Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PEX10	5192	broad.mit.edu	37	1	2338237	2338237	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:2338237C>T	uc001ajh.2	-	4	767	c.698G>A	c.(697-699)GGG>GAG	p.G233E	PEX10_uc001ajg.2_Missense_Mutation_p.G253E	NM_002617	NP_002608	O60683	PEX10_HUMAN	peroxisome biogenesis factor 10 isoform 2	233					protein import into peroxisome matrix|protein import into peroxisome matrix	integral to peroxisomal membrane|peroxisomal membrane	protein binding|protein C-terminus binding|zinc ion binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00102)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0169)|Lung(427;0.199)		CAGCTGCAGCCCCATGGACAG	0.677000												
SPEN	23013	broad.mit.edu	37	1	16260458	16260458	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:16260458C>A	uc001axk.1	+	11	7927	c.7723C>A	c.(7723-7725)CCA>ACA	p.P2575T	SPEN_uc010obp.1_Missense_Mutation_p.P2534T	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2575	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCCGCCCCCGCCAGTTGACTC	0.527000												
NUDC	10726	broad.mit.edu	37	1	27272100	27272100	+	Silent	SNP	G	G	A	rs1048905		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:27272100G>A	uc001bng.1	+	8	983	c.867G>A	c.(865-867)AAG>AAA	p.K289K	NUDC_uc001bnh.1_Silent_p.K346K|NUDC_uc009vsq.1_Silent_p.K263K	NM_006600	NP_006591	Q9Y266	NUDC_HUMAN	nuclear distribution gene C homolog	289					cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)		TGGTGGAAAAGATGATGTATG	0.527000												
GPR3	2827	broad.mit.edu	37	1	27720842	27720842	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:27720842C>T	uc001bod.2	+	2	635	c.540C>T	c.(538-540)GGC>GGT	p.G180G		NM_005281	NP_005272	P46089	GPR3_HUMAN	G protein-coupled receptor 3	180	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane				ovary(1)	1		Breast(348;1.53e-05)|Ovarian(437;0.0606)|all_lung(284;0.157)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.81e-26)|Colorectal(126;1.24e-08)|KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;4.45e-06)|Lung(427;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|LUSC - Lung squamous cell carcinoma(448;0.008)|READ - Rectum adenocarcinoma(331;0.0419)		GCCTGGATGGCCTGACCACAT	0.572000												
ZNF684	127396	broad.mit.edu	37	1	41013022	41013022	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:41013022C>T	uc001cft.1	+	5	1278	c.1027C>T	c.(1027-1029)CTC>TTC	p.L343F		NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	343	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			GTCCCATCTCCTCAGACATCA	0.398000												
SYDE2	84144	broad.mit.edu	37	1	85648868	85648868	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:85648868G>A	uc009wcm.2	-	3	1506	c.1457C>T	c.(1456-1458)GCT>GTT	p.A486V	SYDE2_uc001dku.3_Missense_Mutation_p.A486V	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	486					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		ATTTGTAGCAGCCAGGATCCC	0.323000												
KIAA1324	57535	broad.mit.edu	37	1	109734025	109734025	+	Nonsense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:109734025G>T	uc001dwq.2	+	13	1613	c.1477G>T	c.(1477-1479)GAG>TAG	p.E493*	KIAA1324_uc009wex.1_Nonsense_Mutation_p.E443*|KIAA1324_uc009wey.2_Nonsense_Mutation_p.E406*|KIAA1324_uc010ovg.1_Nonsense_Mutation_p.E391*|KIAA1324_uc001dwr.2_Nonsense_Mutation_p.E143*	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	493	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		AGAGAATAAAGAGGTGGCCAG	0.488000												
SF3B4	10262	broad.mit.edu	37	1	149898433	149898433	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:149898433C>T	uc001etj.1	-	3	592	c.541G>A	c.(541-543)GAC>AAC	p.D181N	SF3B4_uc001eti.1_5'Flank|SF3B4_uc001etk.1_Missense_Mutation_p.D181N|SF3B4_uc009wll.1_Missense_Mutation_p.D181N	NM_005850	NP_005841	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4	181						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CCCTTGGAGTCCTTCTTGAAG	0.522000												
FLG	2312	broad.mit.edu	37	1	152281867	152281867	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:152281867G>A	uc001ezu.1	-	3	5531	c.5495C>T	c.(5494-5496)TCG>TTG	p.S1832L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1832	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTATCTACCGATTGCTCATA	0.577000									Ichthyosis			
HMCN1	83872	broad.mit.edu	37	1	186043953	186043953	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:186043953C>T	uc001grq.1	+	53	8449	c.8220C>T	c.(8218-8220)ACC>ACT	p.T2740T		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2740	Ig-like C2-type 25.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TATCAGACACCGGACGATATA	0.348000												
HMCN1	83872	broad.mit.edu	37	1	186099668	186099668	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:186099668T>G	uc001grq.1	+	85	13298	c.13069T>G	c.(13069-13071)TCT>GCT	p.S4357A	HMCN1_uc001grs.1_5'UTR	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4357	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGATTATCCTTCTAACTGGAT	0.418000												
C4BPA	722	broad.mit.edu	37	1	207287578	207287578	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:207287578G>T	uc001hfo.2	+	3	470	c.276G>T	c.(274-276)CAG>CAT	p.Q92H		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	92	Sushi 1.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						ATTCAACTCAGACGCTTACCT	0.423000												
USH2A	7399	broad.mit.edu	37	1	216270471	216270471	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:216270471G>T	uc001hku.1	-	22	5099	c.4712C>A	c.(4711-4713)GCA>GAA	p.A1571E		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1571	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAACTGAAGTGCAAAATACTC	0.323000										HNSCC(13;0.011)		
H3F3A	3020	broad.mit.edu	37	1	226253371	226253371	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr1:226253371C>A	uc001hpw.2	+	3	258	c.143C>A	c.(142-144)GCG>GAG	p.A48E	H3F3A_uc010pvl.1_Missense_Mutation_p.A48E	NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	48					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding				0	Breast(184;0.179)			GBM - Glioblastoma multiforme(131;0.203)		GGTACTGTGGCGCTCCGTGAA	0.403000												
CALML5	51806	broad.mit.edu	37	10	5540985	5540985	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr10:5540985G>T	uc001iic.2	-	1	549	c.417C>A	c.(415-417)TTC>TTA	p.F139L		NM_017422	NP_059118	Q9NZT1	CALL5_HUMAN	calmodulin-like 5	139	EF-hand 4.				epidermis development|signal transduction		calcium ion binding|protein binding				0						GCATCCTCGCGAACTCCTCGT	0.706000												
PCDH15	65217	broad.mit.edu	37	10	55721598	55721598	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr10:55721598G>C	uc001jju.1	-	22	3318	c.2923C>G	c.(2923-2925)CCT>GCT	p.P975A	PCDH15_uc010qhq.1_Missense_Mutation_p.P980A|PCDH15_uc010qhr.1_Missense_Mutation_p.P975A|PCDH15_uc010qhs.1_Missense_Mutation_p.P987A|PCDH15_uc010qht.1_Missense_Mutation_p.P982A|PCDH15_uc010qhu.1_Missense_Mutation_p.P975A|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P975A|PCDH15_uc010qhw.1_Missense_Mutation_p.P938A|PCDH15_uc010qhx.1_Missense_Mutation_p.P904A|PCDH15_uc010qhy.1_Missense_Mutation_p.P980A|PCDH15_uc010qhz.1_Missense_Mutation_p.P975A|PCDH15_uc010qia.1_Missense_Mutation_p.P953A|PCDH15_uc010qib.1_Missense_Mutation_p.P953A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	975	Extracellular (Potential).|Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.P975T(1)		pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATACTGGCAGGGTAAGGAAAC	0.328000										HNSCC(58;0.16)		
CTNNA3	29119	broad.mit.edu	37	10	67829243	67829243	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr10:67829243T>G	uc009xpn.1	-	15	2105	c.1982A>C	c.(1981-1983)AAG>ACG	p.K661T	CTNNA3_uc001jmw.2_Missense_Mutation_p.K661T	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	661					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TTGAGTCATCTTAGCCTAAAA	0.338000												
CDH23	64072	broad.mit.edu	37	10	73405660	73405660	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr10:73405660G>A	uc001jrx.3	+	12	1590	c.1213G>A	c.(1213-1215)GTC>ATC	p.V405I	CDH23_uc001jrw.3_Missense_Mutation_p.V405I|CDH23_uc001jry.2_Missense_Mutation_p.V21I|CDH23_uc001jrz.2_Missense_Mutation_p.V21I	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	405	Cadherin 4.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCCGACCTCCGTCCAGGGGAA	0.567000												
SORCS3	22986	broad.mit.edu	37	10	106907538	106907538	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr10:106907538T>G	uc001kyi.1	+	9	1693	c.1466T>G	c.(1465-1467)ATT>AGT	p.I489S		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	489	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGGAACATCATTATTGAATTG	0.378000												
PNLIPRP1	5407	broad.mit.edu	37	10	118357380	118357380	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr10:118357380A>T	uc001lco.1	+	7	633	c.615A>T	c.(613-615)GAA>GAT	p.E205D	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.E205D|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	205		Calcium; via carbonyl oxygen.			lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GTACTCCTGAAGAGGTGCGAC	0.488000												
ATE1	11101	broad.mit.edu	37	10	123600613	123600613	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr10:123600613C>T	uc001lfp.2	-	9	1223	c.1141G>A	c.(1141-1143)GTC>ATC	p.V381I	ATE1_uc001lfq.2_Missense_Mutation_p.V381I|ATE1_uc010qtr.1_Missense_Mutation_p.V266I|ATE1_uc010qts.1_Missense_Mutation_p.V285I|ATE1_uc010qtt.1_Missense_Mutation_p.V374I|ATE1_uc001lfr.2_Missense_Mutation_p.V82I|ATE1_uc009xzu.2_RNA	NM_007041	NP_008972	O95260	ATE1_HUMAN	arginyltransferase 1 isoform 2	381					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity				0		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				GCAGAGTAGACGCCCAAAGAC	0.363000												
MUC5B	727897	broad.mit.edu	37	11	1264247	1264247	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:1264247C>T	uc009ycr.1	+	47	8342	c.8216C>T	c.(8215-8217)GCT>GTT	p.A2739V	MUC5B_uc001ltb.2_Missense_Mutation_p.A2049V	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2046	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCAGGAACAGCTCACACTACC	0.642000												
DCHS1	8642	broad.mit.edu	37	11	6648254	6648254	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:6648254T>C	uc001mem.1	-	14	6426	c.6016A>G	c.(6016-6018)ACA>GCA	p.T2006A		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2006	Cadherin 19.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAGGTGGTGTGCCTGCCAGC	0.587000												
RBMXL2	27288	broad.mit.edu	37	11	7111053	7111053	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:7111053G>A	uc001mfc.2	+	1	889	c.702G>A	c.(700-702)TCG>TCA	p.S234S		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	234	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTGCCCCCTCGCCCGGAGAGT	0.687000												
MRGPRX1	259249	broad.mit.edu	37	11	18955509	18955509	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:18955509C>T	uc001mpg.2	-	1	1041	c.823G>A	c.(823-825)GTG>ATG	p.V275M		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	275	Helical; Name=7; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						AAGGAGCCCACGAAGAAGTAA	0.507000												
