCAACTGACATCCTCCT	0.443000													13	345					0	0	1	0	0
CPNE1	8904	broad.mit.edu	37	20	34218857	34218857	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr20:34218857A>G	uc010zvj.2	-	10	1343	c.976T>C	c.(976-978)Tgg>Cgg	p.W326R	CPNE1_uc002xde.3_Missense_Mutation_p.W297R|CPNE1_uc002xdf.3_Missense_Mutation_p.W321R|CPNE1_uc002xdi.3_Missense_Mutation_p.W321R|CPNE1_uc002xdj.3_Missense_Mutation_p.W321R|CPNE1_uc002xdl.3_Missense_Mutation_p.W321R|CPNE1_uc002xdm.3_Missense_Mutation_p.W321R|CPNE1_uc010gfk.2_3'UTR	NM_003915	NP_690905	Q99829	CPNE1_HUMAN	Homo sapiens copine I (CPNE1), transcript variant 3, mRNA.	321	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CCCACACTCCACAGTGCCATC	0.572000													4	88					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr1:115256530G>T	uc009wgu.3	-	2	435	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524	NP_002515	P01111	RASN_HUMAN	Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), mRNA.	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(1229)|p.Q61R(898)|p.Q61L(198)|p.Q61H(123)|p.Q61P(23)|p.Q61E(18)|p.G60E(6)|p.Q61?(5)|p.Q61Q(3)|p.G60>?(2)|p.G60R(1)|p.Q61*(1)|p.Q61_E62>HK(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			56	138					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74274199	74274199	+	Silent	SNP	T	T	C			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr2:74274199T>C	uc002skb.4	+	0	750	c.750T>C	c.(748-750)ccT>ccC	p.P250P	TET3_uc010fez.2_Silent_p.P250P	NM_144993	NP_659430	O43151	TET3_HUMAN	Homo sapiens tet methylcytosine dioxygenase 3 (TET3), mRNA.	250							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCCCCCTTCCTGAGGCCTTGT	0.602000													3	64					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17743871	17743871	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chrX:17743871C>T	uc011mix.2	+	6	1983	c.1645C>T	c.(1645-1647)Cca>Tca	p.P549S	NHS_uc004cxx.3_Missense_Mutation_p.P528S|NHS_uc004cxy.3_Missense_Mutation_p.P372S|NHS_uc004cxz.3_Missense_Mutation_p.P351S|NHS_uc004cya.3_Missense_Mutation_p.P251S	NM_001136024	NP_001129496	Q6T4R5	NHS_HUMAN	Homo sapiens Nance-Horan syndrome (congenital cataracts and dental anomalies) (NHS), transcript variant 2, mRNA.	528						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CAGTGAGGCTCCAAGCAGCCC	0.542000													26	60					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768323	77768323	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr8:77768323C>T	uc003yau.2	+	9	9553	c.9166C>T	c.(9166-9168)Cgg>Tgg	p.R3056W	ZFHX4_uc003yaw.1_Missense_Mutation_p.R3011W	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	Homo sapiens zinc finger homeobox 4 (ZFHX4), mRNA.	3011	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D3056E(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GACCACGGTTCGGCAGCTGAT	0.507000										HNSCC(33;0.089)			6	117					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153033718	153033718	+	Silent	SNP	G	G	A			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chrX:153033718G>A	uc010nuk.2	+	4	1441	c.1170G>A	c.(1168-1170)tcG>tcA	p.S390S	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.2_Silent_p.S49S|PLXNB3_uc004fii.2_Silent_p.S367S|PLXNB3_uc011mzd.1_Silent_p.S6S	NM_001163257	NP_001156729	Q9ULL4	PLXB3_HUMAN	Homo sapiens plexin B3 (PLXNB3), transcript variant 2, mRNA.	367	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCCGAGTCGTACCCCTGTG	0.687000													37	51					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39633418	39633418	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr17:39633418A>G	uc002hws.3	-	6	1301	c.1258T>C	c.(1258-1260)Tcc>Ccc	p.S420P		NM_002280	NP_002271	Q92764	KRT35_HUMAN	Homo sapiens keratin 35 (KRT35), mRNA.	420	Tail.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				CATGACTTGGAGGGTGAGTAG	0.542000													3	65					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75936554	75936554	+	Missense_Mutation	SNP	T	T	C			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr13:75936554T>C	uc001vjl.1	-	1	1035	c.688A>G	c.(688-690)Agc>Ggc	p.S230G	TBC1D4_uc010aer.2_Missense_Mutation_p.S230G|TBC1D4_uc010aes.2_Missense_Mutation_p.S230G	NM_014832	NP_055647	O60343	TBCD4_HUMAN	Homo sapiens TBC1 domain family, member 4 (TBC1D4), mRNA.	230						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TCGTGCAGGCTGAACTTCTCC	0.597000													4	160					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45542148	45542148	+	Missense_Mutation	SNP	T	T	A			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr21:45542148T>A	uc002zeb.3	+	13	1817	c.1727T>A	c.(1726-1728)gTg>gAg	p.V576E		NM_005049	NP_005040	Q15269	PWP2_HUMAN	Homo sapiens PWP2 periodic tryptophan protein homolog (yeast) (PWP2), mRNA.	576						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		GAGAACGCGGTGCAGACGGGC	0.582000													18	100					0	0	1	0	0
