Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
ELTD1	64123	broad.mit.edu	37	1	79404922	79404922	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:79404922T>A	uc001diq.3	-	4	503	c.347A>T	c.(346-348)CAT>CTT	p.H116L		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	116	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ATTATCTAAATGGCAGTTTGC	0.249												
CELSR2	1952	broad.mit.edu	37	1	109811770	109811770	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:109811770G>A	uc001dxa.3	+	20	6731	c.6670G>A	c.(6670-6672)GCC>ACC	p.A2224T		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2224	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCCCGGAGAGGCCCAGGAGCC	0.692												
KCNA10	3744	broad.mit.edu	37	1	111059876	111059876	+	Nonstop_Mutation	SNP	A	A	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:111059876A>C	uc001dzt.1	-	1	1922	c.1534T>G	c.(1534-1536)TGA>GGA	p.*512G		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	512						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TGGACTGATCATTTCCTAGAC	0.303												
SPTA1	6708	broad.mit.edu	37	1	158618325	158618325	+	Silent	SNP	T	T	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:158618325T>G	uc001fst.1	-	26	3887	c.3688A>C	c.(3688-3690)AGG>CGG	p.R1230R		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1230	Spectrin 12.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACGAGGTCCCTTTCAAAGCCC	0.502												
NFASC	23114	broad.mit.edu	37	1	204923461	204923461	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:204923461C>T	uc001hbj.2	+	6	689	c.361C>T	c.(361-363)CGC>TGC	p.R121C	NFASC_uc001hbh.2_Missense_Mutation_p.R121C|NFASC_uc010pqz.1_Missense_Mutation_p.R115C|NFASC_uc010pra.1_Missense_Mutation_p.R115C|NFASC_uc001hbi.2_Missense_Mutation_p.R115C|NFASC_uc009xbg.1_Missense_Mutation_p.R188C|NFASC_uc010prb.1_Missense_Mutation_p.R115C|NFASC_uc010prc.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	121	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GTGCTTCGCCCGCAACAAATT	0.607												
HEATR1	55127	broad.mit.edu	37	1	236730052	236730052	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:236730052T>G	uc001hyd.1	-	30	4327	c.4202A>C	c.(4201-4203)CAA>CCA	p.Q1401P	HEATR1_uc009xgh.1_Missense_Mutation_p.Q563P	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1401					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATCAACAAGTTGAACAAGGAT	0.473												
NLRP3	114548	broad.mit.edu	37	1	247588491	247588491	+	Silent	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:247588491C>T	uc001icr.2	+	5	1884	c.1746C>T	c.(1744-1746)GGC>GGT	p.G582G	NLRP3_uc001ics.2_Silent_p.G582G|NLRP3_uc001icu.2_Silent_p.G582G|NLRP3_uc001icw.2_Silent_p.G582G|NLRP3_uc001icv.2_Silent_p.G582G|NLRP3_uc010pyw.1_Silent_p.G580G|NLRP3_uc001ict.1_Silent_p.G580G	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	582					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCTCTTTGGCCTGGTAAACC	0.448												
MYO3A	53904	broad.mit.edu	37	10	26385407	26385407	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr10:26385407A>T	uc001isn.2	+	16	2020	c.1660A>T	c.(1660-1662)AGG>TGG	p.R554W	MYO3A_uc009xko.1_Missense_Mutation_p.R554W|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.R554W	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	554	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TAAGCCTCCCAGGTAATCTAC	0.318												
DLG5	9231	broad.mit.edu	37	10	79579661	79579661	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr10:79579661G>A	uc001jzk.2	-	16	3588	c.3518C>T	c.(3517-3519)CCG>CTG	p.P1173L	DLG5_uc001jzi.2_5'UTR|DLG5_uc001jzj.2_Missense_Mutation_p.P588L|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.P777L	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1173					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ACCCACAGACGGCCTGCTAGG	0.652												
ABCC2	1244	broad.mit.edu	37	10	101578969	101578969	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr10:101578969T>A	uc001kqf.2	+	19	2702	c.2563T>A	c.(2563-2565)TTT>ATT	p.F855I		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	855	Cytoplasmic (By similarity).|ABC transporter 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AAAAGGAGAGTTTGCTAAGAA	0.448												
SORCS3	22986	broad.mit.edu	37	10	107007060	107007060	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr10:107007060G>T	uc001kyi.1	+	22	3303	c.3076G>T	c.(3076-3078)GGC>TGC	p.G1026C	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1026	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAAAGATATTGGCAATGTCAT	0.388												
OR52A5	390054	broad.mit.edu	37	11	5153403	5153403	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr11:5153403A>G	uc010qyx.1	-	1	470	c.470T>C	c.(469-471)CTT>CCT	p.L157P		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGGTATTATAAGAATGGCAGC	0.473												
C11orf82	220042	broad.mit.edu	37	11	82644674	82644674	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr11:82644674G>C	uc001ozt.2	+	6	2538	c.2294G>C	c.(2293-2295)AGT>ACT	p.S765T	C11orf82_uc010rsr.1_Missense_Mutation_p.S464T|C11orf82_uc010rss.1_Missense_Mutation_p.S464T|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	765					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						TTTGAAAATAGTCAAGACTTT	0.348												
CNTN5	53942	broad.mit.edu	37	11	100170065	100170065	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr11:100170065G>A	uc001pga.2	+	20	2896	c.2557G>A	c.(2557-2559)GTT>ATT	p.V853I	CNTN5_uc001pfz.2_Missense_Mutation_p.V853I|CNTN5_uc001pgb.2_Missense_Mutation_p.V779I|CNTN5_uc010ruk.1_Missense_Mutation_p.V124I	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	853	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GAAAGTTGGCGTTTATAACAA	0.368												