NAV2	89797	broad.mit.edu	37	11	19955484	19955484	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:19955484C>T	uc010rdm.1	+	8	2124	c.1763C>T	c.(1762-1764)CCA>CTA	p.P588L	NAV2_uc001mpp.2_Missense_Mutation_p.P501L|NAV2_uc001mpr.3_Missense_Mutation_p.P565L	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	588						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						AGTGGAATACCAAAACCAGGA	0.572000												
DCDC1	341019	broad.mit.edu	37	11	31128443	31128443	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:31128443G>T	uc001msu.1	-	13	1742	c.509C>A	c.(508-510)TCT>TAT	p.S170Y	uc009yjk.1_5'UTR|uc009yjl.1_5'UTR			P59894	DCDC1_HUMAN	SubName: Full=Putative uncharacterized protein ENSP00000343496;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					CCGCATTGAAGAATAATTGAG	0.438000											OREG0020856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
OR8J1	219477	broad.mit.edu	37	11	56127940	56127940	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:56127940A>C	uc010rjh.1	+	1	218	c.218A>C	c.(217-219)AAC>ACC	p.N73T		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AATCTTGGTAACTCTACTGTC	0.443000												
GLYATL1	92292	broad.mit.edu	37	11	58723084	58723084	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:58723084G>A	uc001nnf.2	+	8	869	c.493G>A	c.(493-495)GAA>AAA	p.E165K	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.E196K|GLYATL1_uc001nni.1_Missense_Mutation_p.E165K|GLYATL1_uc001nnj.1_Missense_Mutation_p.E165K			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	165						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	TGTCTACAGTGAAACTCCCAA	0.428000												
MAP4K2	5871	broad.mit.edu	37	11	64564001	64564001	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:64564001G>C	uc001obh.2	-	23	1689	c.1597C>G	c.(1597-1599)CTC>GTC	p.L533V	MAP4K2_uc001obg.2_5'Flank|MAP4K2_uc001obi.2_Missense_Mutation_p.L525V	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	533	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						ACGCAGTAGAGCCAGGAGCAG	0.662000												
LRP5	4041	broad.mit.edu	37	11	68201141	68201141	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:68201141C>T	uc001ont.2	+	18	3910	c.3835C>T	c.(3835-3837)CGC>TGC	p.R1279C	LRP5_uc009ysg.2_Missense_Mutation_p.R689C	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1279	LDL-receptor class A 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CGGGGCCTGGCGCTGTGACGG	0.677000												
GDPD5	81544	broad.mit.edu	37	11	75188719	75188719	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:75188719C>A	uc001owo.3	-	4	599	c.62G>T	c.(61-63)GGC>GTC	p.G21V	GDPD5_uc001owp.3_Missense_Mutation_p.G21V|GDPD5_uc009yuc.2_5'UTR|GDPD5_uc009yud.2_Missense_Mutation_p.G21V	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	21	Cytoplasmic (Potential).				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						GCCGTAGATGCCCGTGAGGCA	0.662000												
TAF1D	79101	broad.mit.edu	37	11	93471662	93471662	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:93471662A>T	uc001ped.2	-	3	274	c.72T>A	c.(70-72)GAT>GAA	p.D24E	SNORA8_uc001pec.2_5'Flank|TAF1D_uc001pdz.2_RNA|TAF1D_uc001pea.1_RNA	NM_024116	NP_077021	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						CAGAAGAGTTATCACTAGAAA	0.338000												
KBTBD3	143879	broad.mit.edu	37	11	105929644	105929644	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:105929644C>T	uc001pja.2	-	3	821	c.181G>A	c.(181-183)GAA>AAA	p.E61K	KBTBD3_uc001pjb.2_Missense_Mutation_p.E61K|KBTBD3_uc009yxm.2_Intron	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	57	BTB.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		GGGATTATTTCATCTTTCATA	0.318000												
CLDN25	644672	broad.mit.edu	37	11	113650613	113650613	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr11:113650613G>T	uc009yyw.1	+	1	96	c.96G>T	c.(94-96)CAG>CAT	p.Q32H		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	32	Extracellular (Potential).					integral to membrane|tight junction	structural molecule activity				0						TCCTGCCCCAGTGGAAGACTC	0.562000												
A2ML1	144568	broad.mit.edu	37	12	8975820	8975820	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr12:8975820C>T	uc001quz.3	+	2	203	c.105C>T	c.(103-105)TCC>TCT	p.S35S		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	Error:Variant_position_missing_in_B3KVV6_after_alignment						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						ATTTCCCCTCCGTTCAGAAGG	0.443000												
ETV6	2120	broad.mit.edu	37	12	12006418	12006418	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr12:12006418T>C	uc001qzz.2	+	4	660	c.386T>C	c.(385-387)CTT>CCT	p.L129P		NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	129						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCTCGGATTCTTTTTTCACCA	0.428000			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL							
MLL2	8085	broad.mit.edu	37	12	49431844	49431844	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr12:49431844G>A	uc001rta.3	-	34	9295	c.9295C>T	c.(9295-9297)CGC>TGC	p.R3099C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3099					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGGGGAGGGCGCTCCTCAGGG	0.647000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)		
ZMYM2	7750	broad.mit.edu	37	13	20632802	20632802	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:20632802A>G	uc001umr.2	+	16	2879	c.2581A>G	c.(2581-2583)ACT>GCT	p.T861A	ZMYM2_uc001ums.2_Missense_Mutation_p.T861A|ZMYM2_uc001umt.2_Missense_Mutation_p.T861A|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_Missense_Mutation_p.T241A|ZMYM2_uc001umw.2_Missense_Mutation_p.T314A	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	861					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		GACAAAAGCTACTTACTGTAA	0.413000												
RNF6	6049	broad.mit.edu	37	13	26789264	26789264	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:26789264C>T	uc001uqo.2	-	5	1046	c.755G>A	c.(754-756)CGC>CAC	p.R252H	RNF6_uc001uqn.1_Intron|RNF6_uc010aak.2_Missense_Mutation_p.R252H|RNF6_uc001uqp.2_Missense_Mutation_p.R252H|RNF6_uc001uqq.2_Missense_Mutation_p.R252H|RNF6_uc010tdk.1_Intron	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	252					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		GAAATTAGTGCGTGAAGCGTT	0.493000												
RXFP2	122042	broad.mit.edu	37	13	32367089	32367089	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:32367089T>A	uc001utt.2	+	16	1721	c.1650T>A	c.(1648-1650)TTT>TTA	p.F550L	RXFP2_uc010aba.2_Missense_Mutation_p.F509L	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	550	Helical; Name=4; (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TGGCGGGATTTTTAATAGCTG	0.388000												
STARD13	90627	broad.mit.edu	37	13	33741695	33741695	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:33741695T>G	uc001uuw.2	-	2	360	c.234A>C	c.(232-234)TTA>TTC	p.L78F	STARD13_uc001uuu.2_Missense_Mutation_p.L70F|STARD13_uc001uuv.2_5'UTR|STARD13_uc001uux.2_Missense_Mutation_p.L43F|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.L63F	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	78	SAM.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TACCCTCATATAACTGAGCGT	0.443000												
ALG5	29880	broad.mit.edu	37	13	37539797	37539797	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:37539797C>G	uc001uvy.2	-	8	755	c.688G>C	c.(688-690)GGA>CGA	p.G230R	ALG5_uc010teq.1_Missense_Mutation_p.G200R|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	230	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		TCCCTGATTCCTTTGACACAA	0.418000												
KIAA0564	23078	broad.mit.edu	37	13	42149950	42149950	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:42149950C>G	uc001uyj.2	-	43	5366	c.5296G>C	c.(5296-5298)GAT>CAT	p.D1766H		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1766	VWFA.					extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		TTGTAGCCATCTCCAGAGTGT	0.353000												
PCDH20	64881	broad.mit.edu	37	13	61985618	61985618	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:61985618T>A	uc001vid.3	-	2	2978	c.2614A>T	c.(2614-2616)ATC>TTC	p.I872F	PCDH20_uc010thj.1_Missense_Mutation_p.I872F	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	845	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TCTATTGAGATTTGTGGTTCT	0.398000												
SLITRK1	114798	broad.mit.edu	37	13	84454217	84454217	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:84454217G>T	uc001vlk.2	-	1	2312	c.1426C>A	c.(1426-1428)CTC>ATC	p.L476I		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	476	Extracellular (Potential).|LRR 11.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTGAGAATGAGGATCCTCAGT	0.527000												
GPC5	2262	broad.mit.edu	37	13	92346004	92346004	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr13:92346004C>T	uc010tif.1	+	3	1255	c.889C>T	c.(889-891)CGG>TGG	p.R297W		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	297						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGCATATATCCGGTCGTTGGA	0.512000												
TOX4	9878	broad.mit.edu	37	14	21960818	21960818	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr14:21960818C>T	uc001waz.2	+	7	1146	c.1043C>T	c.(1042-1044)TCA>TTA	p.S348L	TOX4_uc001way.2_Missense_Mutation_p.S218L|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Missense_Mutation_p.S325L|TOX4_uc010tlv.1_Missense_Mutation_p.S218L	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	348						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		TCCACCCTTTCATCCTATGTG	0.493000												
MDGA2	161357	broad.mit.edu	37	14	47342743	47342743	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr14:47342743G>T	uc001wwj.3	-	14	2634	c.2438C>A	c.(2437-2439)GCT>GAT	p.A813D	MDGA2_uc001wwh.3_Missense_Mutation_p.A15D|MDGA2_uc001wwi.3_Missense_Mutation_p.A584D|MDGA2_uc010ani.2_Missense_Mutation_p.A373D	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	813	MAM.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GAGAAGTCGAGCCTTTTCGCC	0.378000												
SOS2	6655	broad.mit.edu	37	14	50597407	50597407	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr14:50597407C>T	uc001wxs.3	-	20	3247	c.3149G>A	c.(3148-3150)GGT>GAT	p.G1050D	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.G1017D	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1050					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TCGTAAAGTACCTGAGGTAGA	0.418000												
MED6	10001	broad.mit.edu	37	14	71064347	71064347	+	Nonsense_Mutation	SNP	A	A	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr14:71064347A>T	uc001xmf.2	-	2	200	c.170T>A	c.(169-171)TTA>TAA	p.L57*	MED6_uc010tth.1_Nonsense_Mutation_p.L57*|MED6_uc010tti.1_Nonsense_Mutation_p.L57*|MED6_uc001xmg.1_Nonsense_Mutation_p.L57*|MED6_uc010ttj.1_Nonsense_Mutation_p.L57*	NM_005466	NP_005457	O75586	MED6_HUMAN	mediator of RNA polymerase II transcription,	57					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	transcription coactivator activity				0				all cancers(60;0.00315)|BRCA - Breast invasive adenocarcinoma(234;0.00685)|OV - Ovarian serous cystadenocarcinoma(108;0.0352)		CAAGTGTTCTAATGTTAGCCT	0.348000												
