Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	ensembl_gene_id	tier	title	header	normal_ref_reads	normal_var_reads	normal_VAF	tumor_ref_reads	tumor_var_reads	tumor_VAF
AOAH	0	genome.wustl.edu	37	7	36713561	36713561	+	Missense_Mutation	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	7	36713561	36713561	C	A	SNP	AOAH	ENST00000258749	human	ensembl	74_37	-1	known	missense	c.277	p.D93Y	1.000	pfam_SapB_2,superfamily_Saposin-like,smart_SaposinB,pfscan_SaposinB	pfam_Lipase_GDSL,pfam_SapB_2,superfamily_Saposin-like,smart_SaposinB,pfscan_SaposinB	-	no_errors	AOAH	HGNC	ENSG00000136250	tier1	-	-	33	0	0.00	23	10	30.30
ARHGAP24	0	genome.wustl.edu	37	4	86916560	86916560	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	4	86916560	86916560	G	T	SNP	ARHGAP24	ENST00000395184	human	ensembl	74_37	+1	known	missense	c.1753	p.G585W	0.945	NULL	pfam_RhoGAP_dom,pfam_Pleckstrin_homology,superfamily_Rho_GTPase_activation_prot,smart_Pleckstrin_homology,smart_RhoGAP_dom,pfscan_Pleckstrin_homology,pfscan_RhoGAP_dom	-	no_errors	ARHGAP24	HGNC	ENSG00000138639	tier1	-	-	72	0	0.00	50	36	41.86
ATP6V1H	0	genome.wustl.edu	37	8	54745597	54745597	+	Missense_Mutation	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	8	54745597	54745597	T	C	SNP	ATP6V1H	ENST00000359530	human	ensembl	74_37	-1	known	missense	c.163	p.M55V	0.991	pfam_ATPase_V1-cplx_hsu,superfamily_ARM-type_fold,pirsf_ATPase_V1-cplx_hsu	pfam_ATPase_V1-cplx_hsu,pfam_ATPase_V1-cplx_hsu_C,superfamily_ARM-type_fold,pirsf_ATPase_V1-cplx_hsu	-	no_errors	ATP6V1H	HGNC	ENSG00000047249	tier1	-	-	212	0	0.00	187	45	19.40
ATP7A	0	genome.wustl.edu	37	X	77243898	77243898	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	77243898	77243898	C	T	SNP	ATP7A	ENST00000341514	human	ensembl	74_37	+1	known	missense	c.281	p.A94V	0.120	superfamily_HeavyMe-assoc_HMA	pfam_HeavyMe-assoc_HMA,pfam_ATPase_P-typ_transduc_dom_A,pfam_HAD-like_dom,superfamily_HAD-like_dom,superfamily_HeavyMe-assoc_HMA,pfscan_HeavyMe-assoc_HMA,prints_Cation_transp_P_typ_ATPase,prints_HG_scavenger,tigrfam_Cation_transp_P-typ_ATPase_IB,tigrfam_Cation_transp_P_typ_ATPase,tigrfam_HMA_Cu_ion-bd	-	no_errors	ATP7A	HGNC	ENSG00000165240	tier1	-	-	227	0	0.00	174	84	32.56
AVIL	0	genome.wustl.edu	37	12	58203433	58203433	+	Missense_Mutation	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	12	58203433	58203433	T	C	SNP	AVIL	ENST00000257861	human	ensembl	74_37	-1	known	missense	c.886	p.K296E	1.000	pfam_Gelsolin_dom,smart_Villin/Gelsolin	pfam_Gelsolin_dom,pfam_Villin_headpiece,superfamily_Villin_headpiece,smart_Villin/Gelsolin,smart_Villin_headpiece,pfscan_Villin_headpiece,prints_Villin/Gelsolin	-	no_errors	AVIL	HGNC	ENSG00000135407	tier1	-	-	117	0	0.00	56	11	16.42
B3GALTL	0	genome.wustl.edu	37	13	31903755	31903755	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	13	31903755	31903755	G	A	SNP	B3GALTL	ENST00000343307	human	ensembl	74_37	+1	known	missense	c.1447	p.E483K	0.011	NULL	pfam_Fringe-like	-	no_errors	B3GALTL	HGNC	ENSG00000187676	tier1	-	-	60	0	0.00	44	9	16.98
BCLAF1	0	genome.wustl.edu	37	6	136599142	136599142	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	6	136599142	136599142	G	T	SNP	BCLAF1	ENST00000531224	human	ensembl	74_37	-1	known	missense	c.877	p.H293N	1.000	NULL	NULL	-	no_errors	BCLAF1	HGNC	ENSG00000029363	tier1	-	-	80	0	0.00	77	13	14.44
CACHD1	0	genome.wustl.edu	37	1	65147712	65147712	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	1	65147712	65147712	C	T	SNP	CACHD1	ENST00000371073	human	ensembl	74_37	+1	known	missense	c.3509	p.A1170V	1.000	NULL	pfam_VWA_N,pfam_Cache_domain,pfscan_VWF_A	-	no_errors	CACHD1	HGNC	ENSG00000158966	tier1	-	-	58	0	0.00	29	18	37.50
CARD11	0	genome.wustl.edu	37	7	2984021	2984021	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	7	2984021	2984021	C	T	SNP	CARD11	ENST00000396946	human	ensembl	74_37	-1	known	missense	c.509	p.R170H	0.975	NULL	pfam_CARD,superfamily_DEATH-like_dom,superfamily_P-loop_NTPase,superfamily_PDZ,pfscan_CARD	-	no_errors	CARD11	HGNC	ENSG00000198286	tier1	-	-	87	0	0.00	58	34	36.96
CCDC127	0	genome.wustl.edu	37	5	205697	205697	+	Silent	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	205697	205697	G	T	SNP	CCDC127	ENST00000296824	human	ensembl	74_37	-1	known	silent	c.498	p.L166	0.000	NULL	NULL	-	no_errors	CCDC127	HGNC	ENSG00000164366	tier1	-	-	67	0	0.00	51	16	23.88
CCKBR	0	genome.wustl.edu	37	11	6290930	6290930	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	6290930	6290930	C	T	SNP	CCKBR	ENST00000525462	human	ensembl	74_37	+1	known	silent	c.183	p.Y61	0.738	prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Gastrin_rcpt,prints_Cholcskin_rcpt,prints_GPCR_Rhodpsn,prints_NPY_rcpt	-	no_errors	CCKBR	HGNC	ENSG00000110148	tier1	-	-	52	0	0.00	43	18	29.51
CCNF	0	genome.wustl.edu	37	16	2506773	2506773	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	16	2506773	2506773	G	A	SNP	CCNF	ENST00000397066	human	ensembl	74_37	+1	known	missense	c.2113	p.V705I	0.031	NULL	pfam_Cyclin_N,pfam_Cyclin_C-dom,pfam_F-box_dom,superfamily_Cyclin-like,superfamily_F-box_dom,smart_F-box_dom,smart_Cyclin-like,pfscan_F-box_dom	-	no_errors	CCNF	HGNC	ENSG00000162063	tier1	rs142923904	-	38	0	0.00	14	17	54.84