CCDC15	80071	broad.mit.edu	37	11	124829033	124829033	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr11:124829033A>T	uc001qbm.3	+	3	459	c.200A>T	c.(199-201)GAA>GTA	p.E67V		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	67	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		TTAATTGAAGAAGAACTAAAG	0.294												
CACNA1C	775	broad.mit.edu	37	12	2676928	2676928	+	Silent	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr12:2676928C>T	uc009zdu.1	+	13	2176	c.1863C>T	c.(1861-1863)TGC>TGT	p.C621C	CACNA1C_uc009zdv.1_Silent_p.C618C|CACNA1C_uc001qkb.2_Silent_p.C621C|CACNA1C_uc001qkc.2_Silent_p.C621C|CACNA1C_uc001qke.2_Silent_p.C621C|CACNA1C_uc001qkf.2_Silent_p.C621C|CACNA1C_uc001qjz.2_Silent_p.C621C|CACNA1C_uc001qkd.2_Silent_p.C621C|CACNA1C_uc001qkg.2_Silent_p.C621C|CACNA1C_uc009zdw.1_Silent_p.C621C|CACNA1C_uc001qkh.2_Silent_p.C621C|CACNA1C_uc001qkl.2_Silent_p.C621C|CACNA1C_uc001qkn.2_Silent_p.C621C|CACNA1C_uc001qko.2_Silent_p.C621C|CACNA1C_uc001qkp.2_Silent_p.C621C|CACNA1C_uc001qkr.2_Silent_p.C621C|CACNA1C_uc001qku.2_Silent_p.C621C|CACNA1C_uc001qkq.2_Silent_p.C621C|CACNA1C_uc001qks.2_Silent_p.C621C|CACNA1C_uc001qkt.2_Silent_p.C621C|CACNA1C_uc001qka.1_Silent_p.C156C|CACNA1C_uc001qki.1_Silent_p.C357C|CACNA1C_uc001qkj.1_Silent_p.C357C|CACNA1C_uc001qkk.1_Silent_p.C357C|CACNA1C_uc001qkm.1_Silent_p.C357C	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	621	II.|Helical; Name=S4 of repeat II; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGCTCAGATGCGTCCGGCTGC	0.572												
FGF6	2251	broad.mit.edu	37	12	4554596	4554596	+	Silent	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr12:4554596C>T	uc001qmr.1	-	1	185	c.141G>A	c.(139-141)ACG>ACA	p.T47T		NM_020996	NP_066276	P10767	FGF6_HUMAN	fibroblast growth factor 6 precursor	47					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			lung(2)|ovary(1)	3			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			AGTCCAGCAGCGTGTTGTTGG	0.652												
KRT6B	3854	broad.mit.edu	37	12	52841341	52841341	+	Missense_Mutation	SNP	C	C	A	rs140834481	byFrequency	TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr12:52841341C>A	uc001sak.2	-	8	1489	c.1441G>T	c.(1441-1443)GTT>TTT	p.V481F		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	481	Tail.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		ACTTGTCCAACGCCTTCGCCA	0.567												
NBEA	26960	broad.mit.edu	37	13	36223810	36223810	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr13:36223810C>A	uc001uvb.2	+	51	7932	c.7726C>A	c.(7726-7728)CCG>ACG	p.P2576T	NBEA_uc010abi.2_Missense_Mutation_p.P1232T|NBEA_uc010tee.1_Missense_Mutation_p.P369T|NBEA_uc010tef.1_Missense_Mutation_p.P369T|NBEA_uc001uvd.2_Missense_Mutation_p.P154T	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2576						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TCCACAGAGTCCGCTCATGTT	0.428												
CCNA1	8900	broad.mit.edu	37	13	37014260	37014260	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr13:37014260G>A	uc001uvr.3	+	6	1388	c.1038G>A	c.(1036-1038)CAG>CAA	p.Q346Q	CCNA1_uc010teo.1_Silent_p.Q302Q|CCNA1_uc010abq.2_Silent_p.Q302Q|CCNA1_uc010abp.2_Silent_p.Q302Q|CCNA1_uc001uvs.3_Silent_p.Q345Q|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	346					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		CCACCAACCAGTTTCTCCTTC	0.448												
SPERT	220082	broad.mit.edu	37	13	46287489	46287489	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr13:46287489C>A	uc001van.1	+	3	409	c.329C>A	c.(328-330)GCC>GAC	p.A110D	SPERT_uc001vao.2_Missense_Mutation_p.A74D	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	110						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		ATGTCCCAGGCCGACCTGGAG	0.652												
TMCO3	55002	broad.mit.edu	37	13	114202736	114202736	+	Missense_Mutation	SNP	G	G	A	rs145599687		TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr13:114202736G>A	uc001vtu.3	+	12	2250	c.1889G>A	c.(1888-1890)CGG>CAG	p.R630Q		NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	630						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			CTGGGGAGCCGGGCGCGAAGA	0.647												
LRRC16B	90668	broad.mit.edu	37	14	24538363	24538363	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr14:24538363C>T	uc001wlj.2	+	39	4157	c.4000C>T	c.(4000-4002)CGG>TGG	p.R1334W	LRRC16B_uc001wlk.2_Missense_Mutation_p.R387W|CPNE6_uc010tnv.1_5'Flank|CPNE6_uc001wlm.2_5'Flank|CPNE6_uc001wll.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1334										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		TGATCCAGGCCGGCGGACTGC	0.612												
RYR3	6263	broad.mit.edu	37	15	34102755	34102755	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr15:34102755G>A	uc001zhi.2	+	71	10172	c.10102G>A	c.(10102-10104)GTG>ATG	p.V3368M	RYR3_uc010bar.2_Missense_Mutation_p.V3363M	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3368					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTCCCTCATCGTGGCTGCACT	0.502												
AVEN	57099	broad.mit.edu	37	15	34158855	34158855	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr15:34158855C>T	uc001zhj.2	-	6	1104	c.1048G>A	c.(1048-1050)GAG>AAG	p.E350K		NM_020371	NP_065104	Q9NQS1	AVEN_HUMAN	cell death regulator aven	350					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			kidney(1)	1		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		AGCTCTTCCTCGGTAACATTT	0.428												