GABRA5	2558	broad.mit.edu	37	15	27185160	27185160	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:27185160C>T	uc001zbd.1	+	10	1152	c.813C>T	c.(811-813)ACC>ACT	p.T271T	GABRB3_uc001zbb.2_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	271	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCATAATGACCGTGATCTTAT	0.498000												
ZNF770	54989	broad.mit.edu	37	15	35275208	35275208	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:35275208G>A	uc001ziw.2	-	3	739	c.428C>T	c.(427-429)CCG>CTG	p.P143L		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		CTTAGAGCACGGGTGTAATGC	0.388000												
TYRO3	7301	broad.mit.edu	37	15	41864735	41864735	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:41864735C>T	uc001zof.1	+	15	2072	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	616	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CCTTCCTGCTCGCCTCCCGGA	0.617000												
PYGO1	26108	broad.mit.edu	37	15	55841186	55841186	+	Silent	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:55841186A>G	uc010bfl.1	-	2	113	c.57T>C	c.(55-57)GAT>GAC	p.D19D	PYGO1_uc002adf.1_Silent_p.D19D	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	19					Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		CCAGTCCACTATCACCACCTA	0.338000												
CILP	8483	broad.mit.edu	37	15	65490372	65490372	+	Missense_Mutation	SNP	C	C	T	rs139906949		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:65490372C>T	uc002aon.2	-	9	2433	c.2252G>A	c.(2251-2253)CGG>CAG	p.R751Q		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	751					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						AACAAAGCACCGCCTGCTTTC	0.512000												
TLE3	7090	broad.mit.edu	37	15	70366884	70366884	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:70366884G>A	uc002asm.2	-	6	1479	c.360C>T	c.(358-360)AAC>AAT	p.N120N	TLE3_uc002ask.2_Silent_p.N54N|TLE3_uc002asl.2_Silent_p.N126N|TLE3_uc010ukd.1_Silent_p.N113N|TLE3_uc010bik.1_Intron|TLE3_uc010bil.1_Silent_p.N120N|TLE3_uc002asn.2_Silent_p.N120N|TLE3_uc002asp.2_Silent_p.N120N|TLE3_uc002aso.2_Silent_p.N120N|TLE3_uc010bim.1_RNA	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	120	Gln-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						CGATGATGGCGTTCAGCTCCG	0.552000												
ACSBG1	23205	broad.mit.edu	37	15	78466820	78466820	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:78466820G>A	uc002bdh.2	-	12	1805	c.1749C>T	c.(1747-1749)ATC>ATT	p.I583I	ACSBG1_uc010umw.1_Silent_p.I579I|ACSBG1_uc010umx.1_Silent_p.I341I	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	583					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						CGGCCTCCTCGATGGGCACAG	0.592000												
TELO2	9894	broad.mit.edu	37	16	1550474	1550474	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr16:1550474C>T	uc002cly.2	+	8	1420	c.1129C>T	c.(1129-1131)CGG>TGG	p.R377W	TELO2_uc010uvg.1_Missense_Mutation_p.R377W	NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	377						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				GCCGGAACTGCGGGACAGCCG	0.716000												
OR1F1	4992	broad.mit.edu	37	16	3254894	3254894	+	Silent	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr16:3254894T>G	uc010uwu.1	+	1	648	c.648T>G	c.(646-648)GCT>GCG	p.A216A		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCATCCTGGCTTCTTATATGC	0.517000												
ACSM2A	123876	broad.mit.edu	37	16	20487000	20487000	+	Missense_Mutation	SNP	G	G	A	rs4643305		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr16:20487000G>A	uc010bwe.2	+	9	1242	c.1003G>A	c.(1003-1005)GTC>ATC	p.V335I	ACSM2A_uc010vax.1_Missense_Mutation_p.V256I|ACSM2A_uc002dhf.3_Missense_Mutation_p.V335I|ACSM2A_uc002dhg.3_Missense_Mutation_p.V335I|ACSM2A_uc010vay.1_Missense_Mutation_p.V256I|ACSM2A_uc002dhh.3_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	335					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						ACAGAACTGCGTCACTGTAGG	0.517000												
SETD1A	9739	broad.mit.edu	37	16	30970468	30970468	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr16:30970468C>T	uc002ead.1	+	3	893	c.207C>T	c.(205-207)TCC>TCT	p.S69S	SETD1A_uc002eae.1_Silent_p.S69S	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	69					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						ATGTCAGGTCCAAAAACAGAG	0.517000												
KCTD19	146212	broad.mit.edu	37	16	67329237	67329237	+	Silent	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr16:67329237C>G	uc002esu.2	-	9	1371	c.1320G>C	c.(1318-1320)GGG>GGC	p.G440G	KCTD19_uc002est.2_Silent_p.G212G|KCTD19_uc010vjj.1_Silent_p.G183G	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	440	BTB 2.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TCTGGCCATCCCCGTGGATGA	0.488000												
ADAD2	161931	broad.mit.edu	37	16	84224934	84224934	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr16:84224934G>A	uc002fhr.2	+	1	212	c.98G>A	c.(97-99)CGA>CAA	p.R33Q	ADAD2_uc002fhq.2_Missense_Mutation_p.R33Q	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	33					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						CGCCCCTGGCGACCGCTACCC	0.622000												
NOS2	4843	broad.mit.edu	37	17	26096028	26096028	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:26096028C>T	uc002gzu.2	-	17	2273	c.2009G>A	c.(2008-2010)CGC>CAC	p.R670H	NOS2_uc010wab.1_Missense_Mutation_p.R635H	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	670	Flavodoxin-like.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GGCCCAGCTGCGGAAGGCGTC	0.602000												
FOXN1	8456	broad.mit.edu	37	17	26862160	26862160	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:26862160A>G	uc010crm.2	+	8	1769	c.1571A>G	c.(1570-1572)GAC>GGC	p.D524G	FOXN1_uc002hbj.2_Missense_Mutation_p.D524G	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	524					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CCAGATGGAGACCTTGGCACT	0.622000												
SUPT6H	6830	broad.mit.edu	37	17	27013704	27013704	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:27013704G>A	uc002hby.2	+	21	2687	c.2597G>A	c.(2596-2598)CGC>CAC	p.R866H	SUPT6H_uc010crt.2_Missense_Mutation_p.R866H|SUPT6H_uc002hbz.1_5'Flank	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	866					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GATGTGAAGCGCATTGTACAT	0.488000												
KRT27	342574	broad.mit.edu	37	17	38937500	38937500	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:38937500T>A	uc002hvg.2	-	2	508	c.467A>T	c.(466-468)AAT>ATT	p.N156I		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	156	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				AACATGGGCATTACTGGTAGT	0.323000												
MPP3	4356	broad.mit.edu	37	17	41907404	41907404	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:41907404C>T	uc002iei.3	-	6	460	c.294G>A	c.(292-294)CCG>CCA	p.P98P	MPP3_uc002ieh.2_Silent_p.P123P|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Silent_p.P98P|MPP3_uc010wik.1_Silent_p.P123P|MPP3_uc010czj.1_Silent_p.P98P	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	98	L27 2.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		CCCTCAGGTGCGGGGTGGACA	0.632000												
GFAP	2670	broad.mit.edu	37	17	42992741	42992741	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:42992741G>A	uc002ihq.2	-	1	174	c.114C>T	c.(112-114)TCC>TCT	p.S38S	GFAP_uc002ihr.2_Silent_p.S38S|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	38	Head.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				TTCGAGCCAGGGAGAGGCGGG	0.692000												
CACNA1G	8913	broad.mit.edu	37	17	48680463	48680463	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:48680463G>A	uc002irk.1	+	21	4444	c.4072G>A	c.(4072-4074)GTC>ATC	p.V1358I	CACNA1G_uc002iri.1_Missense_Mutation_p.V1358I|CACNA1G_uc002irj.1_Missense_Mutation_p.V1335I|CACNA1G_uc002irl.1_Missense_Mutation_p.V1335I|CACNA1G_uc002irm.1_Missense_Mutation_p.V1335I|CACNA1G_uc002irn.1_Missense_Mutation_p.V1335I|CACNA1G_uc002iro.1_Missense_Mutation_p.V1335I|CACNA1G_uc002irp.1_Missense_Mutation_p.V1358I|CACNA1G_uc002irq.1_Missense_Mutation_p.V1335I|CACNA1G_uc002irr.1_Missense_Mutation_p.V1358I|CACNA1G_uc002irs.1_Missense_Mutation_p.V1358I|CACNA1G_uc002irt.1_Missense_Mutation_p.V1358I|CACNA1G_uc002irv.1_Missense_Mutation_p.V1358I|CACNA1G_uc002irw.1_Missense_Mutation_p.V1335I|CACNA1G_uc002iru.1_Missense_Mutation_p.V1335I|CACNA1G_uc002irx.1_Missense_Mutation_p.V1271I|CACNA1G_uc002iry.1_Missense_Mutation_p.V1271I|CACNA1G_uc002irz.1_Missense_Mutation_p.V1271I|CACNA1G_uc002isa.1_Missense_Mutation_p.V1271I|CACNA1G_uc002isb.1_Missense_Mutation_p.V1271I|CACNA1G_uc002isc.1_Missense_Mutation_p.V1271I|CACNA1G_uc002isd.1_Missense_Mutation_p.V1271I|CACNA1G_uc002ise.1_Missense_Mutation_p.V1271I|CACNA1G_uc002isf.1_Missense_Mutation_p.V1271I|CACNA1G_uc002isg.1_Missense_Mutation_p.V1271I|CACNA1G_uc002ish.1_Missense_Mutation_p.V1271I|CACNA1G_uc002isi.1_Missense_Mutation_p.V1248I|CACNA1G_uc002isj.2_Missense_Mutation_p.V82I	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1358	III.|Helical; Name=S3 of repeat III; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCTCATCTCCGTCATCGACAT	0.657000												
CA10	56934	broad.mit.edu	37	17	50008434	50008434	+	Silent	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:50008434C>A	uc002itw.3	-	3	1181	c.195G>T	c.(193-195)CGG>CGT	p.R65R	CA10_uc002itv.3_Silent_p.R71R|CA10_uc002itx.3_Silent_p.R65R|CA10_uc002ity.3_Silent_p.R65R|CA10_uc002itz.2_Silent_p.R65R	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	65					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			CTGGCGACTGCCGTTTCCCCA	0.478000												
APOH	350	broad.mit.edu	37	17	64216736	64216736	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:64216736C>T	uc002jfn.3	-	5	599	c.540G>A	c.(538-540)ATG>ATA	p.M180I		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	180	Sushi 3.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			CATTTCCAAACATCGCATGTT	0.418000												
TBC1D16	125058	broad.mit.edu	37	17	77924239	77924239	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:77924239G>A	uc002jxj.2	-	6	1344	c.1228C>T	c.(1228-1230)CAG>TAG	p.Q410*	TBC1D16_uc002jxh.2_Nonsense_Mutation_p.Q48*|TBC1D16_uc002jxi.2_Nonsense_Mutation_p.Q49*|TBC1D16_uc002jxk.1_Nonsense_Mutation_p.Q48*	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	410						intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			TCCTCCACCTGGCCCAGCTCA	0.697000												
LRRC30	339291	broad.mit.edu	37	18	7231239	7231239	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr18:7231239C>T	uc010wzk.1	+	1	103	c.103C>T	c.(103-105)CTC>TTC	p.L35F		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	35										ovary(1)|liver(1)	2						CGATGCCCTGCTCTCGGGAAG	0.622000												
TCEB3B	51224	broad.mit.edu	37	18	44560303	44560303	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr18:44560303C>T	uc002lcr.1	-	1	1686	c.1333G>A	c.(1333-1335)GGC>AGC	p.G445S	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	445					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GAATCAGCGCCGGCCGCCTGC	0.592000												
ZCCHC2	54877	broad.mit.edu	37	18	60243811	60243811	+	Nonstop_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr18:60243811G>T	uc002lip.3	+	14	3536	c.3536G>T	c.(3535-3537)TGA>TTA	p.*1179L	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Nonstop_Mutation_p.*649L	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	1179					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TCTGCAGACTGAAACGAGTAA	0.453000												
