Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
GPR153	387509	broad.mit.edu	37	1	6314738	6314738	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:6314738G>A	uc001amp.1	-	2	488	c.228C>T	c.(226-228)TTC>TTT	p.F76F		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	76	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		CATTCCACTCGAAGTCGGGGC	0.612000												
CLCNKB	1188	broad.mit.edu	37	1	16375656	16375656	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:16375656G>A	uc001axw.3	+	8	777	c.697G>A	c.(697-699)GTC>ATC	p.V233I	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.V233I|CLCNKB_uc001axy.3_Missense_Mutation_p.V64I	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	233					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CCACTTCTCTGTCTGGGATTA	0.632000												
PTPRF	5792	broad.mit.edu	37	1	44071064	44071064	+	Silent	SNP	C	C	T	rs148630488		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:44071064C>T	uc001cjr.2	+	18	3679	c.3339C>T	c.(3337-3339)GAC>GAT	p.D1113D	PTPRF_uc001cjs.2_Silent_p.D1104D|PTPRF_uc001cju.2_Silent_p.D491D|PTPRF_uc009vwt.2_Silent_p.D673D|PTPRF_uc001cjv.2_Silent_p.D573D|PTPRF_uc001cjw.2_Silent_p.D339D	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1113	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACATAGAGGACGGCCGCTTCG	0.667000												
CYP4X1	260293	broad.mit.edu	37	1	47501734	47501734	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:47501734C>T	uc001cqt.2	+	6	916	c.666C>T	c.(664-666)ATC>ATT	p.I222I	CYP4X1_uc001cqr.2_Silent_p.I221I|CYP4X1_uc001cqs.2_Silent_p.I157I	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	222						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						TCAGCAAAATCATATTTCACC	0.383000												
ASB17	127247	broad.mit.edu	37	1	76397900	76397900	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:76397900A>T	uc001dhe.1	-	1	217	c.77T>A	c.(76-78)ATT>AAT	p.I26N	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	26					intracellular signal transduction					ovary(1)	1						TCTTTTAACAATTTTGTCAAG	0.378000												
ATP8B2	57198	broad.mit.edu	37	1	154313404	154313404	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:154313404C>T	uc001fex.2	+	13	1208	c.1208C>T	c.(1207-1209)ACG>ATG	p.T403M		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	389	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AAGAAGCGGACGCCTGCAGAA	0.567000												
POGK	57645	broad.mit.edu	37	1	166819614	166819614	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:166819614T>A	uc001gdt.1	+	5	1918	c.1798T>A	c.(1798-1800)TGT>AGT	p.C600S	POGK_uc010ple.1_Missense_Mutation_p.C515S|POGK_uc010plf.1_Missense_Mutation_p.C482S	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	600					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						ACCAAAAGATTGTGACACCGA	0.348000												
GORAB	92344	broad.mit.edu	37	1	170508603	170508603	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:170508603G>A	uc001gha.2	+	2	416	c.389G>A	c.(388-390)AGT>AAT	p.S130N	GORAB_uc009wvw.2_3'UTR|GORAB_uc001ggz.3_Missense_Mutation_p.S130N|GORAB_uc009wvx.2_5'UTR|GORAB_uc001ghb.2_5'UTR|GORAB_uc001ghc.2_5'UTR	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	130						Golgi apparatus|nucleus					0						GGCATTGAAAGTCAGCCAAAG	0.448000												
FMO3	2328	broad.mit.edu	37	1	171083421	171083421	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:171083421G>A	uc001ghi.2	+	7	1213	c.1102G>A	c.(1102-1104)GTG>ATG	p.V368M	FMO3_uc001ghh.2_Missense_Mutation_p.V368M|FMO3_uc010pmb.1_Missense_Mutation_p.V348M|FMO3_uc010pmc.1_Missense_Mutation_p.V305M	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	368					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AACCATAGCAGTGATTGGCTT	0.448000												
PTPRC	5788	broad.mit.edu	37	1	198721391	198721391	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:198721391A>C	uc001gur.1	+	30	3395	c.3215A>C	c.(3214-3216)CAG>CCG	p.Q1072P	PTPRC_uc001gus.1_Missense_Mutation_p.Q1024P|PTPRC_uc001gut.1_Missense_Mutation_p.Q911P	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1072	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ATCTGTGCTCAGTACTGGGGA	0.378000												
C1orf124	83932	broad.mit.edu	37	1	231488616	231488616	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:231488616G>A	uc001hur.2	+	5	1427	c.979G>A	c.(979-981)GTT>ATT	p.V327I	C1orf124_uc001hus.2_3'UTR|C1orf124_uc001hut.2_3'UTR	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	327					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TCACCAAAATGTTCTAAGCAA	0.388000												
OR2G3	81469	broad.mit.edu	37	1	247769302	247769302	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr1:247769302C>T	uc010pyz.1	+	1	415	c.415C>T	c.(415-417)CGG>TGG	p.R139W		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATGAACCCACGGCTTTGCCA	0.512000												
NRP1	8829	broad.mit.edu	37	10	33496543	33496543	+	Silent	SNP	G	G	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr10:33496543G>T	uc001iwx.3	-	10	2239	c.1716C>A	c.(1714-1716)GGC>GGA	p.G572G	NRP1_uc001iwv.3_Silent_p.G572G|NRP1_uc009xlz.2_Silent_p.G572G|NRP1_uc001iww.3_Silent_p.G391G|NRP1_uc001iwy.3_Silent_p.G572G|NRP1_uc001iwz.2_Silent_p.G572G|NRP1_uc001ixa.2_Silent_p.G572G|NRP1_uc001ixb.1_Silent_p.G572G	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	572	Extracellular (Potential).|F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	GCCCCAGTCCGCCATGAGTGG	0.493000												