DUOX1	53905	broad.mit.edu	37	15	45442866	45442866	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr15:45442866G>A	uc001zus.1	+	23	3201	c.2855G>A	c.(2854-2856)CGG>CAG	p.R952Q	DUOX1_uc001zut.1_Missense_Mutation_p.R952Q|DUOX1_uc010bee.1_Missense_Mutation_p.R332Q|DUOX1_uc001zuu.2_Missense_Mutation_p.R94Q	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	952	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GACCTCTGCCGGCGAGCCTCC	0.597												
SEMA6D	80031	broad.mit.edu	37	15	48063347	48063347	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr15:48063347T>C	uc010bek.2	+	19	2947	c.2587T>C	c.(2587-2589)TCA>CCA	p.S863P	SEMA6D_uc001zvw.2_Missense_Mutation_p.S801P|SEMA6D_uc001zvy.2_Missense_Mutation_p.S863P|SEMA6D_uc001zvz.2_Missense_Mutation_p.S807P|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.S801P|SEMA6D_uc001zwc.2_Missense_Mutation_p.S788P	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	863	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TCTCACAAAGTCATCCAGTAA	0.428												
MEF2A	4205	broad.mit.edu	37	15	100214776	100214776	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr15:100214776C>T	uc010urw.1	+	5	934	c.575C>T	c.(574-576)TCT>TTT	p.S192F	MEF2A_uc010urv.1_Missense_Mutation_p.S122F|MEF2A_uc010bos.2_Missense_Mutation_p.S190F|MEF2A_uc002bvf.2_Missense_Mutation_p.S192F|MEF2A_uc002bve.2_Missense_Mutation_p.S190F|MEF2A_uc002bvg.2_Missense_Mutation_p.S190F|MEF2A_uc002bvi.2_Missense_Mutation_p.S190F|MEF2A_uc010bot.2_Missense_Mutation_p.S122F	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A isoform 1	192					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			AGAAATGTGTCTCCTGGAGCT	0.453												
C16orf11	146325	broad.mit.edu	37	16	613320	613320	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr16:613320G>A	uc002chk.2	+	2	305	c.26G>A	c.(25-27)CGC>CAC	p.R9H		NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	9										central_nervous_system(1)	1						GGCTCATGCCGCGTGGGCACA	0.662												
SOX8	30812	broad.mit.edu	37	16	1035103	1035103	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr16:1035103G>A	uc002ckn.2	+	3	1173	c.1058G>A	c.(1057-1059)CGA>CAA	p.R353Q		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	353					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				GACCAGCCCCGAGGCTCGCCC	0.647												
NLRC3	197358	broad.mit.edu	37	16	3614583	3614583	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr16:3614583C>A	uc010btn.2	-	5	766	c.355G>T	c.(355-357)GCC>TCC	p.A119S		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	119					I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						ACGGTCCTGGCGGGGTGCCCG	0.706												
NETO2	81831	broad.mit.edu	37	16	47143563	47143563	+	Silent	SNP	G	G	A	rs139454743		TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr16:47143563G>A	uc002eer.1	-	7	1099	c.714C>T	c.(712-714)TTC>TTT	p.F238F	NETO2_uc002eeq.1_Silent_p.F11F|NETO2_uc010vgf.1_Silent_p.F95F|NETO2_uc002ees.1_Silent_p.F231F	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	238	Extracellular (Potential).|CUB 2.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				AGACTGCAACGAAGTTTCTCT	0.353										HNSCC(25;0.065)		
CNGB1	1258	broad.mit.edu	37	16	58001053	58001053	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr16:58001053G>A	uc002emt.2	-	2	203	c.138C>T	c.(136-138)GCC>GCT	p.A46A	CNGB1_uc010cdh.2_Silent_p.A46A|CNGB1_uc002emu.2_Silent_p.A46A	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	46	Glu-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						ACTCTGTCTCGGCCTCCTCAG	0.627												
SERPINB2	5055	broad.mit.edu	37	18	61565002	61565002	+	Silent	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr18:61565002C>T	uc010xeu.1	+	6	792	c.459C>T	c.(457-459)CCC>CCT	p.P153P	SERPINB2_uc002ljo.2_Silent_p.P153P|SERPINB2_uc010dqh.2_Silent_p.P83P|SERPINB2_uc002ljp.1_5'UTR|SERPINB2_uc002ljq.1_5'UTR	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	153					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CCTCAGAACCCCAGGCAGTAG	0.353												
MUC16	94025	broad.mit.edu	37	19	9086755	9086755	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr19:9086755C>A	uc002mkp.2	-	1	5264	c.5060G>T	c.(5059-5061)AGT>ATT	p.S1687I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1687	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCTGGAGCACTAGTAACAAG	0.483												
GIPC1	10755	broad.mit.edu	37	19	14591487	14591487	+	Missense_Mutation	SNP	C	C	T	rs151133470		TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr19:14591487C>T	uc002myt.2	-	5	662	c.392G>A	c.(391-393)CGC>CAC	p.R131H	GIPC1_uc002myu.2_Missense_Mutation_p.R131H|GIPC1_uc002myv.2_Missense_Mutation_p.R34H|GIPC1_uc002myw.2_Missense_Mutation_p.R34H|GIPC1_uc002myx.2_Missense_Mutation_p.R131H|GIPC1_uc002myy.2_Missense_Mutation_p.R34H	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	131					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						CACCTCCTTGCGCTGCCCCTT	0.617											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
ZNF567	163081	broad.mit.edu	37	19	37211224	37211224	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr19:37211224A>C	uc010xtl.1	+	6	1820	c.1598A>C	c.(1597-1599)TAT>TCT	p.Y533S	ZNF567_uc002oeo.1_Missense_Mutation_p.Y533S|ZNF567_uc010xtk.1_Missense_Mutation_p.Y533S|ZNF567_uc002oep.3_Missense_Mutation_p.Y502S|ZNF567_uc002oeq.1_Missense_Mutation_p.Y502S	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	533	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GAGAAACCCTATGTTTGTAAT	0.393												
