Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
XRN1	54464	broad.mit.edu	37	3	142133126	142133126	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr3:142133126G>A	uc003eus.3	-	13	1511	c.1444C>T	c.(1444-1446)Cct>Tct	p.P482S	XRN1_uc010huu.3_5'Flank|XRN1_uc003eut.3_Missense_Mutation_p.P482S|XRN1_uc003euu.3_Missense_Mutation_p.P482S|XRN1_uc003euv.1_Missense_Mutation_p.P343S	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	Homo sapiens 5'-3' exoribonuclease 1 (XRN1), transcript variant 1, mRNA.	482					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	Golgi apparatus|cytosol|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|RNA binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TAATGATAAGGATAATACCTA	0.294000													27	51					0	0	1	0	0
FAM222A	84915	broad.mit.edu	37	12	110206377	110206377	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr12:110206377G>A	uc001tpd.2	+	2	1205	c.643G>A	c.(643-645)Gcc>Acc	p.A215T	FAM222A-AS1_uc010sxs.2_Intron|FAM222A-AS1_uc001tpe.3_Intron	NM_032829	NP_116218	Q5U5X8	CL034_HUMAN	Homo sapiens chromosome 12 open reading frame 34 (C12orf34), mRNA.	215	Pro-rich.																GGCCCCGGGCGCCGCACCCCC	0.711000													6	71					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79683052	79683052	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr17:79683052G>A	uc010wut.2	+	8	988	c.856G>A	c.(856-858)Gtg>Atg	p.V286M	SLC25A10_uc002kbi.3_Missense_Mutation_p.V131M|SLC25A10_uc010dif.3_Missense_Mutation_p.V131M|SLC25A10_uc010wuu.2_Missense_Mutation_p.V85M	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	Homo sapiens solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (SLC25A10), nuclear gene encoding mitochondrial protein, mRNA.	131					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	GCAGAACGACGTGAAGCTGCC	0.701000													7	14					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095889	167095889	+	Silent	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr1:167095889G>A	uc001geb.1	+	4	1537	c.1521G>A	c.(1519-1521)agG>agA	p.R507R		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	Homo sapiens dual specificity phosphatase 27 (putative) (DUSP27), mRNA.	507					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CGGCAGACAGGAGCTCAGAAG	0.597000													22	51					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100504662	100504662	+	Silent	SNP	A	A	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr4:100504662A>C	uc011cej.2	+	2	475	c.462A>C	c.(460-462)ctA>ctC	p.L154L	MTTP_uc003hvc.4_Silent_p.L127L|MTTP_uc003hvb.3_Silent_p.L127L	NM_000253	NP_000244	P55157	MTP_HUMAN	Homo sapiens microsomal triglyceride transfer protein (MTTP), mRNA.	127	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TCCTTCATCTAATCCATGGAA	0.388000													4	78					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74003919	74003919	+	Silent	SNP	T	T	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr17:74003919T>C	uc010wss.1	-	21	5661	c.5433A>G	c.(5431-5433)tcA>tcG	p.S1811S	EVPL_uc002jqi.2_Silent_p.S1789S|EVPL_uc010wst.1_Silent_p.S1259S	NM_001988	NP_001979	Q92817	EVPL_HUMAN	Homo sapiens envoplakin (EVPL), mRNA.	1789	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CGATGGAGAGTGAGGAGCTTG	0.607000													4	74					0	0	1	0	0
ADAT1	23536	broad.mit.edu	37	16	75634205	75634205	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr16:75634205G>A	uc002feo.2	-	10	1587	c.1418C>T	c.(1417-1419)gCg>gTg	p.A473V	ADAT1_uc002fep.2_Missense_Mutation_p.A324V	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	Homo sapiens adenosine deaminase, tRNA-specific 1 (ADAT1), transcript variant 1, mRNA.	473	A to I editase.				tRNA processing		RNA binding|metal ion binding|tRNA-specific adenosine deaminase activity	p.A473V(2)		breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)	19						GTAAGAGGACGCAGCCTCCTT	0.532000													31	72					0	0	1	0	0