C10orf137	26098	broad.mit.edu	37	10	127429072	127429072	+	Silent	SNP	A	A	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr10:127429072A>C	uc001liq.1	+	16	2315	c.2022A>C	c.(2020-2022)GGA>GGC	p.G674G	C10orf137_uc001lin.2_Silent_p.G640G|C10orf137_uc001lio.1_Silent_p.G640G|C10orf137_uc001lip.1_Silent_p.G378G|C10orf137_uc001lir.2_Silent_p.G168G|C10orf137_uc001lis.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	674					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GTCAATCTGGAATGATCCCTG	0.423000												
DPYSL4	10570	broad.mit.edu	37	10	134006210	134006210	+	Silent	SNP	C	C	T	rs142922640		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr10:134006210C>T	uc009ybb.2	+	3	331	c.177C>T	c.(175-177)GAC>GAT	p.D59D		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	59					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		AGACCATTGACGCCCACGGCC	0.582000												
OR52H1	390067	broad.mit.edu	37	11	5566092	5566092	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:5566092A>G	uc010qzh.1	-	1	662	c.662T>C	c.(661-663)CTC>CCC	p.L221P	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	221	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AACAGCAATGAGAATCACATC	0.507000												
AHNAK	79026	broad.mit.edu	37	11	62290003	62290003	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:62290003G>A	uc001ntl.2	-	5	12186	c.11886C>T	c.(11884-11886)GAC>GAT	p.D3962D	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3962					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GTCCTGAGACGTCAAGGTCAG	0.483000												
SLC29A2	3177	broad.mit.edu	37	11	66133938	66133938	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:66133938C>T	uc001oht.2	-	8	1060	c.831G>A	c.(829-831)AAG>AAA	p.K277K	SLC29A2_uc001ohs.2_Silent_p.K157K|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Silent_p.K157K|SLC29A2_uc001ohu.2_Silent_p.K277K|SLC29A2_uc001ohv.2_Intron|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	277					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						GTTTTCCTGGCTTCTGGGGCT	0.512000												
CTSC	1075	broad.mit.edu	37	11	88027276	88027276	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:88027276G>A	uc001pck.3	-	7	1391	c.1290C>T	c.(1288-1290)GGC>GGT	p.G430G	CTSC_uc001pcl.3_Silent_p.G282G	NM_001814	NP_001805	P53634	CATC_HUMAN	cathepsin C isoform a preproprotein	430					immune response	lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCCAGCCGGTGCCCCAGCTGT	0.507000												
MTNR1B	4544	broad.mit.edu	37	11	92714934	92714934	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:92714934A>C	uc001pdk.1	+	2	648	c.545A>C	c.(544-546)GAG>GCG	p.E182A		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	182	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GGGTCCCTGGAGTACGACCCA	0.612000												
ANGPTL5	253935	broad.mit.edu	37	11	101762246	101762246	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:101762246G>C	uc001pgl.2	-	9	1527	c.931C>G	c.(931-933)CGC>GGC	p.R311G		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	311	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		CATGCAGGGCGACACCCATCA	0.438000												
APOA1	335	broad.mit.edu	37	11	116706562	116706562	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:116706562C>A	uc001ppu.1	-	4	845	c.766G>T	c.(766-768)GCT>TCT	p.A256S	APOA1_uc001ppv.1_Missense_Mutation_p.A256S	NM_000039	NP_000030	P02647	APOA1_HUMAN	apolipoprotein A-I preproprotein	256	10.|10 X approximate tandem repeats.				Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		TCCTCGAGAGCGCTCAGGAAG	0.632000												
ARCN1	372	broad.mit.edu	37	11	118452182	118452182	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr11:118452182C>T	uc001ptq.2	+	2	386	c.225C>T	c.(223-225)AAC>AAT	p.N75N	ARCN1_uc009zah.2_Intron|ARCN1_uc010ryg.1_Intron|ARCN1_uc009zag.2_Silent_p.N116N	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	75					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		AAAACAGCAACATTTTAGAAG	0.368000												
ADIPOR2	79602	broad.mit.edu	37	12	1882101	1882101	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr12:1882101G>A	uc001qjm.2	+	3	462	c.265G>A	c.(265-267)GAA>AAA	p.E89K	ADIPOR2_uc001qjn.2_Missense_Mutation_p.E89K	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	89	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			TCATGCTATGGAAAAAATGGA	0.413000												
PTPRR	5801	broad.mit.edu	37	12	71158529	71158529	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr12:71158529G>A	uc001swi.1	-	3	803	c.387C>T	c.(385-387)AAC>AAT	p.N129N	PTPRR_uc010stq.1_Silent_p.N17N	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	129	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GCAAGGTTATGTTCAGCTTGT	0.378000												
NAV3	89795	broad.mit.edu	37	12	78400648	78400648	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr12:78400648C>T	uc001syp.2	+	8	1503	c.1330C>T	c.(1330-1332)CCT>TCT	p.P444S	NAV3_uc001syo.2_Missense_Mutation_p.P444S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	444						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAAAGTGTCACCTAAGTTGGC	0.408000										HNSCC(70;0.22)		
DAO	1610	broad.mit.edu	37	12	109293196	109293196	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr12:109293196G>A	uc001tnr.3	+	10	1010	c.857G>A	c.(856-858)CGC>CAC	p.R286H	DAO_uc001tnq.3_Missense_Mutation_p.R220H|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	286					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2						CGGCCAGTACGCCCCCAGATT	0.468000												