MYO1F	4542	broad.mit.edu	37	19	8609309	8609309	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:8609309C>T	uc002mkg.2	-	14	1510	c.1396G>A	c.(1396-1398)GCC>ACC	p.A466T		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	466	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						TGCATGGTGGCGCACACGTCG	0.682000												
MUC16	94025	broad.mit.edu	37	19	9046692	9046692	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:9046692G>C	uc002mkp.2	-	5	35143	c.34939C>G	c.(34939-34941)CCA>GCA	p.P11647A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11649	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCAAAGTTGGAATAGCTGTA	0.517000												
RGS9BP	388531	broad.mit.edu	37	19	33167228	33167228	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:33167228A>C	uc002ntp.1	+	1	916	c.59A>C	c.(58-60)TAC>TCC	p.Y20S	ANKRD27_uc002ntn.1_5'Flank|ANKRD27_uc002nto.1_5'Flank	NM_207391	NP_997274	Q6ZS82	R9BP_HUMAN	RGS9 anchor protein	20	Cytoplasmic (Potential).				negative regulation of signal transduction	integral to membrane				central_nervous_system(1)	1	Esophageal squamous(110;0.137)					ACTGCGTGCTACCACCACCTG	0.602000												
ZNF30	90075	broad.mit.edu	37	19	35434618	35434618	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:35434618C>G	uc010edp.1	+	5	1126	c.748C>G	c.(748-750)CAT>GAT	p.H250D	ZNF30_uc002nxf.2_Missense_Mutation_p.H169D|ZNF30_uc010edq.1_Missense_Mutation_p.H251D|ZNF30_uc010edr.1_Missense_Mutation_p.H251D	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	250	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		GCTTACCCGGCATCAGAGTAC	0.438000												
ZNF829	374899	broad.mit.edu	37	19	37399305	37399305	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:37399305G>A	uc002ofa.1	-	4	515	c.153C>T	c.(151-153)TGC>TGT	p.C51C	ZNF345_uc002oez.2_Intron|ZNF829_uc002ofb.2_Silent_p.C51C	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGCGTCCAGGCATTCCCATT	0.413000												
ZNF569	148266	broad.mit.edu	37	19	37904953	37904953	+	Nonsense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:37904953T>A	uc002ogi.2	-	6	1165	c.607A>T	c.(607-609)AGA>TGA	p.R203*	ZNF569_uc002ogh.2_Nonsense_Mutation_p.R44*|ZNF569_uc002ogj.2_Nonsense_Mutation_p.R227*	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	203	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCAGATGTCTGATGAGGTCC	0.358000												
ZNF229	7772	broad.mit.edu	37	19	44933411	44933411	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:44933411A>C	uc002oze.1	-	6	1979	c.1545T>G	c.(1543-1545)CAT>CAG	p.H515Q	ZNF229_uc010ejk.1_Missense_Mutation_p.H169Q|ZNF229_uc010ejl.1_Missense_Mutation_p.H509Q	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				ATTTGTACAGATGCTGCCCCA	0.502000												
AP2A1	160	broad.mit.edu	37	19	50308972	50308972	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:50308972G>C	uc002ppn.2	+	21	2800	c.2589G>C	c.(2587-2589)AAG>AAC	p.K863N	AP2A1_uc002ppo.2_Missense_Mutation_p.K841N|AP2A1_uc010enk.2_Intron	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	863					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		CCATCAACAAGTTCTTCCAGC	0.662000												
AP2A1	160	broad.mit.edu	37	19	50309020	50309020	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:50309020G>A	uc002ppn.2	+	21	2848	c.2637G>A	c.(2635-2637)TGG>TGA	p.W879*	AP2A1_uc002ppo.2_Nonsense_Mutation_p.W857*|AP2A1_uc010enk.2_Nonsense_Mutation_p.W10*	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	879					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		TCCAGCGCTGGAAGCAGCTGA	0.677000												
SIGLEC11	114132	broad.mit.edu	37	19	50464021	50464021	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:50464021C>A	uc010ybh.1	-	2	339	c.248G>T	c.(247-249)GGT>GTT	p.G83V	SIGLEC11_uc010ybi.1_Missense_Mutation_p.G83V	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	83	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CACAGGAGCACCCGTCTTTGG	0.592000												
KLK12	43849	broad.mit.edu	37	19	51532580	51532580	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:51532580C>T	uc002pvg.1	-	5	845	c.725G>A	c.(724-726)CGG>CAG	p.R242Q	KLK11_uc002pvd.1_5'Flank|KLK11_uc002pve.1_5'Flank|KLK11_uc002pvf.1_5'Flank|KLK11_uc002pvc.3_5'Flank|KLK11_uc010eom.2_5'Flank|KLK12_uc010ycp.1_Intron|KLK12_uc010ycq.1_Intron|KLK12_uc010ycr.1_Missense_Mutation_p.R132Q|KLK12_uc010ycs.1_Missense_Mutation_p.R132Q|KLK12_uc002pvh.1_Intron|KLK12_uc002pvi.1_Missense_Mutation_p.R242Q|KLK12_uc002pvj.1_3'UTR	NM_145894	NP_665901	Q9UKR0	KLK12_HUMAN	kallikrein 12 isoform 2	242	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			ovary(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		CATGATCATCCGGATCCAGTC	0.552000												
ZSCAN1	284312	broad.mit.edu	37	19	58565264	58565264	+	Missense_Mutation	SNP	C	C	T	rs144536843	byFrequency	TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr19:58565264C>T	uc002qrc.1	+	6	1319	c.1072C>T	c.(1072-1074)CGG>TGG	p.R358W		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	358					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CAAGGGCCCCCGGGAGTCCGT	0.662000												
RAD51AP2	729475	broad.mit.edu	37	2	17698511	17698511	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:17698511T>A	uc002rcl.1	-	1	1196	c.1172A>T	c.(1171-1173)AAA>ATA	p.K391I	RAD51AP2_uc010exn.1_Missense_Mutation_p.K382I	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	391										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GTTTTGAGATTTTTCCAGCCT	0.333000												
VSNL1	7447	broad.mit.edu	37	2	17830854	17830854	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:17830854G>A	uc002rcm.2	+	3	724	c.340G>A	c.(340-342)GGC>AGC	p.G114S		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	114	EF-hand 3.|2 (Potential).						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGATGGTGATGGCAAGATCAC	0.587000												
WDR35	57539	broad.mit.edu	37	2	20178532	20178532	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:20178532A>G	uc002rdi.2	-	5	524	c.416T>C	c.(415-417)GTG>GCG	p.V139A	WDR35_uc002rdj.2_Missense_Mutation_p.V139A|WDR35_uc010ext.2_RNA	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	139	WD 3.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCAACTATCACAGCCCCATC	0.378000												
WDR35	57539	broad.mit.edu	37	2	20178576	20178576	+	Silent	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:20178576A>G	uc002rdi.2	-	5	480	c.372T>C	c.(370-372)AAT>AAC	p.N124N	WDR35_uc002rdj.2_Silent_p.N124N|WDR35_uc010ext.2_RNA	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	124	WD 3.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCCGTCAGCATTCCAGCTCA	0.368000												
WDR35	57539	broad.mit.edu	37	2	20178631	20178631	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:20178631A>G	uc002rdi.2	-	5	425	c.317T>C	c.(316-318)ATT>ACT	p.I106T	WDR35_uc002rdj.2_Missense_Mutation_p.I106T|WDR35_uc010ext.2_RNA	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	106	WD 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATCTCCTCAATCCAAGAGCC	0.358000												
PUS10	150962	broad.mit.edu	37	2	61238963	61238963	+	Silent	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:61238963A>G	uc010fci.2	-	2	123	c.63T>C	c.(61-63)TGT>TGC	p.C21C	PUS10_uc002sao.2_Silent_p.C21C|PUS10_uc010ypk.1_5'UTR|PUS10_uc002sap.1_RNA|PUS10_uc002saq.1_RNA	NM_144709	NP_653310	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	21					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(2)|large_intestine(1)|kidney(1)	4			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			TACATCTTGGACAAGTACCAG	0.318000												
PPP3R1	5534	broad.mit.edu	37	2	68415709	68415709	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:68415709G>T	uc002sei.1	-	3	549	c.157C>A	c.(157-159)CCT>ACT	p.P53T		NM_000945	NP_000936	P63098	CANB1_HUMAN	protein phosphatase 3, regulatory subunit B,	53	EF-hand 2.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	calcineurin complex|cytosol	calcium ion binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding				0					Pimecrolimus(DB00337)	TGTACTAAAGGATTCTGTTGT	0.348000												
SNRNP27	11017	broad.mit.edu	37	2	70122244	70122244	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:70122244C>T	uc002sfw.2	+	2	80	c.53C>T	c.(52-54)TCC>TTC	p.S18F	SNRNP27_uc002sfv.2_RNA|SNRNP27_uc002sfx.2_Missense_Mutation_p.S18F	NM_006857	NP_006848	Q8WVK2	SNR27_HUMAN	small nuclear ribonucleoprotein 27kDa	18	Arg-rich.				mRNA processing|RNA splicing	nucleus	nucleic acid binding				0						CGTTCCCGGTCCACATCCCGG	0.547000												
LRP2	4036	broad.mit.edu	37	2	170042037	170042037	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:170042037C>T	uc002ues.2	-	50	10034	c.9821G>A	c.(9820-9822)AGT>AAT	p.S3274N		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3274	LDL-receptor class B 30.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TACAGCCAGACTTTCTGCAGC	0.348000												
TTN	7273	broad.mit.edu	37	2	179455023	179455023	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:179455023C>G	uc010zfg.1	-	253	53949	c.53725G>C	c.(53725-53727)GAA>CAA	p.E17909Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E11604Q|TTN_uc010zfi.1_Missense_Mutation_p.E11537Q|TTN_uc010zfj.1_Missense_Mutation_p.E11412Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18836							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACATCAAGTTCTACTTCTGGA	0.433000												
TTN	7273	broad.mit.edu	37	2	179614932	179614932	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:179614932T>G	uc002unb.2	-	46	12419	c.12195A>C	c.(12193-12195)CAA>CAC	p.Q4065H	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCCTTTTGCTTGGTCAAACA	0.423000												
SESTD1	91404	broad.mit.edu	37	2	180047901	180047901	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:180047901G>A	uc002uni.3	-	3	220	c.70C>T	c.(70-72)CGG>TGG	p.R24W		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	24	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			AGGCCACTCCGTCTGTCTTTT	0.343000												
ZC3H15	55854	broad.mit.edu	37	2	187359984	187359984	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:187359984A>C	uc002upo.2	+	2	325	c.100A>C	c.(100-102)AAG>CAG	p.K34Q		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	34						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			TTTGAAGAATAAGAAAGGAGC	0.323000												
AOX1	316	broad.mit.edu	37	2	201501705	201501705	+	Silent	SNP	G	G	A	rs148411225	byFrequency	TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:201501705G>A	uc002uvx.2	+	22	2519	c.2418G>A	c.(2416-2418)GCG>GCA	p.A806A	AOX1_uc010zhf.1_Silent_p.A362A|AOX1_uc010fsu.2_Silent_p.A172A	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	806					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTGGTGGAGCGTTTGGAGGGA	0.433000												
MAP2	4133	broad.mit.edu	37	2	210557575	210557575	+	Silent	SNP	G	G	C	rs139978953	byFrequency	TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:210557575G>C	uc002vde.1	+	7	929	c.681G>C	c.(679-681)GGG>GGC	p.G227G	MAP2_uc002vdc.1_Silent_p.G227G|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.G223G	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	227					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTTTGTTTGGGCACACTCTTG	0.468000												