MBOAT2	129642	broad.mit.edu	37	2	9008633	9008633	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:9008633G>A	uc002qzg.1	-	9	1063	c.930C>T	c.(928-930)GAC>GAT	p.D310D	MBOAT2_uc010yix.1_Silent_p.D310D	NM_138799	NP_620154	Q6ZWT7	MBOA2_HUMAN	O-acyltransferase (membrane bound) domain	310					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTCCATTTTCGTCATACCCTC	0.333												
DDX1	1653	broad.mit.edu	37	2	15742674	15742674	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:15742674A>G	uc002rce.2	+	7	598	c.310A>G	c.(310-312)ATT>GTT	p.I104V	DDX1_uc010yjq.1_Missense_Mutation_p.I12V	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	104	B30.2/SPRY.|Necessary for interaction with HNRNPK.|Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		AAATCCAGCAATTGGGTCAGA	0.393												
CRIM1	51232	broad.mit.edu	37	2	36749368	36749368	+	Silent	SNP	C	C	T	rs142923562	by1000genomes	TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:36749368C>T	uc002rpd.2	+	13	2379	c.2340C>T	c.(2338-2340)AGC>AGT	p.S780S		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	780	Extracellular (Potential).|VWFC 5.				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				GCATTGATAGCGTAATTAGCT	0.468												
VWA3B	200403	broad.mit.edu	37	2	98804462	98804462	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:98804462G>A	uc002syo.2	+	10	1600	c.1336G>A	c.(1336-1338)GCA>ACA	p.A446T	VWA3B_uc010yvh.1_Missense_Mutation_p.A296T|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_Intron|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.2_Missense_Mutation_p.A446T|VWA3B_uc002syn.1_Intron|VWA3B_uc010yvi.1_Missense_Mutation_p.A103T	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	446								p.A446A(1)		ovary(3)|large_intestine(2)|skin(1)	6						GACAGTCCATGCAAAATATTG	0.478												
NPHP1	4867	broad.mit.edu	37	2	110881384	110881384	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:110881384C>T	uc002tfn.3	-	20	2277	c.2183G>A	c.(2182-2184)AGA>AAA	p.R728K	NPHP1_uc002tfm.3_Missense_Mutation_p.R673K|NPHP1_uc002tfl.3_Missense_Mutation_p.R729K|NPHP1_uc002tfo.3_Missense_Mutation_p.R610K|NPHP1_uc010ywx.1_Missense_Mutation_p.R672K	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	728					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						TGCATTCTTTCTCATTTCACC	0.483												
SCN9A	6335	broad.mit.edu	37	2	167055493	167055493	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:167055493G>A	uc010fpl.2	-	27	5964	c.5623C>T	c.(5623-5625)CGG>TGG	p.R1875W	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1886						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTTGTTTCCGTTTTAGTGTG	0.403												
TLK1	9874	broad.mit.edu	37	2	171854267	171854267	+	Silent	SNP	T	T	C	rs149221901		TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:171854267T>C	uc002ugn.2	-	19	2443	c.1971A>G	c.(1969-1971)GTA>GTG	p.V657V	TLK1_uc002ugo.2_Silent_p.V678V|TLK1_uc002ugp.2_Silent_p.V609V|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Silent_p.V561V	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	657	Protein kinase.				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						CAACCGACCATACATCAACCT	0.368												
WIPF1	7456	broad.mit.edu	37	2	175432646	175432646	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:175432646G>A	uc002uiy.2	-	7	1617	c.1285C>T	c.(1285-1287)CCC>TCC	p.P429S	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.P429S|WIPF1_uc010fqt.1_Missense_Mutation_p.P429S|WIPF1_uc002uiz.2_Missense_Mutation_p.P429S|WIPF1_uc002ujb.1_Missense_Mutation_p.P429S	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	429	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GGAGGTGGGGGAGGTGCCCCA	0.587												
HOXD9	3235	broad.mit.edu	37	2	176987764	176987764	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:176987764G>T	uc010zex.1	+	1	352	c.268G>T	c.(268-270)GCG>TCG	p.A90S		NM_014213	NP_055028	P28356	HXD9_HUMAN	homeobox D9	90						nucleus	sequence-specific DNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CCCGGCAGCGGCGGCGATGAG	0.741												
TTC30B	150737	broad.mit.edu	37	2	178417162	178417162	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:178417162G>A	uc002uln.2	-	1	363	c.330C>T	c.(328-330)GCC>GCT	p.A110A	TTC30B_uc010zfc.1_5'UTR	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	110					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			GGCTGTGGTAGGCGGGGTTAT	0.637												
TTN	7273	broad.mit.edu	37	2	179393870	179393870	+	Silent	SNP	G	G	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr2:179393870G>C	uc010zfg.1	-	309	99128	c.98904C>G	c.(98902-98904)GTC>GTG	p.V32968V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.V26663V|TTN_uc010zfi.1_Silent_p.V26596V|TTN_uc010zfj.1_Silent_p.V26471V|TTN_uc002umq.2_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33895							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCTCTTGGACAACAGCTT	0.388												
TGM6	343641	broad.mit.edu	37	20	2381041	2381041	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr20:2381041G>A	uc002wfy.1	+	7	1001	c.940G>A	c.(940-942)GTG>ATG	p.V314M	TGM6_uc010gal.1_Missense_Mutation_p.V314M	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	314					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GGACAAATACGTGGACTCCTT	0.617												
C20orf79	140856	broad.mit.edu	37	20	18794852	18794852	+	Silent	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr20:18794852C>T	uc002wrk.2	+	1	483	c.393C>T	c.(391-393)GCC>GCT	p.A131A	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	131	SCP2.						sterol binding			skin(3)	3						CTTTCCTTGCCGGAAAGTTCA	0.478												