PDS5B	23047	broad.mit.edu	37	13	33261280	33261280	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr13:33261280C>T	uc010abf.2	+	12	1371	c.1213C>T	c.(1213-1215)CGC>TGC	p.R405C	PDS5B_uc001uuo.2_Missense_Mutation_p.R405C|PDS5B_uc010abg.2_RNA|PDS5B_uc010teb.1_Missense_Mutation_p.R107C	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	405	HEAT.				cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		GTGGAGAGTACGCAAAGAAGC	0.333000												
NBEA	26960	broad.mit.edu	37	13	36167537	36167537	+	Missense_Mutation	SNP	G	G	A	rs116439886	by1000genomes	TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr13:36167537G>A	uc001uvb.2	+	47	7455	c.7249G>A	c.(7249-7251)GTT>ATT	p.V2417I	NBEA_uc010abi.2_Missense_Mutation_p.V1073I|NBEA_uc010tee.1_Missense_Mutation_p.V210I|NBEA_uc010tef.1_Missense_Mutation_p.V210I|NBEA_uc010teg.1_Missense_Mutation_p.V210I|NBEA_uc001uvd.2_5'UTR	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2417	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTCTCATCCGTTGCAAGGTC	0.338000												
DCLK1	9201	broad.mit.edu	37	13	36402445	36402445	+	Splice_Site	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr13:36402445C>T	uc001uvf.2	-	9	1463	c.1230_splice	c.e9-1	p.R410_splice	DCLK1_uc001uve.3_Splice_Site_p.R103_splice|DCLK1_uc010teh.1_Splice_Site_p.R103_splice|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1						cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		AGCAGTCGATCTGCGAAGAGA	0.323000												
FRMD6	122786	broad.mit.edu	37	14	52174910	52174910	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr14:52174910C>T	uc001wzd.2	+	7	958	c.673C>T	c.(673-675)CGA>TGA	p.R225*	FRMD6_uc001wzb.2_Nonsense_Mutation_p.R217*|FRMD6_uc001wzc.2_Nonsense_Mutation_p.R217*|FRMD6_uc001wze.2_Nonsense_Mutation_p.R148*	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	225	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					AGAGGCTGTCCGACTGGATGA	0.408000												
RPAP1	26015	broad.mit.edu	37	15	41813089	41813089	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr15:41813089T>A	uc001zod.2	-	22	3419	c.3295A>T	c.(3295-3297)ACC>TCC	p.T1099S	RPAP1_uc001zoc.2_Missense_Mutation_p.T118S	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1099	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGCCAGTCGGTGGGCAGCAGC	0.667000												
CACNA1H	8912	broad.mit.edu	37	16	1259298	1259298	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr16:1259298G>A	uc002cks.2	+	17	3878	c.3630G>A	c.(3628-3630)CCG>CCA	p.P1210P	CACNA1H_uc002ckt.2_Silent_p.P1210P|CACNA1H_uc002cku.2_5'Flank|CACNA1H_uc010brj.2_5'Flank|CACNA1H_uc002ckv.2_5'Flank	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1210	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCGCCCTCCCGCCTACCAAGT	0.746000												
ABCA3	21	broad.mit.edu	37	16	2331217	2331217	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr16:2331217G>A	uc002cpy.1	-	28	4882	c.4170C>T	c.(4168-4170)TAC>TAT	p.Y1390Y	ABCA3_uc010bsk.1_Silent_p.Y1332Y	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1390	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCCGCTGCTCGTACACCTGCA	0.642000												
MYH11	4629	broad.mit.edu	37	16	15931818	15931818	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr16:15931818C>T	uc002ddy.2	-	2	399	c.292G>A	c.(292-294)GAA>AAA	p.E98K	MYH11_uc002ddv.2_Missense_Mutation_p.E98K|MYH11_uc002ddw.2_Missense_Mutation_p.E98K|MYH11_uc002ddx.2_Missense_Mutation_p.E98K|MYH11_uc010bvg.2_5'UTR|MYH11_uc002deb.3_Missense_Mutation_p.E98K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	98	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ACGGAGGCTTCGTTGAGGCAC	0.532000			T	CBFB	AML							
PPP4C	5531	broad.mit.edu	37	16	30096288	30096288	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr16:30096288G>A	uc002dwe.2	+	9	973	c.829G>A	c.(829-831)GAG>AAG	p.E277K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Missense_Mutation_p.E277K|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_Missense_Mutation_p.E198K	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	277				E->K: Abolishes interaction with PPP4R4; no effect on interaction with PPP4R1 and PPP4R2.	microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						GGAGCTGGACGAGCATCTCCA	0.632000												
NOB1	28987	broad.mit.edu	37	16	69782198	69782198	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr16:69782198G>A	uc002exs.2	-	7	777	c.761C>T	c.(760-762)GCG>GTG	p.A254V		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	254						nucleus	metal ion binding|protein binding				0						GCCGTTCACCGCCAGCACGTG	0.488000												
MYH2	4620	broad.mit.edu	37	17	10424716	10424716	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr17:10424716G>A	uc010coi.2	-	40	5835	c.5707C>T	c.(5707-5709)CGC>TGC	p.R1903C	uc002gml.1_Intron|MYH1_uc002gmo.2_5'Flank|MYH2_uc002gmp.3_Missense_Mutation_p.R1903C|MYH2_uc010coj.2_Missense_Mutation_p.R670C	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1903	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TGGAGCTTGCGGAATTTAGCT	0.473000												
GPR179	440435	broad.mit.edu	37	17	36486359	36486359	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr17:36486359C>T	uc002hpz.2	-	11	3114	c.3093G>A	c.(3091-3093)AGG>AGA	p.R1031R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1031	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CAGAGAGGGCCCTCCAGAGCC	0.597000												