CDADC1	0	genome.wustl.edu	37	13	49852631	49852631	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	13	49852631	49852631	C	T	SNP	CDADC1	ENST00000251108	human	ensembl	74_37	+1	known	missense	c.1196	p.A399V	0.999	pfam_CMP_dCMP_Zn-bd,superfamily_Cytidine_deaminase-like	pfam_CMP_dCMP_Zn-bd,superfamily_Cytidine_deaminase-like	-	no_errors	CDADC1	HGNC	ENSG00000102543	tier1	-	-	115	0	0.00	58	60	50.42
CDH7	0	genome.wustl.edu	37	18	63527038	63527038	+	Missense_Mutation	SNP	A	A	G			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	18	63527038	63527038	A	G	SNP	CDH7	ENST00000323011	human	ensembl	74_37	+1	known	missense	c.1589	p.N530S	1.000	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin	pfam_Cadherin,pfam_Cadherin_cytoplasmic-dom,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	CDH7	HGNC	ENSG00000081138	tier1	-	-	50	0	0.00	20	15	40.54
CHERP	0	genome.wustl.edu	37	19	16640581	16640583	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	TGC	TGC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	16640581	16640583	TGC	-	DEL	CHERP	ENST00000546361	human	ensembl	74_37	-1	known	in_frame_del	c.1007_1005	p.Q339in_frame_del	1.000:1.000:1.000	NULL	pfam_Surp,pfam_G_patch_dom,pfam_RNA_pol_II-bd,superfamily_Surp,superfamily_ENTH_VHS,smart_Surp,smart_G_patch_dom,pfscan_Surp,pfscan_G_patch_dom	-	no_errors	CHERP	HGNC	ENSG00000085872	tier1			28	0	0.00	26	3	10.34
CNTRL	0	genome.wustl.edu	37	9	123900945	123900945	+	Silent	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	9	123900945	123900945	T	C	SNP	CNTRL	ENST00000238341	human	ensembl	74_37	+1	known	silent	c.2325	p.L775	0.079	superfamily_Prefoldin	pfam_Leu-rich_rpt,superfamily_Prefoldin,superfamily_tRNA-bd_arm,smart_Leu-rich_rpt_typical-subtyp	-	no_errors	CNTRL	HGNC	ENSG00000119397	tier1	-	-	60	0	0.00	54	37	40.66
COCH	0	genome.wustl.edu	37	14	31354625	31354625	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	14	31354625	31354625	G	T	SNP	COCH	ENST00000216361	human	ensembl	74_37	+1	known	missense	c.759	p.Q253H	1.000	pfam_VWF_A,smart_VWF_A,pfscan_VWF_A	pfam_VWF_A,pfam_LCCL,superfamily_LCCL,smart_LCCL,smart_VWF_A,pfscan_LCCL,pfscan_VWF_A	-	no_errors	COCH	HGNC	ENSG00000100473	tier1	-	-	54	0	0.00	41	11	21.15
CREB3L1	0	genome.wustl.edu	37	11	46321549	46321549	+	Missense_Mutation	SNP	A	A	G			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	46321549	46321549	A	G	SNP	CREB3L1	ENST00000288400	human	ensembl	74_37	+1	known	missense	c.166	p.S56G	1.000	NULL	pfam_bZIP,superfamily_TF_DNA-bd,smart_bZIP,pfscan_bZIP,prints_Leuzip_CREB	-	no_errors	CREB3L1	HGNC	ENSG00000157613				26	0	0.00	16	3	15.79
CTAG2	0	genome.wustl.edu	37	X	153880703	153880703	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	153880703	153880703	C	T	SNP	CTAG2	ENST00000247306	human	ensembl	74_37	-1	putative	missense	c.472	p.A158T	0.000	NULL	pfam_EKC/KEOPS_Pcc1	-	no_errors	CTAG2	HGNC	ENSG00000126890	tier1	-	-	49	0	0.00	36	19	33.93
CYB5R2	0	genome.wustl.edu	37	11	7690517	7690517	+	Missense_Mutation	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	7690517	7690517	T	C	SNP	CYB5R2	ENST00000299498	human	ensembl	74_37	-1	known	missense	c.307	p.T103A	1.000	pfam_OxRdtase_FAD-bd_dom,superfamily_Riboflavin_synthase-like_b-brl	pfam_OxRdtase_FAD-bd_dom,pfam_OxRdtase_FAD/NAD-bd,superfamily_Riboflavin_synthase-like_b-brl,prints_NADH-Cyt_B5_reductase,prints_Flavoprot_Pyr_Nucl_cyt_Rdtase	-	no_errors	CYB5R2	HGNC	ENSG00000166394	tier1	-	-	66	0	0.00	33	28	45.90
DOCK3	0	genome.wustl.edu	37	3	51370661	51370661	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	3	51370661	51370661	C	T	SNP	DOCK3	ENST00000266037	human	ensembl	74_37	+1	known	silent	c.3588	p.L1196	1.000	NULL	pfam_DOCK_C,pfam_SH3_2,superfamily_SH3_domain,superfamily_ARM-type_fold,smart_SH3_domain,pfscan_SH3_domain	-	no_errors	DOCK3	HGNC	ENSG00000088538	tier1	-	-	129	0	0.00	76	34	30.91
FABP6	0	genome.wustl.edu	37	5	159640782	159640782	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	159640782	159640782	C	T	SNP	FABP6	ENST00000393980	human	ensembl	74_37	+1	known	missense	c.91	p.R31W	0.413	NULL	superfamily_Calycin-like,prints_Fatty_acid-bd	-	no_errors	FABP6	HGNC	ENSG00000170231	tier1	-	-	43	0	0.00	28	12	30.00
FAM129B	0	genome.wustl.edu	37	9	130272485	130272485	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	9	130272485	130272485	C	T	SNP	FAM129B	ENST00000373312	human	ensembl	74_37	-1	known	silent	c.1101	p.K367	1.000	NULL	pfscan_Pleckstrin_homology	-	no_errors	FAM129B	HGNC	ENSG00000136830	tier1	-	-	81	0	0.00	69	9	11.54
FAM155B	0	genome.wustl.edu	37	X	68725671	68725672	+	Frame_Shift_Ins	INS	-	-	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	68725671	68725672	-	A	INS	FAM155B	ENST00000252338	human	ensembl	74_37	+1	known	frame_shift_ins	c.546_547	p.N184fs	1.000:0.996	NULL	NULL	-	no_errors	FAM155B	HGNC	ENSG00000130054	tier1			27	0	0.00	19	3	13.64