BARD1	580	broad.mit.edu	37	2	215593615	215593615	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:215593615G>A	uc002veu.2	-	11	2254	c.2119C>T	c.(2119-2121)CCC>TCC	p.P707S	BARD1_uc010zjm.1_Silent_p.S561S	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	707	BRCT 2.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCTGGCTTGGGCTTTCTACTG	0.488000									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome			
FN1	2335	broad.mit.edu	37	2	216259415	216259415	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:216259415G>T	uc002vfa.2	-	24	3898	c.3632C>A	c.(3631-3633)ACC>AAC	p.T1211N	FN1_uc002vfb.2_Missense_Mutation_p.T1211N|FN1_uc002vfc.2_Missense_Mutation_p.T1211N|FN1_uc002vfd.2_Missense_Mutation_p.T1211N|FN1_uc002vfe.2_Missense_Mutation_p.T1211N|FN1_uc002vff.2_Missense_Mutation_p.T1211N|FN1_uc002vfg.2_Missense_Mutation_p.T1211N|FN1_uc002vfh.2_Missense_Mutation_p.T1211N|FN1_uc002vfi.2_Missense_Mutation_p.T1211N|FN1_uc002vfj.2_Missense_Mutation_p.T1211N|FN1_uc002vez.2_5'Flank|FN1_uc010zjp.1_5'Flank	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1211	Fibronectin type-III 7.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTTGTAGGGGTTGTGGTAAT	0.443000												
MARCH4	57574	broad.mit.edu	37	2	217142568	217142568	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:217142568G>A	uc002vgb.2	-	3	2459	c.692C>T	c.(691-693)ACG>ATG	p.T231M		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	231						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		CTCAATGACCGTCAGAGAGAT	0.567000												
ATG9A	79065	broad.mit.edu	37	2	220086872	220086872	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:220086872G>C	uc002vke.1	-	13	2231	c.2045C>G	c.(2044-2046)GCC>GGC	p.A682G	ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Missense_Mutation_p.A682G	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	682	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCGGAGCTGGCTGTCCTGGC	0.592000												
SCG2	7857	broad.mit.edu	37	2	224462279	224462279	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:224462279C>T	uc002vnm.2	-	2	1855	c.1722G>A	c.(1720-1722)CCG>CCA	p.P574P		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	574					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		CATCATTCTTCGGGGGCCCCA	0.493000												
INPP5D	3635	broad.mit.edu	37	2	234112803	234112803	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:234112803A>G	uc010zmo.1	+	25	3160	c.3007A>G	c.(3007-3009)ACG>GCG	p.T1003A	INPP5D_uc010zmp.1_Missense_Mutation_p.T1002A	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	1003	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CGCAGGGGACACGCTGCCTCA	0.512000												
FERMT1	55612	broad.mit.edu	37	20	6060153	6060153	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr20:6060153G>C	uc002wmr.2	-	14	2579	c.1790C>G	c.(1789-1791)ACC>AGC	p.T597S	FERMT1_uc002wmq.2_Missense_Mutation_p.T150S|FERMT1_uc010gbt.2_Missense_Mutation_p.T340S	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	597	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						TGGAATCCCGGTGGCTGCATC	0.363000												
C20orf106	200232	broad.mit.edu	37	20	55100090	55100090	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr20:55100090C>G	uc002xxx.2	+	1	306	c.226C>G	c.(226-228)CAA>GAA	p.Q76E	GCNT7_uc010zzg.1_Intron|C20orf107_uc010zzh.1_Missense_Mutation_p.Q76E	NM_001012971	NP_001012989	Q5JX71	CT106_HUMAN	hypothetical protein LOC200232 precursor	76	Cytoplasmic (Potential).					integral to membrane					0			Colorectal(105;0.202)			ACTGCAGTGTCAAAGAGACAG	0.453000												
DIDO1	11083	broad.mit.edu	37	20	61512061	61512061	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr20:61512061C>T	uc002ydr.1	-	16	5511	c.5247G>A	c.(5245-5247)CCG>CCA	p.P1749P	DIDO1_uc002yds.1_Silent_p.P1749P	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1749	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GACCCTGAAACGGGGGCTGAG	0.672000												
PCMTD2	55251	broad.mit.edu	37	20	62904872	62904872	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr20:62904872G>A	uc002yil.3	+	6	1205	c.1005G>A	c.(1003-1005)GTG>GTA	p.V335V	PCMTD2_uc002yim.3_Silent_p.V308V	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	335						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					ACCCCCCAGTGAACTTCCTAC	0.502000												
LIPI	149998	broad.mit.edu	37	21	15579146	15579146	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr21:15579146G>A	uc002yjm.2	-	1	109	c.99C>T	c.(97-99)TGC>TGT	p.C33C		NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	11					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		ctgatctcaggcacacaacta	0.229000												
ITSN1	6453	broad.mit.edu	37	21	35166671	35166671	+	Silent	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr21:35166671A>G	uc002yta.1	+	17	2119	c.1851A>G	c.(1849-1851)CAA>CAG	p.Q617Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Silent_p.Q617Q|ITSN1_uc010gmg.2_Silent_p.Q580Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Silent_p.Q617Q|ITSN1_uc010gmi.2_Silent_p.Q580Q|ITSN1_uc010gmj.2_Silent_p.Q501Q|ITSN1_uc002ysy.2_Silent_p.Q617Q|ITSN1_uc002ysx.2_Silent_p.Q580Q|ITSN1_uc002ytb.1_Silent_p.Q617Q|ITSN1_uc002ytc.1_Silent_p.Q617Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Silent_p.Q580Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Silent_p.Q617Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Silent_p.Q551Q	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	617	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						ACAATAAGCAACAACTCCAGA	0.368000												
HLCS	3141	broad.mit.edu	37	21	38128931	38128931	+	Missense_Mutation	SNP	C	C	G	rs150665851	byFrequency	TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr21:38128931C>G	uc010gnb.2	-	10	3122	c.1921G>C	c.(1921-1923)GTG>CTG	p.V641L	HLCS_uc002yvs.2_Missense_Mutation_p.V641L	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	641					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	AGCACAGTCACGACTCTGGCG	0.488000												
BCR	613	broad.mit.edu	37	22	23630318	23630318	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr22:23630318G>A	uc002zww.2	+	12	3157	c.2561G>A	c.(2560-2562)CGT>CAT	p.R854H	BCR_uc002zwx.2_Missense_Mutation_p.R854H|BCR_uc011aiy.1_Missense_Mutation_p.R443H|BCR_uc002zwy.1_Missense_Mutation_p.R140H	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	854	PH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						GACTATGAGCGTGCAGAGTGG	0.567000			T	ABL1| FGFR1|JAK2 	CML|ALL|AML							
ELFN2	114794	broad.mit.edu	37	22	37769709	37769709	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr22:37769709C>T	uc003asq.3	-	3	2652	c.1866G>A	c.(1864-1866)GCG>GCA	p.A622A		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	622	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GGGTCACGGCCGCGTCGGCGC	0.687000												
TRIOBP	11078	broad.mit.edu	37	22	38130551	38130551	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr22:38130551C>T	uc003atr.2	+	9	4479	c.4208C>T	c.(4207-4209)CCT>CTT	p.P1403L	TRIOBP_uc003atu.2_Missense_Mutation_p.P1231L	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1403					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GCCAGGACCCCTGAGAGGGAG	0.657000												
SHANK3	85358	broad.mit.edu	37	22	51159690	51159690	+	Silent	SNP	T	T	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr22:51159690T>C	uc003bne.1	+	22	3477	c.3477T>C	c.(3475-3477)TTT>TTC	p.F1159F	SHANK3_uc003bnf.1_Silent_p.F606F|SHANK3_uc010hbg.1_Silent_p.F341F	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1159										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GACCCCTGTTTGTGGATGTAC	0.716000												
FBLN2	2199	broad.mit.edu	37	3	13672213	13672213	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:13672213G>A	uc011avb.1	+	14	2967	c.2842G>A	c.(2842-2844)GAG>AAG	p.E948K	FBLN2_uc011auz.1_Missense_Mutation_p.E974K|FBLN2_uc011ava.1_Missense_Mutation_p.E995K|FBLN2_uc011avc.1_Missense_Mutation_p.E995K	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	948	EGF-like 8; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GAATGAGTGTGAGGCCCAGCG	0.622000												
TGFBR2	7048	broad.mit.edu	37	3	30713756	30713756	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:30713756C>T	uc003ceo.2	+	4	1463	c.1081C>T	c.(1081-1083)CTC>TTC	p.L361F	TGFBR2_uc003cen.2_Missense_Mutation_p.L386F	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	361	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GATTGCTCACCTCCACAGTGA	0.607000												
C3orf14	57415	broad.mit.edu	37	3	62317026	62317026	+	Silent	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:62317026A>G	uc003dlf.2	+	5	348	c.204A>G	c.(202-204)CTA>CTG	p.L68L	C3orf14_uc010hnq.2_Silent_p.L68L|C3orf14_uc003dlg.2_Silent_p.L68L	NM_020685	NP_065736	Q9HBI5	CC014_HUMAN	hypothetical protein LOC57415	68										central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.00023)|KIRC - Kidney renal clear cell carcinoma(15;0.00877)|Kidney(15;0.0101)		AAAAGTCACTACAGACCAGGA	0.398000												
CADPS	8618	broad.mit.edu	37	3	62459960	62459960	+	Missense_Mutation	SNP	G	G	T	rs151301388		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:62459960G>T	uc003dll.2	-	24	3725	c.3365C>A	c.(3364-3366)ACC>AAC	p.T1122N	CADPS_uc003dlj.1_Missense_Mutation_p.T72N|CADPS_uc003dlk.1_Missense_Mutation_p.T570N|CADPS_uc003dlm.2_Missense_Mutation_p.T1083N|CADPS_uc003dln.2_Missense_Mutation_p.T1043N	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1122	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TGATCGACTGGTTTTTTGCAG	0.393000												
ROBO2	6092	broad.mit.edu	37	3	77623795	77623795	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:77623795T>G	uc003dpy.3	+	14	2760	c.2117T>G	c.(2116-2118)GTG>GGG	p.V706G	ROBO2_uc003dpz.2_Missense_Mutation_p.V710G|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.V710G	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	706	Fibronectin type-III 2.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AAAAAGGGGGTGACTTATGAA	0.428000												
OR5K1	26339	broad.mit.edu	37	3	98188869	98188869	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:98188869T>A	uc003dsm.2	+	1	449	c.449T>A	c.(448-450)ATA>AAA	p.I150K		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						GGGGCCTTCATAGCTGGAAAC	0.453000												
OR5K2	402135	broad.mit.edu	37	3	98217288	98217288	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:98217288T>A	uc011bgx.1	+	1	764	c.764T>A	c.(763-765)ATT>AAT	p.I255N		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TATGGATCTATTTTTTTCCTA	0.343000												
FAM55C	91775	broad.mit.edu	37	3	101520287	101520287	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:101520287C>T	uc003dvn.2	+	5	939	c.302C>T	c.(301-303)ACT>ATT	p.T101I	FAM55C_uc010hpn.2_Missense_Mutation_p.T101I	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	101						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						GTGAAGAGCACTGACCCTTCT	0.552000												