C1QL1	10882	broad.mit.edu	37	17	43044868	43044868	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr17:43044868G>A	uc002ihv.2	-	1	777	c.549C>T	c.(547-549)CGC>CGT	p.R183R		NM_006688	NP_006679	O75973	C1QRF_HUMAN	complement component 1, q subcomponent-like 1	183	C1q.				locomotory behavior	collagen					0		Prostate(33;0.155)				CGTCGCCGCCGCGCATGAGGA	0.642000												
RSAD1	55316	broad.mit.edu	37	17	48559708	48559708	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr17:48559708C>G	uc002iqw.1	+	4	787	c.731C>G	c.(730-732)GCC>GGC	p.A244G	RSAD1_uc010wmq.1_RNA	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	244					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CAGCGGGGTGCCCTTCCAGCC	0.647000											OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
C19orf35	374872	broad.mit.edu	37	19	2280863	2280863	+	Missense_Mutation	SNP	G	G	A	rs141253643		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:2280863G>A	uc002lvn.2	-	2	168	c.68C>T	c.(67-69)ACG>ATG	p.T23M	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	23										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTTGCTATACGTGGGCTGAGT	0.507000												
MUC16	94025	broad.mit.edu	37	19	9090314	9090314	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:9090314C>T	uc002mkp.2	-	1	1705	c.1501G>A	c.(1501-1503)GGG>AGG	p.G501R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	501	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCAGAGCTCCCGTGGGCAGCT	0.547000												
ZNF506	440515	broad.mit.edu	37	19	19905748	19905748	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:19905748C>A	uc010eci.2	-	4	1096	c.948G>T	c.(946-948)GAG>GAT	p.E316D	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.E284D	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	316	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						TGCCACATTCCTCACATTTGT	0.378000												
ZNF43	7594	broad.mit.edu	37	19	21991525	21991525	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:21991525G>A	uc002nqj.2	-	4	1444	c.1314C>T	c.(1312-1314)CCC>CCT	p.P438P	ZNF43_uc010ecv.2_Silent_p.P432P|ZNF43_uc002nql.2_Silent_p.P432P|ZNF43_uc002nqm.2_Silent_p.P432P|ZNF43_uc002nqk.2_Silent_p.P368P	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TAAGGGTTGAGGGCCAGTTAA	0.393000												
C19orf2	8725	broad.mit.edu	37	19	30505944	30505944	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:30505944T>C	uc002nsr.2	+	11	1606	c.1576T>C	c.(1576-1578)TTT>CTT	p.F526L	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Missense_Mutation_p.F486L|C19orf2_uc002nst.2_Missense_Mutation_p.F450L	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	526					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		GGTTTCAAAGTTTAAAGCTGC	0.433000												
ZNF585A	199704	broad.mit.edu	37	19	37647180	37647180	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:37647180G>A	uc002ofo.1	-	3	381	c.150C>T	c.(148-150)AAC>AAT	p.N50N	ZNF585A_uc002ofm.1_5'UTR|ZNF585A_uc002ofn.1_5'UTR	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	50	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCCGGTACAGGTTTCTCTGAG	0.512000												
RYR1	6261	broad.mit.edu	37	19	38956931	38956931	+	Missense_Mutation	SNP	G	G	A	rs148146893		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:38956931G>A	uc002oit.2	+	24	3201	c.3071G>A	c.(3070-3072)CGC>CAC	p.R1024H	RYR1_uc002oiu.2_Missense_Mutation_p.R1024H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1024	6 X approximate repeats.|2.|Cytoplasmic.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTGCCCTACCGCCTGCTGGAT	0.687000												
PSG4	5672	broad.mit.edu	37	19	43708213	43708213	+	Silent	SNP	G	G	A	rs77454946	by1000genomes	TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:43708213G>A	uc002ovy.2	-	2	357	c.255C>T	c.(253-255)GAC>GAT	p.D85D	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Silent_p.D85D|PSG4_uc002ovz.2_Silent_p.D85D	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	85	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				TTCTTTGACCGTCTACTACAT	0.423000												
HRC	3270	broad.mit.edu	37	19	49655303	49655303	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:49655303A>G	uc002pmv.2	-	4	2171	c.1984T>C	c.(1984-1986)TGC>CGC	p.C662R		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	662	Metal-binding (Potential).				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CAGAGATAGCAGAACTGACAG	0.682000												
ZNF784	147808	broad.mit.edu	37	19	56133315	56133315	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:56133315G>C	uc002qll.1	-	2	788	c.774C>G	c.(772-774)GAC>GAG	p.D258E	ZNF784_uc010etb.1_RNA	NM_203374	NP_976308	Q8NCA9	ZN784_HUMAN	zinc finger protein 784	258	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		TGAAGGTGCGGTCGCAGAGCG	0.682000												
BCL11A	53335	broad.mit.edu	37	2	60687922	60687922	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:60687922C>T	uc002sae.1	-	4	2353	c.2125G>A	c.(2125-2127)GGG>AGG	p.G709R	BCL11A_uc002sab.2_Missense_Mutation_p.G709R|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.G378R|BCL11A_uc010ypj.1_Missense_Mutation_p.G675R|BCL11A_uc002sad.1_Missense_Mutation_p.G557R|BCL11A_uc002saf.1_Missense_Mutation_p.G675R	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	709					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CCCGAGATCCCTCCGTCCAGC	0.662000			T	IGH@	B-CLL							