PTPRT	11122	broad.mit.edu	37	20	40733227	40733227	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr20:40733227T>G	uc002xkg.2	-	25	3706	c.3522A>C	c.(3520-3522)CAA>CAC	p.Q1174H	PTPRT_uc010ggj.2_Missense_Mutation_p.Q1193H|PTPRT_uc010ggi.2_Missense_Mutation_p.Q377H	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1174	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CATCTTTGATTTGGCTGGAGT	0.378												
ARFGEF2	10564	broad.mit.edu	37	20	47605094	47605094	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr20:47605094C>A	uc002xtx.3	+	18	2580	c.2428C>A	c.(2428-2430)CTG>ATG	p.L810M	ARFGEF2_uc010zyf.1_Missense_Mutation_p.L103M	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	810					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TAGTAAAGATCTGCCAGAAGA	0.294												
SEZ6L	23544	broad.mit.edu	37	22	26709789	26709789	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr22:26709789G>A	uc003acb.2	+	9	2092	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K	SEZ6L_uc003acc.2_Missense_Mutation_p.E646K|SEZ6L_uc011akc.1_Missense_Mutation_p.E646K|SEZ6L_uc003acd.2_Missense_Mutation_p.E646K|SEZ6L_uc011akd.1_Missense_Mutation_p.E646K|SEZ6L_uc003ace.2_Missense_Mutation_p.E646K|SEZ6L_uc003acf.1_Missense_Mutation_p.E419K|SEZ6L_uc010gvc.1_Missense_Mutation_p.E419K	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	646	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						AAACTGGCCCGAGCCCTACGT	0.493												
NEFH	4744	broad.mit.edu	37	22	29885490	29885490	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr22:29885490C>A	uc003afo.2	+	4	1932	c.1861C>A	c.(1861-1863)CCA>ACA	p.P621T	NEFH_uc003afp.2_Intron	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	621	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament					0						gGCCAAGTCCCCAGTGAAGGA	0.453												
GTSE1	51512	broad.mit.edu	37	22	46724658	46724658	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr22:46724658C>T	uc011aqy.1	+	10	2010	c.1798C>T	c.(1798-1800)CCT>TCT	p.P600S	GTSE1_uc011aqz.1_Missense_Mutation_p.P447S|GTSE1_uc003bhm.1_Missense_Mutation_p.P225S|GTSE1_uc003bhn.2_5'Flank|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	581					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CAGGGGTTCTCCTCCTTCCCG	0.493												
GLB1	2720	broad.mit.edu	37	3	33055719	33055719	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr3:33055719G>A	uc003cfi.1	-	15	1680	c.1563C>T	c.(1561-1563)CGC>CGT	p.R521R	GLB1_uc003cfh.1_Silent_p.R491R|GLB1_uc003cfj.1_Silent_p.R390R|GLB1_uc011axk.1_Silent_p.C569C	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	521					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				CCAGGTGGCTGCACACTGCAT	0.552												
CTNNB1	1499	broad.mit.edu	37	3	41266103	41266103	+	Missense_Mutation	SNP	G	G	A	rs121913399		TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr3:41266103G>A	uc010hia.1	+	4	256	c.100G>A	c.(100-102)GGA>AGA	p.G34R	CTNNB1_uc003ckp.2_Missense_Mutation_p.G34R|CTNNB1_uc003ckq.2_Missense_Mutation_p.G34R|CTNNB1_uc003ckr.2_Missense_Mutation_p.G34R|CTNNB1_uc011azf.1_Missense_Mutation_p.G27R|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	34			G -> E (in PTR).|G -> R (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.G34V(64)|p.G34E(64)|p.A5_A80del(63)|p.G34R(60)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.W25_H36del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.S29_H36del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.W25_I35del(1)|p.V22_G80>NNNNN(1)|p.GIHS34?(1)|p.A5_I35del(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.V22_T102del(1)|p.S33_G34del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.G34_S37del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.D32_H36>D(1)|p.S33_G34insGTS(1)|p.P16_K133del(1)|p.A5_T59del(1)|p.A20_I35del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.V22_Y64del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.S33_G34insS(1)|p.Y30_T40del(1)|p.S33_G34insGI(1)|p.M1_T42del(1)|p.A5_Q143>E(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.S23_I35del(1)|p.V22_S71>A(1)|p.W25_A80del(1)|p.A20_Q72del(1)|p.A20_S111del(1)|p.D32_H36del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CCTGGACTCTGGAATCCATTC	0.488		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of			
SEMA5B	54437	broad.mit.edu	37	3	122630821	122630821	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr3:122630821C>T	uc003efz.1	-	20	3296	c.2992G>A	c.(2992-2994)GCC>ACC	p.A998T	SEMA5B_uc011bju.1_Missense_Mutation_p.A904T|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.A998T|SEMA5B_uc003efy.1_5'UTR	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	998	Extracellular (Potential).|TSP type-1 5.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CCAGCACAGGCGCTGGACCCT	0.667												
FAT4	79633	broad.mit.edu	37	4	126239828	126239828	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr4:126239828A>C	uc003ifj.3	+	1	2262	c.2262A>C	c.(2260-2262)GAA>GAC	p.E754D		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	754	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TAGACAGAGAAGAAAAAACAG	0.428												
C4orf29	80167	broad.mit.edu	37	4	128951826	128951826	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr4:128951826A>G	uc003ifr.2	+	12	1558	c.1240A>G	c.(1240-1242)AGG>GGG	p.R414G	C4orf29_uc003ifs.2_Missense_Mutation_p.R342G|C4orf29_uc003ift.2_Missense_Mutation_p.R279G|C4orf29_uc003ifu.2_Missense_Mutation_p.R279G|C4orf29_uc010inz.2_Missense_Mutation_p.R245G|C4orf29_uc003ifv.2_Missense_Mutation_p.R279G	NM_001039717	NP_001034806	Q0P651	CD029_HUMAN	hypothetical protein LOC80167 precursor	414						extracellular region				ovary(1)	1						AGGACTCTTCAGGTAAGACGG	0.348												