PDIA5	10954	broad.mit.edu	37	3	122808024	122808024	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:122808024C>T	uc003egc.1	+	2	108	c.52C>T	c.(52-54)CCA>TCA	p.P18S	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	18					cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		GGTGGTCCTGCCATCATGGCT	0.542000												
ROPN1	54763	broad.mit.edu	37	3	123695732	123695732	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:123695732C>T	uc003eha.2	-	4	554	c.213G>A	c.(211-213)CTG>CTA	p.L71L		NM_017578	NP_060048	Q9HAT0	ROP1A_HUMAN	ropporin	71					signal transduction		cAMP-dependent protein kinase regulator activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.148)		GGATCTTTAACAGCTCAGGTG	0.547000												
EIF2A	83939	broad.mit.edu	37	3	150290091	150290091	+	Silent	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:150290091A>C	uc003eya.2	+	10	1174	c.1158A>C	c.(1156-1158)GGA>GGC	p.G386G	SERP1_uc003exz.2_Intron|EIF2A_uc003eyb.2_Silent_p.G259G|EIF2A_uc003eyc.2_Silent_p.G259G|EIF2A_uc011bnv.1_Silent_p.G361G|EIF2A_uc011bnw.1_Silent_p.G325G|EIF2A_uc003eyd.2_Silent_p.G161G|uc003eye.1_Intron	NM_032025	NP_114414	Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A	386	WD 3.				regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TTAATAATGGATACAAAATTT	0.418000												
MME	4311	broad.mit.edu	37	3	154866382	154866382	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:154866382A>C	uc010hvr.1	+	16	1752	c.1541A>C	c.(1540-1542)AAT>ACT	p.N514T	MME_uc003fab.1_Missense_Mutation_p.N514T|MME_uc003fac.1_Missense_Mutation_p.N514T|MME_uc003fad.1_Missense_Mutation_p.N514T|MME_uc003fae.1_Missense_Mutation_p.N514T	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	514	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	ATAATTCAAAATTTGAAATTC	0.313000												
SMC4	10051	broad.mit.edu	37	3	160151539	160151539	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr3:160151539A>C	uc003fdh.2	+	24	3922	c.3809A>C	c.(3808-3810)AAC>ACC	p.N1270T	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.N1245T|SMC4_uc003fdj.2_Missense_Mutation_p.N1270T|SMC4_uc010hwd.2_Missense_Mutation_p.N1212T|SMC4_uc003fdl.2_Missense_Mutation_p.N973T	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1270					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAGACATACAACATAACAAAA	0.299000												
IL8	3576	broad.mit.edu	37	4	74606394	74606394	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr4:74606394G>T	uc003hhe.2	+	1	120	c.19G>T	c.(19-21)GTG>TTG	p.V7L	IL8_uc011cbh.1_Missense_Mutation_p.V7L	NM_000584	NP_000575	P10145	IL8_HUMAN	interleukin 8 precursor	7					angiogenesis|calcium-mediated signaling|cell cycle arrest|cellular response to lipopolysaccharide|embryonic digestive tract development|G-protein coupled receptor protein signaling pathway|immune response|induction of positive chemotaxis|inflammatory response|negative regulation of cell proliferation|neutrophil activation|neutrophil chemotaxis|positive regulation of neutrophil chemotaxis|regulation of cell adhesion|regulation of retroviral genome replication	extracellular space|intracellular	chemokine activity|interleukin-8 receptor binding			ovary(2)	2	Breast(15;0.00102)		all cancers(17;0.00169)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)	LUSC - Lung squamous cell carcinoma(721;0.008)	Ketoprofen(DB01009)|Salbutamol(DB01001)|Simvastatin(DB00641)|Zileuton(DB00744)	CAAGCTGGCCGTGGCTCTCTT	0.488000												
ADH5	128	broad.mit.edu	37	4	99997596	99997596	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr4:99997596G>A	uc003hui.2	-	6	752	c.672C>T	c.(670-672)ATC>ATT	p.I224I	ADH5_uc003huk.1_Silent_p.I224I|ADH5_uc003huj.2_Silent_p.I102I	NM_000671	NP_000662	P11766	ADHX_HUMAN	class III alcohol dehydrogenase, chi subunit	224					ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)	TATCTTTATTGATGTCCACAC	0.468000												
NDST3	9348	broad.mit.edu	37	4	119154234	119154234	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr4:119154234A>C	uc003ibx.2	+	9	2290	c.1887A>C	c.(1885-1887)AAA>AAC	p.K629N	NDST3_uc011cgf.1_Missense_Mutation_p.K548N	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	629	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CCAGCCCAAAAACCTTTGAGG	0.368000												
ODZ3	55714	broad.mit.edu	37	4	183609479	183609479	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr4:183609479C>T	uc003ivd.1	+	11	2233	c.2196C>T	c.(2194-2196)GGC>GGT	p.G732G	ODZ3_uc003ive.1_Silent_p.G138G	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	732	Extracellular (Potential).|EGF-like 7.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GCAGCCAGGGCTGGAATGGAG	0.587000												
SLC6A19	340024	broad.mit.edu	37	5	1212459	1212459	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:1212459T>G	uc003jbw.3	+	4	579	c.523T>G	c.(523-525)TTC>GTC	p.F175V		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	175	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGTGGACTACTTCTGGTACCG	0.622000												
SEMA5A	9037	broad.mit.edu	37	5	9063138	9063138	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:9063138C>G	uc003jek.2	-	18	3091	c.2379G>C	c.(2377-2379)TGG>TGC	p.W793C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	793	TSP type-1 5.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TGCACTGTGACCACGACGTCC	0.597000												
PDE8B	8622	broad.mit.edu	37	5	76704759	76704759	+	Silent	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:76704759C>A	uc003kfa.2	+	14	1452	c.1407C>A	c.(1405-1407)GTC>GTA	p.V469V	PDE8B_uc003kfb.2_Silent_p.V449V|PDE8B_uc003kfc.2_Intron|PDE8B_uc003kfd.2_Silent_p.V422V|PDE8B_uc003kfe.2_Silent_p.V372V	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	469					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		ACAGCCCAGTCACAGTAGCGG	0.443000												
IK	3550	broad.mit.edu	37	5	140033632	140033632	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:140033632C>T	uc003lgq.2	+	6	624	c.514C>T	c.(514-516)CAA>TAA	p.Q172*	IK_uc011czk.1_Nonsense_Mutation_p.Q172*	NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	172					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTCTGCTTCAAAAGGTGAG	0.493000												
PCDHB4	56131	broad.mit.edu	37	5	140501697	140501697	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:140501697G>A	uc003lip.1	+	1	117	c.117G>A	c.(115-117)GAG>GAA	p.E39E		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	39	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAAACAGAGAGCGGCTCCT	0.537000												
PCDHGC3	5098	broad.mit.edu	37	5	140856557	140856557	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:140856557C>T	uc003lkv.1	+	1	989	c.874C>T	c.(874-876)CGG>TGG	p.R292W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.R292W|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	292	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCGGCGTGCGGCAACTATT	0.557000												
DOCK2	1794	broad.mit.edu	37	5	169101311	169101311	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:169101311A>G	uc003maf.2	+	6	412	c.332A>G	c.(331-333)AAG>AGG	p.K111R	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	111					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCAGCAAAAAGGAGCGTTTT	0.498000												
MSX2	4488	broad.mit.edu	37	5	174156283	174156283	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:174156283C>T	uc003mcy.2	+	2	589	c.501C>T	c.(499-501)CTC>CTT	p.L167L		NM_002449	NP_002440	P35548	MSX2_HUMAN	msh homeobox 2	167	Homeobox.				cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			AACAGTACCTCTCCATTGCAG	0.567000												
ABT1	29777	broad.mit.edu	37	6	26598840	26598840	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:26598840C>T	uc003nii.2	+	3	817	c.786C>T	c.(784-786)AGC>AGT	p.S262S		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	262					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						CCTCAGAGAGCATGGAGGGAC	0.622000												
CNPY3	10695	broad.mit.edu	37	6	42897330	42897330	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:42897330G>A	uc003ota.3	+	1	471	c.22G>A	c.(22-24)GCG>ACG	p.A8T	CNPY3_uc003osy.2_RNA|CNPY3_uc003osz.2_Missense_Mutation_p.A8T|CNPY3_uc003otc.3_5'UTR|CNPY3_uc003otb.3_5'UTR	NM_006586	NP_006577	Q9BT09	CNPY3_HUMAN	trinucleotide repeat containing 5 precursor	8					innate immune response	endoplasmic reticulum				ovary(1)	1	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			GCCTGAGCCCGCGTCCCGCTG	0.627000												
CNR1	1268	broad.mit.edu	37	6	88854325	88854325	+	Silent	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:88854325G>T	uc011dzq.1	-	2	4232	c.669C>A	c.(667-669)GCC>GCA	p.A223A	CNR1_uc010kbz.2_Silent_p.A223A|CNR1_uc011dzr.1_Silent_p.A223A|CNR1_uc011dzs.1_Silent_p.A223A|CNR1_uc003pmq.3_Silent_p.A223A|CNR1_uc011dzt.1_Silent_p.A223A|CNR1_uc010kca.2_Silent_p.A190A	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	223	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	TCCTCTTATAGGCCAGGGGCC	0.587000												
BACH2	60468	broad.mit.edu	37	6	90660506	90660506	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:90660506T>C	uc011eab.1	-	7	2128	c.1319A>G	c.(1318-1320)CAA>CGA	p.Q440R	BACH2_uc003pnw.2_Missense_Mutation_p.Q440R|BACH2_uc010kch.2_Missense_Mutation_p.Q440R	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	440						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GGTGCTCACTTGGTCACAAGC	0.612000												
COQ3	51805	broad.mit.edu	37	6	99842017	99842017	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:99842017C>A	uc003ppk.2	-	1	66	c.39G>T	c.(37-39)TGG>TGT	p.W13C		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	13					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		CTCTTAAAAACCAACCCCCGG	0.562000												
GRIK2	2898	broad.mit.edu	37	6	102483269	102483269	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:102483269G>T	uc003pqp.3	+	14	2388	c.2139G>T	c.(2137-2139)AGG>AGT	p.R713S	GRIK2_uc003pqo.3_Missense_Mutation_p.R713S|GRIK2_uc010kcw.2_Missense_Mutation_p.R713S	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	713	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GTAGCAGAAGGCAGTCAGTGC	0.393000												
KIAA1919	91749	broad.mit.edu	37	6	111587791	111587791	+	Silent	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:111587791T>A	uc003puv.3	+	4	1448	c.1026T>A	c.(1024-1026)TCT>TCA	p.S342S		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	342	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		GTGGTGTTTCTTGGATTGAGC	0.438000												
EYA4	2070	broad.mit.edu	37	6	133777756	133777756	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:133777756G>A	uc003qec.3	+	6	798	c.340G>A	c.(340-342)GAT>AAT	p.D114N	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Missense_Mutation_p.D114N|EYA4_uc003qee.3_Missense_Mutation_p.D91N|EYA4_uc011ecs.1_Missense_Mutation_p.D114N|uc003qef.1_RNA	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	114					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CACGACTGGAGATGGAGCGCT	0.473000												
AKAP12	9590	broad.mit.edu	37	6	151674697	151674697	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr6:151674697C>G	uc011eep.1	+	4	5411	c.5171C>G	c.(5170-5172)ACC>AGC	p.T1724S	AKAP12_uc003qoe.2_Missense_Mutation_p.T1724S|AKAP12_uc003qof.2_Missense_Mutation_p.T1626S|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.T1619S	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1724					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GGAGGCTTAACCAAAGAGTCC	0.438000												