ZAP70	7535	broad.mit.edu	37	2	98341619	98341619	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:98341619C>T	uc002syd.1	+	4	674	c.467C>T	c.(466-468)ACG>ATG	p.T156M	ZAP70_uc010yvf.1_Missense_Mutation_p.T156M|ZAP70_uc002sye.1_Missense_Mutation_p.T46M	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	156	Interdomain A.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						ATTGCTACGACGGCCCACGAG	0.632000												
EN1	2019	broad.mit.edu	37	2	119600593	119600593	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:119600593C>T	uc002tlm.2	-	2	2116	c.1100G>A	c.(1099-1101)GGC>GAC	p.G367D		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	367					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						CAGCGCCAGGCCGTTCTTGAT	0.552000												
RBMS1	5937	broad.mit.edu	37	2	161133833	161133833	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:161133833G>A	uc002ubo.2	-	12	1568	c.1124C>T	c.(1123-1125)ACG>ATG	p.T375M	RBMS1_uc002ubj.2_Missense_Mutation_p.T355M|RBMS1_uc002ubk.2_Missense_Mutation_p.T339M|RBMS1_uc002ubl.2_Missense_Mutation_p.T370M|RBMS1_uc002ubn.2_Missense_Mutation_p.T372M|RBMS1_uc002ubi.3_Missense_Mutation_p.T388M|RBMS1_uc002ubm.2_Missense_Mutation_p.T358M|RBMS1_uc002ubp.2_Missense_Mutation_p.T391M	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	375					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						AACCGCTGTCGTCTGCATATG	0.433000												
GALNT3	2591	broad.mit.edu	37	2	166618440	166618440	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:166618440T>A	uc010fph.1	-	4	1200	c.813A>T	c.(811-813)GAA>GAT	p.E271D	GALNT3_uc010fpi.1_Missense_Mutation_p.E271D	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	271	Catalytic subdomain A.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						ATGTGAGCGTTTCAGCTGTTG	0.363000												
SLC39A10	57181	broad.mit.edu	37	2	196573489	196573489	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:196573489T>G	uc002utg.3	+	5	1710	c.1496T>G	c.(1495-1497)CTT>CGT	p.L499R	SLC39A10_uc002uth.3_Missense_Mutation_p.L499R|SLC39A10_uc010zgp.1_Missense_Mutation_p.L49R	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	499	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TTGAAAGGACTTGTTGCTCTA	0.348000												
RFTN2	130132	broad.mit.edu	37	2	198540173	198540173	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:198540173C>T	uc002uuo.3	-	1	412	c.10G>A	c.(10-12)GGA>AGA	p.G4R		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	4						plasma membrane					0						TTTCTAAGTCCGCACCCCATG	0.418000												
RNF25	64320	broad.mit.edu	37	2	219529554	219529554	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr2:219529554C>G	uc002vit.2	-	9	797	c.709G>C	c.(709-711)GAA>CAA	p.E237Q	RNF25_uc010fvw.2_Missense_Mutation_p.E125Q	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	237					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCTTGCGTTCTTCTTGCTGG	0.552000												
SCRT2	85508	broad.mit.edu	37	20	644735	644735	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr20:644735C>T	uc002wec.2	-	2	1082	c.504G>A	c.(502-504)TCG>TCA	p.S168S	SRXN1_uc002web.2_Intron	NM_033129	NP_149120	Q9NQ03	SCRT2_HUMAN	scratch 2 protein	168	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCTCAGGTTCGACGACGTGG	0.517000												
XKR7	343702	broad.mit.edu	37	20	30584971	30584971	+	Missense_Mutation	SNP	G	G	A	rs147437006		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr20:30584971G>A	uc002wxe.2	+	3	1625	c.1451G>A	c.(1450-1452)CGG>CAG	p.R484Q		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	484						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGTGCTGAGCGGGATGGGGCC	0.692000												
ZNF295	49854	broad.mit.edu	37	21	43411786	43411786	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr21:43411786C>T	uc002zab.3	-	3	2633	c.2419G>A	c.(2419-2421)GAA>AAA	p.E807K	ZNF295_uc002yzz.3_Missense_Mutation_p.E606K|ZNF295_uc002yzy.3_Missense_Mutation_p.E807K|ZNF295_uc002zaa.3_Missense_Mutation_p.E807K	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	807					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAAAGTTTTCGGTGGGTGCC	0.517000												
CCT8L2	150160	broad.mit.edu	37	22	17071982	17071982	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr22:17071982T>G	uc002zlp.1	-	1	1719	c.1459A>C	c.(1459-1461)AAT>CAT	p.N487H		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	487					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGGCCACATTTATTATCCCT	0.512000												
THOC5	8563	broad.mit.edu	37	22	29924124	29924124	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr22:29924124G>A	uc003afr.2	-	12	1344	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C	THOC5_uc003afq.2_Translation_Start_Site|THOC5_uc003afs.2_Missense_Mutation_p.R337C|THOC5_uc003aft.2_Missense_Mutation_p.R337C|THOC5_uc003afu.2_Missense_Mutation_p.R337C|THOC5_uc010gvo.2_Missense_Mutation_p.R81C	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	337					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						ATCTCCTTGCGTTTGTCGTCC	0.527000												
CACNG2	10369	broad.mit.edu	37	22	36962410	36962410	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr22:36962410G>A	uc003aps.1	-	3	708	c.426C>T	c.(424-426)TTC>TTT	p.F142F		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	142	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						CTGCAGACACGAAGAAGATGC	0.577000												
