Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DGKQ	1609	broad.mit.edu	37	4	959854	959854	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr4:959854G>A	uc003gbw.3	-	12	1515	c.1441C>T	c.(1441-1443)Cag>Tag	p.Q481*	DGKQ_uc010ibn.3_Nonsense_Mutation_p.Q481*	NM_001347	NP_001338	P52824	DGKQ_HUMAN	Homo sapiens diacylglycerol kinase, theta 110kDa (DGKQ), mRNA.	481	Ras-associating.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	ATP binding|activating transcription factor binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			breast(1)|endometrium(2)|kidney(2)|lung(2)|prostate(2)	9			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TGGCTCACCTGCCGCACAGAC	0.662000													5	4					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103908243	103908243	+	Silent	SNP	C	C	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr10:103908243C>T	uc001kum.3	+	9	4554	c.4515C>T	c.(4513-4515)tcC>tcT	p.S1505S	PPRC1_uc001kun.3_Silent_p.S1385S|PPRC1_uc010qqj.2_Silent_p.S1241S|PPRC1_uc009xxa.3_Non-coding_Transcript	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	Homo sapiens peroxisome proliferator-activated receptor gamma, coactivator-related 1 (PPRC1), mRNA.	1505	Arg-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	RNA binding|nucleotide binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCTCACGATCCCCATCCCCCC	0.562000													11	90					0	0	1	0	0
C10orf137	26098	broad.mit.edu	37	10	127408456	127408456	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr10:127408456A>T	uc001liq.1	+	0	373	c.80A>T	c.(79-81)cAg>cTg	p.Q27L	FLJ37035_uc001lim.2_5'Flank|C10orf137_uc001lin.3_Missense_Mutation_p.Q27L|C10orf137_uc001lip.1_5'UTR|C10orf137_uc001lio.1_Missense_Mutation_p.Q27L	NM_001202438	NP_001189367	Q3B7T1	EDRF1_HUMAN	Homo sapiens chromosome 10 open reading frame 137 (C10orf137), transcript variant 1, mRNA.	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CTCCTGTCCCAGGGAGAATCC	0.711000													12	20					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3102815	3102815	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr1:3102815C>T	uc001akf.3	+	1	246	c.164C>T	c.(163-165)cCc>cTc	p.P55L	PRDM16_uc001ake.3_Missense_Mutation_p.P55L|PRDM16_uc009vlh.3_5'UTR|PRDM16_uc001akc.3_Missense_Mutation_p.P55L	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	Homo sapiens PR domain containing 16 (PRDM16), transcript variant 1, mRNA.	55					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TCCCCCTTCCCCACCAGCGAG	0.662000			T	EVI1	"""MDS, AML"""								24	63					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38714267	38714267	+	Missense_Mutation	SNP	G	G	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr12:38714267G>T	uc001rln.4	+	2	813	c.674G>T	c.(673-675)gGa>gTa	p.G225V		NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	Homo sapiens asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast) (ALG10B), mRNA.	225					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	p.G225V(2)		breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				CCTATTAAAGGACCATTTGCA	0.393000													8	138					0	0	1	0	0
CYB5D1	124637	broad.mit.edu	37	17	7761468	7761468	+	Silent	SNP	C	C	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr17:7761468C>T	uc002gjb.4	+	0	405	c.16C>T	c.(16-18)Ctg>Ttg	p.L6L	LSMD1_uc002giz.3_5'Flank|LSMD1_uc002gja.3_5'Flank|CYB5D1_uc021tpi.1_5'Flank	NM_144607	NP_653208	Q6P9G0	CB5D1_HUMAN	Homo sapiens cytochrome b5 domain containing 1 (CYB5D1), mRNA.	6							heme binding			breast(1)|endometrium(1)|large_intestine(2)|skin(2)	6		all_cancers(10;0.11)|Prostate(122;0.219)				GCGCCGGGGCCTGGTGGCTGG	0.587000													25	63					0	0	1	0	0
MORF4L2	9643	broad.mit.edu	37	X	102931475	102931475	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chrX:102931475C>T	uc004ekw.3	-	3	1713	c.481G>A	c.(481-483)Gag>Aag	p.E161K	MORF4L2_uc004ela.3_Missense_Mutation_p.E161K|MORF4L2_uc004elb.3_Missense_Mutation_p.E161K|MORF4L2_uc004ekx.3_Missense_Mutation_p.E161K|MORF4L2_uc004eky.3_Missense_Mutation_p.E161K|MORF4L2_uc010nos.3_Missense_Mutation_p.E161K|MORF4L2_uc004ekz.3_Missense_Mutation_p.E161K|MORF4L2_uc011mry.2_Missense_Mutation_p.E161K|MORF4L2_uc011mrz.2_Missense_Mutation_p.E161K|MORF4L2_uc004elc.3_Missense_Mutation_p.E161K|MORF4L2_uc004ele.3_Missense_Mutation_p.E161K|MORF4L2_uc004elf.3_Missense_Mutation_p.E161K|MORF4L2_uc011msa.2_Missense_Mutation_p.E161K|MORF4L2_uc011msb.2_Missense_Mutation_p.E161K|MORF4L2_uc011msc.2_Missense_Mutation_p.E161K|MORF4L2_uc011msd.2_Missense_Mutation_p.E161K|MORF4L2_uc004eld.3_Missense_Mutation_p.E161K|MORF4L2_uc022cbw.1_Missense_Mutation_p.E161K	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	Homo sapiens mortality factor 4 like 2 (MORF4L2), transcript variant 2, mRNA.	161					DNA repair|chromatin modification|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)	13						TTTGCATACTCCTCCAGAATT	0.388000													61	158					0	0	1	0	0