TCEAL3	85012	broad.mit.edu	37	X	102864558	102864558	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chrX:102864558G>A	uc004ekq.3	+	2	828	c.566G>A	c.(565-567)aGg>aAg	p.R189K	TCEAL3_uc004ekr.3_Missense_Mutation_p.R189K|TCEAL3_uc022cbu.1_Missense_Mutation_p.R189K	NM_001006933	NP_116315	Q969E4	TCAL3_HUMAN	Homo sapiens transcription elongation factor A (SII)-like 3 (TCEAL3), transcript variant 1, mRNA.	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	16						GGTGGAGGTAGGGGCCAGAGG	0.507000													12	190					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754115	76754115	+	Silent	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr18:76754115G>A	uc002lmt.3	+	1	2124	c.2124G>A	c.(2122-2124)aaG>aaA	p.K708K	SALL3_uc010dra.3_Silent_p.K315K	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	Homo sapiens sal-like 3 (Drosophila) (SALL3), mRNA.	708					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGCCGTTCAAGTGCAAGATCT	0.667000													27	37					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32371461	32371461	+	Missense_Mutation	SNP	C	C	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr13:32371461C>A	uc001utt.3	+	16	1981	c.1910C>A	c.(1909-1911)gCa>gAa	p.A637E	RXFP2_uc010aba.3_Missense_Mutation_p.A613E	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	Homo sapiens relaxin/insulin-like family peptide receptor 2 (RXFP2), transcript variant 1, mRNA.	637						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GTGGCTGTTGCAAATCGTTTC	0.398000													15	91					0	0	1	0	0
RSBN1L	222194	broad.mit.edu	37	7	77408244	77408244	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr7:77408244T>C	uc010ldt.1	+	7	2344	c.2300T>C	c.(2299-2301)gTg>gCg	p.V767A		NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	Homo sapiens round spermatid basic protein 1-like (RSBN1L), mRNA.	767						nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAAGAACCTGTGAATGTTAAT	0.308000													4	34					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4523617	4523617	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr19:4523617C>G	uc002mas.3	-	7	1368	c.1315G>C	c.(1315-1317)Ggg>Cgg	p.G439R		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	Homo sapiens perilipin 5 (PLIN5), mRNA.	439						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CAGATGTCCCCGGCAACACCC	0.692000											OREG0025168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	76	157					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90471411	90471411	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr6:90471411G>C	uc003pnn.1	-	16	2529	c.2413C>G	c.(2413-2415)Caa>Gaa	p.Q805E	MDN1_uc003pno.1_Missense_Mutation_p.Q223E	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	Homo sapiens MDN1, midasin homolog (yeast) (MDN1), mRNA.	805					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding	p.Q804H(1)		NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTCATCTGTTGTTGGGCATGG	0.328000													3	107					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189871146	189871146	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr2:189871146C>G	uc002uqj.1	+	42	3286	c.3169C>G	c.(3169-3171)Cca>Gca	p.P1057A		NM_000090	NP_000081	P02461	CO3A1_HUMAN	Homo sapiens collagen, type III, alpha 1 (COL3A1), mRNA.	1057	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TCCTGTCGGTCCAGCTGGAAA	0.488000													4	25					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33959841	33959841	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr1:33959841G>C	uc001bxj.4	+	7	2064	c.1897G>C	c.(1897-1899)Gaa>Caa	p.E633Q	ZSCAN20_uc009vui.3_Missense_Mutation_p.E632Q	NM_145238	NP_660281	P17040	ZSC20_HUMAN	Homo sapiens zinc finger and SCAN domain containing 20 (ZSCAN20), mRNA.	633					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GCATGAGGATGAAGACCAGAT	0.438000													13	40					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234569236	234569236	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr1:234569236T>C	uc001hwd.3	-	13	2314	c.2314A>G	c.(2314-2316)Agg>Ggg	p.R772G		NM_005646	NP_005637	Q13395	TARB1_HUMAN	Homo sapiens TAR (HIV-1) RNA binding protein 1 (TARBP1), mRNA.	772					RNA processing|regulation of transcription from RNA polymerase II promoter	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GGGTTACCCCTTTTCCACCCA	0.398000													3	63					0	0	1	0	0