SELO	83642	broad.mit.edu	37	22	50648639	50648639	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr22:50648639C>T	uc011arr.1	+	4	1027	c.969C>T	c.(967-969)GCC>GCT	p.A323A	SELO_uc010hap.2_Silent_p.A134A|SELO_uc003bjy.2_Silent_p.A3A|SELO_uc003bjz.2_Silent_p.A3A	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	323											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GGATGGTGGCCGAGTGGCAGT	0.657000											OREG0026676	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
ZNF385D	79750	broad.mit.edu	37	3	21552505	21552505	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr3:21552505G>A	uc003cce.2	-	4	695	c.287C>T	c.(286-288)GCG>GTG	p.A96V	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	96	Matrin-type 1.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GTAGTGGGCCGCAGCCTGGCT	0.443000												
MYD88	4615	broad.mit.edu	37	3	38181925	38181925	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr3:38181925C>T	uc003chx.2	+	3	733	c.549C>T	c.(547-549)AGC>AGT	p.S183S	MYD88_uc011ayh.1_3'UTR|MYD88_uc011ayi.1_Silent_p.S183S|MYD88_uc011ayj.1_Intron|MYD88_uc011ayk.1_Intron|MYD88_uc011ayl.1_Silent_p.S138S	NM_002468	NP_002459	Q99836	MYD88_HUMAN	myeloid differentiation primary response gene	170	TIR.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(93)|breast(1)	94				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		ATTGCCCCAGCGACATCCAGT	0.562000			Mis 		ABC-DLBCL							
TRAK1	22906	broad.mit.edu	37	3	42244190	42244190	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr3:42244190T>C	uc003cky.2	+	13	1906	c.1690T>C	c.(1690-1692)TTC>CTC	p.F564L	TRAK1_uc011azh.1_Missense_Mutation_p.F564L|TRAK1_uc011azi.1_Missense_Mutation_p.F564L|TRAK1_uc003ckz.3_Missense_Mutation_p.F490L|TRAK1_uc011azj.1_Missense_Mutation_p.F490L|TRAK1_uc003cla.2_Missense_Mutation_p.F506L	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	564					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TGGCATGTCCTTCAGCAGCCG	0.657000												
CDHR4	389118	broad.mit.edu	37	3	49836305	49836305	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr3:49836305C>T	uc010hkz.2	-	4	458	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	CDHR4_uc003cxp.2_Silent_p.S175S|CDHR4_uc011bcw.1_Missense_Mutation_p.R150Q	NM_001007540	NP_001007541	A6H8M9	CDHR4_HUMAN	cadherin-like 29 precursor	150	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						AGTGTACAGCCGAGCCCCAGG	0.632000												
DNAH1	25981	broad.mit.edu	37	3	52404605	52404605	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr3:52404605G>A	uc011bef.1	+	40	6632	c.6371G>A	c.(6370-6372)CGC>CAC	p.R2124H		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2124					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGCAGTGGCCGCACCAGTTTC	0.597000												
HTT	3064	broad.mit.edu	37	4	3215685	3215685	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr4:3215685G>T	uc011bvq.1	+	51	6926	c.6781G>T	c.(6781-6783)GCC>TCC	p.A2261S		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2259					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTCCCTTTAGGCCCTGTCCTG	0.592000												
STK32B	55351	broad.mit.edu	37	4	5170125	5170125	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr4:5170125C>T	uc003gih.1	+	3	272	c.208C>T	c.(208-210)CGG>TGG	p.R70W	STK32B_uc010ida.1_Missense_Mutation_p.R23W	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	70	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GAATGTTTTCCGGGAGCTGCA	0.537000												
PCDH18	54510	broad.mit.edu	37	4	138452081	138452081	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr4:138452081C>T	uc003ihe.3	-	1	1549	c.1162G>A	c.(1162-1164)GAT>AAT	p.D388N	PCDH18_uc003ihf.3_Missense_Mutation_p.D381N|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.D168N|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	388	Cadherin 4.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AGCCCAGAATCCTTGTCCTGA	0.348000												
DMXL1	1657	broad.mit.edu	37	5	118500266	118500266	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:118500266G>A	uc003ksd.2	+	20	4948	c.4767G>A	c.(4765-4767)ATG>ATA	p.M1589I	DMXL1_uc010jcl.1_Missense_Mutation_p.M1589I	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1589										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TGCTGAACATGTTGCCAGCCA	0.438000												
PCDHA2	56146	broad.mit.edu	37	5	140174841	140174841	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:140174841C>T	uc003lhd.2	+	1	398	c.292C>T	c.(292-294)CGG>TGG	p.R98W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.R98W|PCDHA2_uc011czy.1_Missense_Mutation_p.R98W	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	98	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTGCGGGCGGAGCGCGGA	0.572000												
PCDHA4	56144	broad.mit.edu	37	5	140188818	140188818	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:140188818G>A	uc003lhi.2	+	1	2147	c.2046G>A	c.(2044-2046)GCG>GCA	p.A682A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.A682A|PCDHA4_uc011daa.1_Silent_p.A682A	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	682	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCACGGGCGTTGGTGGGCG	0.637000												
PCDHB15	56121	broad.mit.edu	37	5	140626263	140626263	+	Nonsense_Mutation	SNP	C	C	T	rs139626656		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:140626263C>T	uc003lje.2	+	1	1117	c.1117C>T	c.(1117-1119)CGA>TGA	p.R373*		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	373	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATTAGAGACCGAGACTCTGG	0.413000												