FAT4	0	genome.wustl.edu	37	4	126397344	126397344	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	4	126397344	126397344	G	A	SNP	FAT4	ENST00000394329	human	ensembl	74_37	+1	known	missense	c.12226	p.D4076N	1.000	pfam_Laminin_G,superfamily_ConA-like_lec_gl_sf,smart_Laminin_G,pfscan_Laminin_G	pfam_Cadherin,pfam_Laminin_G,pfam_EG-like_dom,pfam_EGF-like_Ca-bd_dom,superfamily_Cadherin-like,superfamily_ConA-like_lec_gl_sf,smart_Cadherin,smart_EG-like_dom,smart_EGF-like_Ca-bd_dom,smart_Laminin_G,pfscan_EG-like_dom,pfscan_Laminin_G,pfscan_Cadherin,prints_Cadherin	-	no_errors	FAT4	HGNC	ENSG00000196159	tier1	-	-	146	0	0.00	104	74	41.57
FGF9	0	genome.wustl.edu	37	13	22255231	22255231	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	13	22255231	22255231	G	A	SNP	FGF9	ENST00000382353	human	ensembl	74_37	+1	known	missense	c.328	p.V110M	1.000	pfam_Fibroblast_GF_fam,superfamily_Cytokine_IL1-like,smart_Fibroblast_GF_fam,prints_IL-1_fam/FGF_fam	pfam_Fibroblast_GF_fam,superfamily_Cytokine_IL1-like,smart_Fibroblast_GF_fam,prints_Fibroblast_GF_fam,prints_IL-1_fam/FGF_fam	-	no_errors	FGF9	HGNC	ENSG00000102678	tier1	-	-	11	0	0.00	13	9	40.91
FTMT	0	genome.wustl.edu	37	5	121188337	121188337	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	121188337	121188337	G	A	SNP	FTMT	ENST00000321339	human	ensembl	74_37	+1	known	missense	c.679	p.E227K	0.998	superfamily_Ferritin-like_SF	pfam_Ferritin_DPS_dom,superfamily_Ferritin-like_SF,pfscan_Ferritin-like_diiron	-	no_errors	FTMT	HGNC	ENSG00000181867	tier1	-	-	108	0	0.00	97	20	17.09
GJB7	0	genome.wustl.edu	37	6	87993987	87993987	+	Nonsense_Mutation	SNP	A	A	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	6	87993987	87993987	A	T	SNP	GJB7	ENST00000296882	human	ensembl	74_37	-1	known	nonsense	c.644	p.L215*	0.000	NULL	pfam_Connexin_N,pfam_Connexin_CCC,smart_Connexin_N,prints_Connexin	-	no_errors	GJB7	HGNC	ENSG00000164411	tier1	-	-	66	0	0.00	46	16	25.81
GNLY	0	genome.wustl.edu	37	2	85924683	85924683	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	2	85924683	85924683	C	T	SNP	GNLY	ENST00000263863	human	ensembl	74_37	+1	known	missense	c.310	p.R104C	0.000	pfam_SapB_2,superfamily_Saposin-like,smart_SaposinB,pfscan_SaposinB	pfam_SapB_2,superfamily_Saposin-like,smart_SaposinB,pfscan_SaposinB	-	no_errors	GNLY	HGNC	ENSG00000115523	tier1	-	-	48	0	0.00	42	16	27.59
GOLGA8I	0	genome.wustl.edu	37	15	23261866	23261866	+	Silent	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	15	23261866	23261866	C	A	SNP	GOLGA8I	ENST00000450802	human	ensembl	74_37	+1	known	silent	c.978	p.V326	0.972	NULL	NULL	-	no_errors	GOLGA8I	HGNC	ENSG00000153666	tier1	-	-	63	0	0.00	65	11	14.47
GPR18	0	genome.wustl.edu	37	13	99907713	99907713	+	Silent	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	13	99907713	99907713	G	A	SNP	GPR18	ENST00000340807	human	ensembl	74_37	-1	known	silent	c.414	p.A138	0.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	-	no_errors	GPR18	HGNC	ENSG00000125245	tier1	-	-	59	0	0.00	44	7	13.73
GPRASP1	0	genome.wustl.edu	37	X	101909790	101909790	+	Missense_Mutation	SNP	T	T	G			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	101909790	101909790	T	G	SNP	GPRASP1	ENST00000361600	human	ensembl	74_37	+1	known	missense	c.949	p.F317V	0.160	NULL	pfam_ARM-rpt_dom,superfamily_ARM-type_fold	-	no_errors	GPRASP1	HGNC	ENSG00000198932	tier1	-	-	90	0	0.00	15	80	84.21
HGS	0	genome.wustl.edu	37	17	79662908	79662908	+	Silent	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	17	79662908	79662908	G	A	SNP	HGS	ENST00000329138	human	ensembl	74_37	+1	known	silent	c.1272	p.K424	1.000	pfam_HRS_helical,pirsf_Ubi-bd_Hrs_VPS27	pfam_VHS,pfam_HRS_helical,pfam_Znf_FYVE,superfamily_ENTH_VHS,superfamily_Znf_FYVE_PHD,smart_VHS_subgr,smart_Znf_FYVE,pirsf_Ubi-bd_Hrs_VPS27,pfscan_Ubiquitin-int_motif,pfscan_VHS,pfscan_Znf_FYVE-rel	-	no_errors	HGS	HGNC	ENSG00000185359	tier1	-	-	39	0	0.00	28	15	34.88
HNRNPUL2	0	genome.wustl.edu	37	11	62491803	62491803	+	Nonsense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	62491803	62491803	G	A	SNP	HNRNPUL2	ENST00000301785	human	ensembl	74_37	-1	known	nonsense	c.634	p.R212*	1.000	superfamily_ConA-like_lec_gl_sf	pfam_SPRY_rcpt,pfam_SAP_dom,pfam_Zeta_toxin_domain,pfam_Chromatin_KTI12,superfamily_ConA-like_lec_gl_sf,superfamily_P-loop_NTPase,smart_SAP_dom,smart_SPla/RYanodine_receptor_subgr,pfscan_B30.2/SPRY,pfscan_SAP_dom	-	no_errors	HNRNPUL2	HGNC	ENSG00000214753	tier1	-	-	110	0	0.00	81	21	20.59
HPX	0	genome.wustl.edu	37	11	6458345	6458345	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	6458345	6458345	G	A	SNP	HPX	ENST00000265983	human	ensembl	74_37	-1	known	missense	c.766	p.R256C	0.632	superfamily_Hemopexin-like_dom,pirsf_Hemopexin_chordata	pfam_Hemopexin-like_repeat,superfamily_Hemopexin-like_dom,smart_Hemopexin-like_repeat,pirsf_Hemopexin_chordata	-	no_errors	HPX	HGNC	ENSG00000110169	tier1	-	-	33	0	0.00	18	15	45.45
HYDIN	0	genome.wustl.edu	37	16	70863531	70863531	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	16	70863531	70863531	C	T	SNP	HYDIN	ENST00000393567	human	ensembl	74_37	-1	putative	missense	c.14102	p.R4701H	0.992	NULL	superfamily_P-loop_NTPase,superfamily_PapD-like	-	no_errors	HYDIN	HGNC	ENSG00000157423	tier1	-	-	21	0	0.00	13	5	27.78