CCDC106	29903	broad.mit.edu	37	19	56160648	56160648	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr19:56160648C>G	uc002qlr.3	+	2	844	c.109C>G	c.(109-111)Ctg>Gtg	p.L37V	CCDC106_uc021vcc.1_Missense_Mutation_p.L37V|CCDC106_uc021vcd.1_Missense_Mutation_p.L37V|CCDC106_uc002qls.3_Missense_Mutation_p.L37V	NM_013301	NP_037433	Q9BWC9	CC106_HUMAN	Homo sapiens coiled-coil domain containing 106 (CCDC106), mRNA.	37						nucleus				endometrium(2)|large_intestine(3)|lung(5)|skin(1)	11		Colorectal(82;0.00403)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CTTTTACAGTCTGAGCCCCTC	0.592000													3	150					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55964962	55964962	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr4:55964962C>T	uc003has.3	-	15	2577	c.2275G>A	c.(2275-2277)Gaa>Aaa	p.E759K	KDR_uc003hat.1_Missense_Mutation_p.E759K	NM_002253	NP_002244	P35968	VGFR2_HUMAN	Homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR), mRNA.	759					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|Hsp90 protein binding|growth factor binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTCGTCTTTTCCTGGGCACCT	0.408000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			4	55					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55341608	55341608	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr19:55341608G>A	uc021vbm.1	+	8	1246	c.1213G>A	c.(1213-1215)Gtt>Att	p.V405I	KIR3DL2_uc010yfj.2_Intron|KIR3DL2_uc010yfk.1_Intron|KIR3DL2_uc010esf.3_Missense_Mutation_p.V310I|KIR3DL2_uc021vbo.1_Missense_Mutation_p.V388I|KIR3DL2_uc002qhk.4_Missense_Mutation_p.V405I|KIR3DL2_uc002qhl.4_Intron|KIR3DL2_uc010esg.1_5'Flank|KIR3DL2_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43630	KI3L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1), mRNA.	405					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		GGATCACTGCGTTTTCACACA	0.507000													93	152					0	0	1	0	0
WIPF1	7456	broad.mit.edu	37	2	175446092	175446092	+	Missense_Mutation	SNP	C	C	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr2:175446092C>A	uc010fqt.1	-	2	291	c.127G>T	c.(127-129)Ggg>Tgg	p.G43W	BC046497_uc002uiw.3_Intron|BC046497_uc002uix.1_Intron|WIPF1_uc002uja.3_Missense_Mutation_p.G43W|WIPF1_uc002ujc.1_Missense_Mutation_p.G43W|WIPF1_uc002uiz.3_Missense_Mutation_p.G43W|WIPF1_uc002ujb.2_Missense_Mutation_p.G43W|WIPF1_uc010zep.1_Missense_Mutation_p.G43W	NM_003387	NP_003378	O43516	WIPF1_HUMAN	Homo sapiens WAS/WASL interacting protein family, member 1 (WIPF1), transcript variant 1, mRNA.	43	WH2.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						AGTTTCTTCCCTTTGCTGATA	0.438000													6	223					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42169608	42169608	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr17:42169608G>C	uc002iff.1	-	8	1299	c.967C>G	c.(967-969)Ccc>Gcc	p.P323A	HDAC5_uc002ifd.1_Missense_Mutation_p.P322A|HDAC5_uc002ife.1_Missense_Mutation_p.P322A|HDAC5_uc010czp.1_Missense_Mutation_p.P322A|HDAC5_uc002ifh.2_Missense_Mutation_p.P322A	NM_001015053	NP_001015053	Q9UQL6	HDAC5_HUMAN	Homo sapiens histone deacetylase 5 (HDAC5), transcript variant 3, mRNA.	322					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|histone deacetylase activity (H3-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		GAGCTGTTGGGAGAGCTGGGG	0.642000													3	97					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683629	159683629	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr1:159683629C>T	uc001ftw.3	-	1	465	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_Non-coding_Transcript	NM_000567	NP_000558	P02741	CRP_HUMAN	Homo sapiens C-reactive protein, pentraxin-related (CRP), mRNA.	121	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		Gram-positive bacterial cell surface binding|choline binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	ATCCCTGAGGCGGACTCCCAG	0.502000													41	184					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45392355	45392355	+	Missense_Mutation	SNP	T	T	G			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr15:45392355T>G	uc001zun.3	-	23	3280	c.3077A>C	c.(3076-3078)cAa>cCa	p.Q1026P	DUOX2_uc010bea.3_Missense_Mutation_p.Q1026P	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	Homo sapiens dual oxidase 2 (DUOX2), mRNA.	1026	Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	NAD(P)H oxidase activity|calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CTGCAGCTTTTGGGCTAGGAA	0.587000													3	78					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2407561	2407561	+	Silent	SNP	G	G	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chrX:2407561G>A	uc004cqh.2	-	1	1482	c.1200C>T	c.(1198-1200)ctC>ctT	p.L400L	DHRSX_uc004cqf.4_Intron|ZBED1_uc004cqg.2_Silent_p.L400L|ZBED1_uc022brw.1_Silent_p.L400L|ZBED1_uc022brx.1_Silent_p.L400L	NM_001171135	NP_004720	O96006	ZBED1_HUMAN	Homo sapiens zinc finger, BED-type containing 1 (ZBED1), transcript variant 3, mRNA.	400						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGGCTGCAGGAGCTCCACCA	0.637000													17	63					0	0	1	0	0
