Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DSCAM	1826	broad.mit.edu	37	21	41711101	41711101	+	Silent	SNP	G	G	A			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr21:41711101G>A	uc002yyq.1	-	6	1904	c.1452C>T	c.(1450-1452)tgC>tgT	p.C484C	DSCAM_uc002yyr.1_Non-coding_Transcript	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Homo sapiens Down syndrome cell adhesion molecule (DSCAM), transcript variant 1, mRNA.	484	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGTTGGCAGTGCAGCGGTAGA	0.547000													22	44					0	0	1	0	0
MRPL41	64975	broad.mit.edu	37	9	140446894	140446894	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr9:140446894C>T	uc004cnh.4	+	1	491	c.361C>T	c.(361-363)Ccc>Tcc	p.P121S	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank|MRPL41_uc022bqj.1_Missense_Mutation_p.P121S	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	Homo sapiens mitochondrial ribosomal protein L41 (MRPL41), nuclear gene encoding mitochondrial protein, mRNA.	121					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(1)	2	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		CGGCTTCGAGCCCACACAGGA	0.602000													10	26					0	0	1	0	0
KAT2A	2648	broad.mit.edu	37	17	40269530	40269530	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr17:40269530C>T	uc002hyx.2	-	9	1573	c.1513G>A	c.(1513-1515)Ggc>Agc	p.G505S		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	Homo sapiens K(lysine) acetyltransferase 2A (KAT2A), mRNA.	505	N-acetyltransferase.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						AGTGAGTTGCCGATGACATGG	0.637000													21	29					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291666	33291666	+	Silent	SNP	A	A	G			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr14:33291666A>G	uc001wrq.3	+	12	4817	c.4647A>G	c.(4645-4647)acA>acG	p.T1549T		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 6 (AKAP6), mRNA.	1549					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TAGAAAAGACATTCACTGGCA	0.413000													8	123					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61039965	61039965	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr20:61039965G>A	uc002ycx.1	-	6	1183	c.1121C>T	c.(1120-1122)aCg>aTg	p.T374M		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	Homo sapiens GATA binding protein 5 (GATA5), mRNA.	374					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			GCTTGGGGCCGTGGAGGGGAA	0.677000													3	31					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41979174	41979174	+	Silent	SNP	G	G	A	rs141816288		TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr1:41979174G>A	uc001cgz.4	-	7	6931	c.5718C>T	c.(5716-5718)ccC>ccT	p.P1906P	HIVEP3_uc001cha.4_Silent_p.P1906P|HIVEP3_uc001cgy.3_Non-coding_Transcript	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	Homo sapiens human immunodeficiency virus type I enhancer binding protein 3 (HIVEP3), transcript variant 1, mRNA.	1906					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGCCAGAGGCGGGGGCATCTG	0.692000													8	7					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				25	50					0	0	1	0	0
CNN2	1265	broad.mit.edu	37	19	1037875	1037875	+	Nonsense_Mutation	SNP	C	C	G			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr19:1037875C>G	uc010xgc.2	+	6	1332	c.969C>G	c.(967-969)taC>taG	p.Y323*	ABCA7_uc002lqw.4_5'Flank|CNN2_uc002lqu.3_Nonsense_Mutation_p.Y302*|CNN2_uc002lqv.3_Nonsense_Mutation_p.Y263*|CNN2_uc010xgb.2_Nonsense_Mutation_p.Y291*|ABCA7_uc010dsa.3_5'Flank	NM_004368	NP_004359	Q99439	CNN2_HUMAN	Homo sapiens calponin 2 (CNN2), transcript variant 1, mRNA.	302					actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCCCCCTTACTACCAGGAGG	0.602000													27	62					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760593	92760596	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr7:92760593_92760596delTCTT	uc003umh.1	-	4	5905_5908	c.4689_4692delAAGA	c.(4687-4692)gaaagafs	p.E1563fs	SAMD9L_uc003umj.1_Frame_Shift_Del_p.E1563fs|SAMD9L_uc003umi.1_Frame_Shift_Del_p.E1563fs|SAMD9L_uc010lfb.1_Frame_Shift_Del_p.E1563fs|SAMD9L_uc003umk.1_Frame_Shift_Del_p.E1563fs|SAMD9L_uc010lfc.1_Frame_Shift_Del_p.E1563fs|SAMD9L_uc010lfd.1_Frame_Shift_Del_p.E1563fs|SAMD9L_uc022ahh.1_Frame_Shift_Del_p.E1563fs	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	Homo sapiens sterile alpha motif domain containing 9-like (SAMD9L), mRNA.	1563										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGAAAGACACTCTTTCTATGTTCC	0.343													20	31	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72827620	72827621	+	Frame_Shift_Ins	INS	-	-	T			TCGA-EL-A3CL-01A-11D-A19J-08	TCGA-EL-A3CL-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803f5ae9-126f-4e21-b3a0-881513ff137d	6ecb9b78-a40b-4bc9-b4cb-6687daeed335	g.chr16:72827620_72827621insT	uc002fck.3	-	8	9633_9634	c.8960_8961insA	c.(8959-8961)aagfs	p.K2987fs	ZFHX3_uc002fcl.3_Frame_Shift_Ins_p.K2073fs	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	2987					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GAACGACTCTCTTTGGCAGTCC	0.465													44	90	---	---	---	---