WIPI2	26100	broad.mit.edu	37	7	5256764	5256764	+	Silent	SNP	G	G	A	rs149226373	byFrequency	TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:5256764G>A	uc003snv.2	+	6	738	c.522G>A	c.(520-522)GCG>GCA	p.A174A	WIPI2_uc003snw.2_Silent_p.A174A|WIPI2_uc003snx.2_Silent_p.A156A|WIPI2_uc003sny.2_Silent_p.A156A|WIPI2_uc010ksv.2_Silent_p.A30A|WIPI2_uc003snz.2_Silent_p.A115A|WIPI2_uc003soa.2_Silent_p.A115A	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	174					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		GCTACTTGGCGTACCCAGGGA	0.512000												
HNRNPA2B1	3181	broad.mit.edu	37	7	26233297	26233297	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:26233297T>A	uc003sxr.3	-	9	991	c.775A>T	c.(775-777)AGC>TGC	p.S259C	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.S247C	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	259	Gly-rich.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TAACCGGGGCTACCTCCAAAA	0.448000			T	ETV1	prostate							
BBS9	27241	broad.mit.edu	37	7	33384196	33384196	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:33384196G>C	uc003tdn.1	+	12	1792	c.1279G>C	c.(1279-1281)GCG>CCG	p.A427P	BBS9_uc003tdo.1_Missense_Mutation_p.A427P|BBS9_uc003tdp.1_Missense_Mutation_p.A427P|BBS9_uc003tdq.1_Missense_Mutation_p.A427P|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_5'UTR|BBS9_uc011kao.1_Missense_Mutation_p.A305P	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	427					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TTTACAGCAAGCGACCGATGT	0.388000									Bardet-Biedl_syndrome			
NPSR1	387129	broad.mit.edu	37	7	34888196	34888196	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:34888196C>A	uc003teg.1	+	8	1074	c.946C>A	c.(946-948)CAG>AAG	p.Q316K	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.Q316K|NPSR1_uc010kwt.1_Missense_Mutation_p.Q163K|NPSR1_uc010kwu.1_Missense_Mutation_p.Q106K|NPSR1_uc010kwv.1_Missense_Mutation_p.Q250K|NPSR1_uc003tei.1_Missense_Mutation_p.Q316K|NPSR1_uc010kww.1_Missense_Mutation_p.Q305K|NPSR1_uc011kar.1_Missense_Mutation_p.Q250K	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	316	Helical; Name=7; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TGTGATCATTCAGAACCTGCC	0.493000												
OGDH	4967	broad.mit.edu	37	7	44721435	44721435	+	Silent	SNP	C	C	T	rs140074828		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:44721435C>T	uc003tln.2	+	10	1432	c.1323C>T	c.(1321-1323)GTC>GTT	p.V441V	OGDH_uc011kbx.1_Silent_p.V437V|OGDH_uc011kby.1_Silent_p.V291V|OGDH_uc003tlp.2_Silent_p.V452V|OGDH_uc011kbz.1_Silent_p.V236V|OGDH_uc003tlo.1_Silent_p.V274V	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	441					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TGCACGTGGTCGTCAACAACC	0.527000												
TBRG4	9238	broad.mit.edu	37	7	45140909	45140909	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:45140909C>T	uc003tmv.2	-	10	1868	c.1742G>A	c.(1741-1743)CGC>CAC	p.R581H	TBRG4_uc003tmu.2_Missense_Mutation_p.R406H|TBRG4_uc003tmw.2_Missense_Mutation_p.R471H|TBRG4_uc003tmx.2_Missense_Mutation_p.R471H|TBRG4_uc011kcd.1_Missense_Mutation_p.R592H	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	581	RAP.				apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						CAGAACAAAGCGACCCAGCAA	0.572000												
CYP51A1	1595	broad.mit.edu	37	7	91761090	91761090	+	Nonsense_Mutation	SNP	T	T	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:91761090T>A	uc003ulm.3	-	2	451	c.289A>T	c.(289-291)AAG>TAG	p.K97*	CYP51A1_uc011khn.1_5'UTR|CYP51A1_uc003uln.3_Nonsense_Mutation_p.K34*|uc003ulo.1_5'Flank	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	91					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	AGACTTACCTTCTCATATGCA	0.318000												
TRRAP	8295	broad.mit.edu	37	7	98609873	98609873	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:98609873C>T	uc003upp.2	+	72	11684	c.11475C>T	c.(11473-11475)CTC>CTT	p.L3825L	TRRAP_uc011kis.1_Silent_p.L3796L|TRRAP_uc003upr.2_Silent_p.L3531L|TRRAP_uc003ups.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3825	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCACAACCTCGCCCAGTTCG	0.652000												
DOCK4	9732	broad.mit.edu	37	7	111509706	111509706	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:111509706A>G	uc003vfx.2	-	21	2302	c.2033T>C	c.(2032-2034)CTC>CCC	p.L678P	DOCK4_uc003vfw.2_Missense_Mutation_p.L119P|DOCK4_uc003vfy.2_Missense_Mutation_p.L678P|DOCK4_uc003vga.1_Missense_Mutation_p.L283P	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	678					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CACTTTGATGAGATCTCTAAA	0.408000												
MKLN1	4289	broad.mit.edu	37	7	131128366	131128366	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:131128366C>G	uc011kpm.1	+	11	1364	c.1300C>G	c.(1300-1302)CAA>GAA	p.Q434E	MKLN1_uc011kpl.1_Missense_Mutation_p.Q411E|MKLN1_uc010lmh.2_Missense_Mutation_p.Q434E|MKLN1_uc003vqs.2_Missense_Mutation_p.Q227E	NM_013255	NP_037387	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing	434	Kelch 3.				signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)					TTTCAACTGTCAATGTCAAAC	0.453000												
SSPO	23145	broad.mit.edu	37	7	149489542	149489542	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr7:149489542C>T	uc010lpk.2	+	38	5695	c.5695C>T	c.(5695-5697)CGC>TGC	p.R1899C		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1899	EGF-like 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACGGCCCCGACGCTGCCGACT	0.692000												
MYOM2	9172	broad.mit.edu	37	8	2088737	2088737	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:2088737A>G	uc003wpx.3	+	33	4030	c.3892A>G	c.(3892-3894)AAA>GAA	p.K1298E	MYOM2_uc011kwi.1_Missense_Mutation_p.K723E	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1298					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGAGAAGGATAAAGGAAAATA	0.433000												
AMAC1L2	83650	broad.mit.edu	37	8	11189026	11189026	+	Silent	SNP	T	T	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:11189026T>C	uc003wtp.1	+	1	532	c.411T>C	c.(409-411)TCT>TCC	p.S137S		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	137	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		GCAAAGGTTCTTCCACCGTAT	0.587000												
PHYHIP	9796	broad.mit.edu	37	8	22081773	22081773	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:22081773G>A	uc003xbk.3	-	5	1118	c.424C>T	c.(424-426)CGC>TGC	p.R142C	PHYHIP_uc003xbj.3_Missense_Mutation_p.R142C	NM_001099335	NP_001092805	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	142											0				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		TGATGGTTGCGGTAGAAGACG	0.622000												
FBXO16	157574	broad.mit.edu	37	8	28314318	28314318	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:28314318G>C	uc003xgu.2	-	5	570	c.472C>G	c.(472-474)CAA>GAA	p.Q158E	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.Q145E|FBXO16_uc003xgw.2_Missense_Mutation_p.Q145E	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	158										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		TTCACCATTTGAATATAGTGC	0.408000												
ANK1	286	broad.mit.edu	37	8	41526001	41526001	+	Silent	SNP	C	C	T	rs139149232		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:41526001C>T	uc003xok.2	-	39	5262	c.5178G>A	c.(5176-5178)ACG>ACA	p.T1726T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Silent_p.T880T|ANK1_uc003xoi.2_Silent_p.T1726T|ANK1_uc003xoj.2_Silent_p.T1726T|ANK1_uc003xol.2_Silent_p.T1564T|ANK1_uc003xom.2_Silent_p.T1767T	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1726	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGGACCTTGCGTGACCTCCT	0.552000												
RGS20	8601	broad.mit.edu	37	8	54792024	54792024	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:54792024G>A	uc003xrp.2	+	2	464	c.372G>A	c.(370-372)CCG>CCA	p.P124P	RGS20_uc003xrq.2_Intron|RGS20_uc010lye.2_Intron|RGS20_uc010lyf.2_Intron|RGS20_uc003xrr.2_5'Flank|RGS20_uc003xrs.2_5'Flank|RGS20_uc003xrt.2_5'Flank	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	124					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			AGGAGCTGCCGGGCCGCCTCT	0.791000												
RDH10	157506	broad.mit.edu	37	8	74233246	74233246	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:74233246G>C	uc003xzi.2	+	4	964	c.704G>C	c.(703-705)GGA>GCA	p.G235A	RDH10_uc003xzj.2_Missense_Mutation_p.G70A|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	235					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			GAAAAGGATGGAATTAAAACA	0.413000												
ZFHX4	79776	broad.mit.edu	37	8	77768366	77768366	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:77768366C>A	uc003yav.2	+	10	9461	c.9074C>A	c.(9073-9075)GCT>GAT	p.A3025D	ZFHX4_uc003yau.1_Missense_Mutation_p.A3070D|ZFHX4_uc003yaw.1_Missense_Mutation_p.A3025D	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3025						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATAAAGAAAGCTTCAGACGTG	0.577000										HNSCC(33;0.089)		
WWP1	11059	broad.mit.edu	37	8	87455005	87455005	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:87455005A>G	uc003ydt.2	+	18	2276	c.1996A>G	c.(1996-1998)ATG>GTG	p.M666V	WWP1_uc010mai.2_Missense_Mutation_p.M442V	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	666	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TTTTATTGCCATGGTGAGTTC	0.313000												
WWP1	11059	broad.mit.edu	37	8	87464854	87464854	+	Silent	SNP	T	T	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:87464854T>C	uc003ydt.2	+	21	2620	c.2340T>C	c.(2338-2340)TTT>TTC	p.F780F		NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	780	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TTGATGGTTTTAATGAAGTTG	0.363000												
CNGB3	54714	broad.mit.edu	37	8	87738794	87738794	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:87738794C>G	uc003ydx.2	-	3	349	c.303G>C	c.(301-303)CAG>CAC	p.Q101H		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	101	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CCATTTCCTTCTGCTCTGGCA	0.438000												
CNBD1	168975	broad.mit.edu	37	8	88365873	88365873	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:88365873C>T	uc003ydy.2	+	10	1210	c.1162C>T	c.(1162-1164)CAA>TAA	p.Q388*		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	388	cNMP.									ovary(3)	3						GAAAAGATCTCAAAAACTTGT	0.318000												
C8orf38	137682	broad.mit.edu	37	8	96053846	96053846	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:96053846G>A	uc003yhj.2	+	4	485	c.469G>A	c.(469-471)GAT>AAT	p.D157N	C8orf38_uc003yhe.1_RNA|C8orf38_uc003yhf.2_Missense_Mutation_p.D65N|C8orf38_uc011lgs.1_RNA|C8orf38_uc003yhi.2_Missense_Mutation_p.D105N|C8orf38_uc003yhk.2_RNA|C8orf38_uc003yhl.2_Missense_Mutation_p.D65N	NM_152416	NP_689629	Q330K2	CH038_HUMAN	hypothetical protein LOC137682 precursor	157					biosynthetic process	mitochondrion	transferase activity				0	Breast(36;3.32e-06)					GAAAATCGTCGATGAAAGAGT	0.284000												