SH3RF2	153769	broad.mit.edu	37	5	145439671	145439671	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:145439671C>T	uc003lnt.2	+	9	2036	c.1798C>T	c.(1798-1800)CTC>TTC	p.L600F	SH3RF2_uc011dbl.1_Missense_Mutation_p.L600F|SH3RF2_uc011dbm.1_Missense_Mutation_p.L85F|SH3RF2_uc003lnu.2_Missense_Mutation_p.L91F|SH3RF2_uc011dbn.1_Missense_Mutation_p.L91F|SH3RF2_uc011dbo.1_Missense_Mutation_p.L57F	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	600							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCCAGCTCCCTCATTATGGA	0.607000												
NDST1	3340	broad.mit.edu	37	5	149901309	149901309	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:149901309G>A	uc003lsk.3	+	2	995	c.493G>A	c.(493-495)GGC>AGC	p.G165S	NDST1_uc011dcj.1_Missense_Mutation_p.G165S|NDST1_uc003lsl.2_Missense_Mutation_p.G165S	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	165	Heparan sulfate N-deacetylase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTACGGCGTGGGCATCATTGG	0.478000												
CYFIP2	26999	broad.mit.edu	37	5	156766134	156766134	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:156766134A>G	uc003lwq.2	+	24	2593	c.2455A>G	c.(2455-2457)AGC>GGC	p.S819G	CYFIP2_uc011ddn.1_Missense_Mutation_p.S793G|CYFIP2_uc011ddo.1_Missense_Mutation_p.S623G|CYFIP2_uc003lwr.2_Missense_Mutation_p.S819G|CYFIP2_uc003lws.2_Missense_Mutation_p.S819G|CYFIP2_uc003lwt.2_Missense_Mutation_p.S722G|CYFIP2_uc011ddp.1_Missense_Mutation_p.S553G	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	844					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GACGCTGGACAGCTTCGATGC	0.552000												
EBF1	1879	broad.mit.edu	37	5	158250237	158250237	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr5:158250237C>T	uc010jip.2	-	8	1027	c.725G>A	c.(724-726)CGG>CAG	p.R242Q	EBF1_uc011ddw.1_Missense_Mutation_p.R109Q|EBF1_uc011ddx.1_Missense_Mutation_p.R242Q|EBF1_uc003lxl.3_Missense_Mutation_p.R219Q	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	242					multicellular organismal development	nucleus	DNA binding|metal ion binding	p.R242Q(1)	HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCGAGCCCTCCGCCCATGCTT	0.488000			T	HMGA2	lipoma							
F13A1	2162	broad.mit.edu	37	6	6167728	6167728	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr6:6167728T>G	uc003mwv.2	-	13	1994	c.1871A>C	c.(1870-1872)AAG>ACG	p.K624T	F13A1_uc011dib.1_Missense_Mutation_p.K561T	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	624					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CACGGTGGACTTTTGCTTGGC	0.507000												
SLC17A3	10786	broad.mit.edu	37	6	25850092	25850092	+	Silent	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr6:25850092G>A	uc003nfi.3	-	9	1088	c.978C>T	c.(976-978)TGC>TGT	p.C326C	SLC17A3_uc003nfk.3_Silent_p.C404C	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	326	Helical; (Potential).				glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						TGCTTAATCCGCAAGAGAGCG	0.433000												
OR10C1	442194	broad.mit.edu	37	6	29408592	29408592	+	Missense_Mutation	SNP	C	C	T	rs150247833	by1000genomes	TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr6:29408592C>T	uc011dlp.1	+	1	800	c.800C>T	c.(799-801)CCG>CTG	p.P267L	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCTACGATCCGGCCACTGAC	0.567000												
TREML4	285852	broad.mit.edu	37	6	41196170	41196170	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr6:41196170C>A	uc003oqc.2	+	1	109	c.5C>A	c.(4-6)GCC>GAC	p.A2D	TREML4_uc003oqd.2_5'Flank	NM_198153	NP_937796	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid	2						extracellular region				breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					GCTGGAATGGCCTGGGGTGGG	0.602000												
LAMA2	3908	broad.mit.edu	37	6	129722454	129722454	+	Missense_Mutation	SNP	G	G	A	rs150691000	byFrequency	TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr6:129722454G>A	uc003qbn.2	+	38	5636	c.5531G>A	c.(5530-5532)CGT>CAT	p.R1844H	LAMA2_uc003qbo.2_Missense_Mutation_p.R1844H	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1844	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAAGCCAACCGTCTTGCAGAT	0.403000												
SYNE1	23345	broad.mit.edu	37	6	152650951	152650951	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr6:152650951C>T	uc010kiw.2	-	78	15471	c.14869G>A	c.(14869-14871)GAG>AAG	p.E4957K	SYNE1_uc003qot.3_Missense_Mutation_p.E4886K|SYNE1_uc003qou.3_Missense_Mutation_p.E4957K|SYNE1_uc010kiz.2_Missense_Mutation_p.E712K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4957	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAAATCAGCTCCTTGGCCTTT	0.478000										HNSCC(10;0.0054)		
WBSCR17	64409	broad.mit.edu	37	7	70885982	70885982	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr7:70885982G>A	uc003tvy.2	+	5	853	c.853G>A	c.(853-855)GTG>ATG	p.V285M	WBSCR17_uc003tvz.2_Translation_Start_Site	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	285	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CAACTTTGAGGTGCAGCGGTA	0.567000												
SEMA3C	10512	broad.mit.edu	37	7	80374379	80374379	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr7:80374379G>T	uc003uhj.2	-	18	2649	c.2087C>A	c.(2086-2088)GCA>GAA	p.A696E	SEMA3C_uc011kgw.1_Missense_Mutation_p.A714E	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	696					immune response|response to drug	membrane	receptor activity			ovary(1)	1						GTGGCTGAATGCCCCCATGAT	0.502000												