F11	2160	broad.mit.edu	37	4	187209681	187209681	+	Silent	SNP	A	A	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr4:187209681A>G	uc003iza.1	+	15	2124	c.1791A>G	c.(1789-1791)GAA>GAG	p.E597E	uc003izb.1_RNA	NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	597	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GCTGGGGCGAAGGCTGTGCTC	0.557												
ADRB2	154	broad.mit.edu	37	5	148207465	148207465	+	Silent	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr5:148207465C>T	uc003lpr.1	+	1	1310	c.1071C>T	c.(1069-1071)AAC>AAT	p.N357N	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	357	Cytoplasmic.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	ACTCCAGCAACGGCAACACAG	0.527												
MYOZ3	91977	broad.mit.edu	37	5	150050196	150050196	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr5:150050196G>A	uc003lss.2	+	3	799	c.212G>A	c.(211-213)CGG>CAG	p.R71Q	MYOZ3_uc003lsr.2_Missense_Mutation_p.R71Q	NM_001122853	NP_001116325	Q8TDC0	MYOZ3_HUMAN	myozenin 3	71	Binding to FLNC.					sarcomere	protein binding			skin(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCCAGCCAGCGGGCGGTGAGT	0.383												
FAM153A	285596	broad.mit.edu	37	5	177156542	177156542	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr5:177156542G>T	uc010jkp.1	-	18	1067	c.646C>A	c.(646-648)CTG>ATG	p.L216M	FAM153A_uc011dgd.1_Intron|FAM153A_uc003mib.1_RNA|FAM153A_uc003mic.2_Missense_Mutation_p.L216M	NM_173663	NP_775934	Q9UHL3	F153A_HUMAN	hypothetical protein LOC285596	216										skin(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCTCCTCCAGGTCTTCCAGG	0.512												
DDX43	55510	broad.mit.edu	37	6	74110065	74110065	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr6:74110065T>G	uc003pgw.2	+	3	759	c.415T>G	c.(415-417)TAC>GAC	p.Y139D	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	139						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						AGAAGAAAATTACAATTCAGA	0.323												
C6orf165	154313	broad.mit.edu	37	6	88119576	88119576	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr6:88119576G>A	uc003plv.2	+	2	111	c.19G>A	c.(19-21)GAA>AAA	p.E7K	C6orf165_uc003plw.2_5'UTR|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.E7K	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	7										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AACTCAGGCCGAAAGTGTTAT	0.333												
IYD	389434	broad.mit.edu	37	6	150710675	150710675	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr6:150710675G>A	uc003qnu.1	+	2	506	c.366G>A	c.(364-366)ACG>ACA	p.T122T	IYD_uc003qnv.1_Silent_p.T122T|IYD_uc003qnw.1_RNA|IYD_uc003qnx.1_Silent_p.T122T|IYD_uc010kik.1_Intron	NM_203395	NP_981932	Q6PHW0	IYD1_HUMAN	iodotyrosine dehalogenase 1 isoform 2	122	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				ovary(2)	2		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		TCATCAGAACGGCAGGTTTGT	0.388												
SMOC2	64094	broad.mit.edu	37	6	169051410	169051410	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr6:169051410G>A	uc003qws.1	+	10	977	c.957G>A	c.(955-957)GCG>GCA	p.A319A	SMOC2_uc003qwr.1_Silent_p.A330A|SMOC2_uc011egu.1_5'UTR	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	319					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		TTCTGGACGCGCTGTCCACGG	0.532												
KLHL7	55975	broad.mit.edu	37	7	23183596	23183596	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr7:23183596G>C	uc003svs.3	+	6	1038	c.745G>C	c.(745-747)GCT>CCT	p.A249P	KLHL7_uc003svr.3_Missense_Mutation_p.A227P|KLHL7_uc011jys.1_Missense_Mutation_p.A173P|KLHL7_uc011jyt.1_Missense_Mutation_p.A24P|KLHL7_uc003svt.2_Missense_Mutation_p.A201P|KLHL7_uc011jyv.1_Missense_Mutation_p.A24P	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	249						Golgi apparatus|nucleolus|plasma membrane					0						AACGGTACAAGCTGAACCACT	0.358												
LRRC17	10234	broad.mit.edu	37	7	102584659	102584659	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr7:102584659G>A	uc003vau.2	+	4	1320	c.931G>A	c.(931-933)GCT>ACT	p.A311T	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_3'UTR	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	311	LRR 5.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						GTTTCCAGCCGCTTTTTTAGG	0.274												
ST7	7982	broad.mit.edu	37	7	116811007	116811007	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr7:116811007A>C	uc003vin.2	+	10	1269	c.1055A>C	c.(1054-1056)CAG>CCG	p.Q352P	ST7_uc011knl.1_Missense_Mutation_p.Q329P|ST7_uc003vio.2_Missense_Mutation_p.Q329P|ST7_uc003viq.2_Missense_Mutation_p.Q306P|ST7_uc011knm.1_Missense_Mutation_p.Q309P|ST7_uc003vir.2_Missense_Mutation_p.Q277P|ST7_uc011knn.1_Missense_Mutation_p.Q300P|ST7_uc003vix.1_Missense_Mutation_p.Q165P	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	352						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GCTGATGTTCAGGCAGTCTTA	0.378												
C8orf74	203076	broad.mit.edu	37	8	10555329	10555329	+	Silent	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr8:10555329C>T	uc003wtd.1	+	3	491	c.462C>T	c.(460-462)GCC>GCT	p.A154A	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	154											0				COAD - Colon adenocarcinoma(149;0.0811)		TCCCGCTGGCCGAGGGCATGG	0.642												