ANGPT1	284	broad.mit.edu	37	8	108306164	108306164	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:108306164C>A	uc003ymn.2	-	6	1506	c.1038G>T	c.(1036-1038)ATG>ATT	p.M346I	ANGPT1_uc011lhv.1_Missense_Mutation_p.M146I|ANGPT1_uc003ymo.2_Missense_Mutation_p.M345I|ANGPT1_uc003ymp.3_Missense_Mutation_p.M145I	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	346	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGCATCTTACCATTTTATATT	0.353000												
CSMD3	114788	broad.mit.edu	37	8	114111188	114111188	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:114111188T>G	uc003ynu.2	-	5	873	c.714A>C	c.(712-714)GAA>GAC	p.E238D	CSMD3_uc003ynt.2_Missense_Mutation_p.E198D|CSMD3_uc011lhx.1_Missense_Mutation_p.E238D|CSMD3_uc010mcx.1_Missense_Mutation_p.E238D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	238	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACAAGCATCTTCAGCTGTTA	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
GPR20	2843	broad.mit.edu	37	8	142367549	142367549	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:142367549G>A	uc003ywf.2	-	2	564	c.475C>T	c.(475-477)CGC>TGC	p.R159C		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	159	Cytoplasmic (Potential).			GSRR -> APAA (in Ref. 1; AAC51302).		integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CGGCAGCGGCGGGAGCCTTCG	0.692000												
EPPK1	83481	broad.mit.edu	37	8	144940957	144940957	+	Silent	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr8:144940957C>T	uc003zaa.1	-	1	6478	c.6465G>A	c.(6463-6465)GCG>GCA	p.A2155A		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2155						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGATGAGCTGCGCTACCGTCT	0.502000												
LINGO2	158038	broad.mit.edu	37	9	27949741	27949741	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr9:27949741C>T	uc003zqu.1	-	2	1123	c.929G>A	c.(928-930)CGC>CAC	p.R310H	LINGO2_uc010mjf.1_Missense_Mutation_p.R310H|LINGO2_uc003zqv.1_Missense_Mutation_p.R310H	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	310	LRR 11.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CTCAATGGTGCGAAGCTGGGC	0.527000												
NPR2	4882	broad.mit.edu	37	9	35808791	35808791	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr9:35808791G>A	uc003zyd.2	+	20	2927	c.2927G>A	c.(2926-2928)CGT>CAT	p.R976H	NPR2_uc010mlb.2_Missense_Mutation_p.R952H|SPAG8_uc003zye.2_Intron	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	976	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	AAGATGCCCCGTTATTGTCTT	0.502000												
IARS	3376	broad.mit.edu	37	9	95040490	95040490	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr9:95040490A>G	uc004art.1	-	8	1081	c.824T>C	c.(823-825)ATC>ACC	p.I275T	IARS_uc004ars.1_Missense_Mutation_p.I120T|IARS_uc004aru.3_Missense_Mutation_p.I275T|IARS_uc010mqr.2_Missense_Mutation_p.I165T|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	275					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CCTTTCAAGGATCTCATAGTC	0.348000												
CYLC2	1539	broad.mit.edu	37	9	105767266	105767266	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr9:105767266G>A	uc004bbs.2	+	5	423	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	118	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				GGTAAGAAAGGTGAAGACAAG	0.219000												
C9orf4	23732	broad.mit.edu	37	9	111909347	111909347	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr9:111909347G>A	uc004bdw.1	-	3	599	c.599C>T	c.(598-600)TCT>TTT	p.S200F		NM_014334	NP_055149	Q9P0K9	CI004_HUMAN	hypothetical protein LOC23732	200	DOMON.					integral to membrane					0						CTTGTCTGAAGAGAATCCAAC	0.403000												
ASTN2	23245	broad.mit.edu	37	9	119770444	119770444	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr9:119770444G>A	uc004bjs.1	-	7	1619	c.1518C>T	c.(1516-1518)ACC>ACT	p.T506T	ASTN2_uc004bjr.1_Silent_p.T506T|ASTN2_uc004bjt.1_Silent_p.T455T	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	506	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CCCATGGGGAGGTGGCATTGA	0.577000												
SETX	23064	broad.mit.edu	37	9	135156925	135156925	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr9:135156925G>C	uc004cbk.2	-	20	6766	c.6583C>G	c.(6583-6585)CTC>GTC	p.L2195V	SETX_uc004cbj.2_Missense_Mutation_p.L1814V|SETX_uc010mzt.2_Missense_Mutation_p.L1814V	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2195					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CGATGGATGAGTGGAGTAAGA	0.398000												
ARHGAP6	395	broad.mit.edu	37	X	11162141	11162141	+	Nonsense_Mutation	SNP	G	G	C			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chrX:11162141G>C	uc004cup.1	-	11	3008	c.2135C>G	c.(2134-2136)TCA>TGA	p.S712*	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Nonsense_Mutation_p.S712*|ARHGAP6_uc004cum.1_Nonsense_Mutation_p.S509*|ARHGAP6_uc004cun.1_Nonsense_Mutation_p.S532*|ARHGAP6_uc010neb.1_Nonsense_Mutation_p.S534*|ARHGAP6_uc011mif.1_3'UTR	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	712					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CCTTGACTTTGACGACGACAA	0.597000											OREG0019666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
MAGEH1	28986	broad.mit.edu	37	X	55478927	55478927	+	Silent	SNP	A	A	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chrX:55478927A>G	uc004dum.2	+	1	390	c.120A>G	c.(118-120)GTA>GTG	p.V40V		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	40	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCTCTGTGGTAGCGAGCACCC	0.647000												
GABRA3	2556	broad.mit.edu	37	X	151514087	151514087	+	Silent	SNP	G	G	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chrX:151514087G>A	uc010ntk.1	-	3	468	c.228C>T	c.(226-228)GAC>GAT	p.D76D		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	76	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTCATAGCCGTCCAGAAGAC	0.468000												
MINK1	50488	broad.mit.edu	37	17	4794324	4794324	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:4794324delC	uc010vsl.1	+	15	1841	c.1645delC	c.(1645-1647)CCCfs	p.P549fs	MINK1_uc010vsk.1_Frame_Shift_Del_p.P549fs|MINK1_uc010vsm.1_Frame_Shift_Del_p.P549fs|MINK1_uc010vsn.1_Frame_Shift_Del_p.P549fs|MINK1_uc010vso.1_Frame_Shift_Del_p.P494fs|MINK1_uc010vsp.1_Frame_Shift_Del_p.P39fs	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	549					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						GGGGCCTGAGCCCCCCATCCC	0.627												
TP53	7157	broad.mit.edu	37	17	7579470	7579471	+	Frame_Shift_Ins	INS	-	-	G	rs56275308		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:7579470_7579471insG	uc002gim.2	-	4	410_411	c.216_217insC	c.(214-219)CCCGTGfs	p.P72fs	TP53_uc002gig.1_Frame_Shift_Ins_p.P72fs|TP53_uc002gih.2_Frame_Shift_Ins_p.P72fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.P72fs|TP53_uc010cni.1_Frame_Shift_Ins_p.P72fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P72fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.P33fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.P87fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	72_73	Interaction with WWOX.|Interaction with HRMT1L2.		V -> M (in sporadic cancers; somatic mutation).|V -> E (in a sporadic cancer; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.R72fs*51(6)|p.V73L(3)|p.G59fs*23(3)|p.R72C(2)|p.V73fs*76(2)|p.R72H(2)|p.V73M(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.V73fs*50(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGCCACGGGGGGAGCAG	0.604		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
GPR98	84059	broad.mit.edu	37	5	90281206	90281208	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr5:90281206_90281208delGAG	uc003kju.2	+	85	18115_18117	c.18019_18021delGAG	c.(18019-18021)GAGdel	p.E6007del	GPR98_uc003kjt.2_In_Frame_Del_p.E3713del|GPR98_uc003kjw.2_In_Frame_Del_p.E1668del|GPR98_uc003kjx.2_In_Frame_Del_p.E35del	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	6007	Cytoplasmic (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGAGCACACAGAGAGGCGATATC	0.409												
AFF3	3899	broad.mit.edu	37	2	100217914	100217915	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:100217913_100217914T>TG	uc002taf.3	-	12	1573_1574	c.1429_1430A>CA	c.(1429-1431)cacfs	p.H477fs	AFF3_uc002tag.3_Frame_Shift_Ins_p.H452fs|AFF3_uc010fiq.1_Frame_Shift_Ins_p.H452fs|AFF3_uc010yvr.1_Frame_Shift_Ins_p.H605fs|AFF3_uc002tah.1_Frame_Shift_Ins_p.H477fs	NM_001025108	NP_001020279	P51826	AFF3_HUMAN	Homo sapiens AF4/FMR2 family, member 3 (AFF3), transcript variant 2, mRNA.	452					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GCTGGAGAAGTGGGGGGGCTTG	0.629												
KYNU	8942	broad.mit.edu	37	2	143798211	143798212	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr2:143798210_143798211G>GA	uc010fnm.3	+	13	1471_1472	c.1255_1256G>GA	c.(1255-1257)gaafs	p.E419fs	KYNU_uc002tvl.3_Frame_Shift_Ins_p.E419fs	NM_001199241	NP_001186170	Q16719	KYNU_HUMAN	Homo sapiens kynureninase (KYNU), transcript variant 3, mRNA.	419					NAD biosynthetic process|anthranilate metabolic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	CCAAGAACTAGAAAAAAGAGGA	0.396												
AKAP13	11214	broad.mit.edu	37	15	86118467	86118468	+	Frame_Shift_Ins	INS	-	-	CT			TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr15:86118466_86118467C>CCT	uc002blv.1	+	5	937_938	c.767_768C>CCT	c.(766-768)accfs	p.T256fs	AKAP13_uc002blt.1_Frame_Shift_Ins_p.T256fs|AKAP13_uc002blu.1_Frame_Shift_Ins_p.T256fs	NM_007200	NP_009131	Q12802	AKP13_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13), transcript variant 2, mRNA.	256					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	Rho guanyl-nucleotide exchange factor activity|cAMP-dependent protein kinase activity|metal ion binding|protein binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TATACATTAACCTCTGAGTCTG	0.426												
TP53	7157	broad.mit.edu	37	17	7579471	7579472	+	Frame_Shift_Ins	INS	-	-	G	rs56275308		TCGA-HU-A4HD-01A-11D-A25D-08	TCGA-HU-A4HD-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8304b367-d009-4a3f-ac16-2e203bafc9fd	4d53618f-7d90-47bf-ac32-ff6714f4a60c	g.chr17:7579470_7579471C>CG	uc002gim.2	-	3	410_411	c.216_217G>CG	c.(214-219)cccgtgfs	p.P72fs	TP53_uc002gig.1_Frame_Shift_Ins_p.P72fs|TP53_uc002gih.3_Frame_Shift_Ins_p.P72fs|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cni.1_Frame_Shift_Ins_p.P72fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.P72fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P72fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.2_Frame_Shift_Ins_p.P33fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.P87fs	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	72	Interaction with HRMT1L2.|Interaction with WWOX.		P -> C (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> G (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).|P -> L (in a sporadic cancer; somatic mutation).|P -> R (in dbSNP:rs1042522).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V73fs*76(16)|p.R72fs*51(9)|p.0?(8)|p.V73L(6)|p.V73M(4)|p.G59fs*23(3)|p.R72P(3)|p.V73fs*50(3)|p.D57_A76del20(2)|p.V73fs*9(2)|p.R72H(2)|p.R72C(2)|p.P71fs*78(1)|p.P71fs*79(1)|p.E68fs*76(1)|p.P13fs*18(1)|p.P71fs*53(1)|p.D48fs*55(1)|p.S33fs*23(1)|p.V73fs*75(1)|p.R65_P71delRMPEAAP(1)|p.R65fs*38(1)|p.E68_A78del(1)|p.V73E(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGCCACGGGGGGAGCAG	0.604		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)