PDCD1LG2	80380	broad.mit.edu	37	9	5534909	5534909	+	Missense_Mutation	SNP	A	A	G			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr9:5534909A>G	uc011lmc.2	+	2	493	c.220A>G	c.(220-222)Act>Gct	p.T74A	PLGRKT_uc003zjd.3_Intron|PDCD1LG2_uc003zjg.4_Missense_Mutation_p.T74A|PDCD1LG2_uc011lmd.2_Missense_Mutation_p.T74A|PDCD1LG2_uc010mhp.1_Missense_Mutation_p.T74A|PDCD1LG2_uc010mho.1_Missense_Mutation_p.T74A	NM_025239	NP_079515	Q9BQ51	PD1L2_HUMAN	Homo sapiens programmed cell death 1 ligand 2 (PDCD1LG2), mRNA.	74	Ig-like V-type.				T cell costimulation|immune response	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(2)|lung(4)|prostate(2)	8	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		TGAAAGAGCCACTTTGCTGGA	0.493000													23	43					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				22	36					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24201264	24201264	+	Missense_Mutation	SNP	C	C	A			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr1:24201264C>A	uc001bif.3	-	1	971	c.844G>T	c.(844-846)Gct>Tct	p.A282S	CNR2_uc021oij.1_Missense_Mutation_p.A282S	NM_001841	NP_001832	P34972	CNR2_HUMAN	Homo sapiens cannabinoid receptor 2 (macrophage) (CNR2), mRNA.	282					G-protein signaling, coupled to cyclic nucleotide second messenger|behavior|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity	p.A282T(3)|p.A282A(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	GAGCAGAAAGCAAAGGCCTTC	0.577000													23	57					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263052	248263052	+	Silent	SNP	C	C	T			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr1:248263052C>T	uc001ids.3	+	2	712	c.375C>T	c.(373-375)atC>atT	p.I125I	OR2L13_uc021pmc.1_Silent_p.I125I	NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily L, member 13 (OR2L13), mRNA.	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.A124D(1)|p.A124T(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATTTGGCCATCTGCCACTCTC	0.502000													4	216					0	0	1	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117432306	117432306	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr7:117432306T>C	uc003vjf.3	-	3	1036	c.944A>G	c.(943-945)aAt>aGt	p.N315S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	Homo sapiens cortactin binding protein 2 (CTTNBP2), mRNA.	315										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GTGGTCAGCATTTTCTGTCAC	0.473000													5	243					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48459614	48459614	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr3:48459614G>C	uc003csw.2	-	14	3478	c.3208C>G	c.(3208-3210)Ccc>Gcc	p.P1070A	PLXNB1_uc003csu.2_Missense_Mutation_p.P887A|PLXNB1_uc003csx.2_Missense_Mutation_p.P1070A|PLXNB1_uc010hjx.1_Non-coding_Transcript|PLXNB1_uc003csy.1_5'Flank	NM_002673	NP_002664	O43157	PLXB1_HUMAN	Homo sapiens plexin B1 (PLXNB1), transcript variant 1, mRNA.	1070	IPT/TIG 1.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGGATGAGGGGCGCTGGGCAC	0.657000													3	21					0	0	1	0	0
abParts	0	broad.mit.edu	37	14	106733181	106733181	+	RNA	SNP	A	A	T			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr14:106733181A>T	uc021ser.1	-	876		c.21365T>A								Parts of antibodies, mostly variable regions.																		CTCAGATCTCAGGCTGCTCAG	0.527000													12	374					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154190917	154190918	+	Splice_Site	INS	-	-	T			TCGA-DE-A0XZ-01A-11D-A17V-08	TCGA-DE-A0XZ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f6212c4-e48b-4052-b894-e283ca951c97	4b0c366e-31db-4344-953e-454a4ec5fb73	g.chr5:154190917_154190918insT	uc003lvo.3	+	17	2746	c.2722_splice	c.e17+1	p.G908_splice	LARP1_uc021ygh.1_Splice_Site_p.G780_splice	NM_015315	NP_056130	Q6PKG0	LARP1_HUMAN	Homo sapiens La ribonucleoprotein domain family, member 1 (LARP1), transcript variant 1, mRNA.	985							RNA binding|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TATGAAGCTGGTAAGAGCCAGA	0.490													24	44	---	---	---	---