KALRN	0	genome.wustl.edu	37	3	124438079	124438079	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	3	124438079	124438079	G	A	SNP	KALRN	ENST00000360013	human	ensembl	74_37	+1	known	missense	c.8723	p.S2908N	1.000	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_DH-domain,pfam_Prot_kinase_dom,pfam_Spectrin_repeat,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Ig_V-set,pfam_Immunoglobulin,superfamily_Kinase-like_dom,superfamily_DH-domain,superfamily_Fibronectin_type3,superfamily_SH3_domain,superfamily_CRAL-TRIO_dom,smart_CRAL-TRIO_dom,smart_Spectrin/alpha-actinin,smart_DH-domain,smart_Pleckstrin_homology,smart_SH3_domain,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_CRAL-TRIO_dom,pfscan_Fibronectin_type3,pfscan_Pleckstrin_homology,pfscan_SH3_domain,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,pfscan_DH-domain	-	no_errors	KALRN	HGNC	ENSG00000160145	tier1	-	-	57	0	0.00	25	37	59.68
KCND2	0	genome.wustl.edu	37	7	119915481	119915481	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	7	119915481	119915481	C	T	SNP	KCND2	ENST00000331113	human	ensembl	74_37	+1	known	silent	c.795	p.I265	0.956	pfam_Ion_trans_dom,prints_K_chnl	pfam_K_chnl_volt-dep_Kv4_C,pfam_T1-type_BTB,pfam_Ion_trans_dom,pfam_Shal-type,pfam_2pore_dom_K_chnl_dom,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,prints_K_chnl,prints_K_chnl_volt-dep_Kv4,prints_K_chnl_volt-dep_Kv4.2,prints_K_chnl_volt-dep_Kv,prints_K_chnl_volt-dep_Kv3	-	no_errors	KCND2	HGNC	ENSG00000184408	tier1	-	-	51	0	0.00	44	14	24.14
KIAA1024	0	genome.wustl.edu	37	15	79760594	79760594	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	15	79760594	79760594	C	T	SNP	KIAA1024	ENST00000305428	human	ensembl	74_37	+1	known	silent	c.2619	p.Y873	0.996	pfam_UPF0258	pfam_UPF0258	-	no_errors	KIAA1024	HGNC	ENSG00000169330	tier1	-	-	44	0	0.00	27	8	22.86
KIAA1522	0	genome.wustl.edu	37	1	33236678	33236679	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	TA	TA					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	1	33236678	33236679	TA	-	DEL	KIAA1522	ENST00000401073	human	ensembl	74_37	+1	known	frame_shift_del	c.1898_1899	p.C634fs	0.257:0.244	NULL	NULL	-	no_errors	KIAA1522	HGNC	ENSG00000162522	tier1			55	0	0.00	24	25	51.02
KIF26B	0	genome.wustl.edu	37	1	245851229	245851231	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	CAG	CAG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	1	245851229	245851231	CAG	-	DEL	KIF26B	ENST00000407071	human	ensembl	74_37	+1	known	in_frame_del	c.4944_4946	p.S1652in_frame_del	0.206:0.210:0.240	NULL	pfam_Kinesin_motor_dom,superfamily_P-loop_NTPase,smart_Kinesin_motor_dom,pfscan_Kinesin_motor_dom,prints_Kinesin_motor_dom	-	no_errors	KIF26B	HGNC	ENSG00000162849	tier1			10	0	0.00	12	2	14.29
KLHL25	0	genome.wustl.edu	37	15	86311422	86311422	+	Silent	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	15	86311422	86311422	G	A	SNP	KLHL25	ENST00000337975	human	ensembl	74_37	-1	known	silent	c.1620	p.L540	0.992	pfam_Kelch_1,smart_Kelch_1,pirsf_Kelch-like_gigaxonin	pfam_Kelch_1,pfam_BACK,pfam_BTB_POZ,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,smart_BACK,smart_Kelch_1,pirsf_Kelch-like_gigaxonin,pfscan_BTB/POZ-like	-	no_errors	KLHL25	HGNC	ENSG00000183655	tier1	-	-	72	0	0.00	63	11	14.86
KPNA6	0	genome.wustl.edu	37	1	32573735	32573735	+	Missense_Mutation	SNP	G	G	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	1	32573735	32573735	G	C	SNP	KPNA6	ENST00000373625	human	ensembl	74_37	+1	known	missense	c.4	p.E2Q	1.000	pfscan_Importin-a_IBB	pfam_Armadillo,pfam_Importin-a_IBB,pfam_HEAT,superfamily_ARM-type_fold,smart_Armadillo,pfscan_Armadillo,pfscan_Importin-a_IBB	-	no_errors	KPNA6	HGNC	ENSG00000025800	tier1	-	-	105	0	0.00	55	17	23.29
KRAS	0	genome.wustl.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	12	25398284	25398284	C	A	SNP	KRAS	ENST00000256078	human	ensembl	74_37	-1	known	missense	c.35	p.G12V	1.000	pfam_Small_GTPase,pfam_MIRO-like,pfam_Small_GTPase_ARF/SAR,superfamily_P-loop_NTPase,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,smart_Ran_GTPase,prints_Small_GTPase,tigrfam_Small_GTP-bd_dom	pfam_Small_GTPase,pfam_MIRO-like,pfam_Small_GTPase_ARF/SAR,pfam_EF_GTP-bd_dom,superfamily_P-loop_NTPase,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,smart_Ran_GTPase,prints_Small_GTPase,tigrfam_Small_GTP-bd_dom	-	no_errors	KRAS	HGNC	ENSG00000133703	tier1	rs121913529	-	73	0	0.00	47	20	29.85
LHX3	0	genome.wustl.edu	37	9	139091542	139091542	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	9	139091542	139091542	C	T	SNP	LHX3	ENST00000371746	human	ensembl	74_37	-1	known	missense	c.451	p.E151K	1.000	pfam_Znf_LIM,pfscan_Znf_LIM	pfam_Znf_LIM,pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Znf_LIM,smart_Homeobox_dom,pfscan_Znf_LIM,pfscan_Homeobox_dom	-	no_errors	LHX3	HGNC	ENSG00000107187	tier1	-	-	57	0	0.00	58	15	20.55
LOC220729	0	genome.wustl.edu	37	3	197349143	197349143	+	RNA	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	3	197349143	197349143	T	C	SNP	LOC220729	ENST00000414207	human	ensembl	74_37	-1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	AC024560.3	Clone_based_vega_gene	ENSG00000214135	tier1	rs202141824	-	25	0	0.00	21	5	19.23