MTUS1	57509	broad.mit.edu	37	8	17612060	17612060	+	Silent	SNP	G	G	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr8:17612060G>C	uc003wxv.2	-	2	1731	c.1257C>G	c.(1255-1257)GTC>GTG	p.V419V	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Silent_p.V419V|MTUS1_uc010lsz.2_Silent_p.V419V	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	419						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		CTGTGCTAATGACCATATCAT	0.443												
KCNQ3	3786	broad.mit.edu	37	8	133192544	133192544	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr8:133192544C>A	uc003ytj.2	-	4	862	c.637G>T	c.(637-639)GTT>TTT	p.V213F	KCNQ3_uc010mdt.2_Missense_Mutation_p.V213F	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	213	Helical; Name=Segment S3; (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CCCACAGCAACCACTGGCACA	0.582												
TLN1	7094	broad.mit.edu	37	9	35715063	35715063	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr9:35715063C>T	uc003zxt.2	-	21	3101	c.2747G>A	c.(2746-2748)CGC>CAC	p.R916H		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	916					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CACCTCCAGGCGCTGCACCAG	0.587												
ZER1	10444	broad.mit.edu	37	9	131503885	131503885	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr9:131503885C>T	uc004bwa.1	-	11	2099	c.1666G>A	c.(1666-1668)GAT>AAT	p.D556N		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	556	ARM 2.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						GGAGTTTCATCTGTGATGTTC	0.582												
NOTCH1	4851	broad.mit.edu	37	9	139391079	139391079	+	Missense_Mutation	SNP	G	G	C			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr9:139391079G>C	uc004chz.2	-	34	7112	c.7112C>G	c.(7111-7113)ACC>AGC	p.T2371S		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2371	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCCAGCCGGGTGCTGGGCAG	0.642			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)		
TPRN	286262	broad.mit.edu	37	9	140093635	140093635	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr9:140093635C>A	uc004clt.2	-	1	1346	c.1346G>T	c.(1345-1347)GGG>GTG	p.G449V	TPRN_uc004clu.2_Missense_Mutation_p.G449V	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	510					sensory perception of sound	stereocilium					0						CTGCAGAGTCCCTGGCTTCCT	0.677												
USP9X	8239	broad.mit.edu	37	X	41000004	41000004	+	Silent	SNP	A	A	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chrX:41000004A>G	uc004dfb.2	+	7	1383	c.750A>G	c.(748-750)CAA>CAG	p.Q250Q	USP9X_uc004dfc.2_Silent_p.Q250Q	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	250					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TAAACGTTCAAATAATTGCAG	0.333												
IQSEC2	23096	broad.mit.edu	37	X	53280144	53280144	+	Silent	SNP	T	T	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chrX:53280144T>G	uc004dsd.2	-	5	1815	c.1614A>C	c.(1612-1614)CCA>CCC	p.P538P	IQSEC2_uc004dsc.2_Silent_p.P333P	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	528	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						GGCCCTGGGGTGGGGGTTCTG	0.632												
TBX22	50945	broad.mit.edu	37	X	79283522	79283522	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chrX:79283522C>T	uc010nmg.1	+	8	1030	c.896C>T	c.(895-897)CCA>CTA	p.P299L	TBX22_uc004edi.1_Missense_Mutation_p.P179L|TBX22_uc004edj.1_Missense_Mutation_p.P299L	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	299					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						GAGACCTACCCATGGAGGCCT	0.353												
ACTRT1	139741	broad.mit.edu	37	X	127185409	127185409	+	Silent	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chrX:127185409G>A	uc004eum.2	-	1	974	c.777C>T	c.(775-777)CCC>CCT	p.P259P		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	259						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						AAAGAACCTCGGGCACTTGGT	0.532												
SMARCA1	6594	broad.mit.edu	37	X	128622973	128622973	+	Nonsense_Mutation	SNP	T	T	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chrX:128622973T>A	uc004eun.3	-	16	2151	c.2038A>T	c.(2038-2040)AAA>TAA	p.K680*	SMARCA1_uc004eup.3_Nonsense_Mutation_p.K668*|SMARCA1_uc011muk.1_Nonsense_Mutation_p.K680*|SMARCA1_uc011mul.1_Nonsense_Mutation_p.K668*	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	680					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TCACTCTCTTTAGAAGCAAAA	0.363												
PLXNA3	55558	broad.mit.edu	37	X	153698478	153698478	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chrX:153698478G>A	uc004flm.2	+	29	5127	c.4954G>A	c.(4954-4956)GAG>AAG	p.E1652K		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1652	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GATGGTCTCCGAGATCTACCT	0.637												
PRKCA	5578	broad.mit.edu	37	17	64683380	64683397	+	Splice_Site	DEL	TACATTGTAAGTGGTCTC	TACATTGTAAGTGGTCTC	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr17:64683380_64683397delTACATTGTAAGTGGTCTC	uc002jfp.1	+	6	730	c.686_splice	c.e6+1	p.F229_splice	PRKCA_uc002jfo.1_Splice_Site_p.F100_splice	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha						activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	ATGAGTCCTTTACATTGTAAGTGGTCTCTCCTTGATCA	0.385												
RIPK4	54101	broad.mit.edu	37	21	43165916	43165917	+	Splice_Site	INS	-	-	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr21:43165916_43165917insA	uc002yzn.1	-	6	984	c.936_splice	c.e6+1	p.E312_splice		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3							cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						AAGGACTCGTTACCTCGCTCCT	0.569												