CHCHD2	51142	broad.mit.edu	37	7	56172116	56172116	+	Missense_Mutation	SNP	G	G	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr7:56172116G>T	uc003tsa.3	-	1	184	c.103C>A	c.(103-105)Cca>Aca	p.P35T	PSPH_uc003trj.3_Intron	NM_016139	NP_057223	Q9Y6H1	CHCH2_HUMAN	Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), nuclear gene encoding mitochondrial protein, mRNA.	35						mitochondrion				endometrium(1)|large_intestine(1)|lung(3)	5	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GCCGCTGCTGGTGGCTGAGCG	0.597000													4	10					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				22	47					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70464983	70464983	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr4:70464983G>A	uc011caq.2	-	3	1591	c.1475C>T	c.(1474-1476)cCt>cTt	p.P492L	UGT2A1_uc010ihu.3_Missense_Mutation_p.P326L|UGT2A1_uc003hem.4_Missense_Mutation_p.P282L|UGT2A1_uc010ihs.3_Missense_Mutation_p.P291L|UGT2A1_uc021xox.1_Missense_Mutation_p.P291L|UGT2A1_uc010iht.3_Missense_Mutation_p.P282L	NM_001252274	NP_001239203	Q9Y4X1	UD2A1_HUMAN	Homo sapiens UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus (UGT2A1), transcript variant 2, mRNA.	282					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						AGGTTTGGCAGGTTTGCAGTG	0.348000													5	39					0	0	1	0	0
RGS18	64407	broad.mit.edu	37	1	192150498	192150498	+	Silent	SNP	A	A	G			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr1:192150498A>G	uc001gsg.3	+	3	536	c.360A>G	c.(358-360)gaA>gaG	p.E120E		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	Homo sapiens regulator of G-protein signaling 18 (RGS18), mRNA.	120	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			kidney(1)|large_intestine(2)|lung(15)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TAGCCTGTGAAGATTTCAAGA	0.313000													3	35					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129519127	129519127	+	Missense_Mutation	SNP	T	T	G			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chrX:129519127T>G	uc011muv.2	-	0	385	c.295A>C	c.(295-297)Atc>Ctc	p.I99L		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	Homo sapiens G protein-coupled receptor 119 (GPR119), mRNA.	99						integral to membrane|plasma membrane	lipid binding	p.I99M(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						TCAAAGGTGATCAGCATGACC	0.592000													52	114					0	0	1	0	0
FGF20	26281	broad.mit.edu	37	8	16850687	16850687	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr8:16850687T>C	uc003wxc.1	-	2	663	c.530A>G	c.(529-531)gAt>gGt	p.D177G	FGF20_uc010lsw.1_3'UTR	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	Homo sapiens fibroblast growth factor 20 (FGF20), mRNA.	177					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	11				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		CCTGGCGCCATCTCTTGGAGT	0.428000													39	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179436988	179436988	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr2:179436988G>A	uc021vsy.1	-	274	66392	c.66167C>T	c.(66166-66168)aCt>aTt	p.T22056I	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002umo.3_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Missense_Mutation_p.T15751I|TTN_uc021vta.1_Missense_Mutation_p.T15684I|TTN_uc021vtb.1_Missense_Mutation_p.T15559I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	22983	Ig-like 115.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCCATCAAAGTTATTTTTCC	0.468000													9	30					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152325310	152325310	+	Missense_Mutation	SNP	G	G	T			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr1:152325310G>T	uc001ezw.4	-	2	5025	c.4952C>A	c.(4951-4953)tCt>tAt	p.S1651Y	AK056431_uc001ezv.3_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	Homo sapiens filaggrin family member 2 (FLG2), mRNA.	1651							calcium ion binding|structural molecule activity	p.S1651Y(2)|p.R1650I(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTGTGGCTAGATCTCTGTCT	0.512000													111	298					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38318081	38318081	+	Silent	SNP	G	G	A			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr22:38318081G>A	uc003aui.3	+	5	947	c.672G>A	c.(670-672)ggG>ggA	p.G224G		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	Homo sapiens MICAL-like 1 (MICALL1), mRNA.	224	LIM zinc-binding.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					TGGGCCCGGGGACACGGTCGG	0.652000													4	40					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144548018	144548018	+	Splice_Site	SNP	T	T	A			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr8:144548018T>A	uc003yyd.2	-	9	2205	c.2176_splice	c.e9-1	p.M726_splice		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	Homo sapiens zinc finger CCCH-type containing 3 (ZC3H3), mRNA.	726					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CACACCGGCATCTGCAGGGAG	0.652000													3	17					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17601284	17601285	+	Frame_Shift_Ins	INS	-	-	A			TCGA-EL-A3CU-01A-11D-A19J-08	TCGA-EL-A3CU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8fbab446-f05f-4385-ac05-7566aa524929	e62e18f2-a371-4ed6-99d9-7c9e705a81a7	g.chr20:17601284_17601285insA	uc010gcm.1	-	7	1000_1001	c.642_643insT	c.(640-645)tctgtcfs	p.S214fs	RRBP1_uc010zrp.1_5'Flank|RRBP1_uc002wpt.1_Intron|RRBP1_uc002wpu.3_Intron|RRBP1_uc002wpw.1_Intron|RRBP1_uc010gcl.1_Intron|RRBP1_uc002wpv.1_Intron			Q9P2E9	RRBP1_HUMAN	Homo sapiens ribosome binding protein 1 homolog 180kDa (dog) (RRBP1), transcript variant 2, mRNA.	889	41 X 10 AA approximate tandem repeats of [TN]-Q-[GSA]-[KRQT]-K-[ATGSV]-[ED]- [GTAS]-[ATIS]-[PQTAS].				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						TCACAGGTGACAGAGACAATCC	0.624													4	7	---	---	---	---