LRRC18	0	genome.wustl.edu	37	10	50121980	50121980	+	Missense_Mutation	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	10	50121980	50121980	T	C	SNP	LRRC18	ENST00000374160	human	ensembl	74_37	-1	known	missense	c.221	p.N74S	0.995	pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp	pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp	-	no_errors	LRRC18	HGNC	ENSG00000165383	tier1	-	-	60	0	0.00	9	27	75.00
LRTM1	0	genome.wustl.edu	37	3	54952554	54952554	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	3	54952554	54952554	G	T	SNP	LRTM1	ENST00000273286	human	ensembl	74_37	-1	known	missense	c.970	p.P324T	0.001	NULL	pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp,smart_Cys-rich_flank_reg_C	-	no_errors	LRTM1	HGNC	ENSG00000144771	tier1	-	-	143	0	0.00	121	43	26.22
MAGIX	0	genome.wustl.edu	37	X	49021421	49021421	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	49021421	49021421	G	A	SNP	MAGIX	ENST00000412696	human	ensembl	74_37	+1	known	missense	c.500	p.R167H	0.132	pfam_PDZ,superfamily_PDZ,smart_PDZ,pfscan_PDZ	pfam_PDZ,superfamily_PDZ,smart_PDZ,pfscan_PDZ	-	no_errors	MAGIX	HGNC	ENSG00000017621	tier1	-	-	21	0	0.00	20	8	28.57
MAP2	0	genome.wustl.edu	37	2	210560819	210560819	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	2	210560819	210560819	G	A	SNP	MAP2	ENST00000360351	human	ensembl	74_37	+1	known	missense	c.3925	p.V1309M	1.000	pfam_MAP2_projctn	pfam_MAP2_projctn,pfam_MAP_tubulin-bd_rpt	-	no_errors	MAP2	HGNC	ENSG00000078018	tier1	-	-	77	0	0.00	69	16	18.82
MCM10	0	genome.wustl.edu	37	10	13217565	13217565	+	Silent	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	10	13217565	13217565	G	T	SNP	MCM10	ENST00000484800	human	ensembl	74_37	+1	known	silent	c.651	p.T217	0.000	NULL	pfam_Rep_factor_Mcm10,pfam_Znf_Mcm10/DnaG	-	no_errors	MCM10	HGNC	ENSG00000065328	tier1	-	-	98	0	0.00	15	55	78.57
MLIP	0	genome.wustl.edu	37	6	53989365	53989365	+	Missense_Mutation	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	6	53989365	53989365	T	C	SNP	MLIP	ENST00000274897	human	ensembl	74_37	+1	known	missense	c.314	p.I105T	0.006	NULL	NULL	-	no_errors	MLIP	HGNC	ENSG00000146147	tier1	-	-	54	0	0.00	70	11	13.58
MOGAT2	0	genome.wustl.edu	37	11	75429008	75429010	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	CTC	CTC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	75429008	75429010	CTC	-	DEL	MOGAT2	ENST00000198801	human	ensembl	74_37	+1	known	in_frame_del	c.75_77	p.S26in_frame_del	0.996:0.826:0.679	NULL	pfam_DAGAT	-	no_errors	MOGAT2	HGNC	ENSG00000166391	tier1			54	0	0.00	26	8	23.53
MUC6	0	genome.wustl.edu	37	11	1016374	1016377	+	Frame_Shift_Del	DEL	AAGA	AAGA	-			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	AAGA	AAGA					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	1016374	1016377	AAGA	-	DEL	MUC6	ENST00000421673	human	ensembl	74_37	-1	known	frame_shift_del	c.6427_6424	p.S2142fs	0.000:0.000:0.002:0.002	NULL	pfam_VWF_type-D,pfam_Unchr_dom_Cys-rich,pfam_TIL_dom,superfamily_TIL_dom,smart_VWF_type-D,smart_Unchr_dom_Cys-rich,smart_VWC_out,smart_Cys_knot_C,pfscan_Cys_knot_C	-	no_errors	MUC6	HGNC	ENSG00000184956	tier1			26	0	0.00	22	11	33.33
MYH9	0	genome.wustl.edu	37	22	36684790	36684790	+	Missense_Mutation	SNP	T	T	G			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	22	36684790	36684790	T	G	SNP	MYH9	ENST00000216181	human	ensembl	74_37	-1	known	missense	c.4753	p.K1585Q	1.000	pfam_Myosin_tail	pfam_Myosin_head_motor_dom,pfam_Myosin_tail,pfam_Myosin_N,pfam_IQ_motif_EF-hand-BS,superfamily_P-loop_NTPase,superfamily_Regulat_G_prot_signal_superfam,superfamily_Prefoldin,superfamily_Myosin_S1_N,superfamily_STAT_TF_coiled-coil,superfamily_tRNA-bd_arm,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH9	HGNC	ENSG00000100345	tier1	rs149169068	-	165	0	0.00	25	54	66.67
NALCN-AS1	0	genome.wustl.edu	37	13	101710438	101710438	+	RNA	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	13	101710438	101710438	G	A	SNP	NALCN-AS1	ENST00000457843	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	NALCN-AS1	HGNC	ENSG00000233009				41	0	0.00	30	4	11.76
NDFIP1	0	genome.wustl.edu	37	5	141511421	141511421	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	141511421	141511421	G	T	SNP	NDFIP1	ENST00000253814	human	ensembl	74_37	+1	known	missense	c.112	p.A38S	1.000	NULL	pfam_NEDD4/BSD2	-	no_errors	NDFIP1	HGNC	ENSG00000131507	tier1	-	-	164	0	0.00	85	56	39.72
OBFC1	0	genome.wustl.edu	37	10	105659870	105659870	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	10	105659870	105659870	C	T	SNP	OBFC1	ENST00000224950	human	ensembl	74_37	-1	known	missense	c.407	p.G136D	0.989	pfam_NA-bd_OB_tRNA,superfamily_NA-bd_OB-fold,pirsf_CST_STN1	pfam_CST_STN1_C,pfam_NA-bd_OB_tRNA,superfamily_NA-bd_OB-fold,pirsf_CST_STN1	-	no_errors	OBFC1	HGNC	ENSG00000107960	tier1	-	-	114	0	0.00	56	30	34.88
OPRM1	0	genome.wustl.edu	37	6	154360838	154360838	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	6	154360838	154360838	C	T	SNP	OPRM1	ENST00000434900	human	ensembl	74_37	+1	known	silent	c.438	p.G146	0.791	prints_Mu_opioid_rcpt	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfam_7TM_GPCR_serpentine_rcpt_Srx,pfscan_GPCR_Rhodpsn_7TM,prints_Mu_opioid_rcpt,prints_GPCR_Rhodpsn,prints_Opioid_rcpt,prints_Somatstn_rcpt,prints_Neuropept_B/W_rcpt,prints_NPY_rcpt	-	no_errors	OPRM1	HGNC	ENSG00000112038	tier1	-	-	38	0	0.00	27	10	27.03