C14orf49	161176	broad.mit.edu	37	14	95906371	95906371	+	Missense_Mutation	SNP	G	G	C			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr14:95906371G>C	uc001yei.4	-	10	1968	c.1953C>G	c.(1951-1953)tgC>tgG	p.C651W	C14orf49_uc010avi.3_Missense_Mutation_p.C651W	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	Homo sapiens chromosome 14 open reading frame 49 (C14orf49), mRNA.	651					cytoskeletal anchoring at nuclear membrane	SUN-KASH complex|integral to membrane|nuclear outer membrane	actin binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(27)|prostate(5)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	50		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GGCTGAAGGTGCAGTGCTCCT	0.682000													40	85					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58131103	58131103	+	Silent	SNP	G	G	A			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr12:58131103G>A	uc001spq.3	-	0	927	c.927C>T	c.(925-927)tcC>tcT	p.S309S	AGAP2_uc001spp.3_Silent_p.S309S|AGAP2_uc001spr.3_Intron	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), transcript variant 1, mRNA.	309	Interaction with PLCG1 (By similarity).				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding	p.R309C(1)		breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						GGGGCTGCGCGGAAGCAGCGG	0.687000													3	58					0	0	1	0	0
SCMH1	22955	broad.mit.edu	37	1	41582675	41582675	+	Silent	SNP	C	C	T			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr1:41582675C>T	uc001cgo.3	-	6	759	c.390G>A	c.(388-390)cgG>cgA	p.R130R	SCMH1_uc010ojr.2_Intron|SCMH1_uc001cgp.3_Silent_p.R69R|SCMH1_uc001cgr.3_Silent_p.R69R|SCMH1_uc001cgq.3_Silent_p.R83R|SCMH1_uc001cgs.3_Silent_p.R140R|SCMH1_uc001cgt.3_Silent_p.R69R|SCMH1_uc010ojs.1_Non-coding_Transcript	NM_001031694	NP_001165692	Q96GD3	SCMH1_HUMAN	Homo sapiens sex comb on midleg homolog 1 (Drosophila) (SCMH1), transcript variant 1, mRNA.	130					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(2)|pancreas(2)|upper_aerodigestive_tract(1)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				ACGCATTCAGCCGAAATCCTG	0.478000													3	45					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17472966	17472966	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr22:17472966C>T	uc002zlw.3	-	1	383	c.275G>A	c.(274-276)cGc>cAc	p.R92H	GAB4_uc010gqs.1_Missense_Mutation_p.R92H	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	Homo sapiens GRB2-associated binding protein family, member 4 (GAB4), mRNA.	92	PH.							p.R92P(2)		breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GTTGATGGTGCGCAGGGGCTT	0.502000													18	244					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31683024	31683024	+	Missense_Mutation	SNP	G	G	T			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr7:31683024G>T	uc011kae.2	+	10	2130	c.2118G>T	c.(2116-2118)agG>agT	p.R706S	CCDC129_uc011kad.1_Missense_Mutation_p.R690S|CCDC129_uc003tcj.1_Missense_Mutation_p.R680S|CCDC129_uc003tci.1_Missense_Mutation_p.R531S|CCDC129_uc003tck.1_Missense_Mutation_p.R588S	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	Homo sapiens coiled-coil domain containing 129 (CCDC129), mRNA.	680										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TGAAGTCAAGGTCTGGTACTT	0.483000													25	29					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183072526	183072526	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr1:183072526C>G	uc001gpy.4	+	1	739	c.482C>G	c.(481-483)gCc>gGc	p.A161G	LAMC1_uc001gpx.3_Missense_Mutation_p.A161G	NM_002293	NP_002284	P11047	LAMC1_HUMAN	Homo sapiens laminin, gamma 1 (formerly LAMB2) (LAMC1), mRNA.	161	Laminin N-terminal.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGAGCTTTGCCATTTACAAG	0.512000													61	104					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135275452	135275452	+	Silent	SNP	A	A	G			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr9:135275452A>G	uc004cbl.3	-	2	1630	c.1561T>C	c.(1561-1563)Ttg>Ctg	p.L521L	TTF1_uc004cbm.3_Silent_p.L6L|TTF1_uc011mcp.2_Non-coding_Transcript	NM_007344	NP_031370	Q15361	TTF1_HUMAN	Homo sapiens transcription termination factor, RNA polymerase I (TTF1), transcript variant 1, mRNA.	521					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		AACCGTTCCAAGTCGTCCCGG	0.473000													54	101					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140209539	140209539	+	Silent	SNP	G	G	A			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr5:140209539G>A	uc003lho.2	+	0	1890	c.1863G>A	c.(1861-1863)ccG>ccA	p.P621P	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc011dab.2_Silent_p.P621P	NM_018909	NP_061732	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 6 (PCDHA6), transcript variant 1, mRNA.	632	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCTTCCCGTTTCGCGTGG	0.657000													32	55					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33507620	33507620	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr17:33507620C>A	uc002hja.3	+	17	2401	c.2304C>A	c.(2302-2304)aaC>aaA	p.N768K	UNC45B_uc002hjb.3_Missense_Mutation_p.N766K|UNC45B_uc002hjc.3_Missense_Mutation_p.N766K|UNC45B_uc010cto.3_Missense_Mutation_p.N687K	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	Homo sapiens unc-45 homolog B (C. elegans) (UNC45B), transcript variant 1, mRNA.	768					cell differentiation|muscle organ development	cytosol	binding	p.E767K(1)		breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				ACATCGAGAACTACATGTTTG	0.557000													30	63					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133900513	133900517	+	Frame_Shift_Del	DEL	ATTCA	ATTCA	-			TCGA-ET-A25I-01A-11D-A16O-08	TCGA-ET-A25I-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69fbd819-2f6b-4fd4-86dd-f9370cbbcd95	010ad109-f038-42e6-9efb-a24f5c53ea11	g.chr8:133900513_133900517delATTCA	uc003ytw.3	+	9	2502_2506	c.2461_2465delATTCA	c.(2461-2466)attcaafs	p.I821fs		NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	821	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGTCTCTTTATTCAAAGTCTGTAT	0.527													20	41	---	---	---	---