RIPK4	54101	broad.mit.edu	37	21	43165917	43165918	+	Splice_Site	INS	-	-	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr21:43165916_43165917T>TA	uc002yzn.1	-	6	984	c.936_splice	c.e6+1	p.E312_splice		NM_020639	NP_065690	Q96T11	Q96T11_HUMAN	Homo sapiens receptor-interacting serine-threonine kinase 4 (RIPK4), mRNA.	312						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AAGGACTCGTTACCTCGCTCCT	0.569												
ARID1A	8289	broad.mit.edu	37	1	27100852	27100852	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:27100852delC	uc001bmv.1	+	18	4507	c.4134delC	c.(4132-4134)GGCfs	p.G1378fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.G1377fs|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Frame_Shift_Del_p.G995fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.G224fs|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1378	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCACATATGGCCCTCCTGCCA	0.587			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
FAM46C	54855	broad.mit.edu	37	1	118165775	118165775	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr1:118165775delC	uc001ehe.2	+	2	484	c.285delC	c.(283-285)TTCfs	p.F95fs		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	95											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		ACCTAATCTTCCATGTGGCTC	0.517										Multiple Myeloma(3;1.13e-06)		
PRKCA	5578	broad.mit.edu	37	17	64683380	64683397	+	Splice_Site	DEL	TACATTGTAAGTGGTCTC	TACATTGTAAGTGGTCTC	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr17:64683380_64683397delTACATTGTAAGTGGTCTC	uc002jfp.1	+	6	730	c.686_splice	c.e6+1	p.F229_splice	PRKCA_uc002jfo.1_Splice_Site_p.F100_splice	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha						activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	ATGAGTCCTTTACATTGTAAGTGGTCTCTCCTTGATCA	0.385												
RIPK4	54101	broad.mit.edu	37	21	43165916	43165917	+	Splice_Site	INS	-	-	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr21:43165916_43165917insA	uc002yzn.1	-	6	984	c.936_splice	c.e6+1	p.E312_splice		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3							cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						AAGGACTCGTTACCTCGCTCCT	0.569												
KIAA1549	57670	broad.mit.edu	37	7	138564334	138564334	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr7:138564334delT	uc011kql.1	-	12	4344	c.4295delA	c.(4294-4296)AAGfs	p.K1432fs	KIAA1549_uc011kqi.1_Frame_Shift_Del_p.K216fs|KIAA1549_uc003vuk.3_Frame_Shift_Del_p.K1382fs|KIAA1549_uc011kqj.1_Frame_Shift_Del_p.K1432fs|KIAA1549_uc011kqk.1_Frame_Shift_Del_p.K216fs	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1432						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TCCCGGCGTCTTATCTCCTGC	0.517			O	BRAF	pilocytic astrocytoma							
RNF128	79589	broad.mit.edu	37	X	105937253	105937254	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chrX:105937253_105937254delCA	uc004emk.2	+	1	186_187	c.21_22delCA	c.(19-24)TCCAGTfs	p.S7fs		NM_024539	NP_078815	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 2	Error:Variant_position_missing_in_Q8TEB7_after_alignment						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGAATAGGTCCAGTTTTTTTTG	0.347												
DOM3Z	1797	broad.mit.edu	37	6	31938556	31938579	+	In_Frame_Del	DEL	GTTGGTGTTAACCTCCCCAGAGGG	GTTGGTGTTAACCTCCCCAGAGGG	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr6:31938555_31938578CGTTGGTGTTAACCTCCCCAGAGGG>C	uc003nyp.1	-	3	950_973	c.617_640CCCTCTGGGGAGGTTAACACCAACG>G	c.(616-642)ccctctggggaggttaacaccaacgtg>cGtg	p.206_214PSGEVNTNV>R	DOM3Z_uc003nyq.1_Intron|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.3_5'Flank|STK19_uc011dow.2_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.3_5'Flank|STK19_uc003nyw.3_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	Homo sapiens dom-3 homolog Z (C. elegans) (DOM3Z), mRNA.	206							identical protein binding|metal ion binding|nucleotide binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	7						CAGAAGGCCACGTTGGTGTTAACCTCCCCAGAGGGGTCTGGGGA	0.625												
LIPF	8513	broad.mit.edu	37	10	90438326	90438326	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr10:90438325_90438325AT>A	uc001kfg.2	+	9	1198	c.1084_1084AT>A	c.(1084-1086)attfs	p.I362fs	LIPF_uc001kfh.2_Frame_Shift_Del_p.I339fs|LIPF_uc010qmt.2_Frame_Shift_Del_p.I372fs|LIPF_uc010qmu.2_Frame_Shift_Del_p.I329fs	NM_004190	NP_004181	P07098	LIPG_HUMAN	Homo sapiens lipase, gastric (LIPF), transcript variant 2, mRNA.	362					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		CCCCAATCTTATTTACCACAA	0.438												
AOC3	8639	broad.mit.edu	37	17	41003597	41003598	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr17:41003596_41003597T>TG	uc002ibv.3	+	0	396_397	c.236_237T>TG	c.(235-237)ctgfs	p.L79fs		NM_003734	NP_003725	Q16853	AOC3_HUMAN	Homo sapiens amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3), mRNA.	79					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	ACCCAGCGGCTGGGGCCAGGGC	0.658												
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653												
RIPK4	54101	broad.mit.edu	37	21	43165917	43165918	+	Splice_Site	INS	-	-	A			TCGA-HU-A4G6-01A-11D-A24D-08	TCGA-HU-A4G6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c79ce3d3-4758-4f52-9da1-38f994c99f4e	e3e2739f-5f19-4924-8505-3babfd62f636	g.chr21:43165916_43165917T>TA	uc002yzn.1	-	6	984	c.936_splice	c.e6+1	p.E312_splice		NM_020639	NP_065690	Q96T11	Q96T11_HUMAN	Homo sapiens receptor-interacting serine-threonine kinase 4 (RIPK4), mRNA.	312						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AAGGACTCGTTACCTCGCTCCT	0.569