OR13C4	0	genome.wustl.edu	37	9	107288928	107288928	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	9	107288928	107288928	G	A	SNP	OR13C4	ENST00000277216	human	ensembl	74_37	-1	known	missense	c.563	p.A188V	0.142	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR13C4	HGNC	ENSG00000148136	tier1	-	-	71	0	0.00	77	12	13.48
OR2T5	0	genome.wustl.edu	37	1	248651905	248651905	+	Missense_Mutation	SNP	A	A	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	1	248651905	248651905	A	T	SNP	OR2T5	ENST00000366473	human	ensembl	74_37	+1	known	missense	c.16	p.R6W	0.000	NULL	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR2T5	HGNC	ENSG00000203661	tier1	rs199833498	-	12	0	0.00	7	7	50.00
OR4C15	0	genome.wustl.edu	37	11	55322504	55322504	+	Missense_Mutation	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	55322504	55322504	C	A	SNP	OR4C15	ENST00000314644	human	ensembl	74_37	+1	known	missense	c.722	p.A241D	0.998	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4C15	HGNC	ENSG00000181939	tier1	-	-	21	0	0.00	16	8	33.33
OR7E24	0	genome.wustl.edu	37	19	9361867	9361867	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	9361867	9361867	C	T	SNP	OR7E24	ENST00000456448	human	ensembl	74_37	+1	known	silent	c.148	p.L50	0.001	prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR7E24	HGNC	ENSG00000237521	tier1	-	-	58	0	0.00	14	40	74.07
PAM	0	genome.wustl.edu	37	5	102309945	102309945	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	102309945	102309945	G	T	SNP	PAM	ENST00000304400	human	ensembl	74_37	+1	known	missense	c.1288	p.V430F	1.000	NULL	pfam_NHL_repeat,pfam_Cu2_ascorb_mOase_N,superfamily_PHM/PNGase_F_dom,pfscan_NHL_repeat_subgr,prints_Pep_amidat_mOase	-	no_errors	PAM	HGNC	ENSG00000145730	tier1	-	-	78	0	0.00	80	13	13.98
PCTP	0	genome.wustl.edu	37	17	53851152	53851152	+	Frame_Shift_Del	DEL	G	G	-			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	17	53851152	53851152	G	-	DEL	PCTP	ENST00000268896	human	ensembl	74_37	+1	known	frame_shift_del	c.407	p.S137fs	0.996	pfam_START_lipid-bd_dom,smart_START_lipid-bd_dom,pfscan_START_lipid-bd_dom	pfam_START_lipid-bd_dom,smart_START_lipid-bd_dom,pfscan_START_lipid-bd_dom	-	no_errors	PCTP	HGNC	ENSG00000141179	tier1			26	0	0.00	25	2	7.41
PLD1	0	genome.wustl.edu	37	3	171427373	171427373	+	Silent	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	3	171427373	171427373	G	A	SNP	PLD1	ENST00000351298	human	ensembl	74_37	-1	known	silent	c.1038	p.I346	0.994	pirsf_PLipase_D_euk	pfam_Phox,pfam_PLipase_D/transphosphatidylase,pfam_Pleckstrin_homology,superfamily_Phox,smart_Phox,smart_Pleckstrin_homology,smart_PLipase_D/transphosphatidylase,pirsf_PLipase_D_euk,pfscan_Phox,pfscan_PLipase_D/transphosphatidylase	-	no_errors	PLD1	HGNC	ENSG00000075651	tier1	-	-	87	0	0.00	46	19	29.23
PLEKHG4B	0	genome.wustl.edu	37	5	169623	169623	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	169623	169623	C	T	SNP	PLEKHG4B	ENST00000283426	human	ensembl	74_37	+1	known	silent	c.2577	p.H859	0.020	pfam_DH-domain,superfamily_DH-domain,smart_DH-domain,pfscan_DH-domain	pfam_DH-domain,superfamily_DH-domain,superfamily_CRAL-TRIO_dom,smart_DH-domain,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology,pfscan_DH-domain	-	no_errors	PLEKHG4B	HGNC	ENSG00000153404	tier1	-	-	97	0	0.00	74	35	32.11
POSTN	0	genome.wustl.edu	37	13	38145443	38145443	+	RNA	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	13	38145443	38145443	C	A	SNP	POSTN	ENST00000497145	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	POSTN	HGNC	ENSG00000133110	tier1	-	-	42	0	0.00	31	25	44.64
POSTN	0	genome.wustl.edu	37	13	38145444	38145444	+	RNA	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	13	38145444	38145444	C	A	SNP	POSTN	ENST00000497145	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	POSTN	HGNC	ENSG00000133110	tier1	-	-	45	0	0.00	31	25	44.64
PRDM8	0	genome.wustl.edu	37	4	81123252	81123252	+	Missense_Mutation	SNP	G	G	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	4	81123252	81123252	G	C	SNP	PRDM8	ENST00000339711	human	ensembl	74_37	+1	known	missense	c.636	p.Q212H	0.000	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	PRDM8	HGNC	ENSG00000152784				58	0	0.00	46	3	6.12
PRLR	0	genome.wustl.edu	37	5	35084585	35084585	+	Silent	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	35084585	35084585	G	A	SNP	PRLR	ENST00000382002	human	ensembl	74_37	-1	known	silent	c.360	p.D120	0.998	pfam_Growth/epo_recpt_lig-bind,superfamily_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Growth/epo_recpt_lig-bind,pfam_IL-6_rcpt_alpha-bd,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	-	no_errors	PRLR	HGNC	ENSG00000113494	tier1	-	-	155	0	0.00	108	75	40.98
PRR12	0	genome.wustl.edu	37	19	50128134	50128134	+	Nonsense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	50128134	50128134	G	T	SNP	PRR12	ENST00000418929	human	ensembl	74_37	+1	novel	nonsense	c.5755	p.E1919*	1.000	NULL	NULL	-	no_errors	PRR12	HGNC	ENSG00000126464	tier1	-	-	52	0	0.00	61	11	15.28