CLCN1	1180	broad.mit.edu	37	7	143013337	143013337	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr7:143013337G>T	uc003wcr.1	+	1	119	c.32G>T	c.(31-33)GGT>GTT	p.G11V	CLCN1_uc011ktc.1_5'UTR	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	11	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CAGCGTGGGGGTGAACAAAGC	0.627000												
CRYGN	155051	broad.mit.edu	37	7	151133409	151133409	+	Silent	SNP	G	G	A	rs146240466		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr7:151133409G>A	uc003wke.2	-	3	369	c.273C>T	c.(271-273)CAC>CAT	p.H91H	CRYGN_uc003wkf.2_Intron|CRYGN_uc003wkg.2_RNA|CRYGN_uc010lqd.1_RNA	NM_144727	NP_653328	Q8WXF5	CRGN_HUMAN	gammaN-crystallin	91											0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AATGTTCTCCGTGCTCCAAGA	0.547000												
DLGAP2	9228	broad.mit.edu	37	8	1645408	1645408	+	Silent	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr8:1645408C>T	uc003wpl.2	+	11	2749	c.2652C>T	c.(2650-2652)GAC>GAT	p.D884D	DLGAP2_uc003wpm.2_Silent_p.D870D	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	963					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGAAGTTCGACGAGCTGCAGC	0.632000												
DCAF4L2	138009	broad.mit.edu	37	8	88886059	88886059	+	Silent	SNP	G	G	A	rs142584363	byFrequency	TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr8:88886059G>A	uc003ydz.2	-	1	238	c.141C>T	c.(139-141)CGC>CGT	p.R47R		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	47										ovary(1)	1						CACGCAGCTCGCGAGCTATAC	0.498000												
ZNF707	286075	broad.mit.edu	37	8	144776021	144776021	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr8:144776021C>T	uc003yze.3	+	7	752	c.437C>T	c.(436-438)ACG>ATG	p.T146M	ZNF707_uc010mfh.2_Missense_Mutation_p.T146M|ZNF707_uc010mfi.2_Missense_Mutation_p.T146M|ZNF707_uc003yzf.3_Missense_Mutation_p.T146M|ZNF707_uc003yzh.3_Missense_Mutation_p.T73M|ZNF707_uc011lkq.1_RNA	NM_173831	NP_776192	Q96C28	ZN707_HUMAN	zinc finger protein 707	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCCAAGCCCACGGCTTTCCCG	0.647000												
NPR2	4882	broad.mit.edu	37	9	35799621	35799621	+	Silent	SNP	T	T	C			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr9:35799621T>C	uc003zyd.2	+	3	880	c.880T>C	c.(880-882)TTG>CTG	p.L294L	NPR2_uc010mlb.2_Silent_p.L294L	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	294	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ACAGACTGTATTGGTGATCAC	0.483000												
SEMA4D	10507	broad.mit.edu	37	9	92002361	92002361	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr9:92002361C>T	uc004aqo.1	-	14	1842	c.1270G>A	c.(1270-1272)GTG>ATG	p.V424M	SEMA4D_uc011ltm.1_Missense_Mutation_p.V424M|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Missense_Mutation_p.V422M	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	424	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						CGGTCCACCACGATCTGGGTG	0.532000												
VCX	26609	broad.mit.edu	37	X	7811739	7811739	+	Silent	SNP	C	C	T	rs151212725		TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chrX:7811739C>T	uc004crz.2	+	3	522	c.303C>T	c.(301-303)CAC>CAT	p.H101H		NM_013452	NP_038480	Q9H320	VCX1_HUMAN	variable charge, X chromosome	101	Glu-rich.				chromatin organization|ribosome assembly|spermatogenesis	nucleolus	chromatin binding				0		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				GGACCCAGCACGACCCCCTGA	0.682000												
ACRC	93953	broad.mit.edu	37	X	70823670	70823670	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chrX:70823670C>A	uc004eae.2	+	8	1044	c.543C>A	c.(541-543)GAC>GAA	p.D181E	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	181	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					CTCCCGACGACAATAGTGATG	0.498000												
RGAG4	340526	broad.mit.edu	37	X	71349770	71349770	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chrX:71349770G>A	uc010nlh.1	-	1	1982	c.1621C>T	c.(1621-1623)CGC>TGC	p.R541C	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	541										ovary(2)|skin(1)	3	Renal(35;0.156)					CGAACTTGGCGTTGTCCTAAA	0.597000												
IL9R	3581	broad.mit.edu	37	X	155227302	155227302	+	Translation_Start_Site	SNP	G	G	A			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chrX:155227302G>A	uc004fnv.1	+	1	57	c.-122G>A	c.(-124--120)TCGTG>TCATG		IL9R_uc010nvn.2_Translation_Start_Site|IL9R_uc004fnu.1_Translation_Start_Site	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor						cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGAACCTGTCGTGCAAAGCTC	0.527000												
LAIR1	3903	broad.mit.edu	37	19	54868000	54868001	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HU-A4H6-01A-11D-A25D-08	TCGA-HU-A4H6-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ea56632-805f-4c0e-a396-ed3c34ae3628	13caa5d8-ddfe-43eb-91b6-cf308ef7c28f	g.chr19:54867999_54868000T>TG	uc002qfk.1	-	6	901_902	c.591_592A>CA	c.(589-594)cccagafs	p.P197fs	LAIR1_uc002qfl.1_Frame_Shift_Ins_p.P180fs|LAIR1_uc002qfm.1_Frame_Shift_Ins_p.P196fs|LAIR1_uc002qfn.1_Frame_Shift_Ins_p.P179fs|LAIR1_uc010yex.2_Frame_Shift_Ins_p.P190fs|LAIR1_uc002qfo.3_Frame_Shift_Ins_p.P179fs	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	Homo sapiens leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), transcript variant a, mRNA.	197						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		TCCTTGCTTCTGGGGGGCCCTA	0.634