PTPRJ	0	genome.wustl.edu	37	11	48166372	48166372	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	48166372	48166372	C	T	SNP	PTPRJ	ENST00000418331	human	ensembl	74_37	+1	known	silent	c.2721	p.D907	0.000	smart_Fibronectin_type3	pfam_Tyr_Pase_rcpt/non-rcpt,pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,smart_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pfscan_Fibronectin_type3,pfscan_Tyr/Dual-sp_Pase,pfscan_Tyr_Pase_rcpt/non-rcpt,prints_Tyr_Pase_rcpt/non-rcpt	-	no_errors	PTPRJ	HGNC	ENSG00000149177	tier1	-	-	119	0	0.00	120	41	25.47
RTN4IP1	0	genome.wustl.edu	37	6	107076789	107076789	+	Silent	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	6	107076789	107076789	G	T	SNP	RTN4IP1	ENST00000369063	human	ensembl	74_37	-1	known	silent	c.108	p.T36	0.237	NULL	pfam_ADH_C,pfam_ADH_GroES-like,superfamily_GroES-like,smart_PKS_ER	-	no_errors	RTN4IP1	HGNC	ENSG00000130347	tier1	-	-	101	0	0.00	73	21	22.11
SEMA3A	0	genome.wustl.edu	37	7	83643593	83643593	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	7	83643593	83643593	G	T	SNP	SEMA3A	ENST00000265362	human	ensembl	74_37	-1	known	missense	c.742	p.R248S	1.000	pfam_Semap_dom,superfamily_Semap_dom,smart_Semap_dom,pfscan_Semap_dom	pfam_Semap_dom,superfamily_Semap_dom,superfamily_Plexin-like_fold,smart_Semap_dom,smart_Plexin-like_fold,smart_Ig_sub,pfscan_Semap_dom,pfscan_Ig-like_dom	-	no_errors	SEMA3A	HGNC	ENSG00000075213	tier1	-	-	98	0	0.00	105	22	17.32
SGPP2	0	genome.wustl.edu	37	2	223423347	223423347	+	Missense_Mutation	SNP	T	T	G			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	2	223423347	223423347	T	G	SNP	SGPP2	ENST00000321276	human	ensembl	74_37	+1	known	missense	c.930	p.I310M	0.015	NULL	pfam_P_Acid_Pase_2/haloperoxidase,superfamily_P_Acid_Pase_2/haloperoxidase,smart_P_Acid_Pase_2/haloperoxidase	-	no_errors	SGPP2	HGNC	ENSG00000163082	tier1	-	-	39	0	0.00	28	16	36.36
STK11	0	genome.wustl.edu	37	19	1207203	1207203	+	Splice_Site	SNP	G	G	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	1207203	1207203	G	C	SNP	STK11	ENST00000326873	human	ensembl	74_37	+1	known	splice_site	c.290+1	e1+1	1.000	-	-	-	no_errors	STK11	HGNC	ENSG00000118046	tier1	-	-	12	0	0.00	1	4	80.00
STXBP5L	0	genome.wustl.edu	37	3	121097589	121097589	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	3	121097589	121097589	C	T	SNP	STXBP5L	ENST00000273666	human	ensembl	74_37	+1	known	missense	c.2275	p.P759S	1.000	NULL	pfam_LLGL2,pfam_WD40_repeat,pfam_Lgl_C_dom,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom,pfscan_Synaptobrevin,prints_Lethal2_giant	-	no_errors	STXBP5L	HGNC	ENSG00000145087	tier1	-	-	45	0	0.00	51	18	26.09
TAF1L	0	genome.wustl.edu	37	9	32630702	32630702	+	Missense_Mutation	SNP	A	A	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	9	32630702	32630702	A	T	SNP	TAF1L	ENST00000242310	human	ensembl	74_37	-1	known	missense	c.4876	p.Y1626N	1.000	pirsf_TAF1_animal,superfamily_Bromodomain,smart_Bromodomain	pirsf_TAF1_animal,pfam_TFIID_sub1_DUF3591,pfam_Bromodomain,pfam_TAF_II_230-bd,superfamily_Bromodomain,superfamily_TAF_II_230-bd,smart_Bromodomain,prints_Bromodomain,pfscan_Bromodomain	-	no_errors	TAF1L	HGNC	ENSG00000122728	tier1	-	-	134	0	0.00	19	21	52.50
TCOF1	0	genome.wustl.edu	37	5	149748319	149748319	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	5	149748319	149748319	C	T	SNP	TCOF1	ENST00000451292	human	ensembl	74_37	+1	known	missense	c.419	p.P140L	0.013	NULL	pfam_TCS_treacle,smart_LisH_dimerisation,pfscan_LisH_dimerisation,prints_Treacle-like_TCS	-	no_errors	TCOF1	HGNC	ENSG00000070814	tier1	-	-	31	0	0.00	20	25	55.56
TDGF1P3	0	genome.wustl.edu	37	X	109764857	109764857	+	RNA	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	109764857	109764857	C	A	SNP	TDGF1P3	ENST00000602699	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	TDGF1P3	HGNC	ENSG00000225366	tier1	-	-	25	0	0.00	20	17	45.95
TEX11	0	genome.wustl.edu	37	X	70080718	70080718	+	Nonsense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	70080718	70080718	G	A	SNP	TEX11	ENST00000344304	human	ensembl	74_37	-1	known	nonsense	c.358	p.R120*	0.812	NULL	pfam_Meiosis_specific_SPO22,smart_TPR_repeat	-	no_errors	TEX11	HGNC	ENSG00000120498	tier1	-	-	15	0	0.00	10	11	52.38
TIE1	0	genome.wustl.edu	37	1	43779725	43779726	+	RNA	DEL	TG	TG	-			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	TG	TG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	1	43779725	43779726	TG	-	DEL	TIE1	ENST00000471187	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002:0.002	-	-	-	no_errors	TIE1	HGNC	ENSG00000066056	tier1			8	0	0.00	2	2	50.00
TIGD3	0	genome.wustl.edu	37	11	65123435	65123435	+	Silent	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	11	65123435	65123435	G	A	SNP	TIGD3	ENST00000309880	human	ensembl	74_37	+1	known	silent	c.156	p.K52	1.000	pfam_HTH_Psq,superfamily_Homeodomain-like,pfscan_HTH_Psq	pfam_HTH_CenpB_DNA-bd_dom,pfam_DDE_SF_endonuclease_CENPB-like,pfam_HTH_Psq,superfamily_Homeodomain-like,smart_HTH_CenpB_DNA-bd_dom,pfscan_HTH_Psq	-	no_errors	TIGD3	HGNC	ENSG00000173825	tier1	-	-	92	0	0.00	60	20	25.00
TIMM23B	0	genome.wustl.edu	37	10	51374391	51374391	+	Missense_Mutation	SNP	C	C	G			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	10	51374391	51374391	C	G	SNP	TIMM23B	ENST00000478381	human	ensembl	74_37	+1	novel	missense	c.128	p.S43C	1.000	NULL	NULL	-	no_errors	TIMM23B	HGNC	ENSG00000204152	tier1	rs200196438	-	29	0	0.00	1	4	80.00
TMEM35	0	genome.wustl.edu	37	X	100349861	100349861	+	Silent	SNP	T	T	C			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	X	100349861	100349861	T	C	SNP	TMEM35	ENST00000372930	human	ensembl	74_37	+1	known	silent	c.420	p.S140	0.777	NULL	NULL	-	no_errors	TMEM35	HGNC	ENSG00000126950	tier1	-	-	35	0	0.00	42	21	32.81
TRDMT1	0	genome.wustl.edu	37	10	17195515	17195515	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	10	17195515	17195515	G	A	SNP	TRDMT1	ENST00000377799	human	ensembl	74_37	-1	known	missense	c.1066	p.P356S	1.000	pfam_C5_MeTfrase,tigrfam_C5_MeTfrase	pfam_C5_MeTfrase,prints_C5_MeTfrase,tigrfam_C5_MeTfrase	-	no_errors	TRDMT1	HGNC	ENSG00000107614	tier1	-	-	74	0	0.00	29	12	29.27
TSHZ3	0	genome.wustl.edu	37	19	31770543	31770543	+	Silent	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	31770543	31770543	G	A	SNP	TSHZ3	ENST00000240587	human	ensembl	74_37	-1	known	silent	c.156	p.L52	0.509	NULL	superfamily_Homeodomain-like,smart_Znf_C2H2-like,smart_Homeobox_dom,pfscan_Homeobox_dom,pfscan_Znf_C2H2	-	no_errors	TSHZ3	HGNC	ENSG00000121297	tier1	-	-	47	0	0.00	10	37	78.72
TTN	0	genome.wustl.edu	37	2	179416648	179416648	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	2	179416648	179416648	G	T	SNP	TTN	ENST00000342992	human	ensembl	74_37	-1	known	missense	c.83275	p.P27759T	0.860	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,pfam_Ig_V-set,pfam_Titin_Z,pfam_PPAK_motif,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	-	no_errors	TTN	HGNC	ENSG00000155657	tier1	-	-	100	0	0.00	48	60	55.56
UBR4	0	genome.wustl.edu	37	1	19524517	19524517	+	Silent	SNP	T	T	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	1	19524517	19524517	T	A	SNP	UBR4	ENST00000375267	human	ensembl	74_37	-1	known	silent	c.675	p.S225	0.480	NULL	superfamily_WD40_repeat_dom,superfamily_ARM-type_fold,smart_Znf_N-recognin_met,pfscan_Znf_N-recognin	-	no_errors	UBR4	HGNC	ENSG00000127481	tier1	-	-	129	0	0.00	94	9	8.74
UNC5CL	0	genome.wustl.edu	37	6	40996259	40996259	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	6	40996259	40996259	C	T	SNP	UNC5CL	ENST00000244565	human	ensembl	74_37	-1	known	silent	c.1410	p.E470	1.000	pfam_Death_domain,superfamily_DEATH-like_dom,smart_Death_domain,pfscan_Death_domain	pfam_ZU5,pfam_Death_domain,superfamily_DEATH-like_dom,smart_ZU5,smart_Death_domain,pfscan_Death_domain,pfscan_ZU5	-	no_errors	UNC5CL	HGNC	ENSG00000124602	tier1	-	-	55	0	0.00	44	17	27.87
WDR17	0	genome.wustl.edu	37	4	177052815	177052815	+	Missense_Mutation	SNP	G	G	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	4	177052815	177052815	G	A	SNP	WDR17	ENST00000280190	human	ensembl	74_37	+1	known	missense	c.1096	p.V366M	0.960	superfamily_WD40_repeat_dom	pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom,prints_G-protein_beta_WD-40_rep	-	no_errors	WDR17	HGNC	ENSG00000150627	tier1	-	-	182	0	0.00	153	76	33.19
WNK1	0	genome.wustl.edu	37	12	968440	968440	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	12	968440	968440	C	T	SNP	WNK1	ENST00000530271	human	ensembl	74_37	+1	known	missense	c.1430	p.A477V	1.000	pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Kinase_OSR1/WNK_CCT,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	WNK1	HGNC	ENSG00000060237	tier1	-	-	83	0	0.00	76	19	20.00
XPNPEP1	0	genome.wustl.edu	37	10	111640682	111640682	+	Missense_Mutation	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	10	111640682	111640682	C	T	SNP	XPNPEP1	ENST00000502935	human	ensembl	74_37	-1	known	missense	c.1049	p.R350H	1.000	NULL	pfam_Pept_M24_structural-domain,pfam_Creatinase,superfamily_Pept_M24_structural-domain	-	no_errors	XPNPEP1	HGNC	ENSG00000108039	tier1	-	-	57	0	0.00	34	10	22.73
ZNF667	0	genome.wustl.edu	37	19	56954101	56954101	+	Missense_Mutation	SNP	G	G	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	56954101	56954101	G	T	SNP	ZNF667	ENST00000342634	human	ensembl	74_37	-1	known	missense	c.647	p.S216Y	0.070	NULL	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF667	HGNC	ENSG00000198046	tier1	-	-	97	0	0.00	122	20	14.08
ZNF681	0	genome.wustl.edu	37	19	23927148	23927148	+	Missense_Mutation	SNP	C	C	A			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	23927148	23927148	C	A	SNP	ZNF681	ENST00000402377	human	ensembl	74_37	-1	known	missense	c.1204	p.A402S	0.041	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF681	HGNC	ENSG00000196172	tier1	-	-	69	0	0.00	49	8	14.04
ZNF880	0	genome.wustl.edu	37	19	52887913	52887913	+	Silent	SNP	C	C	T			TCGA-VQ-A94T-01A-11D-A410-08	TCGA-VQ-A94T-10A-01D-A413-08	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	9e39a460-5a48-423c-90c5-2c0afc9a6857	44c4a371-0d19-4f7b-88f3-490bdda07d3e	19	52887913	52887913	C	T	SNP	ZNF880	ENST00000422689	human	ensembl	74_37	+1	known	silent	c.1080	p.V360	0.003	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF880	HGNC	ENSG00000221923	tier1	-	-	25	0	0.00	18	14	43.75